SRP14

Summary

SRP14 (signal recognition particle 14, HGNC:11299) is a protein-coding gene on chromosome 15q22, encoding Signal recognition particle 14 kDa protein (P37108). Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). It is a common-essential gene (DepMap: required in 94.9% of cancer cell lines).

Enables RNA binding activity. Involved in protein targeting to ER. Located in nucleus. Part of signal recognition particle, endoplasmic reticulum targeting.

Source: NCBI Gene 6727 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 23 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 94.9% of screened cell lines (common-essential)
• MANE Select transcript: NM_003134

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11299
Approved symbol	SRP14
Name	signal recognition particle 14
Location	15q22
Locus type	gene with protein product
Status	Approved
Aliases	ALURBP, MGC14326
Ensembl gene	ENSG00000140319
Ensembl biotype	protein_coding
OMIM	600708
Entrez	6727

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 6 protein_coding, 3 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000267884, ENST00000558243, ENST00000558527, ENST00000558720, ENST00000559081, ENST00000559439, ENST00000559475, ENST00000560773, ENST00000922618, ENST00000922619

RefSeq mRNA: 2 — MANE Select: NM_003134 NM_001309434, NM_003134

CCDS: CCDS42017

Canonical transcript exons

ENST00000267884 — 5 exons

Exon	Start	End
ENSE00001099638	40035690	40036500
ENSE00001099640	40039093	40039181
ENSE00003535495	40038282	40038394
ENSE00003546861	40038876	40038948
ENSE00003611911	40036986	40037018

Expression profiles

Bgee: expression breadth ubiquitous, 288 present calls, max score 99.79.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 341.0138 / max 5274.0314, expressed in 1828 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
149471	268.9032	1828
149470	70.5147	1815
149469	1.5959	1023

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
renal medulla	UBERON:0000362	99.79	gold quality
pons	UBERON:0000988	99.76	gold quality
pericardium	UBERON:0002407	99.72	gold quality
cerebellar vermis	UBERON:0004720	99.72	gold quality
superior vestibular nucleus	UBERON:0007227	99.72	gold quality
epithelium of nasopharynx	UBERON:0001951	99.70	gold quality
substantia nigra pars compacta	UBERON:0001965	99.70	gold quality
substantia nigra pars reticulata	UBERON:0001966	99.70	gold quality
dorsal root ganglion	UBERON:0000044	99.68	gold quality
trigeminal ganglion	UBERON:0001675	99.68	gold quality
tongue squamous epithelium	UBERON:0006919	99.68	gold quality
thymus	UBERON:0002370	99.67	gold quality
urethra	UBERON:0000057	99.66	gold quality
cardia of stomach	UBERON:0001162	99.66	gold quality
caput epididymis	UBERON:0004358	99.65	gold quality
pylorus	UBERON:0001166	99.64	gold quality
orbitofrontal cortex	UBERON:0004167	99.64	gold quality
mammary duct	UBERON:0001765	99.63	gold quality
olfactory bulb	UBERON:0002264	99.63	gold quality
postcentral gyrus	UBERON:0002581	99.63	gold quality
seminal vesicle	UBERON:0000998	99.62	gold quality
pigmented layer of retina	UBERON:0001782	99.62	gold quality
parotid gland	UBERON:0001831	99.62	gold quality
ventral tegmental area	UBERON:0002691	99.61	gold quality
corpus epididymis	UBERON:0004359	99.61	gold quality
calcaneal tendon	UBERON:0003701	99.60	gold quality
parietal lobe	UBERON:0001872	99.59	gold quality
medulla oblongata	UBERON:0001896	99.59	gold quality
synovial joint	UBERON:0002217	99.59	gold quality
trabecular bone tissue	UBERON:0002483	99.59	gold quality

Single-cell (SCXA)

Detected in 26 experiment(s), a significant marker in 17.

