SRBD1

Summary

SRBD1 (S1 RNA binding domain 1, HGNC:25521) is a protein-coding gene on chromosome 2p21, encoding S1 RNA-binding domain-containing protein 1 (Q8N5C6). DNA- and histone-binding protein that localizes to the central axes of mitotic chromosomes. It is a common-essential gene (DepMap: required in 99.8% of cancer cell lines).

Predicted to enable mRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in translation.

Source: NCBI Gene 55133 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 195 total
• Cancer dependency (DepMap): dependent in 99.8% of screened cell lines (common-essential)
• MANE Select transcript: NM_018079

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25521
Approved symbol	SRBD1
Name	S1 RNA binding domain 1
Location	2p21
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10379
Ensembl gene	ENSG00000068784
Ensembl biotype	protein_coding
Entrez	55133

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 4 protein_coding_CDS_not_defined, 2 protein_coding

ENST00000263736, ENST00000461805, ENST00000475073, ENST00000490133, ENST00000493649, ENST00000922966

RefSeq mRNA: 1 — MANE Select: NM_018079 NM_018079

CCDS: CCDS1823

Canonical transcript exons

ENST00000263736 — 21 exons

Exon	Start	End
ENSE00000750903	45476993	45477075
ENSE00000809785	45573207	45573342
ENSE00001005792	45601903	45602083
ENSE00001168815	45388680	45389599
ENSE00001168825	45574627	45574723
ENSE00001169403	45599449	45599835
ENSE00001346089	45579875	45580013
ENSE00001346093	45581693	45581810
ENSE00001346095	45585608	45585774
ENSE00001346110	45611219	45611267
ENSE00003485772	45605362	45605441
ENSE00003488067	45553623	45553730
ENSE00003491896	45413114	45413293
ENSE00003495723	45392945	45393129
ENSE00003544055	45547522	45547612
ENSE00003553851	45488240	45488331
ENSE00003625240	45419788	45419894
ENSE00003638927	45546732	45546839
ENSE00003657505	45562653	45562756
ENSE00003671817	45418365	45418541
ENSE00003694516	45551125	45551282

Expression profiles

Bgee: expression breadth ubiquitous, 214 present calls, max score 89.56.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.8930 / max 234.2335, expressed in 1778 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
28180	11.7225	1773
28175	0.8981	263
28176	0.2724	124

Top tissues by expression

280 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.56	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.38	gold quality
monocyte	CL:0000576	86.96	gold quality
mononuclear cell	CL:0000842	86.62	gold quality
leukocyte	CL:0000738	86.33	gold quality
calcaneal tendon	UBERON:0003701	86.21	gold quality
islet of Langerhans	UBERON:0000006	84.57	gold quality
ventricular zone	UBERON:0003053	84.52	gold quality
corpus epididymis	UBERON:0004359	83.32	gold quality
rectum	UBERON:0001052	81.27	gold quality
ganglionic eminence	UBERON:0004023	80.72	gold quality
blood	UBERON:0000178	80.46	gold quality
tendon	UBERON:0000043	80.23	gold quality
pancreas	UBERON:0001264	80.22	gold quality
sural nerve	UBERON:0015488	79.93	gold quality
granulocyte	CL:0000094	79.49	gold quality
stromal cell of endometrium	CL:0002255	79.38	gold quality
adrenal tissue	UBERON:0018303	78.96	gold quality
body of pancreas	UBERON:0001150	78.87	gold quality
choroid plexus epithelium	UBERON:0003911	77.98	silver quality
gall bladder	UBERON:0002110	76.98	gold quality
bone marrow cell	CL:0002092	76.80	gold quality
ectocervix	UBERON:0012249	76.21	gold quality
popliteal artery	UBERON:0002250	76.15	gold quality
tibial artery	UBERON:0007610	76.15	gold quality
right adrenal gland cortex	UBERON:0035827	75.86	gold quality
smooth muscle tissue	UBERON:0001135	75.80	gold quality
secondary oocyte	CL:0000655	75.79	gold quality
colonic epithelium	UBERON:0000397	75.73	gold quality
caput epididymis	UBERON:0004358	75.68	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.14

