ST18

Summary

ST18 (ST18 C2H2C-type zinc finger transcription factor, HGNC:18695) is a protein-coding gene on chromosome 8q11.23, encoding Suppression of tumorigenicity 18 protein (O60284). Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5’-AAAGTTT-3’ separated by 2-9 nucleotides.

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cytokine-mediated signaling pathway; negative regulation of cell population proliferation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of protein-DNA complex.

Source: NCBI Gene 9705 — RefSeq curated summary.

At a glance

• GWAS associations: 17
• Clinical variants (ClinVar): 158 total
• MANE Select transcript: NM_001352837

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18695
Approved symbol	ST18
Name	ST18 C2H2C-type zinc finger transcription factor
Location	8q11.23
Locus type	gene with protein product
Status	Approved
Aliases	KIAA0535, ZC2HC10, NZF3, NZF-3, ZC2H2C3
Ensembl gene	ENSG00000147488
Ensembl biotype	protein_coding
OMIM	617155
Entrez	9705

Gene structure

Transcript identifiers

Ensembl transcripts: 35 — 14 protein_coding, 11 protein_coding_CDS_not_defined, 7 retained_intron, 3 nonsense_mediated_decay

ENST00000276480, ENST00000517456, ENST00000517580, ENST00000518037, ENST00000518053, ENST00000518453, ENST00000518501, ENST00000518545, ENST00000519118, ENST00000519201, ENST00000520257, ENST00000520279, ENST00000520716, ENST00000520811, ENST00000521119, ENST00000521549, ENST00000521582, ENST00000521824, ENST00000522102, ENST00000522251, ENST00000522861, ENST00000523652, ENST00000524078, ENST00000524183, ENST00000689386, ENST00000693301, ENST00000699087, ENST00000874147, ENST00000874148, ENST00000874149, ENST00000874150, ENST00000874151, ENST00000874152, ENST00000874153, ENST00000874154

RefSeq mRNA: 59 — MANE Select: NM_001352837 NM_001352826, NM_001352827, NM_001352828, NM_001352829, NM_001352830, NM_001352831, NM_001352832, NM_001352833, NM_001352834, NM_001352835, NM_001352836, NM_001352837, NM_001352838, NM_001352839, NM_001352840, NM_001352841, NM_001352842, NM_001352843, NM_001352844, NM_001352845, NM_001352846, NM_001352847, NM_001352848, NM_001352849, NM_001352850, NM_001352851, NM_001352852, NM_001352853, NM_001352854, NM_001352855, NM_001352856, NM_001352857, NM_001352858, NM_001352859, NM_001352860, NM_001352861, NM_001352862, NM_001352863, NM_001352864, NM_001352865, NM_001352866, NM_001352867, NM_001352868, NM_001352869, NM_001352870, NM_001352871, NM_001352872, NM_001352873, NM_001352874, NM_001352875, NM_001352876, NM_001352877, NM_001352878, NM_001352879, NM_001352880, NM_001352882, NM_001352883, NM_001352884, NM_014682

CCDS: CCDS6149

Canonical transcript exons

ENST00000689386 — 26 exons

Exon	Start	End
ENSE00001019604	52217746	52217901
ENSE00001251003	52220741	52220848
ENSE00001251007	52221640	52221793
ENSE00001251017	52230032	52230077
ENSE00001294032	52409328	52409452
ENSE00003460130	52116275	52116418
ENSE00003475621	52131958	52132179
ENSE00003477738	52165135	52165225
ENSE00003487228	52133057	52133137
ENSE00003510513	52149732	52149977
ENSE00003552032	52126052	52126140
ENSE00003558320	52161375	52161568
ENSE00003564654	52180122	52180312
ENSE00003579355	52166852	52166986
ENSE00003586802	52212079	52212109
ENSE00003618594	52137421	52137483
ENSE00003633221	52133239	52133301
ENSE00003636385	52171792	52172583
ENSE00003646784	52163986	52164090
ENSE00003647128	52158898	52159109
ENSE00003652254	52118338	52118441
ENSE00003657268	52214203	52214257
ENSE00003662572	52136590	52136658
ENSE00003679380	52142930	52143045
ENSE00003928828	52110838	52113338
ENSE00003928849	52409548	52409756

Expression profiles

Bgee: expression breadth ubiquitous, 192 present calls, max score 98.56.