Experiment	Marker?	Max mean expression
E-MTAB-10287	yes	7559.47
E-MTAB-8322	yes	4170.82
E-HCAD-4	yes	62.14
E-HCAD-11	yes	43.58
E-HCAD-1	yes	32.91
E-MTAB-8410	yes	32.78
E-CURD-46	yes	31.93
E-MTAB-6701	yes	27.40
E-GEOD-84465	yes	22.91
E-MTAB-9467	yes	14.87
E-MTAB-10042	yes	13.56
E-HCAD-25	yes	9.01
E-MTAB-9801	yes	6.05
E-CURD-122	yes	5.87
E-CURD-88	yes	5.41

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

38 targeting SRP14, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4425	100.00	67.59	1049
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-548AR-3P	99.85	71.26	3889
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-548AZ-3P	99.82	70.56	3549
HSA-MIR-548BC	99.82	70.61	3524
HSA-MIR-548E-3P	99.82	70.59	3514
HSA-MIR-548F-3P	99.82	70.59	3540
HSA-MIR-6739-5P	99.80	67.87	2806
HSA-MIR-548A-3P	99.76	70.58	3524
HSA-MIR-6733-5P	99.74	67.94	2759
HSA-MIR-3682-3P	99.58	67.63	865
HSA-MIR-7844-5P	99.55	68.56	1428
HSA-MIR-3153	99.55	67.59	2337
HSA-MIR-6165	99.44	67.12	1389
HSA-MIR-4777-5P	99.33	67.53	1148
HSA-MIR-1244	99.33	68.38	832
HSA-MIR-664A-3P	99.22	71.08	2696
HSA-MIR-3926	98.95	69.26	1438
HSA-MIR-3190-5P	98.87	64.89	1345
HSA-MIR-876-3P	98.76	68.23	945
HSA-MIR-3945	98.68	64.21	553
HSA-MIR-4700-5P	98.63	67.43	1915
HSA-MIR-548S	98.50	67.17	1213
HSA-MIR-4662A-5P	98.48	67.18	1007

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 94.9% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 4)

• SRP14 mutant proteins with absence of a peptide elongation delay caused inefficient targeting of preproteins leading to defects in secretion, depletion of proteins in the endogenous membranes, and reduced cell growth. (PMID:18455985)
• mutational study on SRP9/14 that identified and characterized regions and single residues essential for elongation arrest activity (PMID:20348448)
• Dats show that Alu RNA promotes functional binding of Signal Recognition Particle proteins SRP9/14 to 40S ribosomal subunits. (PMID:25697503)
• Expression of signal recognition particle 14 in hepatocellular carcinoma and its relationship with disease progression and patient survival. (PMID:39183055)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	srp14	ENSDARG00000115987
mus_musculus	Srp14	ENSMUSG00000009549
rattus_norvegicus	Srp14	ENSRNOG00000007512
rattus_norvegicus	AABR07068253.1	ENSRNOG00000022614
caenorhabditis_elegans		WBGENE00017800

Protein

Protein identifiers

Signal recognition particle 14 kDa protein — P37108 (reviewed: P37108)

Alternative names: 18 kDa Alu RNA-binding protein

All UniProt accessions (3): P37108, H0YLA2, H0YLW0

UniProt curated annotations — full annotation on UniProt →

Function. Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.

Subunit / interactions. Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

Subcellular location. Cytoplasm.

Similarity. Belongs to the SRP14 family.

RefSeq proteins (2): NP_001296363, NP_003125* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003210	Signal_recog_particle_SRP14	Family
IPR009018	Signal_recog_particle_SRP9/14	Homologous_superfamily

Pfam: PF02290

UniProt features (18 total): sequence variant 6, strand 4, helix 2, initiator methionine 1, chain 1, sequence conflict 1, turn 1, region of interest 1, modified residue 1

Structure

Experimental structures (PDB)

7 structures.

