ST13

Summary

ST13 (ST13 Hsp70 interacting protein, HGNC:11343) is a protein-coding gene on chromosome 22q13.2, encoding Hsc70-interacting protein (P50502). One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40.

The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms.

Source: NCBI Gene 6767 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• Clinical variants (ClinVar): 65 total
• MANE Select transcript: NM_003932

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11343
Approved symbol	ST13
Name	ST13 Hsp70 interacting protein
Location	22q13.2
Locus type	gene with protein product
Status	Approved
Aliases	SNC6, HSPABP1, HIP, P48, FAM10A1
Ensembl gene	ENSG00000100380
Ensembl biotype	protein_coding
OMIM	606796
Entrez	6767

Gene structure

Transcript identifiers

Ensembl transcripts: 20 — 16 protein_coding, 2 nonsense_mediated_decay, 2 retained_intron

ENST00000216218, ENST00000411695, ENST00000413424, ENST00000455824, ENST00000480048, ENST00000495652, ENST00000893861, ENST00000893862, ENST00000893863, ENST00000893864, ENST00000893865, ENST00000893866, ENST00000893867, ENST00000893868, ENST00000893869, ENST00000893870, ENST00000893871, ENST00000930430, ENST00000930431, ENST00000960885

RefSeq mRNA: 2 — MANE Select: NM_003932 NM_001278589, NM_003932

CCDS: CCDS14006

Canonical transcript exons

ENST00000216218 — 12 exons

Exon	Start	End
ENSE00000654945	40827096	40827229
ENSE00000654955	40848294	40848369
ENSE00000880425	40824535	40826666
ENSE00000880427	40856431	40856639
ENSE00003461432	40830840	40830956
ENSE00003556709	40844839	40844909
ENSE00003566742	40835803	40835887
ENSE00003614078	40829626	40829674
ENSE00003614848	40835560	40835670
ENSE00003617145	40850823	40850880
ENSE00003635293	40840626	40840692
ENSE00003686480	40832569	40832671

Expression profiles

Bgee: expression breadth ubiquitous, 304 present calls, max score 99.47.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 91.8099 / max 2182.7804, expressed in 1824 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
194332	88.4960	1824
194331	2.8747	1260
194333	0.4391	173

Top tissues by expression

304 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left ovary	UBERON:0002119	99.47	gold quality
calcaneal tendon	UBERON:0003701	99.45	gold quality
right ovary	UBERON:0002118	99.32	gold quality
ovary	UBERON:0000992	99.29	gold quality
colonic epithelium	UBERON:0000397	99.17	gold quality
ganglionic eminence	UBERON:0004023	99.12	gold quality
adrenal tissue	UBERON:0018303	99.11	gold quality
body of uterus	UBERON:0009853	99.09	gold quality
ventricular zone	UBERON:0003053	99.08	gold quality
stromal cell of endometrium	CL:0002255	99.02	gold quality
endocervix	UBERON:0000458	98.98	gold quality
gall bladder	UBERON:0002110	98.84	gold quality
cortical plate	UBERON:0005343	98.82	gold quality
right adrenal gland	UBERON:0001233	98.80	gold quality
cranial nerve II	UBERON:0000941	98.78	gold quality
hindlimb stylopod muscle	UBERON:0004252	98.78	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	98.77	gold quality
left adrenal gland	UBERON:0001234	98.77	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	98.77	gold quality
right adrenal gland cortex	UBERON:0035827	98.76	gold quality
mucosa of stomach	UBERON:0001199	98.75	gold quality
popliteal artery	UBERON:0002250	98.72	gold quality
tibial artery	UBERON:0007610	98.72	gold quality
left adrenal gland cortex	UBERON:0035825	98.71	gold quality
ectocervix	UBERON:0012249	98.67	gold quality
adrenal gland	UBERON:0002369	98.61	gold quality
left uterine tube	UBERON:0001303	98.60	gold quality
artery	UBERON:0001637	98.59	gold quality
nephron tubule	UBERON:0001231	98.54	gold quality
islet of Langerhans	UBERON:0000006	98.49	gold quality

Single-cell (SCXA)

Detected in 8 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-MTAB-10042	yes	14.11
E-GEOD-125970	yes	12.87
E-MTAB-9801	yes	5.65
E-CURD-77	no	655.58
E-MTAB-10596	no	565.48
E-GEOD-150728	no	317.77
E-MTAB-10287	no	47.86
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): E2F1, ESR2

miRNA regulators (miRDB)