FANTOM5 (CAGE): breadth broad, TPM avg 7.7739 / max 1573.9504, expressed in 338 samples.

FANTOM5 promoters (11 alternative TSS)

Promoter ID	TPM avg	Samples expressed
93045	3.3888	88
93046	1.6517	85
93033	1.1199	111
93031	0.4949	60
93051	0.3984	127
93048	0.1490	50
93034	0.1293	31
93047	0.1293	55
93052	0.1250	55
93030	0.0956	30

Top tissues by expression

287 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	98.56	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	96.94	gold quality
spinal cord	UBERON:0002240	96.18	gold quality
inferior vagus X ganglion	UBERON:0005363	95.93	gold quality
medial globus pallidus	UBERON:0002477	93.84	gold quality
globus pallidus	UBERON:0001875	93.68	gold quality
subthalamic nucleus	UBERON:0001906	93.19	gold quality
cerebellum	UBERON:0002037	92.60	gold quality
cerebellar cortex	UBERON:0002129	92.52	gold quality
cerebellar hemisphere	UBERON:0002245	92.45	gold quality
substantia nigra pars reticulata	UBERON:0001966	92.40	gold quality
pons	UBERON:0000988	92.01	gold quality
medulla oblongata	UBERON:0001896	91.88	gold quality
inferior olivary complex	UBERON:0002127	91.35	gold quality
lateral globus pallidus	UBERON:0002476	91.26	gold quality
substantia nigra	UBERON:0002038	91.04	gold quality
right hemisphere of cerebellum	UBERON:0014890	90.99	gold quality
superior vestibular nucleus	UBERON:0007227	90.95	gold quality
islet of Langerhans	UBERON:0000006	90.92	gold quality
midbrain	UBERON:0001891	90.78	gold quality
cranial nerve II	UBERON:0000941	90.51	gold quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	89.60	gold quality
cortical plate	UBERON:0005343	89.42	gold quality
CA1 field of hippocampus	UBERON:0003881	88.66	gold quality
substantia nigra pars compacta	UBERON:0001965	87.60	gold quality
cerebellar vermis	UBERON:0004720	87.55	gold quality
Ammon’s horn	UBERON:0001954	87.46	gold quality
dorsal plus ventral thalamus	UBERON:0001897	87.04	gold quality
buccal mucosa cell	CL:0002336	86.54	gold quality
putamen	UBERON:0001874	85.31	gold quality

Single-cell (SCXA)

Detected in 12 experiment(s), a significant marker in 12.

Experiment	Marker?	Max mean expression
E-GEOD-180759	yes	4718.08
E-HCAD-35	yes	4552.97
E-HCAD-30	yes	4422.75
E-HCAD-25	yes	4337.51
E-GEOD-76312	yes	2198.59
E-GEOD-75140	yes	769.87
E-MTAB-6911	yes	254.48
E-GEOD-81547	yes	24.52
E-CURD-114	yes	11.55
E-GEOD-84465	yes	10.04
E-ANND-3	yes	8.29
E-GEOD-93593	yes	7.09

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

2 targets.