PDB	Method	Resolution (Å)
5AOX	X-RAY DIFFRACTION	2.04
1E8O	X-RAY DIFFRACTION	3.2
7NFX	ELECTRON MICROSCOPY	3.2
4UYK	X-RAY DIFFRACTION	3.22
4UYJ	X-RAY DIFFRACTION	3.35
1E8S	X-RAY DIFFRACTION	4
1RY1	ELECTRON MICROSCOPY	12

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P37108-F1	77.38	0.49

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 27

Function

Pathways and Gene Ontology

Reactome pathways

6 pathways

ID	Pathway
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane
R-HSA-6798695	Neutrophil degranulation
R-HSA-168249	Innate Immune System
R-HSA-168256	Immune System
R-HSA-392499	Metabolism of proteins
R-HSA-72766	Translation

MSigDB gene sets: 160 (showing top): REACTOME_INNATE_IMMUNE_SYSTEM, GOCC_SECRETORY_GRANULE, MORF_SNRP70, MORF_UBE2I, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, MORF_HDAC1, GOBP_PROTEIN_TARGETING, HSIAO_HOUSEKEEPING_GENES, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE, MODULE_503, MORF_SKP1A, GOBP_PROTEIN_TARGETING_TO_MEMBRANE, MODULE_195, MORF_CCNI

GO Biological Process (3): cotranslational protein targeting to membrane (GO:0006613), SRP-dependent cotranslational protein targeting to membrane (GO:0006614), protein targeting to ER (GO:0045047)

GO Molecular Function (4): RNA binding (GO:0003723), 7S RNA binding (GO:0008312), endoplasmic reticulum signal sequence receptor activity (GO:0030942), protein binding (GO:0005515)

GO Cellular Component (9): extracellular region (GO:0005576), nucleus (GO:0005634), cytoplasm (GO:0005737), signal recognition particle, endoplasmic reticulum targeting (GO:0005786), cytosol (GO:0005829), secretory granule lumen (GO:0034774), ficolin-1-rich granule lumen (GO:1904813), signal recognition particle (GO:0048500), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
Translation	1
Innate Immune System	1
Immune System	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
cytoplasm	2
protein targeting to membrane	1
translation	1
cotranslational protein targeting to membrane	1
protein targeting to ER	1
protein targeting	1
establishment of protein localization to endoplasmic reticulum	1
nucleic acid binding	1
RNA binding	1
signal sequence receptor activity	1
binding	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
signal recognition particle	1
secretory granule	1
cytoplasmic vesicle lumen	1
intracellular organelle lumen	1
ficolin-1-rich granule	1
ribonucleoprotein complex	1
protein-containing complex	1

Protein interactions and networks

STRING

2231 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SRP14	SRP72	O76094	999
SRP14	SRP19	P09132	999
SRP14	SRP54	P13624	999
SRP14	SRP9	P49458	999
SRP14	SRP68	Q9UHB9	999
SRP14	SRPRB	Q9Y5M8	678
SRP14	SRPRA	P08240	649
SRP14	RPL23A	P29316	633
SRP14	SZRD1	Q7Z422	532
SRP14	SPCS2	Q15005	528
SRP14	SEC61A1	P38378	503
SRP14	SEC63	Q9UGP8	453
SRP14	TMEM179	Q6ZVK1	430
SRP14	TRIM25	Q14258	428
SRP14	PYROXD1	Q8WU10	425

IntAct

228 interactions, top by confidence:

A	B	Type	Score
SRP9	SRP14	psi-mi:“MI:0915”(physical association)	0.890
SRP14	SRP9	psi-mi:“MI:0915”(physical association)	0.890
YBX1	HNRNPR	psi-mi:“MI:0914”(association)	0.770
SRP9	SRP72	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
SRP14	PPM1G	psi-mi:“MI:0914”(association)	0.640
CFTR	HAX1	psi-mi:“MI:0914”(association)	0.610
SRP14	SRP9	psi-mi:“MI:0407”(direct interaction)	0.560
DDX31	SRP14	psi-mi:“MI:0915”(physical association)	0.560
SRP14	SPANXN2	psi-mi:“MI:0915”(physical association)	0.560
SRP14	EAF1	psi-mi:“MI:0915”(physical association)	0.560
NP	KPNA6	psi-mi:“MI:0914”(association)	0.550
KLC2	KIF5B	psi-mi:“MI:0914”(association)	0.530
ZBTB48	ZBTB24	psi-mi:“MI:0914”(association)	0.530
DDX31	MAGEB2	psi-mi:“MI:0914”(association)	0.530
RRP8	MAGEB2	psi-mi:“MI:0914”(association)	0.530
SRP68	MAGEB2	psi-mi:“MI:0914”(association)	0.530
CFTR	PLEKHG3	psi-mi:“MI:0914”(association)	0.480

