SPDYE8

Summary

SPDYE8 (speedy/RINGO cell cycle regulator family member E8, HGNC:33771) is a protein-coding gene on chromosome 7q11.23, encoding Speedy protein E8 (P0DUD1).

Enables acetylcholine receptor regulator activity.

Source: NCBI Gene 728524 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001382525

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33771
Approved symbol	SPDYE8
Name	speedy/RINGO cell cycle regulator family member E8
Location	7q11.23
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000273520
Ensembl biotype	protein_coding
Entrez	728524

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000333385

RefSeq mRNA: 2 — MANE Select: NM_001382525 NM_001382525, NM_001422015

CCDS: CCDS94114

Canonical transcript exons

ENST00000333385 — 8 exons

Exon	Start	End
ENSE00002432238	73029645	73029766
ENSE00002445114	73027837	73028419
ENSE00003711758	73022054	73022158
ENSE00003735145	73025543	73025601
ENSE00003843385	73022281	73022524
ENSE00003846053	73024230	73024315
ENSE00003847665	73026635	73026853
ENSE00003924683	73019719	73021200

Expression profiles

Bgee: expression breadth broad, 12 present calls, max score 53.89.

Top tissues by expression

100 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	53.89	gold quality
cortical plate	UBERON:0005343	48.37	gold quality
colonic epithelium	UBERON:0000397	46.84	gold quality
superior frontal gyrus	UBERON:0002661	46.60	silver quality
placenta	UBERON:0001987	43.57	gold quality
prefrontal cortex	UBERON:0000451	42.78	silver quality
bone marrow	UBERON:0002371	41.89	gold quality
muscle tissue	UBERON:0002385	40.94	gold quality
bone marrow cell	CL:0002092	40.24	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	40.05	silver quality
skeletal muscle tissue	UBERON:0001134	38.66	gold quality
cortex of kidney	UBERON:0001225	38.54	silver quality
adrenal tissue	UBERON:0018303	38.51	gold quality
granulocyte	CL:0000094	37.55	gold quality
kidney	UBERON:0002113	35.94	gold quality
smooth muscle tissue	UBERON:0001135	35.90	silver quality
hindlimb stylopod muscle	UBERON:0004252	35.69	gold quality
cerebellum	UBERON:0002037	35.56	gold quality
apex of heart	UBERON:0002098	35.48	gold quality
fallopian tube	UBERON:0003889	35.48	gold quality
blood	UBERON:0000178	35.41	gold quality
monocyte	CL:0000576	35.31	gold quality
sural nerve	UBERON:0015488	35.29	gold quality
cerebellar cortex	UBERON:0002129	35.27	gold quality
leukocyte	CL:0000738	35.21	gold quality
cerebellar hemisphere	UBERON:0002245	34.94	gold quality
mucosa of stomach	UBERON:0001199	34.85	gold quality
left uterine tube	UBERON:0001303	34.74	silver quality
corpus callosum	UBERON:0002336	33.86	gold quality
muscle of leg	UBERON:0001383	33.80	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Spdye4b	ENSMUSG00000029586
mus_musculus	Spdye4a	ENSMUSG00000039296
rattus_norvegicus	Spdye4	ENSRNOG00000058563

Paralogs (18): SPDYE1 (ENSG00000136206), SPDYE5 (ENSG00000170092), SPDYE2B (ENSG00000173678), SPDYE4 (ENSG00000183318), SPDYE12 (ENSG00000184616), SPDYE16 (ENSG00000185040), SPDYE17 (ENSG00000186645), SPDYE2 (ENSG00000205238), SPDYE18 (ENSG00000205482), SPDYE3 (ENSG00000214300), SPDYE21 (ENSG00000230358), SPDYE6 (ENSG00000260097), SPDYE9 (ENSG00000262461), SPDYE10 (ENSG00000274570), SPDYE11 (ENSG00000275976), SPDYE15 (ENSG00000286014), SPDYE13 (ENSG00000286038), SPDYE14 (ENSG00000286137)

Protein

Protein identifiers

Speedy protein E8 — P0DUD1 (reviewed: P0DUD1)

All UniProt accessions (1): P0DUD1

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the Speedy/Ringo family.

