SPINT1-AS1

Summary

SPINT1-AS1 (SPINT1 antisense RNA 1, HGNC:53162) is a long non-coding RNA gene on chromosome 15q15.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53162
Approved symbol	SPINT1-AS1
Name	SPINT1 antisense RNA 1
Location	15q15.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP11-532F12.5
Ensembl gene	ENSG00000261183
Ensembl biotype	lncRNA
Entrez	102724362
RNAcentral	URS0000BC4408 — lncRNA, 795 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000563217, ENST00000564302, ENST00000565315, ENST00000568419, ENST00000568525, ENST00000721787, ENST00000721788

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000563217 — 2 exons

Exon	Start	End
ENSE00002590816	40840380	40840493
ENSE00002614309	40838551	40838686

Expression profiles

Bgee: expression breadth ubiquitous, 207 present calls, max score 96.64.

FANTOM5 (CAGE): breadth broad, TPM avg 2.9618 / max 87.9166, expressed in 602 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
149512	1.7650	440
149511	0.9415	405
149510	0.2554	152

Top tissues by expression

237 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	96.64	gold quality
palpebral conjunctiva	UBERON:0001812	95.64	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	95.33	gold quality
left lobe of thyroid gland	UBERON:0001120	94.82	gold quality
right lobe of thyroid gland	UBERON:0001119	94.49	gold quality
minor salivary gland	UBERON:0001830	94.22	gold quality
thyroid gland	UBERON:0002046	94.19	gold quality
saliva-secreting gland	UBERON:0001044	93.76	gold quality
corpus epididymis	UBERON:0004359	92.84	gold quality
mouth mucosa	UBERON:0003729	92.66	gold quality
lower esophagus mucosa	UBERON:0035834	92.53	gold quality
skin of abdomen	UBERON:0001416	91.91	gold quality
pancreatic ductal cell	CL:0002079	91.61	gold quality
skin of leg	UBERON:0001511	91.39	gold quality
metanephros cortex	UBERON:0010533	91.04	gold quality
zone of skin	UBERON:0000014	90.79	gold quality
esophagus mucosa	UBERON:0002469	90.70	gold quality
nasal cavity mucosa	UBERON:0001826	90.53	gold quality
right uterine tube	UBERON:0001302	90.24	gold quality
parotid gland	UBERON:0001831	90.13	gold quality
upper arm skin	UBERON:0004263	90.13	silver quality
body of pancreas	UBERON:0001150	89.97	gold quality
rectum	UBERON:0001052	89.95	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.79	gold quality
adult mammalian kidney	UBERON:0000082	89.72	gold quality
prostate gland	UBERON:0002367	88.63	gold quality
duodenum	UBERON:0002114	88.51	gold quality
epithelial cell of pancreas	CL:0000083	87.99	gold quality
kidney epithelium	UBERON:0004819	87.99	gold quality
bronchial epithelial cell	CL:0002328	87.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	16.13

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LncRNA SPINT1-AS1 promotes breast cancer proliferation and metastasis by sponging let-7 a/b/i-5p. (PMID:33246290)
• Specificity protein 1-induced serine peptidase inhibitor, Kunitz Type 1 antisense RNA1 regulates colorectal cancer cell proliferation, migration, invasion and apoptosis through targeting heparin binding growth factor via sponging microRNA-214. (PMID:35068341)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.