SPIN2B

Summary

SPIN2B (spindlin family member 2B, HGNC:33147) is a protein-coding gene on chromosome Xp11.21, encoding Spindlin-2B (Q9BPZ2). Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors.

Enables methylated histone binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in cytosol and nucleoplasm.

Source: NCBI Gene 474343 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 13 total
• Druggable target: yes
• MANE Select transcript: NM_001006681

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33147
Approved symbol	SPIN2B
Name	spindlin family member 2B
Location	Xp11.21
Locus type	gene with protein product
Status	Approved
Aliases	SPIN-2, TDRD26
Ensembl gene	ENSG00000186787
Ensembl biotype	protein_coding
OMIM	300517
Entrez	474343

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 15 protein_coding

ENST00000275988, ENST00000333933, ENST00000374910, ENST00000434397, ENST00000460948, ENST00000867875, ENST00000867876, ENST00000867877, ENST00000867878, ENST00000867879, ENST00000867880, ENST00000867881, ENST00000867882, ENST00000936879, ENST00000947950

RefSeq mRNA: 5 — MANE Select: NM_001006681 NM_001006681, NM_001006682, NM_001006683, NM_001282461, NM_001282462

CCDS: CCDS35311, CCDS65274

Canonical transcript exons

ENST00000434397 — 2 exons

Exon	Start	End
ENSE00001600116	57119682	57120631
ENSE00001757041	57121238	57121548

Expression profiles

Bgee: expression breadth ubiquitous, 136 present calls, max score 93.02.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.1704 / max 51.7022, expressed in 1718 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
199427	7.1581	1701
199426	1.0122	617

Top tissues by expression

136 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	93.02	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.22	gold quality
hypothalamus	UBERON:0001898	86.10	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	85.23	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	85.07	gold quality
anterior cingulate cortex	UBERON:0009835	85.05	gold quality
right frontal lobe	UBERON:0002810	85.04	gold quality
prefrontal cortex	UBERON:0000451	85.02	gold quality
frontal cortex	UBERON:0001870	85.00	gold quality
Brodmann (1909) area 9	UBERON:0013540	84.92	gold quality
fundus of stomach	UBERON:0001160	84.77	gold quality
right coronary artery	UBERON:0001625	84.77	gold quality
cerebral cortex	UBERON:0000956	84.76	gold quality
muscle layer of sigmoid colon	UBERON:0035805	84.75	gold quality
substantia nigra	UBERON:0002038	84.63	gold quality
apex of heart	UBERON:0002098	84.52	gold quality
primary visual cortex	UBERON:0002436	84.48	gold quality
descending thoracic aorta	UBERON:0002345	84.35	gold quality
ascending aorta	UBERON:0001496	84.30	gold quality
thoracic aorta	UBERON:0001515	84.28	gold quality
superior frontal gyrus	UBERON:0002661	84.28	gold quality
popliteal artery	UBERON:0002250	84.12	gold quality
left coronary artery	UBERON:0001626	84.11	gold quality
tibial artery	UBERON:0007610	84.10	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	84.08	gold quality
mucosa of transverse colon	UBERON:0004991	84.05	gold quality
lower esophagus	UBERON:0013473	84.03	gold quality
lower esophagus muscularis layer	UBERON:0035833	84.02	gold quality
brain	UBERON:0000955	83.89	gold quality
Ammon’s horn	UBERON:0001954	83.61	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-4850	no	1181.89
E-ENAD-17	no	207.68
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