95 targeting ST13, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3120-5P	100.00	65.56	965
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-6835-3P	99.93	70.49	2904
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-450B-5P	99.92	71.48	3175
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-137-3P	99.87	74.74	2401
HSA-MIR-6857-5P	99.87	65.32	985
HSA-MIR-4503	99.85	71.45	1869
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-4698	99.84	71.41	4303
HSA-MIR-6715A-3P	99.83	68.05	1473
HSA-MIR-6785-5P	99.82	68.68	4428

Literature-anchored findings (GeneRIF, showing 16)

• Hip functions to promote the efficiency of glucocorticoid receptor maturation in cells (PMID:15071092)
• The expression of ST13 decreases in colorectal cancer tissue compared with that in adjacent normal tissue. ST13 is mostly expressed in colorectal epithelia and adenocarcinoma cells. (PMID:15637739)
• tetratricopeptide repeat domain is required for effects of CHIP on alpha-synuclein inclusion morphology, number of inclusions, and proteasomal degradation as well as the direct interaction of CHIP with Hsp70 implicates their cooperation in these processes (PMID:15845543)
• The expression levels of the ST13 gene were significantly decreased in primary tumors compared with adjacent mucosa (P<0.05). (PMID:16358374)
• results suggest that granzyme B-mediated loss of HIP expression occurs in vivo, and in a coordinate fashion with loss of BID, pro-caspase-8 and pro-caspase-3; data implicate the Hsp70 co-chaperone HIP in the proteolytic cascade of some apoptotic pathways (PMID:17013759)
• analysis of similarity between the chloroplast translocon component, Tic40, and the human co-chaperone, Hsp70-interacting protein (PMID:17535810)
• The expression levels of ST13 cannot serve as a biomarker for early stages of PD. (PMID:20193743)
• These results strongly indicate ST13 mediated by adenovirus triggers colorectal cell apoptosis via ASK1-JNK signaling cascade (PMID:20512919)
• S-nitrosoglutathione corrects DeltaF508 CFTR trafficking by inhibiting Hop expression (PMID:20534503)
• A single amino acid substitution (L211S) resulted in a loss of Hip function. This mutation also appears to disrupt the interaction of Hip with Hsp70 in vitro (PMID:21240662)
• Hip has been identified as a novel substrate of GRK5 in vitro and in cells, and phosphorylation of Hip by GRK5 plays a role in modulating CXCR4 internalization (PMID:21728385)
• Akt phosphorylation at Thr308 and Ser473 is required for CHIP-mediated ubiquitination of the kinase. (PMID:21767636)
• St13 is a proliferation regulator that inhibits tumor growth in colorectal neoplasms and may affect cell migration. (PMID:23125081)
• A novel susceptibility gene, ST13, coding for a cochaperone of the glucocorticoid receptor, is associated with exacerbations in asthmatic children and young adults despite their ICS use. (PMID:25616159)
• An autophagy-related model of 4 key genes for predicting prognosis of patients with laryngeal cancer. (PMID:32791689)
• Polymorphism in Genes Encoding Adaptor Proteins ST13 and STIP1 and the Risk of Ischemic Stroke: a Pilot Study. (PMID:38492099)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	st13	ENSDARG00000021973
mus_musculus	St13	ENSMUSG00000022403
rattus_norvegicus	St13-ps2	ENSRNOG00000004239
rattus_norvegicus	Slc25a17	ENSRNOG00000018920
drosophila_melanogaster	HIP-R	FBGN0029676
drosophila_melanogaster	Spag1	FBGN0039463
drosophila_melanogaster	HIP	FBGN0260484

Paralogs (18): RPAP3 (ENSG00000005175), TOMM34 (ENSG00000025772), STUB1 (ENSG00000103266), SPAG1 (ENSG00000104450), SGTA (ENSG00000104969), TTC1 (ENSG00000113312), TTC31 (ENSG00000115282), UNC45A (ENSG00000140553), UNC45B (ENSG00000141161), SPATA16 (ENSG00000144962), TTC12 (ENSG00000149292), TOMM70 (ENSG00000154174), SUGT1 (ENSG00000165416), STIP1 (ENSG00000168439), TTC32 (ENSG00000183891), SGTB (ENSG00000197860), TTC4 (ENSG00000243725), DNAAF4 (ENSG00000256061)