RefSeq proteins (2): NP_001369454, NP_001408944 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR020984	Speedy	Family
IPR057742	Speedy_E	Family

Pfam: PF11357

UniProt features (3 total): chain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DUD1-F1	70.40	0.42

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 3 (showing top): chr7q11, GOMF_KINASE_BINDING, MCCABE_BOUND_BY_HOXC6

GO Biological Process (1): positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)

GO Molecular Function (1): protein kinase binding (GO:0019901)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of cyclin-dependent protein serine/threonine kinase activity	1
cyclin-dependent protein serine/threonine kinase activity	1
positive regulation of cell cycle	1
positive regulation of protein serine/threonine kinase activity	1
positive regulation of cyclin-dependent protein kinase activity	1
kinase binding	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A0J9YY54, A0A494C086, A0A494C0Z2, A0A494C191, A6NHP3, A6NIY4, A6NJR5, A6NNV3, B4DH59, F6SZT2, P0C6Y7, P0CI01, P0DKJ7, P0DKJ8, P0DTA3, P0DUD1, P0DUD2, P0DUD3, P0DUD4, P0DUX0, P0DUX1, P0DV79, P79386, Q08AG5, Q13342, Q16666, Q3BBV2, Q495Y8, Q587J8, Q5JRC9, Q5QGU6, Q5RD14, Q5RKG3, Q63HK3, Q6ITT4, Q7TQI8, Q86T75, Q8IWY8, Q8N660, Q8NFV5

Diamond homologs: A0A494C086, A0A494C0Z2, A0A494C191, A6NHP3, A6NIY4, A6NJR5, A6NKU9, A6NLX3, A6NNV3, P0CI01, P0DTA3, P0DUD1, P0DUD2, P0DUD3, P0DUD4, P0DUX0, P0DUX1, P0DV79, Q495Y7, Q495Y8, Q5IBH6, Q5IBH7, Q5MJ68, Q5MJ70, Q8NFV5, Q8R496, Q9PU13, Q9YGL1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS112179766 (7:73023576 T>A), RS1174598588 (7:73027456 C>T), RS1176834952 (7:73027468 CTTTTTTTTTTTTTTT>C,CTT,CTTT,CTTTTTTT,CTTTTTTTT,CTTTTTTTTTTTTT,CTTTTTTTTTTTTTT,CTTTTTTTTTTTTTTTT), RS1203833240 (7:73026876 C>T), RS1206588594 (7:73027502 T>C), RS1211267149 (7:73027744 G>A), RS1216245338 (7:73027120 G>T), RS1222826543 (7:73027772 C>T), RS1234610275 (7:73027143 G>T), RS1273713002 (7:73027099 T>C), RS1277269167 (7:73027265 C>T), RS1279372751 (7:73027682 T>A), RS1280743919 (7:73027870 C>G), RS1302375855 (7:73027138 G>T), RS1304490010 (7:73027758 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

14 total (human), top 14 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
butyraldehyde	decreases expression	1
pentanal	decreases expression	1
erucylphospho-N,N,N-trimethylpropylammonium	increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Cadmium	decreases expression	1
Folic Acid	decreases expression	1
Gasoline	affects cotreatment, decreases expression, increases abundance	1
Plant Extracts	affects cotreatment, decreases expression	1
Polycyclic Aromatic Hydrocarbons	affects cotreatment, decreases expression, increases abundance	1
Silicon Dioxide	decreases expression	1
Tobacco Smoke Pollution	increases methylation	1
Tretinoin	increases expression	1
1-Butanol	affects cotreatment, decreases expression, increases abundance	1
Particulate Matter	affects cotreatment, decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.