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

58 targeting SRBD1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-511-3P	99.99	68.85	1467
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-381-3P	99.93	71.87	2854
HSA-MIR-300	99.92	71.76	2856
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-6124	99.87	69.78	3551
HSA-MIR-579-3P	99.86	71.66	3628
HSA-MIR-664B-3P	99.84	71.65	3590
HSA-MIR-4698	99.84	71.41	4303
HSA-MIR-4668-5P	99.79	70.58	3782
HSA-MIR-4694-3P	99.79	69.53	2640

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 99.8% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 3)

• Our genome-wide association study identified SRBD1 and ELOVL5 as new susceptibility genes for (normal tension glaucoma) NTG. (PMID:20363506)
• Dogs and humans share a common susceptibility gene SRBD1 for glaucoma risk. (PMID:24040232)
• rs3213787 and rs11884064 not associated with genetic susceptibility to normal-tension glaucoma in a Korean cohort (PMID:32569157)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	srbd1	ENSDARG00000079827
danio_rerio	srbd1	ENSDARG00000092855
mus_musculus	Srbd1	ENSMUSG00000024135
rattus_norvegicus	Srbd1	ENSRNOG00000014720
drosophila_melanogaster	CG31156	FBGN0051156
caenorhabditis_elegans	ZK973.1	WBGENE00022830

Protein

Protein identifiers

S1 RNA-binding domain-containing protein 1 — Q8N5C6 (reviewed: Q8N5C6)

All UniProt accessions (1): Q8N5C6

UniProt curated annotations — full annotation on UniProt →

Function. DNA- and histone-binding protein that localizes to the central axes of mitotic chromosomes. Promotes chromosome segregation by facilitating TOP2A recruitment to mitotic chromosomes, thereby preventing anaphase failure. During prophase, safeguards the decatenation process to avoid the formation of difficult-to-resolve DNA structures, preventing chromosome missegregation. Also contributes to the regulation of nucleus pulposus cell senescence.

Subunit / interactions. Interacts with NBR1; this interaction clears SRBD1 through the autophagic-lysosomal pathway.

Subcellular location. Nucleus. Nucleolus. Cytoplasm. Chromosome.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8N5C6-1	1	yes
Q8N5C6-2	2

RefSeq proteins (1): NP_060549* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003029	S1_domain	Domain
IPR006641	YqgF/RNaseH-like_dom	Domain
IPR010994	RuvA_2-like	Homologous_superfamily
IPR012337	RNaseH-like_sf	Homologous_superfamily
IPR012340	NA-bd_OB-fold	Homologous_superfamily
IPR018974	Tex-like_N	Domain
IPR023319	Tex-like_HTH_dom_sf	Homologous_superfamily
IPR023323	Tex-like_dom_sf	Homologous_superfamily
IPR032639	Tex_YqgF	Domain
IPR037027	YqgF/RNaseH-like_dom_sf	Homologous_superfamily
IPR041692	HHH_9	Domain
IPR044146	S1_Tex	Domain
IPR050437	Ribos_protein_bS1-like	Family
IPR055179	Tex-like_central_region	Domain

Pfam: PF00575, PF09371, PF12836, PF16921, PF17674, PF22706

UniProt features (23 total): cross-link 8, sequence variant 3, sequence conflict 3, region of interest 2, modified residue 2, chain 1, domain 1, splice variant 1, coiled-coil region 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N5C6-F1	75.68	0.52

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (10): 166, 167, 183, 185, 185, 955, 861, 964, 84, 134