Protein

Protein identifiers

Hsc70-interacting protein — P50502 (reviewed: P50502)

Alternative names: Aging-associated protein 2, Progesterone receptor-associated p48 protein, Protein FAM10A1, Putative tumor suppressor ST13, Renal carcinoma antigen NY-REN-33, Suppression of tumorigenicity 13 protein

All UniProt accessions (6): P50502, A0A140VKA6, B4E0U6, F6VDH7, F8WAQ7, H7C3I1

UniProt curated annotations — full annotation on UniProt →

Function. One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins.

Subunit / interactions. Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90. Interacts (via the C-terminus 303- 319 AA) with GRK5.

Subcellular location. Cytoplasm.

Similarity. Belongs to the FAM10 family.

RefSeq proteins (2): NP_001265518, NP_003923* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006636	STI1_HS-bd	Domain
IPR011990	TPR-like_helical_dom_sf	Homologous_superfamily
IPR019734	TPR_rpt	Repeat
IPR034649	Hip_N	Domain
IPR041243	STI1/HOP_DP	Domain

Pfam: PF13181, PF17830, PF18253

UniProt features (17 total): repeat 3, modified residue 3, sequence conflict 3, compositionally biased region 3, region of interest 2, chain 1, sequence variant 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P50502-F1	82.20	0.50

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 346, 353, 360

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-3371453	Regulation of HSF1-mediated heat shock response

MSigDB gene sets: 254 (showing top): GSE45365_NK_CELL_VS_CD8_TCELL_DN, WAMUNYOKOLI_OVARIAN_CANCER_LMP_DN, GGGACCA_MIR133A_MIR133B, RNGTGGGC_UNKNOWN, TSENG_IRS1_TARGETS_UP, DORSAM_HOXA9_TARGETS_UP, STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, MORF_ATRX, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, EFC_Q6, GOBP_PROTEIN_MATURATION, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, GNF2_FBL

GO Biological Process (2): protein folding (GO:0006457), response to bacterium (GO:0009617)

GO Molecular Function (4): Hsp70 protein binding (GO:0030544), protein-macromolecule adaptor activity (GO:0030674), protein dimerization activity (GO:0046983), protein binding (GO:0005515)

GO Cellular Component (3): cytoplasm (GO:0005737), cytosol (GO:0005829), extracellular exosome (GO:0070062)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Cellular response to heat stress	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein binding	2
cellular anatomical structure	2
cellular process	1
protein maturation	1
response to other organism	1
heat shock protein binding	1
protein-folding chaperone binding	1
molecular adaptor activity	1
binding	1
intracellular anatomical structure	1
cytoplasm	1
extracellular vesicle	1

Protein interactions and networks

STRING

1626 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ST13	HSP90AA1	P07900	994
ST13	HSP90AB1	P08238	994
ST13	HSPA4	P34932	993
ST13	HSPA8	P11142	992
ST13	DNAJB1	P25685	942
ST13	BAG1	Q99933	823
ST13	ATXN3L	Q9H3M9	783
ST13	UBE2D1	P51668	698
ST13	ATXN3	P54252	670
ST13	GSK3B	P49841	667
ST13	UBXN2A	P68543	651
ST13	BAG3	O95817	625
ST13	UBE4B	O95155	594
ST13	ST14	Q9Y5Y6	594
ST13	BAG2	O95816	590

IntAct

115 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
HTT	ST13	psi-mi:“MI:0915”(physical association)	0.670
ST13		psi-mi:“MI:0915”(physical association)	0.560
CD209	ST13	psi-mi:“MI:0915”(physical association)	0.560
BAG1	ST13	psi-mi:“MI:0407”(direct interaction)	0.560
APOE	ST13	psi-mi:“MI:0914”(association)	0.480
NOS3	ST13	psi-mi:“MI:0914”(association)	0.480
ST13	NOS3	psi-mi:“MI:0914”(association)	0.480
ST13	PSEN1	psi-mi:“MI:0914”(association)	0.480
APOE	ST13	psi-mi:“MI:0915”(physical association)	0.480