Target	Regulation
IL6
TNF

Upstream regulators (CollecTRI, top): FOXA2, NEUROD1, PDX1

Literature-anchored findings (GeneRIF, showing 16)

• ectopic ST18 expression in MCF-7 breast cancer cells strongly inhibits colony formation in soft agar and the formation of tumors in a xenograft mouse model (PMID:15489893)
• Fibroblasts that overexpress ST18 by transient transfection exhibit significantly increased apoptosis and increased expression of TNF-alpha, interleukin (IL) -1alpha, and IL-6. (PMID:18676404)
• a significant association between ST18 and predisposition to Pemphigus vulgaris (PV). (PMID:22437316)
• Presence of at least one A allele (AG or AA genotype) for rs1015213 was associated with a shallower anterior chamber depth (-0.07 mm, 95% CI -0.01 to -0.14 mm, p=0.028) after adjusting for age and sex (both p</=0.001). (PMID:23505305)
• In our study, rs1015213 (located in the intergenic region between PCMTD1 and ST18) was associated significantly with primary angle closure. (PMID:23847314)
• ST18 expression and activity are increased in cytotoxic conditions in pancreatic beta-cells. Overexpression of ST18 causes apoptosis. (PMID:24509857)
• a Chinese population shows no remarkable association with the SNP rs2304365 in the region of ST18 and pemphigus, which suggests the relationship of ST18 and pemphigus may act in a population-specific manner (PMID:24612320)
• the present findings indicate that ST18 may play a direct role in Pemphigus vulgaris (PV) and consequently represents a potential target for the treatment of this disease. (PMID:27148741)
• In this study, 2 of 8 (primary angle-closure glaucoma) PACG-associated loci were associated significantly with PACS status, the earliest stage in the angle-closure glaucoma disease course. The association of these PACG loci with PACS status suggests that these loci may confer susceptibility to a narrow angle configuration. (PMID:29310965)
• allele A in rs2304365 of ST18 may have a role in pemphigus in Iranian patients (PMID:30192416)
• The suppression of tumorigenicity 18 protein ST18 (ST18) -497-65050T>C polymorphisms (rs17315309) exhibit a very strong association in the pathogenesis of Pemphigus Vulgaris (PV) and could represent a new potential molecular target for the treatment of disease. (PMID:30926339)
• ST18 Enhances PV-IgG-Induced Loss of Keratinocyte Cohesion in Parallel to Increased ERK Activation. (PMID:31057535)
• ST18 affects cell-cell adhesion in pemphigus vulgaris in a tumour necrosis factor-alpha-dependent fashion. (PMID:33205400)
• Genome-wide association study identifies susceptibility loci of brain atrophy to NFIA and ST18 in Alzheimer’s disease. (PMID:33640202)
• Measurable Residual Disease Monitoring of SPAG6, ST18, PRAME, and XAGE1A Expression in Peripheral Blood May Detect Imminent Relapse in Childhood Acute Myeloid Leukemia. (PMID:34600138)
• Up-regulation of ST18 in pemphigus vulgaris drives a self-amplifying p53-dependent pathomechanism resulting in decreased desmoglein 3 expression. (PMID:35396567)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
mus_musculus	St18	ENSMUSG00000033740
rattus_norvegicus	St18	ENSRNOG00000006200
drosophila_melanogaster	Pits	FBGN0030400
caenorhabditis_elegans	ztf-11	WBGENE00009939
caenorhabditis_elegans		WBGENE00010867

Paralogs (5): IRF2BPL (ENSG00000119669), IRF2BP2 (ENSG00000168264), IRF2BP1 (ENSG00000170604), MYT1L (ENSG00000186487), MYT1 (ENSG00000196132)

Protein

Protein identifiers

Suppression of tumorigenicity 18 protein — O60284 (reviewed: O60284)

Alternative names: Zinc finger protein 387

All UniProt accessions (6): O60284, E5RFE8, E5RHS3, E5RHY1, E5RID0, E5RK88

UniProt curated annotations — full annotation on UniProt →

Function. Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5’-AAAGTTT-3’ separated by 2-9 nucleotides. Represses basal transcription activity from target promoters. Inhibits colony formation in cultured breast cancer cells.

Subcellular location. Nucleus.

Tissue specificity. Detected at low levels in heart, liver, kidney, skeletal muscle, pancreas, testis, ovary and prostate. Detected at even lower levels in mammary epithelial cells and breast cancer cells.