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 105 (showing top): GOBP_TRANSLATION, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, AACTTT_UNKNOWN, NUYTTEN_EZH2_TARGETS_DN, SCGGAAGY_ELK1_02, GOMF_MRNA_BINDING, GOMF_STRUCTURAL_MOLECULE_ACTIVITY, ELK1_02, PANGAS_TUMOR_SUPPRESSION_BY_SMAD1_AND_SMAD5_DN, ATF5_TARGET_GENES, ELF2_TARGET_GENES, FOXE1_TARGET_GENES, HES2_TARGET_GENES, KAT5_TARGET_GENES, MAFG_TARGET_GENES

GO Biological Process (2): nucleobase-containing compound metabolic process (GO:0006139), translation (GO:0006412)

GO Molecular Function (4): mRNA binding (GO:0003729), structural constituent of ribosome (GO:0003735), nucleic acid binding (GO:0003676), RNA binding (GO:0003723)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
primary metabolic process	1
peptidyltransferase activity	1
translational initiation	1
translational elongation	1
translational termination	1
macromolecule biosynthetic process	1
protein metabolic process	1
protein biosynthetic process	1
RNA binding	1
structural molecule activity	1
ribosome	1
binding	1
nucleic acid binding	1

Protein interactions and networks

STRING

1932 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SRBD1	TMCO1	Q9UM00	613
SRBD1	SIX1	Q15475	606
SRBD1	ASB10	Q8WXI3	573
SRBD1	ELOVL5	Q9NYP7	571
SRBD1	MYOC	Q99972	549
SRBD1	WDR36	Q8NI36	530
SRBD1	SIX6	O95475	507
SRBD1	ATOH7	Q8N100	505
SRBD1	ZNF362	Q5T0B9	490
SRBD1	ZNF276	Q8N554	490
SRBD1	CAV2	P51636	474
SRBD1	RRP15	Q9Y3B9	472
SRBD1	GAS7	O60861	466
SRBD1	FEZ2	Q9UHY8	462
SRBD1	NAIF1	Q69YI7	448

IntAct

104 interactions, top by confidence:

A	B	Type	Score
SART3	PRPF4	psi-mi:“MI:0914”(association)	0.730
ZC3HC1	TPR	psi-mi:“MI:0914”(association)	0.640
KPNA1	TCERG1	psi-mi:“MI:0914”(association)	0.640
MECP2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
TRIM44	ODAD3	psi-mi:“MI:0914”(association)	0.530
RRP8	NVL	psi-mi:“MI:0914”(association)	0.530
RPL18A	RRP8	psi-mi:“MI:0914”(association)	0.530
ZBTB48	ZBTB24	psi-mi:“MI:0914”(association)	0.530
ARIH1	SPOP	psi-mi:“MI:0914”(association)	0.530
SRBD1	PPP3CC	psi-mi:“MI:0914”(association)	0.530
RPS3	ZNF316	psi-mi:“MI:0914”(association)	0.530
MAGEB2	POLRMT	psi-mi:“MI:0914”(association)	0.530
CCDC59	GAPDHS	psi-mi:“MI:0914”(association)	0.530
MYL6	MYL6B	psi-mi:“MI:0914”(association)	0.530
ABT1	ZNF316	psi-mi:“MI:0914”(association)	0.530
MAGEB2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
RPL13	RRP8	psi-mi:“MI:0914”(association)	0.530
H3C1	SMCHD1	psi-mi:“MI:2364”(proximity)	0.410
SRBD1	GAPDHS	psi-mi:“MI:0915”(physical association)	0.400
Lyplal1	PARP10	psi-mi:“MI:0914”(association)	0.350
Naa50	WDR46	psi-mi:“MI:0914”(association)	0.350

BioGRID (150): SRBD1 (Affinity Capture-RNA), SRBD1 (Affinity Capture-MS), SRBD1 (Proximity Label-MS), SRBD1 (Proximity Label-MS), SRBD1 (Proximity Label-MS), SRBD1 (Affinity Capture-MS), SRBD1 (Affinity Capture-MS), SRBD1 (Affinity Capture-MS), SRBD1 (Affinity Capture-MS), SRBD1 (Affinity Capture-MS), SRBD1 (Synthetic Lethality), RCAN1 (Affinity Capture-MS), GSK3A (Affinity Capture-MS), SRBD1 (Affinity Capture-MS), SRBD1 (Affinity Capture-MS)