30 targeting SPIN2B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-129-5P	99.88	70.26	3273
HSA-MIR-3941	99.86	70.54	2735
HSA-MIR-3680-3P	99.75	72.51	3095
HSA-MIR-3618	99.69	68.57	1012
HSA-MIR-1283	99.69	72.42	3009
HSA-MIR-4470	99.66	69.35	1767
HSA-MIR-4666B	99.64	68.69	1282
HSA-MIR-587	99.64	70.86	2611
HSA-MIR-488-3P	99.61	68.79	1731
HSA-MIR-3128	99.50	67.85	1258
HSA-MIR-4441	99.49	66.56	3216
HSA-MIR-100-3P	99.20	67.33	672
HSA-MIR-4270	99.02	66.26	1987
HSA-MIR-3149	98.77	67.13	1639
HSA-MIR-455-5P	98.74	67.31	795
HSA-MIR-4709-5P	98.51	67.25	1335
HSA-MIR-934	98.49	70.44	581
HSA-MIR-10395-3P	98.10	66.70	1726
HSA-MIR-6730-5P	98.03	68.12	1299
HSA-MIR-5681A	97.99	67.17	1658
HSA-MIR-9851-5P	97.57	67.49	1067
HSA-MIR-1227-3P	97.36	66.94	834
HSA-MIR-101-5P	96.84	65.66	649
HSA-MIR-125B-2-3P	96.69	68.38	1210
HSA-MIR-12128	96.67	66.98	1471

Literature-anchored findings (GeneRIF, showing 1)

• SERPINA3K is a high-affinity, endogenous antagonist of LRP6 (PMID:20351274)