BioGRID (475): SRP14 (Affinity Capture-MS), SRP14 (Affinity Capture-MS), SRP14 (Affinity Capture-MS), SRP14 (Affinity Capture-MS), SRP14 (Affinity Capture-MS), SRP14 (Affinity Capture-MS), SRP14 (Affinity Capture-MS), SRP14 (Affinity Capture-MS), NIFK (Co-fractionation), NOLC1 (Co-fractionation), SRP14 (Co-fractionation), SRP14 (Co-fractionation), SRP14 (Co-fractionation), SRP68 (Co-fractionation), SRP72 (Co-fractionation)

ESM2 similar proteins: A1XQU3, A1XQU5, G1SE28, G1SKF7, G1SZ12, G1TXF6, O65743, O94776, P21533, P37108, P38666, P47911, P50888, P50914, P55844, P61122, P61353, P61354, P61355, P61356, P61357, P61358, P83731, P83732, Q02878, Q2YGT9, Q3T0U2, Q42347, Q4R5C7, Q4R8Z4, Q58DQ3, Q63507, Q66WF5, Q6QMZ4, Q6Y263, Q862I1, Q8BP67, Q8ISQ3, Q8JGR4, Q90YQ0

Diamond homologs: A6QQL9, O04421, O04433, O16927, O18881, P16254, P16255, P37108, Q4R5C7, Q556L1, Q5RBX7, Q9P372

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 138 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
negative regulation of innate immune response	6	25.3×	1e-04
mRNA processing	9	5.9×	8e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

23 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	14
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

648 predictions. Top by Δscore:

Variant	Effect	Δscore
15:40036496:TAAGC:T	acceptor_gain	1.0000
15:40036497:AAGC:A	acceptor_gain	1.0000
15:40036498:AGC:A	acceptor_gain	1.0000
15:40036499:GC:G	acceptor_gain	1.0000
15:40036499:GCC:G	acceptor_loss	1.0000
15:40036500:CC:C	acceptor_gain	1.0000
15:40036501:C:CC	acceptor_gain	1.0000
15:40036501:C:CG	acceptor_loss	1.0000
15:40036502:T:G	acceptor_loss	1.0000
15:40037015:TCAC:T	acceptor_gain	1.0000
15:40037016:CAC:C	acceptor_gain	1.0000
15:40037016:CACC:C	acceptor_gain	1.0000
15:40037018:CCTG:C	acceptor_loss	1.0000
15:40038280:A:AC	donor_gain	1.0000
15:40038281:C:CC	donor_gain	1.0000
15:40038281:CCA:C	donor_gain	1.0000
15:40038281:CCACA:C	donor_gain	1.0000
15:40038870:GCTTA:G	donor_loss	1.0000
15:40038871:CTTAC:C	donor_loss	1.0000
15:40038873:TACAC:T	donor_loss	1.0000
15:40038874:A:AC	donor_gain	1.0000
15:40038874:A:T	donor_loss	1.0000
15:40038875:C:CA	donor_loss	1.0000
15:40038875:C:CC	donor_gain	1.0000
15:40038875:CA:C	donor_gain	1.0000
15:40038875:CACTT:C	donor_gain	1.0000
15:40038879:T:TA	donor_gain	1.0000
15:40038949:C:CC	acceptor_gain	1.0000
15:40036508:A:AC	acceptor_gain	0.9900
15:40036978:AAACT:A	donor_loss	0.9900