ESM2 similar proteins: A0A8J1M587, A2PYH4, A2RUV5, A8WK63, B2RR83, B3MMA5, B3P3W1, B4K5R2, B4MX21, B6DMK2, B8A4F4, D3Z4R1, F1NTD6, O09053, O13799, O14232, O18475, O48534, O60072, O75417, O93530, P46063, P51979, P53327, Q14BI7, Q1LXK4, Q2VPA6, Q3EBC8, Q3MHU3, Q3YK19, Q497V5, Q5D892, Q5N870, Q5R746, Q5RDI0, Q5RF63, Q5SXJ3, Q6AYJ1, Q6J5K9, Q7QCW2

Diamond homologs: A0LE14, A0Q0Q1, A0QYY6, A1WXU7, A2ZLC1, A3PNG0, A4WWP0, A5GF91, A6LSR0, A7IC03, A8IGA3, A8J637, A8LKE7, A9KNK6, B0K1D0, B0K9P4, B0T175, B2FN86, B2TJ61, B2V4H5, B3EAF2, B4SQR6, B5EI63, B6IVG3, B7JJ84, B8I2R5, B9KP47, B9M1G5, C6E2P5, O06000, O31489, P0AG67, P0AG68, P0AG69, P0AG70, P14128, P14129, P37985, P38494, P46836

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 131 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
SARS-CoV-1 modulates host translation machinery	7	24.0×	4e-07
Eukaryotic Translation Initiation	6	20.6×	8e-06
Cap-dependent Translation Initiation	6	20.6×	8e-06
Eukaryotic Translation Elongation	6	18.6×	1e-05
Peptide chain elongation	13	18.3×	3e-11
Viral mRNA Translation	13	18.3×	3e-11
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	13	18.1×	3e-11
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	6	18.1×	2e-05

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	14	21.8×	2e-12
ribosomal small subunit biogenesis	9	17.2×	6e-07
translation	12	10.4×	6e-07
regulation of alternative mRNA splicing, via spliceosome	5	10.3×	1e-02
negative regulation of translation	6	9.9×	3e-03
rRNA processing	8	9.5×	3e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

195 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	159
Likely benign	11
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

4367 predictions. Top by Δscore:

Variant	Effect	Δscore
2:45389595:AAAAT:A	acceptor_gain	1.0000
2:45389596:AAAT:A	acceptor_gain	1.0000
2:45389597:AAT:A	acceptor_gain	1.0000
2:45389597:AATCT:A	acceptor_loss	1.0000
2:45389598:AT:A	acceptor_gain	1.0000
2:45389599:TCTG:T	acceptor_loss	1.0000
2:45389600:C:CC	acceptor_gain	1.0000
2:45389600:C:CG	acceptor_loss	1.0000
2:45392940:TTTA:T	donor_loss	1.0000
2:45392941:TTA:T	donor_loss	1.0000
2:45392942:TA:T	donor_loss	1.0000
2:45392943:A:AG	donor_loss	1.0000
2:45392944:C:A	donor_loss	1.0000
2:45393125:AAAAC:A	acceptor_gain	1.0000
2:45393126:AAAC:A	acceptor_gain	1.0000
2:45393126:AAACC:A	acceptor_loss	1.0000
2:45393127:AAC:A	acceptor_gain	1.0000
2:45393127:AACCT:A	acceptor_loss	1.0000
2:45393128:AC:A	acceptor_gain	1.0000
2:45393129:CC:C	acceptor_gain	1.0000
2:45393129:CCTG:C	acceptor_loss	1.0000
2:45393130:C:CC	acceptor_gain	1.0000
2:45393130:C:CG	acceptor_loss	1.0000
2:45393131:T:A	acceptor_loss	1.0000
2:45393134:A:T	acceptor_gain	1.0000
2:45393135:G:GC	acceptor_gain	1.0000
2:45413109:CTTA:C	donor_loss	1.0000
2:45413111:TACC:T	donor_loss	1.0000
2:45413112:A:T	donor_loss	1.0000
2:45413113:CCT:C	donor_gain	1.0000

