SRRM4

Summary

SRRM4 (serine/arginine repetitive matrix 4, HGNC:29389) is a protein-coding gene on chromosome 12q24.23, encoding Serine/arginine repetitive matrix protein 4 (A7MD48). Splicing factor specifically required for neural cell differentiation.

SRRM4 promotes alternative splicing and inclusion of neural-specific exons in target mRNAs (Calarco et al., 2009 [PubMed 19737518]).

Source: NCBI Gene 84530 — RefSeq curated summary.

At a glance

• GWAS associations: 9
• Clinical variants (ClinVar): 102 total
• MANE Select transcript: NM_194286

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29389
Approved symbol	SRRM4
Name	serine/arginine repetitive matrix 4
Location	12q24.23
Locus type	gene with protein product
Status	Approved
Aliases	nSR100
Ensembl gene	ENSG00000139767
Ensembl biotype	protein_coding
OMIM	613103
Entrez	84530

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 5 protein_coding_CDS_not_defined, 2 protein_coding, 1 nonsense_mediated_decay

ENST00000267260, ENST00000534886, ENST00000537597, ENST00000545224, ENST00000641899, ENST00000641910, ENST00000651431, ENST00000902270

RefSeq mRNA: 1 — MANE Select: NM_194286 NM_194286

CCDS: CCDS44994

Canonical transcript exons

ENST00000267260 — 13 exons

Exon	Start	End
ENSE00000940093	119102236	119102382
ENSE00000940098	119145381	119145685
ENSE00000940099	119151017	119151220
ENSE00000940100	119153539	119153649
ENSE00000940101	119154243	119154383
ENSE00001111306	118981541	118982013
ENSE00001250091	119156495	119163051
ENSE00003467392	119116937	119117008
ENSE00003568418	119125381	119125479
ENSE00003579685	119122070	119122120
ENSE00003617666	119120250	119120276
ENSE00003617723	119130678	119130834
ENSE00003629750	119114278	119114364

Expression profiles

Bgee: expression breadth ubiquitous, 184 present calls, max score 94.25.

FANTOM5 (CAGE): breadth broad, TPM avg 5.9661 / max 721.1407, expressed in 264 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
128280	4.3585	239
128279	0.8160	163
128281	0.3125	93
128278	0.1949	85
206921	0.1874	73
128277	0.0812	39
128286	0.0157	4

Top tissues by expression

259 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cerebellar vermis	UBERON:0004720	94.25	gold quality
cortical plate	UBERON:0005343	93.69	gold quality
cerebellar cortex	UBERON:0002129	93.32	gold quality
cerebellar hemisphere	UBERON:0002245	93.29	gold quality
cerebellum	UBERON:0002037	93.21	gold quality
right hemisphere of cerebellum	UBERON:0014890	93.14	gold quality
ganglionic eminence	UBERON:0004023	90.34	gold quality
middle temporal gyrus	UBERON:0002771	89.78	gold quality
Brodmann (1909) area 23	UBERON:0013554	88.70	gold quality
primary visual cortex	UBERON:0002436	88.62	gold quality
occipital lobe	UBERON:0002021	87.31	gold quality
superior frontal gyrus	UBERON:0002661	86.77	gold quality
postcentral gyrus	UBERON:0002581	85.59	gold quality
parietal lobe	UBERON:0001872	85.53	gold quality
right frontal lobe	UBERON:0002810	84.87	gold quality
frontal cortex	UBERON:0001870	84.62	gold quality
frontal lobe	UBERON:0016525	84.62	gold quality
entorhinal cortex	UBERON:0002728	84.44	gold quality
Brodmann (1909) area 9	UBERON:0013540	84.31	gold quality
neocortex	UBERON:0001950	84.17	gold quality
prefrontal cortex	UBERON:0000451	83.73	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	83.72	gold quality
left ventricle myocardium	UBERON:0006566	82.93	gold quality
cardiac muscle of right atrium	UBERON:0003379	82.84	gold quality
cerebral cortex	UBERON:0000956	82.56	gold quality
anterior cingulate cortex	UBERON:0009835	81.87	gold quality
lateral nuclear group of thalamus	UBERON:0002736	81.16	gold quality
Brodmann (1909) area 46	UBERON:0006483	80.86	gold quality
brain	UBERON:0000955	78.38	gold quality
temporal lobe	UBERON:0001871	77.39	gold quality

Single-cell (SCXA)

Detected in 9 experiment(s), a significant marker in 8.

