SPEN-AS1

Summary

SPEN-AS1 (SPEN antisense RNA 1, HGNC:55937) is a long non-coding RNA gene on chromosome 1p36.21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55937
Approved symbol	SPEN-AS1
Name	SPEN antisense RNA 1
Location	1p36.21
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ37453
Ensembl gene	ENSG00000179743
Ensembl biotype	lncRNA
Entrez	729614
RNAcentral	URS000075D5B6 — lncRNA, 2732 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 56 — 56 lncRNA

ENST00000317122, ENST00000746503, ENST00000746504, ENST00000746505, ENST00000746506, ENST00000746507, ENST00000746508, ENST00000746509, ENST00000746510, ENST00000746511, ENST00000746512, ENST00000746513, ENST00000746514, ENST00000746515, ENST00000746516, ENST00000746517, ENST00000746518, ENST00000746519, ENST00000746520, ENST00000746521, ENST00000746522, ENST00000746523, ENST00000746524, ENST00000746525, ENST00000746527, ENST00000746528, ENST00000746529, ENST00000746530, ENST00000746531, ENST00000746532, ENST00000746533, ENST00000746534, ENST00000746535, ENST00000746536, ENST00000746537, ENST00000746538, ENST00000746539, ENST00000746540, ENST00000746541, ENST00000746542, ENST00000746543, ENST00000746544, ENST00000746545, ENST00000746546, ENST00000746547, ENST00000746548, ENST00000746550, ENST00000746552, ENST00000746554, ENST00000746562, ENST00000746563, ENST00000746564, ENST00000746565, ENST00000746566, ENST00000746567, ENST00000746568

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000317122 — 2 exons

Exon	Start	End
ENSE00001276194	15834474	15836906
ENSE00001368466	15848108	15848147

Expression profiles

Bgee: expression breadth ubiquitous, 236 present calls, max score 90.58.

FANTOM5 (CAGE): breadth broad, TPM avg 0.7673 / max 58.7314, expressed in 348 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
10479	0.5181	198
10477	0.2492	129

Top tissues by expression

252 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vastus lateralis	UBERON:0001379	90.58	gold quality
pancreatic ductal cell	CL:0002079	90.04	gold quality
tibialis anterior	UBERON:0001385	89.89	silver quality
quadriceps femoris	UBERON:0001377	89.63	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	89.30	gold quality
deltoid	UBERON:0001476	87.22	silver quality
biceps brachii	UBERON:0001507	87.11	gold quality
skeletal muscle tissue	UBERON:0001134	85.01	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	84.04	gold quality
endothelial cell	CL:0000115	82.37	gold quality
muscle tissue	UBERON:0002385	82.06	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.49	gold quality
thymus	UBERON:0002370	80.56	gold quality
ileal mucosa	UBERON:0000331	80.24	gold quality
pigmented layer of retina	UBERON:0001782	79.90	gold quality
germinal epithelium of ovary	UBERON:0001304	79.77	gold quality
middle temporal gyrus	UBERON:0002771	79.26	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.97	gold quality
muscle of leg	UBERON:0001383	78.62	gold quality
gastrocnemius	UBERON:0001388	78.53	gold quality
esophagus squamous epithelium	UBERON:0006920	77.37	gold quality
Brodmann (1909) area 23	UBERON:0013554	77.28	gold quality
tibia	UBERON:0000979	77.23	gold quality
amniotic fluid	UBERON:0000173	76.84	gold quality
corpus epididymis	UBERON:0004359	75.99	gold quality
hindlimb stylopod muscle	UBERON:0004252	75.89	gold quality
medial globus pallidus	UBERON:0002477	75.87	gold quality
palpebral conjunctiva	UBERON:0001812	75.82	gold quality
inferior vagus X ganglion	UBERON:0005363	75.52	gold quality
seminal vesicle	UBERON:0000998	75.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.03

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.