Similarity. Belongs to the MYT1 family.

RefSeq proteins (54): NP_001339755, NP_001339756, NP_001339757, NP_001339758, NP_001339759, NP_001339760, NP_001339761, NP_001339762, NP_001339763, NP_001339764, NP_001339765, NP_001339766, NP_001339767, NP_001339768, NP_001339769, NP_001339770, NP_001339771, NP_001339772, NP_001339773, NP_001339774, NP_001339775, NP_001339776, NP_001339777, NP_001339778, NP_001339779, NP_001339780, NP_001339781, NP_001339782, NP_001339783, NP_001339784, NP_001339785, NP_001339786, NP_001339787, NP_001339788, NP_001339789, NP_001339790, NP_001339791, NP_001339792, NP_001339793, NP_001339794, NP_001339795, NP_001339796, NP_001339797, NP_001339798, NP_001339799, NP_001339800, NP_001339801, NP_001339802, NP_001339803, NP_001339804, NP_001339805, NP_001339806, NP_001339807, NP_055497 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002515	Znf_C2H2C	Repeat
IPR013681	Myelin_TF	Domain
IPR036060	Znf_C2H2C_sf	Homologous_superfamily

Pfam: PF01530, PF08474

UniProt features (48 total): binding site 24, zinc finger region 6, region of interest 5, compositionally biased region 4, strand 3, helix 2, chain 1, coiled-coil region 1, sequence variant 1, turn 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
2CS8	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O60284-F1	53.98	0.08

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (24): 368; 373; 386; 392; 412; 417; 430; 436; 724; 729; 742; 748 …

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 177 (showing top): VERHAAK_AML_WITH_NPM1_MUTATED_DN, AP1_01, AAGCAAT_MIR137, YAGI_AML_WITH_INV_16_TRANSLOCATION, GOBP_RESPONSE_TO_PEPTIDE, ASTON_MAJOR_DEPRESSIVE_DISORDER_DN, ATGCAGT_MIR217, ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP, CEBPB_01, MODULE_66, BLALOCK_ALZHEIMERS_DISEASE_UP, CAATGCA_MIR33, WTGAAAT_UNKNOWN, GOBP_RESPONSE_TO_INTERLEUKIN_1, AAAGACA_MIR511

GO Biological Process (7): negative regulation of cell population proliferation (GO:0008285), regulation of gene expression (GO:0010468), tumor necrosis factor-mediated signaling pathway (GO:0033209), positive regulation of transcription by RNA polymerase II (GO:0045944), interleukin-6-mediated signaling pathway (GO:0070102), interleukin-1-mediated signaling pathway (GO:0070498), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (5): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (3): chromatin (GO:0000785), nucleus (GO:0005634), protein-DNA complex (GO:0032993)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytokine-mediated signaling pathway	3
regulation of transcription by RNA polymerase II	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
cell population proliferation	1
regulation of cell population proliferation	1
negative regulation of cellular process	1
gene expression	1
regulation of macromolecule biosynthetic process	1
cellular response to tumor necrosis factor	1
transcription by RNA polymerase II	1
positive regulation of DNA-templated transcription	1
cellular response to interleukin-6	1
cellular response to interleukin-1	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
chromosome	1
cellular anatomical structure	1
intracellular membrane-bounded organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

400 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ST18	PCMTD1	Q96MG8	573
ST18	C10orf53	Q8N6V4	518
ST18	PLEKHA7	Q6IQ23	446
ST18	PHF20	Q9BVI0	398
ST18	DPM2	O94777	340
ST18	EPDR1	Q9UM22	328
ST18	SIN3B	O75182	319
ST18	ZRANB1	Q9UGI0	315
ST18	EEIG1	Q5T9C2	301
ST18	MFRP	Q9BY79	294
ST18	A0A087WUC5	A0A087WUC5	275
ST18	PTGR2	Q8N8N7	274
ST18	COL11A1	P12107	273
ST18	NF1	P21359	267
ST18	NPDC1	Q9NQX5	258