BioGRID (267): ST13 (Affinity Capture-MS), HSP90AA1 (Reconstituted Complex), HSPA4 (Reconstituted Complex), CFL2 (Co-fractionation), CLIC1 (Co-fractionation), DSTN (Co-fractionation), HEATR3 (Co-fractionation), PACSIN2 (Co-fractionation), PACSIN3 (Co-fractionation), ST13 (Co-fractionation), SUB1 (Co-fractionation), ST13 (Affinity Capture-MS), ST13 (Affinity Capture-MS), ST13 (Affinity Capture-MS), HSP90AA1 (Reconstituted Complex)

ESM2 similar proteins: A1A0A3, A1A3P4, A4WDH8, A7ZQ54, A8A3C0, B1IVM0, B1VMF2, B1W5F4, B1XBT4, B2TYN5, B2VEC6, B3DQ30, B6I635, B7GPW0, B7LDK2, B7M983, B7MIV1, B7MYA6, B7N6J9, B7NSB2, B7UH62, B8DT61, B9JZG5, C4ZYN1, C6D9J8, O76031, O86810, P09372, P50502, Q05562, Q0T181, Q0TEM6, Q1R8B1, Q31XD2, Q32CX5, Q3YYM5, Q5R7N3, Q5RF31, Q5U2U0, Q7ABI1

Diamond homologs: A0A3L6DPG1, C4NYP8, O13797, P15705, P50502, P50503, P53041, P53042, Q08168, Q0JL44, Q28IV3, Q388N2, Q5RF31, Q5WA76, Q5ZLF0, Q60676, Q68FQ7, Q6ES52, Q6NU95, Q86DS1, Q8IZP2, Q8NFI4, Q8VWG7, Q93YR3, Q99L47, Q9D706, Q9H6T3, Q9HGM9, Q9LNB6, Q9NES8, Q9STH1, F8RP11, Q07617, Q4R8N7, Q54DA8, Q7ZWU1, Q80XJ3, Q80ZX8, Q8BW49, Q96AY4

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
GRK5	“up-regulates activity”	ST13	phosphorylation

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 109 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Dengue Virus Genome Translation and Replication	7	31.7×	1e-06
Activation of STAT3 by cadherin engagement	5	11.7×	9e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

65 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	43
Likely benign	2
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

2696 predictions. Top by Δscore:

Variant	Effect	Δscore
22:40826667:C:CA	acceptor_loss	1.0000
22:40826667:C:CC	acceptor_gain	1.0000
22:40827094:A:AC	donor_gain	1.0000
22:40827095:C:CC	donor_gain	1.0000
22:40827095:CCTG:C	donor_gain	1.0000
22:40827225:GCCAC:G	acceptor_gain	1.0000
22:40827226:CCAC:C	acceptor_gain	1.0000
22:40827226:CCACC:C	acceptor_gain	1.0000
22:40827227:CAC:C	acceptor_gain	1.0000
22:40827227:CACC:C	acceptor_gain	1.0000
22:40827227:CACCT:C	acceptor_loss	1.0000
22:40827228:AC:A	acceptor_gain	1.0000
22:40827229:CC:C	acceptor_gain	1.0000
22:40827229:CCTG:C	acceptor_loss	1.0000
22:40827230:C:CC	acceptor_gain	1.0000
22:40827232:G:GC	acceptor_gain	1.0000
22:40827235:A:AC	acceptor_gain	1.0000
22:40830824:G:C	donor_gain	1.0000
22:40830835:TTTAC:T	donor_loss	1.0000
22:40830836:TTAC:T	donor_loss	1.0000
22:40830837:TA:T	donor_loss	1.0000
22:40830838:AC:A	donor_gain	1.0000
22:40830839:CC:C	donor_gain	1.0000
22:40830839:CCCT:C	donor_gain	1.0000
22:40830877:A:C	donor_gain	1.0000
22:40830952:TGTGC:T	acceptor_gain	1.0000
22:40830953:GTGC:G	acceptor_gain	1.0000
22:40830954:TGC:T	acceptor_gain	1.0000
22:40830955:GC:G	acceptor_gain	1.0000
22:40830956:CC:C	acceptor_gain	1.0000