Experiment	Marker?	Max mean expression
E-GEOD-137537	yes	2390.87
E-HCAD-35	yes	63.65
E-HCAD-25	yes	42.63
E-GEOD-93593	yes	12.09
E-MTAB-9067	yes	11.57
E-HCAD-5	yes	7.72
E-GEOD-84465	yes	6.63
E-ANND-3	yes	5.68
E-GEOD-83139	no	2.89

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

255 targeting SRRM4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-23B-5P	99.98	66.07	587
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-10523-5P	99.91	69.22	2038
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-1343-3P	99.89	66.78	1815
HSA-MIR-9902	99.89	69.15	2250
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-6780A-5P	99.88	66.69	2776

Literature-anchored findings (GeneRIF, showing 13)

• findings show that nSR100 plays a role in the alternative splicing of REST in small cell lung cancer (SCLC); study provides new insight into the role of nSR100 in the expression of sREST, possibly in the pathogenesis of SCLC (PMID:23928058)
• Neural microexons are regulated by the neuronal-specific splicing factor nSR100/SRRM4, through its binding to adjacent intronic enhancer motifs; neural microexons are frequently misregulated in the brains of individuals with autism spectrum disorder, and this misregulation is associated with reduced levels of nSR100. (PMID:25525873)
• The splicing of REST by SRRM4 could promote the neuroendocrine phenotype in CRPC. (PMID:26071481)
• SRRM4 regulates alternative splicing programs to drive neuroendocrine prostate cancer progression (an aggressive subtype of castration-resistant prostate cancer) under androgen receptor pathway inhibition. (PMID:27180064)
• Neuronal activity-dependent microexons are nSR100 targets and are misregulated in autism. (PMID:27984743)
• data indicate that SRRM4 regulates alternative RNA splicing of the Bif-1 gene that enables PCa cells resistant to apoptotic stimuli under anti-cancer therapies, and may contribute to AdPC progression into t-NEPC. (PMID:29759485)
• a novel mechanism by which SRRM4 drives neuroendocrine prostate cancer progression via a pluripotency gene network, is reported. (PMID:30100395)
• SRRM4 expression in castrate-resistant pancreatic cancer is highly correlated with neuroendocrine prostate cancer and poor survival. (PMID:30155992)
• RNA Splicing of the BHC80 Gene Contributes to Neuroendocrine Prostate Cancer Progression. (PMID:30910347)
• A gapmer antisense oligonucleotide targeting SRRM4 is a novel therapeutic medicine for lung cancer. (PMID:31110284)
• Alternative splicing of LSD1+8a in neuroendocrine prostate cancer is mediated by SRRM4. (PMID:32403054)
• SRRM4 Expands the Repertoire of Circular RNAs by Regulating Microexon Inclusion. (PMID:33207694)
• RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular Phenotypes of Castration-Resistant Neuroendocrine Prostate Cancer. (PMID:34312180)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Srrm4	ENSMUSG00000063919
rattus_norvegicus	Srrm4	ENSRNOG00000001141

Protein

Protein identifiers

Serine/arginine repetitive matrix protein 4 — A7MD48 (reviewed: A7MD48)

Alternative names: Medulloblastoma antigen MU-MB-2.76, Neural-specific serine/arginine repetitive splicing factor of 100 kDa

All UniProt accessions (3): A7MD48, A0A286YF08, V5T9A0

UniProt curated annotations — full annotation on UniProt →

Function. Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts. Promotes alternative splicing of REST transcripts to produce REST isoform 3 (REST4) with greatly reduced repressive activity, thereby activating expression of REST targets in neural cells. Plays an important role during embryonic development as well as in the proper functioning of the adult nervous system. Regulates alternative splicing events in genes with important neuronal functions.