IntAct

5 interactions, top by confidence:

A	B	Type	Score
ST18	H2BC9	psi-mi:“MI:0915”(physical association)	0.400
TRPV2	ST18	psi-mi:“MI:0915”(physical association)	0.370
PCNT	ST18	psi-mi:“MI:0915”(physical association)	0.000
HSPA13	ST18	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (12): HIST1H2BH (Proximity Label-MS), ST18 (Affinity Capture-MS), ST18 (Two-hybrid), ST18 (Two-hybrid), ST18 (Affinity Capture-MS), ST18 (Cross-Linking-MS (XL-MS)), ST18 (Cross-Linking-MS (XL-MS)), ZC3H18 (Cross-Linking-MS (XL-MS)), ST18 (Co-fractionation), ST18 (Co-fractionation), ST18 (Co-fractionation), ST18 (Co-fractionation)

ESM2 similar proteins: A0A140LFM6, A0A1B0GUA6, A0JMD2, A4IGV6, A6H5Y1, A6NFA0, A6NKB5, A8E653, B3DHS1, D3ZJ47, D3ZMK9, E9Q309, O14513, O60284, P0CAX8, Q1RMQ5, Q32LN6, Q3URK1, Q3UTJ2, Q3ZBS1, Q49A88, Q5DU28, Q5RDK8, Q5REU9, Q5SW75, Q5VT06, Q60664, Q62417, Q642A3, Q68D20, Q6A065, Q6DFB0, Q6NRK3, Q6NWJ0, Q6ZVD7, Q76I79, Q7TSH4, Q8K2J4, Q8K3V7, Q8VEB3

Diamond homologs: A2A5N8, B1B1A0, D3YUG0, D3YXK1, D3ZWK4, E1C2V1, O02274, O60284, O95251, P39769, P59178, P70047, P70475, P78364, P97500, Q01538, Q05BQ5, Q1JQD9, Q1RNF8, Q29L50, Q32N90, Q3MIF2, Q4V7W5, Q5DTW2, Q5R737, Q5SVQ0, Q5VUG0, Q5VXD3, Q64028, Q6DIN3, Q6P5G3, Q6SPE9, Q6SPF0, Q7Z3H4, Q80TY4, Q810T5, Q8BLB7, Q8C8Y5, Q8CFC2, Q8CHP6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

158 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	138
Likely benign	7
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

6395 predictions. Top by Δscore:

Variant	Effect	Δscore
8:52118324:CTT:C	donor_gain	1.0000
8:52118326:T:TA	donor_gain	1.0000
8:52118440:TCCT:T	acceptor_loss	1.0000
8:52118442:C:CC	acceptor_gain	1.0000
8:52118443:T:C	acceptor_loss	1.0000
8:52133053:TTACT:T	donor_loss	1.0000
8:52133055:A:AC	donor_gain	1.0000
8:52133055:A:AT	donor_loss	1.0000
8:52133055:ACTT:A	donor_gain	1.0000
8:52133056:C:CC	donor_gain	1.0000
8:52133056:CT:C	donor_gain	1.0000
8:52133056:CTT:C	donor_gain	1.0000
8:52133056:CTTC:C	donor_gain	1.0000
8:52133134:CAAG:C	acceptor_gain	1.0000
8:52133135:AAG:A	acceptor_gain	1.0000
8:52133136:AG:A	acceptor_gain	1.0000
8:52133137:GC:G	acceptor_loss	1.0000
8:52133138:C:CC	acceptor_gain	1.0000
8:52133138:CTGAA:C	acceptor_loss	1.0000
8:52133139:T:G	acceptor_loss	1.0000
8:52133143:A:AC	acceptor_gain	1.0000
8:52133151:C:CT	acceptor_gain	1.0000
8:52133152:C:CT	acceptor_gain	1.0000
8:52133152:C:T	acceptor_gain	1.0000
8:52133153:G:T	acceptor_gain	1.0000
8:52142928:A:AC	donor_gain	1.0000
8:52142929:C:CC	donor_gain	1.0000
8:52159105:CTTTG:C	acceptor_gain	1.0000
8:52159110:C:CC	acceptor_gain	1.0000
8:52161373:A:AC	donor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000004585 (8:52359480 A>T), RS1000024418 (8:52237936 C>G), RS1000053180 (8:52147263 A>G), RS1000067850 (8:52304758 C>T), RS1000069019 (8:52186158 A>C), RS1000070649 (8:52311036 G>A), RS1000087245 (8:52262898 A>G), RS1000094096 (8:52222291 T>C), RS1000094807 (8:52380362 G>A), RS1000109306 (8:52160988 T>C), RS1000138255 (8:52229792 T>A), RS1000157883 (8:52302269 G>A), RS1000159826 (8:52356148 G>A), RS1000170873 (8:52250356 T>G), RS1000183285 (8:52127770 T>A)