AlphaMissense

6549 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:45562740:C:G	R441P	1.000
2:45389332:A:G	L989P	0.999
2:45389500:C:T	G933E	0.999
2:45389521:A:T	V926D	0.999
2:45389527:C:T	G924D	0.999
2:45418491:C:G	R736P	0.999
2:45477060:C:G	R661P	0.999
2:45488244:A:C	S654R	0.999
2:45488244:A:T	S654R	0.999
2:45488246:T:G	S654R	0.999
2:45488298:A:C	S636R	0.999
2:45488298:A:T	S636R	0.999
2:45488300:T:G	S636R	0.999
2:45546819:C:T	G596E	0.999
2:45551178:C:T	G541E	0.999
2:45551179:C:G	G541R	0.999
2:45551179:C:T	G541R	0.999
2:45551226:A:G	L525P	0.999
2:45562719:A:G	L448P	0.999
2:45562741:G:T	R441S	0.999
2:45389374:A:T	V975D	0.998
2:45389464:A:G	L945P	0.998
2:45389491:A:T	V936E	0.998
2:45389501:C:G	G933R	0.998
2:45389501:C:T	G933R	0.998
2:45389502:A:C	F932L	0.998
2:45389502:A:T	F932L	0.998
2:45389504:A:G	F932L	0.998
2:45389533:A:G	L922P	0.998
2:45418403:G:C	F765L	0.998

dbSNP variants (sampled 300 via entrez): RS1000009040 (2:45425594 C>T), RS1000010518 (2:45422723 A>T), RS1000021574 (2:45567714 G>A), RS1000026370 (2:45427926 T>C), RS1000033028 (2:45569183 CTTT>C), RS1000047315 (2:45580610 C>G,T), RS1000048450 (2:45604078 A>C), RS1000055072 (2:45533213 C>T), RS1000072872 (2:45464810 G>C), RS1000095355 (2:45564284 A>C), RS1000120697 (2:45412659 T>A), RS1000125919 (2:45514248 T>C), RS1000130664 (2:45562158 CTTATT>C), RS1000144775 (2:45497613 T>A), RS1000147270 (2:45502648 G>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST000645_1	Glaucoma	3.000000e-09
GCST002806_1	Type 2 diabetes	1.000000e-06
GCST002815_3	Bipolar disorder (inflammation and infection response interaction)	8.000000e-07
GCST002875_30	Diisocyanate-induced asthma	2.000000e-06
GCST004750_67	Squamous cell lung carcinoma	5.000000e-06
GCST009426_1	Retinal arteriole-to-venule ratio	7.000000e-07
GCST90014033_9	Haemorrhoidal disease	3.000000e-10

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0007050	HSV1 seropositivity
EFO:0006995	response to diisocyanate
EFO:0010554	retinal vasculature measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases expression	3
GSK-J4	decreases expression	1
FR900359	increases phosphorylation	1
TAK-243	increases sumoylation	1
arsenite	affects binding, decreases reaction	1
sodium arsenite	decreases expression	1
potassium chromate(VI)	decreases expression, affects cotreatment	1
beta-methylcholine	affects expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
entinostat	increases expression	1
(+)-JQ1 compound	decreases expression	1
Sunitinib	increases expression	1
Acetaminophen	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Cadmium	increases abundance, increases expression	1
Caffeine	affects phosphorylation	1
Cisplatin	decreases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Ribonucleotides	affects binding	1
Tretinoin	increases expression	1
Urethane	decreases expression	1
Valproic Acid	affects expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Cyclosporine	increases expression	1
Cadmium Chloride	increases expression, increases abundance	1
Particulate Matter	increases abundance, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.