Cross-species orthologs

112 orthologs

Organism	Symbol	Gene ID
danio_rerio	spinb	ENSDARG00000035697
danio_rerio	spina	ENSDARG00000058949
mus_musculus	Gm21719	ENSMUSG00000079806
mus_musculus	Gm21292	ENSMUSG00000091077
mus_musculus	Gm20865	ENSMUSG00000093848
mus_musculus	Gm20809	ENSMUSG00000093868
mus_musculus	Gm21454	ENSMUSG00000093903
mus_musculus	Gm20918	ENSMUSG00000093927
mus_musculus	Gm20823	ENSMUSG00000093950
mus_musculus	Gm21118	ENSMUSG00000094052
mus_musculus	Gm20826	ENSMUSG00000094081
mus_musculus	Gm20909	ENSMUSG00000094294
mus_musculus	Gm20831	ENSMUSG00000094325
mus_musculus	Gm21244	ENSMUSG00000094484
mus_musculus	Gm20821	ENSMUSG00000094556
mus_musculus	Gm20738	ENSMUSG00000094575
mus_musculus	Gm21394	ENSMUSG00000094660
mus_musculus	Gm21721	ENSMUSG00000094679
mus_musculus	Gm20747	ENSMUSG00000094729
mus_musculus	Gm20806	ENSMUSG00000094739
mus_musculus	Gm21812	ENSMUSG00000094773
mus_musculus	Gm20777	ENSMUSG00000094813
mus_musculus	Gm20828	ENSMUSG00000094838
mus_musculus	Gm21310	ENSMUSG00000095032
mus_musculus	Gm20873	ENSMUSG00000095148
mus_musculus	Gm20822	ENSMUSG00000095172
mus_musculus	Gm20834	ENSMUSG00000095242
mus_musculus	Ssty1	ENSMUSG00000095267
mus_musculus	Ssty2	ENSMUSG00000095302
mus_musculus	Gm20825	ENSMUSG00000095324
mus_musculus	Gm20795	ENSMUSG00000095452
mus_musculus	Gm20812	ENSMUSG00000095508
mus_musculus	Gm20877	ENSMUSG00000095520
mus_musculus	Gm20816	ENSMUSG00000095634
mus_musculus	Gm20854	ENSMUSG00000095650
mus_musculus	Gm20924	ENSMUSG00000095785
mus_musculus	Gm20917	ENSMUSG00000095867
mus_musculus	Gm20773	ENSMUSG00000095900
mus_musculus	Gm20737	ENSMUSG00000095950
mus_musculus	Gm21778	ENSMUSG00000096036
mus_musculus	Gm21943	ENSMUSG00000096122
mus_musculus	Gm21874	ENSMUSG00000096223
mus_musculus	Gm20914	ENSMUSG00000096268
mus_musculus	Gm20852	ENSMUSG00000096666
mus_musculus	Gm20830	ENSMUSG00000096686
mus_musculus	Gm21854	ENSMUSG00000096706
mus_musculus	Gm21425	ENSMUSG00000096820
mus_musculus	Gm20867	ENSMUSG00000096898
mus_musculus	Gm29049	ENSMUSG00000099861
mus_musculus	Gm29424	ENSMUSG00000099948
mus_musculus	Gm28171	ENSMUSG00000100634
mus_musculus	Gm20815	ENSMUSG00000101053
mus_musculus	Gm20772	ENSMUSG00000102739
mus_musculus	Gm21440	ENSMUSG00000103468
mus_musculus	Gm20807	ENSMUSG00000104267
rattus_norvegicus	LOC134486221	ENSRNOG00000048867
rattus_norvegicus	LOC134486240	ENSRNOG00000049619
rattus_norvegicus	LOC120099686	ENSRNOG00000064259
rattus_norvegicus		ENSRNOG00000065734
rattus_norvegicus	LOC134486234	ENSRNOG00000067676
rattus_norvegicus		ENSRNOG00000068289
rattus_norvegicus	LOC134484257	ENSRNOG00000069646
rattus_norvegicus	Ssty1-ps5	ENSRNOG00000070707
rattus_norvegicus		ENSRNOG00000072094
rattus_norvegicus		ENSRNOG00000072522
rattus_norvegicus		ENSRNOG00000072683
rattus_norvegicus		ENSRNOG00000072719
rattus_norvegicus		ENSRNOG00000073240
rattus_norvegicus		ENSRNOG00000073388
rattus_norvegicus		ENSRNOG00000073718
rattus_norvegicus		ENSRNOG00000074289
rattus_norvegicus		ENSRNOG00000074627
rattus_norvegicus		ENSRNOG00000075048
rattus_norvegicus		ENSRNOG00000075217
rattus_norvegicus		ENSRNOG00000075704
rattus_norvegicus		ENSRNOG00000075715
rattus_norvegicus		ENSRNOG00000076756
rattus_norvegicus		ENSRNOG00000076768
rattus_norvegicus		ENSRNOG00000077163
rattus_norvegicus		ENSRNOG00000077684
rattus_norvegicus		ENSRNOG00000077860
		ENSRNOG00000078153
rattus_norvegicus		ENSRNOG00000078247
rattus_norvegicus		ENSRNOG00000078425
rattus_norvegicus		ENSRNOG00000078859
rattus_norvegicus		ENSRNOG00000079273
rattus_norvegicus		ENSRNOG00000079973
rattus_norvegicus		ENSRNOG00000080258
rattus_norvegicus		ENSRNOG00000082759
rattus_norvegicus		ENSRNOG00000083031
rattus_norvegicus		ENSRNOG00000083094
rattus_norvegicus		ENSRNOG00000083348
rattus_norvegicus		ENSRNOG00000083477
		ENSRNOG00000084216
rattus_norvegicus		ENSRNOG00000084517
rattus_norvegicus		ENSRNOG00000084670
rattus_norvegicus		ENSRNOG00000084696
		ENSRNOG00000085197
rattus_norvegicus		ENSRNOG00000085381
rattus_norvegicus		ENSRNOG00000085696
rattus_norvegicus		ENSRNOG00000085874
rattus_norvegicus		ENSRNOG00000086556
rattus_norvegicus		ENSRNOG00000088152
rattus_norvegicus		ENSRNOG00000088255
rattus_norvegicus		ENSRNOG00000088275
rattus_norvegicus		ENSRNOG00000089025
rattus_norvegicus		ENSRNOG00000089042
rattus_norvegicus		ENSRNOG00000089633
rattus_norvegicus		ENSRNOG00000089769
rattus_norvegicus		ENSRNOG00000089859
rattus_norvegicus		ENSRNOG00000089969
rattus_norvegicus		ENSRNOG00000090248

Paralogs (4): SPIN1 (ENSG00000106723), SPIN2A (ENSG00000147059), SPIN4 (ENSG00000186767), SPIN3 (ENSG00000204271)

Protein

Protein identifiers

Spindlin-2B — Q9BPZ2 (reviewed: Q9BPZ2)

Alternative names: Spindlin-like protein 2B

All UniProt accessions (4): Q9BPZ2, A0A1B0GU50, Q5JZB7, Q5JZB8

UniProt curated annotations — full annotation on UniProt →

Function. Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors. Exhibits H3K4me3-binding activity.

