SRARP

Summary

SRARP (steroid receptor associated and regulated protein, HGNC:28339) is a protein-coding gene on chromosome 1p36.13, encoding Steroid receptor-associated and regulated protein (Q8NEQ6). May regulate the transcriptional function of androgen and estrogen receptors.

Enables nuclear estrogen receptor binding activity. Involved in positive regulation of intracellular estrogen receptor signaling pathway. Located in cytoplasm and nucleus.

Source: NCBI Gene 149563 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• MANE Select transcript: NM_178840

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28339
Approved symbol	SRARP
Name	steroid receptor associated and regulated protein
Location	1p36.13
Locus type	gene with protein product
Status	Approved
Aliases	MGC24047, ERRF
Ensembl gene	ENSG00000183888
Ensembl biotype	protein_coding
OMIM	619448
Entrez	149563

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000329454

RefSeq mRNA: 1 — MANE Select: NM_178840 NM_178840

CCDS: CCDS166

Canonical transcript exons

ENST00000329454 — 2 exons

Exon	Start	End
ENSE00001294049	16005919	16008807
ENSE00001310857	16004236	16004385

Expression profiles

Bgee: expression breadth ubiquitous, 106 present calls, max score 82.85.

FANTOM5 (CAGE): breadth broad, TPM avg 2.2599 / max 141.5120, expressed in 214 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
938	2.2599	214

Top tissues by expression

214 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
medial globus pallidus	UBERON:0002477	82.85	gold quality
globus pallidus	UBERON:0001875	80.78	gold quality
parotid gland	UBERON:0001831	79.38	gold quality
pancreatic ductal cell	CL:0002079	76.92	silver quality
nasal cavity epithelium	UBERON:0005384	76.60	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	74.83	gold quality
upper arm skin	UBERON:0004263	73.79	gold quality
left ventricle myocardium	UBERON:0006566	73.63	gold quality
cardiac muscle of right atrium	UBERON:0003379	73.58	gold quality
substantia nigra	UBERON:0002038	73.51	gold quality
inferior vagus X ganglion	UBERON:0005363	73.40	gold quality
midbrain	UBERON:0001891	73.37	gold quality
ventral tegmental area	UBERON:0002691	72.93	gold quality
lateral nuclear group of thalamus	UBERON:0002736	72.83	silver quality
dorsal plus ventral thalamus	UBERON:0001897	72.51	gold quality
subthalamic nucleus	UBERON:0001906	72.46	gold quality
putamen	UBERON:0001874	72.08	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	71.29	gold quality
cerebellar vermis	UBERON:0004720	71.22	silver quality
spinal cord	UBERON:0002240	71.11	gold quality
postcentral gyrus	UBERON:0002581	70.55	silver quality
medulla oblongata	UBERON:0001896	70.51	gold quality
parietal lobe	UBERON:0001872	70.50	silver quality
quadriceps femoris	UBERON:0001377	70.48	gold quality
epithelium of mammary gland	UBERON:0003244	70.46	silver quality
Ammon’s horn	UBERON:0001954	70.35	gold quality
mammary duct	UBERON:0001765	70.29	silver quality
caudate nucleus	UBERON:0001873	70.29	gold quality
myocardium	UBERON:0002349	70.27	gold quality
pons	UBERON:0000988	70.03	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.27

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

12 targeting SRARP, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-8063	99.91	69.76	3146
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-6515-3P	99.82	68.19	1933
HSA-MIR-6132	99.60	65.83	1554
HSA-MIR-6836-5P	99.60	65.62	1538
HSA-MIR-4999-5P	99.35	69.15	926
HSA-MIR-7156-3P	98.25	67.66	859
HSA-MIR-506-5P	98.02	67.41	1065
HSA-MIR-3665	97.73	65.08	975
HSA-MIR-3190-3P	97.61	66.95	1406
HSA-MIR-212-5P	96.83	67.43	950

Literature-anchored findings (GeneRIF, showing 4)

• These results suggest that ERRF plays a role in estrogen-ER-mediated growth of breast cancer cells. (PMID:22341523)
• Further mechanism study proved ERRF to be an interacting partner of ERalpha. In total, these data revealed that ERRF is essential for the activity of E2-ERalpha pathway. (PMID:27125460)
• SRARP and HSPB7 are tumor suppressors that are commonly inactivated in malignancies. (PMID:29577611)
• Steroid receptor-associated and regulated protein is a biomarker in predicting the clinical outcome and treatment response in malignancies. (PMID:32706923)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Srarp	ENSMUSG00000070637
rattus_norvegicus	Srarp	ENSRNOG00000054155

Protein

Protein identifiers

Steroid receptor-associated and regulated protein — Q8NEQ6 (reviewed: Q8NEQ6)

Alternative names: Estrogen receptor-related factor, Steroid receptor-regulated protein

All UniProt accessions (1): Q8NEQ6

UniProt curated annotations — full annotation on UniProt →

Function. May regulate the transcriptional function of androgen and estrogen receptors.

