SREBF2-AS1

Summary

SREBF2-AS1 (SREBF2 antisense RNA 1, HGNC:53953) is a long non-coding RNA gene on chromosome 22q13.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53953
Approved symbol	SREBF2-AS1
Name	SREBF2 antisense RNA 1
Location	22q13.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP5, 821D11.7
Ensembl gene	ENSG00000184068
Ensembl biotype	lncRNA
Entrez	112637020
RNAcentral	URS0001981162 — lncRNA, 6723 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000333487

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000333487 — 2 exons

Exon	Start	End
ENSE00001296773	41831215	41833980
ENSE00001317858	41834443	41834665

Expression profiles

Bgee: expression breadth ubiquitous, 130 present calls, max score 82.60.

Top tissues by expression

130 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.60	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.33	gold quality
sural nerve	UBERON:0015488	78.41	gold quality
ventricular zone	UBERON:0003053	68.90	gold quality
cortical plate	UBERON:0005343	65.79	gold quality
ganglionic eminence	UBERON:0004023	65.63	gold quality
bone marrow cell	CL:0002092	64.95	silver quality
colonic epithelium	UBERON:0000397	64.86	silver quality
bone marrow	UBERON:0002371	62.91	gold quality
adrenal tissue	UBERON:0018303	62.01	gold quality
left adrenal gland	UBERON:0001234	61.40	gold quality
adrenal gland	UBERON:0002369	61.12	gold quality
left adrenal gland cortex	UBERON:0035825	61.09	gold quality
right adrenal gland cortex	UBERON:0035827	60.93	gold quality
right adrenal gland	UBERON:0001233	60.79	gold quality
lower esophagus mucosa	UBERON:0035834	60.24	gold quality
prefrontal cortex	UBERON:0000451	57.63	gold quality
blood	UBERON:0000178	57.17	gold quality
primary visual cortex	UBERON:0002436	57.17	gold quality
leukocyte	CL:0000738	56.93	gold quality
monocyte	CL:0000576	56.92	gold quality
granulocyte	CL:0000094	56.81	gold quality
right atrium auricular region	UBERON:0006631	56.77	gold quality
hindlimb stylopod muscle	UBERON:0004252	56.18	gold quality
heart left ventricle	UBERON:0002084	55.89	gold quality
heart	UBERON:0000948	55.87	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	55.75	gold quality
apex of heart	UBERON:0002098	55.38	gold quality
frontal cortex	UBERON:0001870	54.93	gold quality
superior frontal gyrus	UBERON:0002661	54.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.07

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• lncRNA RP5-916L7.2 was up regulated in tumor tissue and positively correlated with tumor stage, and promoted cells proliferation while inhibited cells apoptosis by targeting miR-328-5p and miR-939-5p in tongue squamous cell carcinoma. (PMID:30825424)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.