Subunit / interactions. Interacts with C11orf84/SPINDOC.

Subcellular location. Nucleus.

Tissue specificity. Detected in all the examined tissues with highest expression in liver, followed by heart, stomach, kidney, skeletal muscle, placenta, and pancreas.

Miscellaneous. Overexpression in murine myeloid cell line 32Dcl3 causes G2/M arrest.

Similarity. Belongs to the SPIN/STSY family.

RefSeq proteins (5): NP_001006682, NP_001006683, NP_001006684, NP_001269390, NP_001269391 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003671	SPIN/Ssty	Family
IPR042567	SPIN/Ssty_sf	Homologous_superfamily

Pfam: PF02513

UniProt features (30 total): strand 15, region of interest 6, site 3, helix 2, compositionally biased region 2, chain 1, turn 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
5LUG	X-RAY DIFFRACTION	1.7

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BPZ2-F1	81.78	0.66

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (3): 176 (histone h3k4me3 and h3r8me2a binding); 180 (histone h3k4me3 and h3r8me2a binding); 169 (histone h3k4me3 and h3r8me2a binding)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 33 (showing top): GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS, chrXp11, GRYDER_PAX3FOXO1_ENHANCERS_KO_DOWN, FORTSCHEGGER_PHF8_TARGETS_DN, HMGA1_TARGET_GENES, SKIL_TARGET_GENES, ZNF322_TARGET_GENES, ZNF407_TARGET_GENES, MIR8485, MIR9983_3P, MIR1283, MIR9851_5P, MIR3618, MIR934, MIR101_5P

GO Biological Process (4): regulation of DNA-templated transcription (GO:0006355), apoptotic process (GO:0006915), gamete generation (GO:0007276), chromatin organization (GO:0006325)

GO Molecular Function (2): histone H3K4me3 reader activity (GO:0140002), protein binding (GO:0005515)

GO Cellular Component (3): nucleoplasm (GO:0005654), cytosol (GO:0005829), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
programmed cell death	1
apoptotic signaling pathway	1
execution phase of apoptosis	1
sexual reproduction	1
multicellular organismal reproductive process	1
cellular component organization	1
histone H3 reader activity	1
binding	1
nuclear lumen	1
cytoplasm	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

206 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SPIN2B	SPINDOC	Q9BUA3	431
SPIN2B	NALF2	O75949	384
SPIN2B	TERF1	P54274	380
SPIN2B	RPP40	O75818	307
SPIN2B	SPATA4	Q8NEY3	303
SPIN2B	SPNS1	Q9H2V7	300
SPIN2B	RPA3	P35244	293
SPIN2B	RPL10	P27635	285
SPIN2B	WDR76	Q9H967	273
SPIN2B	ELMOD1	Q8N336	271
SPIN2B	GARIN1A	Q6NXP2	270
SPIN2B	INSL6	Q9Y581	270
SPIN2B	RCC2	Q9P258	261
SPIN2B	NCAPH	Q15003	254
SPIN2B	CBX1	P23197	253

IntAct

20 interactions, top by confidence:

A	B	Type	Score
PFDN4	PFDN6	psi-mi:“MI:0914”(association)	0.730
PFDN1	PFDN6	psi-mi:“MI:0914”(association)	0.640
SPIN2B	LAMP2	psi-mi:“MI:0915”(physical association)	0.560
SPIN2B	SH3GLB1	psi-mi:“MI:0915”(physical association)	0.560
SPINDOC	SPIN3	psi-mi:“MI:0914”(association)	0.560
SPIN2B	WDHD1	psi-mi:“MI:0914”(association)	0.530
GALNS	FBXO21	psi-mi:“MI:0914”(association)	0.530
MAPT	SHTN1	psi-mi:“MI:0914”(association)	0.350
DEFB107A	ZZEF1	psi-mi:“MI:0914”(association)	0.350
SPIN1	VPS37C	psi-mi:“MI:0914”(association)	0.350

