ST7-AS1

Summary

ST7-AS1 (ST7 antisense RNA 1, HGNC:16000) is a long non-coding RNA gene on chromosome 7q31.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16000
Approved symbol	ST7-AS1
Name	ST7 antisense RNA 1
Location	7q31.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	ST7AS1
Ensembl gene	ENSG00000227199
Ensembl biotype	lncRNA
Entrez	93653
RNAcentral	URS000075E6C1 — lncRNA, 1908 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000456775

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000456775 — 1 exons

Exon	Start	End
ENSE00001634653	116952446	116954334

Expression profiles

Bgee: expression breadth ubiquitous, 159 present calls, max score 77.00.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.0944 / max 74.2322, expressed in 1313 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
85832	3.0944	1313

Top tissues by expression

240 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	77.00	gold quality
colonic epithelium	UBERON:0000397	70.94	silver quality
left lobe of thyroid gland	UBERON:0001120	70.32	gold quality
tibial artery	UBERON:0007610	69.90	gold quality
popliteal artery	UBERON:0002250	69.85	gold quality
mucosa of stomach	UBERON:0001199	69.81	gold quality
right lobe of thyroid gland	UBERON:0001119	69.57	gold quality
thyroid gland	UBERON:0002046	69.01	gold quality
right lung	UBERON:0002167	68.87	gold quality
aorta	UBERON:0000947	68.49	gold quality
ventricular zone	UBERON:0003053	68.04	gold quality
islet of Langerhans	UBERON:0000006	67.88	gold quality
right coronary artery	UBERON:0001625	67.63	gold quality
stromal cell of endometrium	CL:0002255	67.53	gold quality
left uterine tube	UBERON:0001303	67.44	gold quality
descending thoracic aorta	UBERON:0002345	67.20	gold quality
thoracic aorta	UBERON:0001515	67.07	gold quality
adenohypophysis	UBERON:0002196	66.99	gold quality
ganglionic eminence	UBERON:0004023	66.91	gold quality
ascending aorta	UBERON:0001496	66.86	gold quality
left ovary	UBERON:0002119	66.51	gold quality
left coronary artery	UBERON:0001626	66.32	gold quality
monocyte	CL:0000576	65.64	gold quality
pituitary gland	UBERON:0000007	65.46	gold quality
cortical plate	UBERON:0005343	65.45	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.37	gold quality
lower esophagus	UBERON:0013473	65.30	gold quality
endocervix	UBERON:0000458	65.17	gold quality
left adrenal gland cortex	UBERON:0035825	65.16	gold quality
right ovary	UBERON:0002118	65.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• ST7-AS1 might mediate its oncogenic effect by signaling through CARM1-Sox-2 axis to enhance Sox-2 self-association and transactivation activity. Collectively, we have unraveled a ST7-AS1/CARM1/Sox-2 signaling axis in laryngeal squamous cell carcinoma and may have created novel interconnections between noncoding RNAs and cancer development. (PMID:30853182)
• p53-targeted lncRNA ST7-AS1 acts as a tumour suppressor by interacting with PTBP1 to suppress the Wnt/beta-catenin signalling pathway in glioma. (PMID:33476649)
• CAF-derived midkine promotes EMT and cisplatin resistance by upregulating lncRNA ST7-AS1 in gastric cancer. (PMID:35588343)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.