Subcellular location. Nucleus.

Tissue specificity. Specifically expressed in neuronal cells (at protein level). Expressed in the cerebellum.

Post-translational modifications. Phosphorylated.

Similarity. Belongs to the nSR100 family.

RefSeq proteins (1): NP_919262* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR029360	SRRM_C	Domain
IPR052109	SRRM_Domain-Containing	Family

Pfam: PF15230

UniProt features (25 total): compositionally biased region 18, sequence variant 3, region of interest 2, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A7MD48-F1	48.31	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 145 (showing top): GSE18804_BRAIN_VS_COLON_TUMORAL_MACROPHAGE_UP, ATF_B, RNGTGGGC_UNKNOWN, TAATAAT_MIR126, BENPORATH_ES_WITH_H3K27ME3, GOBP_SENSORY_PERCEPTION_OF_MECHANICAL_STIMULUS, GOBP_NEURON_MATURATION, GOBP_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME, GOBP_NEUROGENESIS, CACCAGC_MIR138, GGGTGGRR_PAX4_03, GOBP_ANATOMICAL_STRUCTURE_MATURATION, TCF4_Q5, ATF1_Q6, GOBP_CELL_MATURATION

GO Biological Process (8): regulation of alternative mRNA splicing, via spliceosome (GO:0000381), mRNA processing (GO:0006397), nervous system development (GO:0007399), sensory perception of sound (GO:0007605), RNA splicing (GO:0008380), cell differentiation (GO:0030154), neuron maturation (GO:0042551), regulation of RNA splicing (GO:0043484)

GO Molecular Function (4): mRNA binding (GO:0003729), identical protein binding (GO:0042802), RNA binding (GO:0003723), protein binding (GO:0005515)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA processing	2
alternative mRNA splicing, via spliceosome	1
regulation of mRNA splicing, via spliceosome	1
mRNA metabolic process	1
system development	1
sensory perception of mechanical stimulus	1
cellular developmental process	1
cell maturation	1
neuron development	1
RNA splicing	1
regulation of gene expression	1
regulation of primary metabolic process	1
RNA binding	1
protein binding	1
nucleic acid binding	1
binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1706 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SRRM4	PTBP2	Q9UKA9	926
SRRM4	DAAM1	Q9Y4D1	899
SRRM4	SRSF11	Q05519	786
SRRM4	NOVA1	P51513	647
SRRM4	NOVA2	Q9UNW9	636
SRRM4	KHDRBS1	Q07666	635
SRRM4	RNPS1	Q15287	632
SRRM4	SRRM2	Q9UQ35	622
SRRM4	PTBP1	P26599	597
SRRM4	RBFOX1	Q9NWB1	593
SRRM4	U2AF1	Q01081	577
SRRM4	SFSWAP	Q12872	542
SRRM4	REST	Q13127	499
SRRM4	MYO7A	P78427	497
SRRM4	MBNL1	Q9NR56	481

IntAct

92 interactions, top by confidence:

A	B	Type	Score
ARL6IP4	SRRM4	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	CDC37	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	RSRC1	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	RBMX2	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	ZNF699	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	ZRSR2	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	C16orf87	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	LUC7L2	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	U2AF1	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	SRRM4	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	CLK1	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	MMTAG2	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	RBM39	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	ZRSR2P1	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	ZNF286A	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	SRSF11	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	SRRM1	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	RNPS1	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	WDR5	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	FAM9B	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	RBM25	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	CLK4	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	ZNF124	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	SNIP1	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	LUZP4	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	MCRS1	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	AKAP17A	psi-mi:“MI:0915”(physical association)	0.560
SRRM4	SNRNP70	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (50): SRRM4 (Affinity Capture-MS), SRRM4 (Two-hybrid), SRRM4 (Two-hybrid), SRRM4 (Two-hybrid), SRRM4 (Two-hybrid), SRRM4 (Two-hybrid), SRRM4 (Two-hybrid), SRRM4 (Two-hybrid), SRRM4 (Two-hybrid), SRRM4 (Two-hybrid), SRRM4 (Two-hybrid), SRRM4 (Two-hybrid), C1orf35 (Two-hybrid), LUC7L2 (Two-hybrid), C16orf87 (Two-hybrid)

ESM2 similar proteins: A4D2P6, A6NNA2, A7MD48, A8IHN8, C9JLR9, G3V9M2, O00287, O95644, P04198, P12755, P18444, P49796, P49797, P51608, P55199, Q00566, Q08DA0, Q0PHV7, Q13387, Q1W6H9, Q29RS4, Q3UPL5, Q3YEC7, Q4QQU1, Q4VA45, Q5XKK7, Q61976, Q6NV74, Q6R891, Q7Z6J2, Q80WV7, Q80YR4, Q86UK7, Q8BKA3, Q8N554, Q8R149, Q8R4T5, Q8TF61, Q8VCG9, Q95LG8

Diamond homologs: A7MD48, P0CB65, Q80WV7, Q8BKA3, A6NNA2, Q5AP89, Q6C0M9, Q8BTI8, Q9U213, Q9UQ35

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 28 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
mRNA 3’-end processing	5	54.7×	1e-06
Transport of Mature mRNA derived from an Intron-Containing Transcript	5	42.3×	2e-06
mRNA Splicing	5	30.5×	7e-06
Processing of Capped Intron-Containing Pre-mRNA	6	27.4×	1e-06
mRNA Splicing - Major Pathway	9	27.3×	8e-10
mRNA Polyadenylation	5	24.4×	2e-05
Metabolism of RNA	6	13.9×	3e-05

GO biological processes:

GO term	Partners	Fold	FDR
RNA splicing	10	35.3×	6e-12
mRNA splicing, via spliceosome	8	29.3×	6e-09
mRNA processing	6	18.9×	1e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

102 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	93
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2268 predictions. Top by Δscore:

Variant	Effect	Δscore
12:118982010:CAAGG:C	donor_loss	1.0000
12:118982014:GTAAT:G	donor_loss	1.0000
12:119101505:G:GT	donor_gain	1.0000
12:119101505:G:T	donor_gain	1.0000
12:119102231:TGTA:T	acceptor_loss	1.0000
12:119102232:GTA:G	acceptor_loss	1.0000
12:119102234:A:AG	acceptor_gain	1.0000
12:119102234:AG:A	acceptor_gain	1.0000
12:119102235:G:A	acceptor_loss	1.0000
12:119102235:G:GG	acceptor_gain	1.0000
12:119102235:GG:G	acceptor_gain	1.0000
12:119102235:GGAC:G	acceptor_gain	1.0000
12:119102235:GGACA:G	acceptor_gain	1.0000
12:119114274:ACAGT:A	acceptor_gain	1.0000
12:119114275:C:G	acceptor_gain	1.0000
12:119114275:CAGT:C	acceptor_loss	1.0000
12:119114276:A:AG	acceptor_gain	1.0000
12:119114276:A:C	acceptor_loss	1.0000
12:119114276:AGT:A	acceptor_gain	1.0000
12:119114277:G:GA	acceptor_gain	1.0000
12:119114277:GT:G	acceptor_gain	1.0000
12:119114277:GTG:G	acceptor_gain	1.0000
12:119114277:GTGC:G	acceptor_gain	1.0000
12:119114277:GTGCC:G	acceptor_gain	1.0000
12:119114361:GGAG:G	donor_gain	1.0000
12:119114362:G:GT	donor_gain	1.0000
12:119114362:GAG:G	donor_gain	1.0000
12:119114363:AG:A	donor_loss	1.0000
12:119114365:G:GG	donor_gain	1.0000
12:119114366:T:G	donor_loss	1.0000