AlphaMissense

2459 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
22:40826578:A:G	L357P	1.000
22:40826587:A:T	V354D	1.000
22:40826606:A:C	Y348D	1.000
22:40826632:G:T	A339D	1.000
22:40826633:C:G	A339P	1.000
22:40826644:A:G	F335S	1.000
22:40826647:G:T	A334D	1.000
22:40826656:A:T	V331D	1.000
22:40826665:T:C	D328G	1.000
22:40827104:C:G	A325P	1.000
22:40832615:T:A	D212V	1.000
22:40832656:C:A	W198C	1.000
22:40832656:C:G	W198C	1.000
22:40832658:A:G	W198R	1.000
22:40832658:A:T	W198R	1.000
22:40835572:C:T	G189E	1.000
22:40835573:C:A	G189W	1.000
22:40835573:C:G	G189R	1.000
22:40835573:C:T	G189R	1.000
22:40835809:C:A	R154M	1.000
22:40826566:A:G	L361S	0.999
22:40826575:A:T	I358N	0.999
22:40826578:A:T	L357H	0.999
22:40826605:T:C	Y348C	0.999
22:40826605:T:G	Y348S	0.999
22:40826635:A:T	V338E	0.999
22:40826638:T:A	D337V	0.999
22:40826639:C:G	D337H	0.999
22:40826648:C:G	A334P	0.999
22:40826665:T:A	D328V	0.999

dbSNP variants (sampled 300 via entrez): RS1000014107 (22:40858414 C>A), RS1000066028 (22:40827471 A>G), RS1000074137 (22:40847378 C>A), RS1000157111 (22:40856615 C>A,G,T), RS1000259599 (22:40844449 T>A,C), RS1000347997 (22:40833529 C>A), RS1000381831 (22:40839210 G>T), RS1000383655 (22:40852155 G>C,T), RS1000477359 (22:40843381 A>G), RS1000549011 (22:40843147 G>A), RS1000590475 (22:40844755 G>A), RS1000757149 (22:40837677 G>T), RS1000881433 (22:40830642 G>A), RS1000930770 (22:40858635 G>A), RS1000934216 (22:40824591 C>T)

Disease associations

OMIM: gene MIM:606796 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST004521_42	Autism spectrum disorder or schizophrenia	1.000000e-08
GCST004521_55	Autism spectrum disorder or schizophrenia	9.000000e-09
GCST006948_57	Feeling nervous	2.000000e-08
GCST008103_42	Bipolar disorder	2.000000e-07
GCST008115_35	Bipolar I disorder	3.000000e-07
GCST010002_83	Refractive error	2.000000e-27

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0009597	feeling nervous measurement
EFO:0009963	bipolar I disorder

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB clinical annotations

2 annotations.

Variant	Type	Level	Drugs	Phenotypes
rs138335	Efficacy	3	corticosteroids	Asthma
rs138337	Efficacy	3	corticosteroids	Asthma

PharmGKB variants

2 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs138335	ST13	3	1.25	1	corticosteroids
rs138337	ST13	3	1.50	1	corticosteroids

CTD chemical–gene interactions

50 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Tobacco Smoke Pollution	affects expression, increases expression	4
bisphenol A	decreases expression, increases expression	3
sodium arsenite	increases expression	2
cobaltous chloride	increases expression	2
Doxorubicin	affects expression, increases expression	2
Ivermectin	increases expression, decreases expression, affects cotreatment	2
bisphenol F	increases expression	1
2,4,6-tribromophenol	decreases expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
butyraldehyde	decreases expression	1
ochratoxin A	increases expression	1
cupric oxide	increases expression	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
CGP 52608	increases reaction, affects binding	1
CD 437	decreases expression	1
nickel acetate	affects expression	1
monomethylarsonous acid	increases expression	1
3-(4’-hydroxy-3’-adamantylbiphenyl-4-yl)acrylic acid	decreases expression	1
nutlin 3	affects cotreatment, increases secretion	1
bisphenol B	increases expression	1
bisphenol S	affects expression	1
bisphenol AF	increases expression	1
Resveratrol	increases expression	1
Temozolomide	decreases expression	1
Arsenic Trioxide	increases expression	1
Acrolein	increases abundance, affects cotreatment, increases oxidation	1
Air Pollutants	increases oxidation, affects cotreatment, increases abundance	1
Atrazine	decreases expression	1
Caffeine	increases expression	1
Dactinomycin	affects cotreatment, increases secretion	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.