Subunit / interactions. Interacts with 14-3-3 proteins.

Tissue specificity. Expressed in breast tumors with a higher expression level in estrogen receptor-positive cancers.

Induction. Up-regulated in breast cancers.

RefSeq proteins (1): NP_849162* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR027852	C1ORF64	Family

Pfam: PF15547

UniProt features (4 total): sequence variant 3, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NEQ6-F1	52.25	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 43 (showing top): GOBP_CELLULAR_RESPONSE_TO_LIPID, GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY, GOBP_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY, GOBP_HORMONE_MEDIATED_SIGNALING_PATHWAY, GOBP_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY, GOBP_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS, GOBP_RESPONSE_TO_STEROID_HORMONE, GOBP_RESPONSE_TO_HORMONE, GOBP_RESPONSE_TO_LIPID, GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, GOBP_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS, GOBP_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY, GOBP_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY, GOBP_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY, MASSARWEH_TAMOXIFEN_RESISTANCE_UP

GO Biological Process (1): positive regulation of intracellular estrogen receptor signaling pathway (GO:0033148)

GO Molecular Function (2): nuclear estrogen receptor binding (GO:0030331), protein binding (GO:0005515)

GO Cellular Component (2): nucleus (GO:0005634), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
estrogen receptor signaling pathway	1
positive regulation of intracellular steroid hormone receptor signaling pathway	1
regulation of intracellular estrogen receptor signaling pathway	1
nuclear receptor binding	1
binding	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

138 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SRARP	ABCC11	Q96J66	465
SRARP	F11R	Q9Y624	405
SRARP	IL4	P05112	374
SRARP	HID1	Q8IV36	370
SRARP	OR2C1	O95371	369
SRARP	LBH	Q53QV2	357
SRARP	TTC33	Q6PID6	357
SRARP	KLK3	P07288	324
SRARP	FAM234B	A2RU67	323
SRARP	CLCNKA	P51800	314
SRARP	CCDC192	P0DO97	311
SRARP	RAB5IF	Q9BUV8	305
SRARP	ATOSA	Q32MH5	300
SRARP	ADGRF2P	Q8IZF7	272
SRARP	TMEM89	A2RUT3	271

IntAct

19 interactions, top by confidence:

A	B	Type	Score
NRF1	SRARP	psi-mi:“MI:0915”(physical association)	0.560
FNDC3B	SRARP	psi-mi:“MI:0915”(physical association)	0.560
BANP	SRARP	psi-mi:“MI:0915”(physical association)	0.560
QRICH1	SRARP	psi-mi:“MI:0915”(physical association)	0.560
SRARP	WFS1	psi-mi:“MI:0915”(physical association)	0.560
SRARP	SLC4A2	psi-mi:“MI:0915”(physical association)	0.500
SRARP	SLC4A2	psi-mi:“MI:0914”(association)	0.500
SRARP	SLC4A2	psi-mi:“MI:0915”(physical association)	0.400
BANP	SRARP	psi-mi:“MI:0915”(physical association)	0.000
QRICH1	SRARP	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (9): SLC4A2 (Affinity Capture-MS), TOMM22 (Co-fractionation), C1orf64 (Two-hybrid), C1orf64 (Two-hybrid), C1orf64 (Two-hybrid), QRICH1 (Two-hybrid), SLC4A2 (Affinity Capture-MS), HARS2 (Affinity Capture-MS), APP (Reconstituted Complex)

ESM2 similar proteins: A0A1B0GTK4, A0A1B0GTK5, A0JNL8, A2RUT3, A4D250, B2KGE5, F1MQW7, F2Z3F1, F5HHT4, O93195, O95411, P04610, P05905, P0C733, P0C7M3, P0DP71, P16722, P17758, P47939, P47940, P57738, Q0VD86, Q1HVB5, Q1RN00, Q1X6Y7, Q1X6Z1, Q1X6Z2, Q3ZN08, Q5PR19, Q5PXH1, Q5TC04, Q5TEZ4, Q64902, Q66669, Q66HF0, Q67863, Q6DGF6, Q6UYE1, Q7L4S7, Q8AZJ3

Diamond homologs: Q3ULG3, Q8NEQ6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

100 predictions. Top by Δscore:

Variant	Effect	Δscore
1:16004383:CCGGT:C	donor_loss	1.0000
1:16004385:GGT:G	donor_loss	1.0000
1:16004386:G:C	donor_loss	1.0000
1:16004386:G:GG	donor_gain	1.0000
1:16004387:T:G	donor_loss	1.0000
1:16005915:CTAG:C	acceptor_loss	1.0000
1:16005916:TAGGT:T	acceptor_loss	1.0000
1:16005917:A:AG	acceptor_gain	1.0000
1:16005917:AG:A	acceptor_gain	1.0000
1:16005917:AGGT:A	acceptor_gain	1.0000
1:16005917:AGGTG:A	acceptor_gain	1.0000
1:16005918:G:GT	acceptor_gain	1.0000
1:16005918:GG:G	acceptor_gain	1.0000
1:16005918:GGT:G	acceptor_gain	1.0000
1:16005918:GGTG:G	acceptor_gain	1.0000
1:16005918:GGTGG:G	acceptor_gain	1.0000
1:16005916:TAGG:T	acceptor_gain	0.9700
1:16005917:AGG:A	acceptor_gain	0.9700
1:16004363:G:GT	donor_gain	0.9400
1:16005915:CTAGG:C	acceptor_gain	0.9400
1:16005914:TCTAG:T	acceptor_gain	0.9100
1:16005918:G:T	acceptor_gain	0.9100
1:16005360:CAAG:C	acceptor_gain	0.9000
1:16005359:ACAAG:A	acceptor_gain	0.8700
1:16004388:A:C	donor_gain	0.8500
1:16005361:AAGC:A	acceptor_gain	0.7900
1:16005362:A:G	acceptor_gain	0.7700
1:16005363:G:T	acceptor_gain	0.7300
1:16005260:T:TA	acceptor_gain	0.7100
1:16005913:TTCTA:T	acceptor_gain	0.7100

AlphaMissense

1066 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:16005969:T:C	F45L	0.977
1:16005971:T:A	F45L	0.977
1:16005971:T:G	F45L	0.977
1:16006294:T:A	V153D	0.935
1:16006298:G:C	K154N	0.920
1:16006298:G:T	K154N	0.920
1:16006286:G:C	W150C	0.919
1:16006286:G:T	W150C	0.919
1:16006327:T:A	V164D	0.913
1:16006306:T:C	L157P	0.912
1:16006310:A:C	K158N	0.902
1:16006310:A:T	K158N	0.902
1:16005973:T:A	V46D	0.899
1:16006323:T:C	C163R	0.896
1:16006086:T:C	F84L	0.887
1:16006088:C:A	F84L	0.887
1:16006088:C:G	F84L	0.887
1:16006306:T:A	L157Q	0.884
1:16006087:T:C	F84S	0.877
1:16005970:T:C	F45S	0.870
1:16006081:T:A	I82N	0.861
1:16006073:G:C	K79N	0.851
1:16006073:G:T	K79N	0.851
1:16005991:G:T	G52V	0.849
1:16005976:T:A	I47N	0.848
1:16006325:T:G	C163W	0.845
1:16005979:A:T	D48V	0.844
1:16005967:C:T	T44I	0.841
1:16006302:T:C	S156P	0.840
1:16006315:T:A	L160H	0.839

dbSNP variants (sampled 300 via entrez): RS1000173300 (1:16005062 G>T), RS1000775103 (1:16004049 G>A), RS1001083012 (1:16003790 G>A), RS1001176024 (1:16004452 T>C), RS1001270813 (1:16004669 G>A,C,T), RS1002176993 (1:16003561 T>C), RS1003036506 (1:16006702 C>T), RS1003273475 (1:16002374 T>C), RS1004480275 (1:16007477 T>C), RS1005373318 (1:16003031 C>T), RS1005427937 (1:16008566 G>A,T), RS1005468407 (1:16008945 G>A), RS1006038652 (1:16003267 A>T), RS1006328746 (1:16003851 T>G), RS1006379350 (1:16004096 A>C,G)

Disease associations

OMIM: gene MIM:619448 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST005984_23	Glomerular filtration rate	1.000000e-12
GCST006956_22	Erectile dysfunction	3.000000e-06
GCST010796_4092	Electrocardiogram morphology (amplitude at temporal datapoints)	1.000000e-17
GCST010796_4093	Electrocardiogram morphology (amplitude at temporal datapoints)	3.000000e-13
GCST010796_4094	Electrocardiogram morphology (amplitude at temporal datapoints)	5.000000e-20

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004327	electrocardiography

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

13 total (human), top 13 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
dicrotophos	increases expression	1
bisphenol A	affects expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
Leflunomide	increases expression	1
Benzo(a)pyrene	decreases methylation	1
Caffeine	decreases phosphorylation	1
Coumestrol	decreases expression	1
Oxygen	increases expression	1
Quercetin	decreases expression	1
Tretinoin	decreases expression	1
Urethane	increases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	increases expression	1
Aflatoxin B1	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.