BioGRID (70): SPIN1 (Affinity Capture-MS), XPC (Affinity Capture-MS), WDHD1 (Affinity Capture-MS), SUPT16H (Affinity Capture-MS), CGGBP1 (Affinity Capture-MS), PARP2 (Affinity Capture-MS), WDR76 (Affinity Capture-MS), MCM2 (Affinity Capture-MS), XPNPEP1 (Affinity Capture-MS), HIST1H2BJ (Affinity Capture-MS), MCM6 (Affinity Capture-MS), SSRP1 (Affinity Capture-MS), HIST1H2AG (Affinity Capture-MS), HIST2H2AB (Affinity Capture-MS), YRDC (Affinity Capture-MS)

ESM2 similar proteins: A2Z4C5, A7X680, B8AJL9, F4HVW5, F4I933, F4IV66, F4JR57, K4DF01, P0C7Q8, P13675, Q0WPN7, Q10PL5, Q1ECE0, Q2KI39, Q33BI9, Q4V8J7, Q56A73, Q5JUX0, Q5R997, Q5RA80, Q5RAW7, Q61142, Q6NVE3, Q6YZM6, Q8GVE5, Q8K1L2, Q8L7G0, Q8LJW3, Q8RWD9, Q8RWY4, Q8RY82, Q8W4F0, Q90WG1, Q90WG2, Q93VH2, Q93XX4, Q93YR9, Q944S3, Q94BM7, Q99865

Diamond homologs: P13675, Q2KI39, Q4V8J7, Q56A73, Q5JUX0, Q5R997, Q5RA80, Q5RAW7, Q61142, Q6NVE3, Q8K1L2, Q90WG1, Q90WG2, Q99865, Q9BPZ2, Q9Y657

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

13 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	9
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

288 predictions. Top by Δscore:

Variant	Effect	Δscore
X:57121228:ATGG:A	donor_gain	0.9900
X:57121305:T:TA	donor_gain	0.9900
X:57120630:GCCTG:G	acceptor_gain	0.9800
X:57120631:CCTGC:C	acceptor_gain	0.9800
X:57120632:CTG:C	acceptor_gain	0.9800
X:57121197:C:A	donor_gain	0.9800
X:57121224:A:AC	donor_gain	0.9800
X:57121225:C:CC	donor_gain	0.9800
X:57121227:AATGG:A	donor_gain	0.9800
X:57121274:A:AC	donor_gain	0.9800
X:57121275:C:CC	donor_gain	0.9800
X:57121275:CGTG:C	donor_gain	0.9800
X:57121168:TC:T	donor_gain	0.9700
X:57121169:CC:C	donor_gain	0.9700
X:57121294:T:TA	donor_gain	0.9700
X:57120633:TG:T	acceptor_gain	0.9600
X:57121362:G:A	donor_gain	0.9600
X:57120635:C:CC	acceptor_gain	0.9500
X:57121196:T:TA	donor_gain	0.9500
X:57121302:G:GA	donor_gain	0.9500
X:57121315:G:A	donor_gain	0.9500
X:57120629:TGC:T	acceptor_gain	0.9400
X:57121250:C:CT	donor_gain	0.9400
X:57121251:C:CT	donor_gain	0.9400
X:57121311:ACGAG:A	donor_gain	0.9400
X:57121312:CGAGC:C	donor_gain	0.9400
X:57121200:ATCCC:A	donor_gain	0.9300
X:57121249:TCC:T	donor_gain	0.9300
X:57120628:ATGCC:A	acceptor_loss	0.9200
X:57120629:TGCC:T	acceptor_loss	0.9200

