SPDYE21

Summary

SPDYE21 (speedy/RINGO cell cycle regulator family member E21, HGNC:51517) is a protein-coding gene on chromosome 7q11.21, encoding Speedy protein E21 (A0A494C086).

Predicted to enable protein kinase binding activity.

Source: NCBI Gene 442572 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001382715

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51517
Approved symbol	SPDYE21
Name	speedy/RINGO cell cycle regulator family member E21
Location	7q11.21
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000230358
Ensembl biotype	protein_coding
Entrez	442572

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000424157

RefSeq mRNA: 1 — MANE Select: NM_001382715 NM_001382715

CCDS: CCDS94109

Canonical transcript exons

ENST00000424157 — 9 exons

Exon	Start	End
ENSE00001709029	67282635	67282693
ENSE00001758696	67286560	67286664
ENSE00001763734	67279818	67280036
ENSE00001779446	67281374	67281604
ENSE00003483720	67283913	67283998
ENSE00003845774	67278292	67278873
ENSE00003846088	67286044	67286437
ENSE00003934992	67276941	67277062
ENSE00003935521	67287518	67289005

Expression profiles

Bgee: expression breadth ubiquitous, 113 present calls, max score 77.52.

Top tissues by expression

121 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.52	gold quality
bone marrow cell	CL:0002092	58.02	gold quality
bone marrow	UBERON:0002371	55.22	silver quality
tonsil	UBERON:0002372	53.93	silver quality
colonic epithelium	UBERON:0000397	52.48	gold quality
adrenal tissue	UBERON:0018303	50.80	gold quality
lower esophagus mucosa	UBERON:0035834	50.08	gold quality
apex of heart	UBERON:0002098	49.17	gold quality
granulocyte	CL:0000094	48.16	silver quality
lymph node	UBERON:0000029	47.70	gold quality
uterine cervix	UBERON:0000002	47.41	gold quality
ectocervix	UBERON:0012249	47.32	gold quality
cortex of kidney	UBERON:0001225	47.20	gold quality
smooth muscle tissue	UBERON:0001135	47.08	gold quality
left adrenal gland	UBERON:0001234	46.89	gold quality
testis	UBERON:0000473	46.83	gold quality
hindlimb stylopod muscle	UBERON:0004252	46.72	gold quality
kidney	UBERON:0002113	46.69	gold quality
adrenal gland	UBERON:0002369	46.52	gold quality
left adrenal gland cortex	UBERON:0035825	46.34	gold quality
adult mammalian kidney	UBERON:0000082	46.18	gold quality
left testis	UBERON:0004533	46.02	gold quality
urinary bladder	UBERON:0001255	45.69	silver quality
gastrocnemius	UBERON:0001388	45.23	gold quality
right lobe of thyroid gland	UBERON:0001119	45.10	gold quality
blood	UBERON:0000178	45.00	gold quality
right testis	UBERON:0004534	44.97	gold quality
stromal cell of endometrium	CL:0002255	44.89	gold quality
myometrium	UBERON:0001296	44.81	gold quality
muscle of leg	UBERON:0001383	44.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.77

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Spdye4b	ENSMUSG00000029586
mus_musculus	Spdye4a	ENSMUSG00000039296
rattus_norvegicus	Spdye4	ENSRNOG00000058563

Paralogs (18): SPDYE1 (ENSG00000136206), SPDYE5 (ENSG00000170092), SPDYE2B (ENSG00000173678), SPDYE4 (ENSG00000183318), SPDYE12 (ENSG00000184616), SPDYE16 (ENSG00000185040), SPDYE17 (ENSG00000186645), SPDYE2 (ENSG00000205238), SPDYE18 (ENSG00000205482), SPDYE3 (ENSG00000214300), SPDYE6 (ENSG00000260097), SPDYE9 (ENSG00000262461), SPDYE8 (ENSG00000273520), SPDYE10 (ENSG00000274570), SPDYE11 (ENSG00000275976), SPDYE15 (ENSG00000286014), SPDYE13 (ENSG00000286038), SPDYE14 (ENSG00000286137)

Protein

Protein identifiers

Speedy protein E21 — A0A494C086 (reviewed: A0A494C086)

All UniProt accessions (1): A0A494C086

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the Speedy/Ringo family.