AlphaMissense

876 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:40036459:C:A	K95N	1.000
15:40036459:C:G	K95N	1.000
15:40036463:A:G	L94P	1.000
15:40036480:T:A	R88S	1.000
15:40036480:T:G	R88S	1.000
15:40036487:A:G	L86P	1.000
15:40036992:A:C	F79L	1.000
15:40036992:A:T	F79L	1.000
15:40036993:A:G	F79S	1.000
15:40036994:A:G	F79L	1.000
15:40038313:G:T	A60D	1.000
15:40038315:T:A	R59S	1.000
15:40038315:T:G	R59S	1.000
15:40038316:C:A	R59I	1.000
15:40038316:C:G	R59T	1.000
15:40038322:A:G	L57P	1.000
15:40038322:A:T	L57Q	1.000
15:40038324:A:C	C56W	1.000
15:40038326:A:G	C56R	1.000
15:40038880:C:A	K31N	1.000
15:40038880:C:G	K31N	1.000
15:40038896:A:T	V26D	1.000
15:40038926:A:G	L16P	1.000
15:40038935:A:G	L13P	1.000
15:40038946:G:C	F9L	1.000
15:40038946:G:T	F9L	1.000
15:40038947:A:G	F9S	1.000
15:40038948:A:G	F9L	1.000
15:40036456:C:A	K96N	0.999
15:40036456:C:G	K96N	0.999

dbSNP variants (sampled 300 via entrez): RS1000550258 (15:40039699 C>A,T), RS1001391436 (15:40039996 A>G), RS1001654700 (15:40040283 A>G), RS1002036696 (15:40040261 A>G), RS1002152936 (15:40035499 A>C), RS1002184074 (15:40035766 A>T), RS1003152837 (15:40036825 T>C), RS1003182293 (15:40037105 G>A), RS1003556703 (15:40036100 T>C), RS1004158196 (15:40038207 G>A), RS1004189276 (15:40038529 C>A,G), RS1005236158 (15:40039590 A>C,G), RS1005614869 (15:40039306 G>A,C,T), RS1006083736 (15:40035468 A>T), RS1006204914 (15:40040896 G>C)

Disease associations

OMIM: gene MIM:600708 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST001407_2	Ewing sarcoma	7.000000e-09
GCST001762_806	Obesity-related traits	2.000000e-06
GCST90002405_381	Reticulocyte count	7.000000e-11
GCST90002406_383	Reticulocyte fraction of red cells	2.000000e-14
GCST90011898_38	Alanine aminotransferase levels	1.000000e-17
GCST90011899_39	Aspartate aminotransferase levels	2.000000e-17
GCST90013405_136	Liver enzyme levels (alanine transaminase)	1.000000e-23
GCST90020028_1879	Hip circumference adjusted for BMI	2.000000e-10

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0007986	reticulocyte count
EFO:0004736	aspartate aminotransferase measurement
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5725081 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 4 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.45	Kd	3593	nM	CHEMBL5653589
5.45	ED50	3593	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 10 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149483: Binding affinity to human SRP14 incubated for 45 mins by Kinobead based pull down assay	kd	3.5933	uM

CTD chemical–gene interactions

31 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects expression, increases expression, affects cotreatment	3
arsenite	affects binding, increases reaction, decreases methylation	2
sodium arsenite	decreases expression, increases expression	2
TAK-243	increases sumoylation	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
methylparaben	decreases expression	1
zinc chromate	increases abundance, increases expression	1
artenimol	affects binding	1
chromium hexavalent ion	increases abundance, increases expression	1
CGP 52608	affects binding, increases reaction	1
chloropicrin	affects expression	1
abrine	decreases expression	1
2-amino-14,16-dimethyloctadecan-3-ol	decreases expression	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	increases expression	1
Temozolomide	decreases expression	1
Sunitinib	decreases expression	1
Air Pollutants	affects expression, increases abundance	1
Atrazine	decreases expression	1
Benzo(a)pyrene	increases methylation	1
Carmustine	decreases expression	1
Diuron	decreases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Ivermectin	decreases expression	1
Ozone	affects expression, increases abundance	1
Phenolsulfonphthalein	affects cotreatment, increases expression	1
Ribonucleotides	affects binding	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	affects expression	1
Antirheumatic Agents	increases expression	1

ChEMBL screening assays

7 unique, capped per target: 7 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652525	Binding	Binding affinity to human SRP14 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B3I4	Abcam HEK293T SRP14 KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.