AlphaMissense

1620 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:57119901:A:C	F243L	1.000
X:57119901:A:T	F243L	1.000
X:57119903:A:G	F243L	1.000
X:57120219:A:C	F137L	1.000
X:57120219:A:T	F137L	1.000
X:57120221:A:G	F137L	1.000
X:57120091:T:A	D180V	0.999
X:57120115:A:G	L172S	0.999
X:57120134:A:G	Y166H	0.999
X:57120144:A:C	F162L	0.999
X:57120144:A:T	F162L	0.999
X:57120146:A:G	F162L	0.999
X:57120175:A:G	L152S	0.999
X:57120185:C:A	G149W	0.999
X:57120185:C:G	G149R	0.999
X:57120185:C:T	G149R	0.999
X:57120220:A:C	F137C	0.999
X:57120371:A:G	Y87H	0.999
X:57120415:A:T	V72D	0.999
X:57119902:A:G	F243S	0.998
X:57119904:C:A	K242N	0.998
X:57119904:C:G	K242N	0.998
X:57119906:T:C	K242E	0.998
X:57119908:A:T	I241N	0.998
X:57119944:A:T	I229N	0.998
X:57119953:C:T	G226D	0.998
X:57120073:A:G	L186P	0.998
X:57120073:A:T	L186H	0.998
X:57120091:T:C	D180G	0.998
X:57120091:T:G	D180A	0.998

dbSNP variants (sampled 300 via entrez): RS1000667621 (X:57121046 T>C), RS1001205815 (X:57121486 G>C,T), RS1002076885 (X:57122601 ATGT>A), RS1002274964 (X:57122042 T>G), RS1002892326 (X:57121174 C>T), RS1005405839 (X:57122189 T>C,G), RS1005477909 (X:57121889 A>G), RS1006417889 (X:57119498 G>C), RS1006549070 (X:57120978 C>T), RS1006696563 (X:57121535 C>G), RS1006747171 (X:57119678 C>G,T), RS1008895026 (X:57123361 C>T), RS1013460956 (X:57121557 C>G), RS1014260068 (X:57122301 C>A), RS1014644006 (X:57122658 T>C)

Disease associations

OMIM: gene MIM:300517 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST006661_145	Male-pattern baldness	6.000000e-19
GCST009799_6	Alcohol consumption (drinkers vs non-drinkers)	2.000000e-08

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004329	alcohol drinking

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4523440 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

3 potent at pChembl≥5 of 3 total, top 3 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
7.34	Kd	46.1	nM	CHEMBL4451634
6.77	Kd	170	nM	CHEMBL4552020
6.25	Kd	560	nM	CHEMBL5594627

PubChem BioAssay actives

3 with measured affinity, of 5 total; 3 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
2-[4-[2-[[2-[3-[2-amino-5-(cyclopropylmethoxy)-3,3-dimethylindol-6-yl]oxypropyl]-1,3-dihydroisoindol-5-yl]oxy]ethyl]triazol-1-yl]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone	1526489: Binding affinity to recombinant human His-tagged SPIN2B (45 to 258 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by isothermal titration calorimetry	kd	0.0461	uM
[3-(aminomethyl)-5-[3-(1,3-dihydroisoindol-2-yl)propoxy]-4-methoxyphenyl]methanamine	1578925: Inhibition of recombinant human N-terminal His6-tagged SPIN2B (45 to 258 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by isothermal titration calorimetry	kd	0.1700	uM
N-[7-[3-(1,3-dihydroisoindol-2-yl)propoxy]-6-methoxy-4-pyrrolidin-1-ylquinazolin-2-yl]-N’,N’-dimethylethane-1,2-diamine	2103451: Binding affinity to human N-terminal His6 tagged SPIN2B (P45 to S258 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by isothermal titration calorimetry	kd	0.5600	uM

CTD chemical–gene interactions

14 total (human), top 14 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects cotreatment, increases abundance, increases expression, decreases expression	2
Arsenic	increases abundance, increases expression, affects methylation, affects cotreatment	2
manganese chloride	affects cotreatment, increases abundance, increases expression	1
abrine	increases expression	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Cisplatin	decreases expression	1
Doxorubicin	increases expression	1
Manganese	increases expression, affects cotreatment, increases abundance	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Valproic Acid	decreases methylation	1
Aflatoxin B1	decreases methylation	1
Acrylamide	decreases expression	1
Particulate Matter	decreases expression	1

ChEMBL screening assays

4 unique, capped per target: 4 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4323089	Binding	Binding affinity to recombinant human His-tagged SPIN2B (45 to 258 residues) expressed in Escherichia coli BL21 (DE3) assessed as melting temperature at 20 uM by Sypro orange dye based differential scanning fluorimetry	A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function. — J Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.