SSTR5-AS1

Summary

SSTR5-AS1 (SSTR5 antisense RNA 1, HGNC:26502) is a long non-coding RNA gene on chromosome 16p13.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26502
Approved symbol	SSTR5-AS1
Name	SSTR5 antisense RNA 1
Location	16p13.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000261713
Ensembl biotype	lncRNA
Entrez	146336
RNAcentral	URS000075EBD1 — lncRNA, 2948 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000565992, ENST00000566499, ENST00000569734, ENST00000569832, ENST00000624643, ENST00000711618, ENST00000711619

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000565992 — 4 exons

Exon	Start	End
ENSE00002577061	1066919	1067043
ENSE00002590856	1064087	1066526
ENSE00002622402	1073566	1073645
ENSE00004016203	1073087	1073219

Expression profiles

Bgee: expression breadth ubiquitous, 131 present calls, max score 96.54.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.4414 / max 94.5545, expressed in 105 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
155806	0.4202	98
155805	0.0120	6
155807	0.0091	5

Top tissues by expression

209 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	96.54	gold quality
oocyte	CL:0000023	93.86	gold quality
right atrium auricular region	UBERON:0006631	79.31	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.80	gold quality
apex of heart	UBERON:0002098	78.75	gold quality
cardiac atrium	UBERON:0002081	78.69	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.44	silver quality
right adrenal gland cortex	UBERON:0035827	78.15	gold quality
left adrenal gland	UBERON:0001234	77.53	gold quality
left adrenal gland cortex	UBERON:0035825	77.49	gold quality
adrenal cortex	UBERON:0001235	76.61	gold quality
adrenal gland	UBERON:0002369	76.50	gold quality
right adrenal gland	UBERON:0001233	75.81	gold quality
islet of Langerhans	UBERON:0000006	73.09	gold quality
heart left ventricle	UBERON:0002084	71.52	gold quality
heart	UBERON:0000948	71.15	gold quality
cardiac ventricle	UBERON:0002082	71.12	gold quality
metanephros cortex	UBERON:0010533	68.75	gold quality
tibia	UBERON:0000979	67.32	gold quality
cartilage tissue	UBERON:0002418	65.86	silver quality
duodenum	UBERON:0002114	65.07	gold quality
descending thoracic aorta	UBERON:0002345	64.77	gold quality
ascending aorta	UBERON:0001496	64.53	gold quality
thoracic aorta	UBERON:0001515	64.35	gold quality
superior surface of tongue	UBERON:0007371	64.25	gold quality
pancreas	UBERON:0001264	63.53	gold quality
minor salivary gland	UBERON:0001830	62.35	gold quality
sural nerve	UBERON:0015488	62.33	silver quality
pituitary gland	UBERON:0000007	61.63	gold quality
adenohypophysis	UBERON:0002196	61.45	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.54

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• SSTR5-AS1 may play antitumor role in LSCC and may be regulated by the hypermethylation of the same CpG sites with SSTR5. SSTR5-AS1 inhibits laryngeal carcinoma cells proliferation, migration, and invasion. (PMID:31196171)
• The present study suggests that SSTR5AS1 functions as a competing endogenous RNA to regulate CA2 by sponging miR15b5p for the development and prognosis of hepatitis B virus related hepatocellular carcinoma. (PMID:31638225)
• Long non-coding RNA SSTR5-AS1 facilitates gemcitabine resistance via stabilizing NONO in gallbladder carcinoma. (PMID:31810606)
• Diagnostic and prognostic significance of long noncoding RNA SSTR5-AS1 in patients with gastric cancer. (PMID:32495873)
• lncRNA SSTR5-AS1 Predicts Poor Prognosis and Contributes to the Progression of Esophageal Cancer. (PMID:36726845)
• LncRNA SSTR5-AS1 as a Prognostic Marker Promotes Cell Proliferation and Epithelial-to-Mesenchymal Transition in Prostate Cancer. (PMID:36734853)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.