Disease associations

OMIM: gene MIM:617155 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

17 associations (top):

Study	Trait	p-value
GCST001915_23	Alzheimer’s disease (cognitive decline)	5.000000e-07
GCST002759_18	Motion sickness	7.000000e-11
GCST003467_14	Glaucoma (primary angle closure)	5.000000e-16
GCST003467_15	Glaucoma (primary angle closure)	2.000000e-13
GCST003472_22	Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder	3.000000e-06
GCST003472_23	Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder	3.000000e-06
GCST003472_24	Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder	3.000000e-06
GCST006147_3	Frontotemporal dementia (age at onset)	8.000000e-07
GCST006149_3	Frontotemporal dementia with GRN mutation (age at onset)	9.000000e-06
GCST006291_33	Spherical equivalent or myopia (age of diagnosis)	6.000000e-13
GCST007325_134	General risk tolerance (MTAG)	9.000000e-11
GCST007565_150	Morning person	8.000000e-19
GCST007576_19	Chronotype	8.000000e-19
GCST008114_30	Type 2 diabetes	5.000000e-06
GCST008896_2	Psychotic experience (distressing)	5.000000e-08
GCST010002_299	Refractive error	7.000000e-25
GCST90000047_156	Age at first sexual intercourse	5.000000e-08

EFO canonical traits (7, from GWAS)

EFO ID	Trait name
EFO:0006928	motion sickness
EFO:0007679	oppositional defiant disorder measurement
EFO:0004847	age at onset
EFO:0008579	risk-taking behaviour
EFO:0008328	chronotype measurement
EFO:0005940	psychotic symptoms
EFO:0009749	age at first sexual intercourse measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

19 total (human), top 19 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases expression, affects methylation, decreases expression	3
Benzo(a)pyrene	affects methylation, decreases expression	3
Tobacco Smoke Pollution	decreases expression, increases expression	2
methyleugenol	decreases expression	1
bisphenol A	affects methylation	1
kojic acid	decreases expression	1
beta-lapachone	decreases expression	1
benzo(e)pyrene	increases methylation	1
cadmium sulfate	decreases expression	1
abrine	increases expression	1
bisphenol S	increases methylation	1
Cytarabine	increases expression	1
Methapyrilene	increases methylation	1
N-Nitrosopyrrolidine	decreases expression	1
Testosterone	decreases expression	1
Valproic Acid	decreases expression	1
Aflatoxin B1	increases methylation	1
Antirheumatic Agents	increases expression	1
Okadaic Acid	decreases expression	1

Cellosaurus cell lines

3 cell lines: 3 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A6T6	SEES3-1V human ST18, clone1	Embryonic stem cell	Male
CVCL_A6T7	SEES3-1V human ST18, clone2	Embryonic stem cell	Male
CVCL_A6T8	SEES3-1V human ST18, clone3	Embryonic stem cell	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.