AlphaMissense

3952 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:118981926:T:C	F15S	1.000
12:119154377:T:C	I509T	1.000
12:118981925:T:C	F15L	0.999
12:118981926:T:G	F15C	0.999
12:118981927:C:A	F15L	0.999
12:118981927:C:G	F15L	0.999
12:118981928:T:A	W16R	0.999
12:118981928:T:C	W16R	0.999
12:118981940:T:C	F20L	0.999
12:118981942:C:A	F20L	0.999
12:118981942:C:G	F20L	0.999
12:118981970:A:C	S30R	0.999
12:118981972:C:A	S30R	0.999
12:118981972:C:G	S30R	0.999
12:118981977:T:A	I32N	0.999
12:118981977:T:G	I32S	0.999
12:119154337:C:A	R496S	0.999
12:119154355:A:C	S502R	0.999
12:119154357:C:A	S502R	0.999
12:119154357:C:G	S502R	0.999
12:119154374:G:C	R508T	0.999
12:119154374:G:T	R508M	0.999
12:119154375:G:C	R508S	0.999
12:119154375:G:T	R508S	0.999
12:119154377:T:A	I509K	0.999
12:119154377:T:G	I509R	0.999
12:119156503:A:T	K514I	0.999
12:119156504:A:C	K514N	0.999
12:119156504:A:T	K514N	0.999
12:119156505:C:A	R515S	0.999

dbSNP variants (sampled 300 via entrez): RS1000013536 (12:119140875 C>G), RS1000015427 (12:119100203 C>G,T), RS1000018901 (12:119060583 G>A), RS1000052422 (12:118983299 G>A,T), RS1000088306 (12:119100425 G>C,T), RS1000091327 (12:119089289 G>C), RS1000094051 (12:119146941 A>G), RS1000112693 (12:119128045 C>G,T), RS1000139094 (12:119026925 T>C), RS1000139478 (12:119107637 T>A), RS1000166741 (12:119002403 G>A), RS1000214129 (12:119008802 A>T), RS1000225825 (12:119044753 A>C,G), RS1000251454 (12:119032148 A>C), RS1000267998 (12:119054251 G>A)

Disease associations

OMIM: gene MIM:613103 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

9 associations (top):

Study	Trait	p-value
GCST001762_100	Obesity-related traits	3.000000e-06
GCST003445_9	Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis	4.000000e-06
GCST003771_19	Loneliness	8.000000e-06
GCST003772_17	Loneliness (linear analysis)	5.000000e-06
GCST003992_47	Photic sneeze reflex	3.000000e-12
GCST004307_4	Facial morphology (factor 3, length of philtrum)	4.000000e-08
GCST004867_27	Systemic lupus erythematosus	5.000000e-06
GCST007002_6	Cerebrospinal fluid t-tau levels in normal cognition	2.000000e-09
GCST011176_23	Stroke	2.000000e-07

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0003940	physical activity
EFO:0007865	loneliness measurement
EFO:0007887	autosomal dominant compelling helio-ophthalmic outburst syndrome
EFO:0004760	t-tau measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

17 total (human), top 17 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression	3
bisphenol A	decreases methylation, increases expression	2
trichostatin A	affects cotreatment, increases expression	2
Resveratrol	affects cotreatment, decreases expression	2
methylmercuric chloride	increases expression	1
sodium arsenite	increases expression	1
entinostat	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
Sunitinib	decreases expression	1
Vorinostat	decreases expression	1
Acetaminophen	decreases expression	1
Atrazine	decreases expression	1
Benzo(a)pyrene	increases methylation	1
Copper	affects cotreatment, decreases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Tobacco Smoke Pollution	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.