SRI-AS1

Summary

SRI-AS1 (SRI antisense RNA 1, HGNC:40564) is a long non-coding RNA gene on chromosome 7q21.12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40564
Approved symbol	SRI-AS1
Name	SRI antisense RNA 1
Location	7q21.12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000254003
Ensembl biotype	lncRNA
Entrez	102723885
RNAcentral	URS000075B2AD — lncRNA, 587 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 18 lncRNA

ENST00000434733, ENST00000447058, ENST00000447758, ENST00000520993, ENST00000591739, ENST00000594469, ENST00000595121, ENST00000600908, ENST00000627345, ENST00000627520, ENST00000628577, ENST00000629560, ENST00000629712, ENST00000629782, ENST00000631117, ENST00000718156, ENST00000718157, ENST00000810383

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000434733 — 3 exons

Exon	Start	End
ENSE00001692923	88283832	88283909
ENSE00001798521	88277001	88277169
ENSE00003769777	88292188	88292988

Expression profiles

Bgee: expression breadth ubiquitous, 127 present calls, max score 78.00.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0239 / max 24.3586, expressed in 3 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
79416	0.0239	3

Top tissues by expression

127 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.00	silver quality
bone marrow	UBERON:0002371	71.14	gold quality
ganglionic eminence	UBERON:0004023	70.71	gold quality
rectum	UBERON:0001052	70.60	gold quality
bone marrow cell	CL:0002092	70.44	gold quality
sural nerve	UBERON:0015488	70.30	gold quality
ventricular zone	UBERON:0003053	69.73	gold quality
colonic epithelium	UBERON:0000397	67.79	silver quality
cortical plate	UBERON:0005343	67.52	gold quality
mucosa of transverse colon	UBERON:0004991	65.42	gold quality
testis	UBERON:0000473	63.51	gold quality
left testis	UBERON:0004533	63.12	gold quality
monocyte	CL:0000576	61.45	gold quality
leukocyte	CL:0000738	61.26	gold quality
transverse colon	UBERON:0001157	61.17	gold quality
skeletal muscle tissue	UBERON:0001134	60.73	gold quality
granulocyte	CL:0000094	60.24	gold quality
right testis	UBERON:0004534	60.02	gold quality
superior frontal gyrus	UBERON:0002661	58.29	gold quality
colon	UBERON:0001155	58.17	gold quality
intestine	UBERON:0000160	57.11	gold quality
calcaneal tendon	UBERON:0003701	56.83	gold quality
duodenum	UBERON:0002114	56.74	gold quality
stromal cell of endometrium	CL:0002255	56.72	gold quality
lymph node	UBERON:0000029	56.53	gold quality
prefrontal cortex	UBERON:0000451	55.91	gold quality
islet of Langerhans	UBERON:0000006	55.27	gold quality
blood	UBERON:0000178	55.24	gold quality
vermiform appendix	UBERON:0001154	55.20	gold quality
liver	UBERON:0002107	54.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.68

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.