SPRY4-AS1

Summary

SPRY4-AS1 (SPRY4 antisense RNA 1, HGNC:53465) is a long non-coding RNA gene on chromosome 5q31.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53465
Approved symbol	SPRY4-AS1
Name	SPRY4 antisense RNA 1
Location	5q31.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	THCAT68, AC005592.2
Ensembl gene	ENSG00000231185
Ensembl biotype	lncRNA
Entrez	101926941
RNAcentral	URS000009C154 — lncRNA, 591 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 97 — 97 lncRNA

ENST00000414314, ENST00000425963, ENST00000432677, ENST00000443800, ENST00000510311, ENST00000514303, ENST00000515288, ENST00000652722, ENST00000652991, ENST00000654613, ENST00000654654, ENST00000655828, ENST00000658361, ENST00000658433, ENST00000658459, ENST00000659517, ENST00000659596, ENST00000659959, ENST00000660053, ENST00000660321, ENST00000662893, ENST00000664609, ENST00000665462, ENST00000666274, ENST00000666438, ENST00000666541, ENST00000667174, ENST00000667247, ENST00000668207, ENST00000668371, ENST00000669649, ENST00000670541, ENST00000700840, ENST00000702107, ENST00000715765, ENST00000724958, ENST00000724959, ENST00000724960, ENST00000724961, ENST00000724962, ENST00000724963, ENST00000724964, ENST00000724965, ENST00000724966, ENST00000724967, ENST00000724968, ENST00000724969, ENST00000724970, ENST00000724971, ENST00000724972, ENST00000724973, ENST00000724974, ENST00000724975, ENST00000724976, ENST00000724977, ENST00000724978, ENST00000724979, ENST00000724980, ENST00000724981, ENST00000724982, ENST00000724983, ENST00000724984, ENST00000724985, ENST00000724986, ENST00000724987, ENST00000724988, ENST00000724989, ENST00000724990, ENST00000724991, ENST00000724992, ENST00000724993, ENST00000724994, ENST00000724995, ENST00000724996, ENST00000724997, ENST00000724998, ENST00000724999, ENST00000725000, ENST00000725001, ENST00000725002, ENST00000725003, ENST00000725004, ENST00000725005, ENST00000725006, ENST00000725007, ENST00000725008, ENST00000725009, ENST00000725010, ENST00000725011, ENST00000725012, ENST00000725013, ENST00000725014, ENST00000725015, ENST00000725016, ENST00000725017, ENST00000795850, ENST00000850659

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414314 — 4 exons

Exon	Start	End
ENSE00001645560	142626737	142627190
ENSE00001653554	142581802	142581914
ENSE00001711696	142463970	142464059
ENSE00004048177	142403874	142404010

Expression profiles

Bgee: expression breadth ubiquitous, 126 present calls, max score 91.03.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0156 / max 3.8140, expressed in 10 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
59080	0.8883	541
59078	0.6310	328
59079	0.3674	166
59085	0.3203	67
59082	0.0816	29
59083	0.0651	29
59084	0.0631	15
59088	0.0156	10

Top tissues by expression

126 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	91.03	gold quality
sural nerve	UBERON:0015488	84.71	gold quality
corpus callosum	UBERON:0002336	80.98	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.33	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.80	gold quality
stromal cell of endometrium	CL:0002255	71.87	gold quality
pituitary gland	UBERON:0000007	68.37	gold quality
adenohypophysis	UBERON:0002196	68.24	gold quality
cortical plate	UBERON:0005343	67.78	gold quality
hindlimb stylopod muscle	UBERON:0004252	66.96	gold quality
prefrontal cortex	UBERON:0000451	66.11	gold quality
thyroid gland	UBERON:0002046	66.10	gold quality
ventricular zone	UBERON:0003053	66.10	gold quality
monocyte	CL:0000576	65.91	gold quality
primary visual cortex	UBERON:0002436	65.64	gold quality
left coronary artery	UBERON:0001626	65.60	gold quality
ganglionic eminence	UBERON:0004023	65.49	gold quality
ascending aorta	UBERON:0001496	65.46	gold quality
thoracic aorta	UBERON:0001515	65.31	gold quality
superior frontal gyrus	UBERON:0002661	65.29	gold quality
adrenal tissue	UBERON:0018303	65.13	gold quality
descending thoracic aorta	UBERON:0002345	64.98	gold quality
frontal cortex	UBERON:0001870	64.94	gold quality
right lung	UBERON:0002167	64.94	gold quality
tonsil	UBERON:0002372	64.89	silver quality
left lobe of thyroid gland	UBERON:0001120	64.85	gold quality
right lobe of thyroid gland	UBERON:0001119	64.65	gold quality
placenta	UBERON:0001987	64.59	gold quality
anterior cingulate cortex	UBERON:0009835	64.56	gold quality
apex of heart	UBERON:0002098	63.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.53

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.