RefSeq proteins (1): NP_001369644* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR020984	Speedy	Family
IPR057742	Speedy_E	Family

Pfam: PF11357

UniProt features (4 total): compositionally biased region 2, chain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A494C086-F1	60.84	0.19

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 2 (showing top): chr7q11, GOMF_KINASE_BINDING

GO Biological Process (1): positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)

GO Molecular Function (1): protein kinase binding (GO:0019901)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of cyclin-dependent protein serine/threonine kinase activity	1
cyclin-dependent protein serine/threonine kinase activity	1
positive regulation of cell cycle	1
positive regulation of protein serine/threonine kinase activity	1
positive regulation of cyclin-dependent protein kinase activity	1
kinase binding	1

Protein interactions and networks

STRING

4 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SPDYE21	SPDYA	Q5MJ70	0
SPDYE21	SPDYC	Q5MJ68	0

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A0J9YY54, A0A494C086, A0A494C0Z2, A0A494C191, A6NHP3, A6NIY4, A6NJR5, A6NNV3, B4DH59, F6SZT2, P0C6Y7, P0CI01, P0DKJ7, P0DKJ8, P0DTA3, P0DUD1, P0DUD2, P0DUD3, P0DUD4, P0DUX0, P0DUX1, P0DV79, P79386, Q08AG5, Q13342, Q16666, Q3BBV2, Q495Y8, Q587J8, Q5JRC9, Q5QGU6, Q5RD14, Q5RKG3, Q63HK3, Q6ITT4, Q7TQI8, Q86T75, Q8IWY8, Q8N660, Q8NFV5

Diamond homologs: A0A494C086, A0A494C0Z2, A0A494C191, A6NHP3, A6NIY4, A6NJR5, A6NKU9, A6NLX3, A6NNV3, P0CI01, P0DTA3, P0DUD1, P0DUD2, P0DUD3, P0DUD4, P0DUX0, P0DUX1, P0DV79, Q495Y7, Q495Y8, Q5IBH6, Q5IBH7, Q5MJ68, Q5MJ70, Q8NFV5, Q8R496, Q9PU13, Q9YGL1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

2649 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:67282655:T:C	F211L	0.978
7:67282657:C:A	F211L	0.978
7:67282657:C:G	F211L	0.978
7:67281589:T:C	F199L	0.970
7:67281591:C:A	F199L	0.970
7:67281591:C:G	F199L	0.970
7:67283940:T:C	F233L	0.959
7:67283942:C:A	F233L	0.959
7:67283942:C:G	F233L	0.959
7:67286086:A:C	K266N	0.951
7:67286086:A:T	K266N	0.951
7:67286102:T:C	F272L	0.949
7:67286104:C:A	F272L	0.949
7:67286104:C:G	F272L	0.949
7:67283988:T:C	F249L	0.948
7:67283990:C:A	F249L	0.948
7:67283990:C:G	F249L	0.948
7:67282656:T:C	F211S	0.942
7:67282668:A:T	D215V	0.902
7:67282668:A:C	D215A	0.900
7:67286085:A:T	K266I	0.899
7:67283985:T:C	F248L	0.898
7:67283987:C:A	F248L	0.898
7:67283987:C:G	F248L	0.898
7:67282666:G:C	W214C	0.897
7:67282666:G:T	W214C	0.897
7:67282667:G:C	D215H	0.881
7:67281590:T:C	F199S	0.879
7:67282638:A:G	D205G	0.878
7:67282639:T:A	D205E	0.877

dbSNP variants (sampled 300 via entrez): RS1001071444 (7:67281491 A>G,T), RS1001123750 (7:67280302 A>C), RS1001305551 (7:67288059 T>C), RS1001346610 (7:67288909 G>A), RS1003083438 (7:67276559 C>T), RS1004207200 (7:67276864 G>A), RS1004494358 (7:67275121 G>C), RS1005079182 (7:67283976 C>A,T), RS1005257401 (7:67278869 A>T), RS1005436569 (7:67284673 G>A), RS1005653076 (7:67286991 C>T), RS1005705177 (7:67286797 T>G), RS1005721294 (7:67278675 C>G), RS1006031665 (7:67286015 C>G,T), RS1006493592 (7:67285825 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	increases expression	1
bisphenol F	affects cotreatment, decreases expression	1
butyraldehyde	decreases expression	1
Dexamethasone	affects cotreatment, decreases expression	1
Indomethacin	affects cotreatment, decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.