ST20

Summary

ST20 (suppressor of tumorigenicity 20, HGNC:33520) is a long non-coding RNA gene on chromosome 15q25.1. May act as a tumor suppressor.

Enables cysteine-type endopeptidase activator activity. Involved in apoptotic signaling pathway and cellular response to UV-C.

Source: NCBI Gene 400410 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33520
Approved symbol	ST20
Name	suppressor of tumorigenicity 20
Location	15q25.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	HCCS-1
Ensembl gene	ENSG00000180953
Ensembl biotype	lncRNA
Entrez	400410
RNAcentral	URS0000EEACBF — lncRNA, 641 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000478497, ENST00000485386, ENST00000562759

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000478497 — 3 exons

Exon	Start	End
ENSE00001912176	79898847	79899125
ENSE00002572427	79914588	79915256
ENSE00003465552	79907629	79907684

Expression profiles

Bgee: expression breadth ubiquitous, 220 present calls, max score 92.47.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 14.6192 / max 354.8066, expressed in 1802 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
151187	14.6192	1802

Top tissues by expression

268 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	92.47	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.91	gold quality
right lobe of liver	UBERON:0001114	88.31	gold quality
granulocyte	CL:0000094	86.78	gold quality
spleen	UBERON:0002106	86.54	gold quality
mucosa of transverse colon	UBERON:0004991	86.04	gold quality
monocyte	CL:0000576	85.97	gold quality
mononuclear cell	CL:0000842	85.81	gold quality
leukocyte	CL:0000738	85.78	gold quality
pancreatic ductal cell	CL:0002079	85.35	gold quality
lower esophagus mucosa	UBERON:0035834	84.46	gold quality
sperm	CL:0000019	83.84	silver quality
periodontal ligament	UBERON:0008266	83.20	gold quality
apex of heart	UBERON:0002098	82.93	gold quality
adenohypophysis	UBERON:0002196	82.44	gold quality
oocyte	CL:0000023	82.33	silver quality
right lobe of thyroid gland	UBERON:0001119	82.10	gold quality
right hemisphere of cerebellum	UBERON:0014890	81.98	gold quality
cerebellar hemisphere	UBERON:0002245	81.96	gold quality
cerebellar cortex	UBERON:0002129	81.85	gold quality
left lobe of thyroid gland	UBERON:0001120	81.70	gold quality
pituitary gland	UBERON:0000007	81.69	gold quality
metanephros cortex	UBERON:0010533	81.16	gold quality
male germ cell	CL:0000015	80.99	silver quality
small intestine Peyer’s patch	UBERON:0003454	80.71	gold quality
thyroid gland	UBERON:0002046	80.65	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.39	gold quality
upper lobe of left lung	UBERON:0008952	80.33	gold quality
cerebellum	UBERON:0002037	80.01	gold quality
upper lobe of lung	UBERON:0008948	79.88	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.76
E-MTAB-7249	no	40.84
E-HCAD-13	no	2.79

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.