ST7-AS1

Summary

ST7-AS1 (ST7 antisense RNA 1, HGNC:16000) is a long non-coding RNA gene on chromosome 7q31.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product.
• Sense gene: antisense to ST7 — the sense gene carries 8 GWAS associations, 65 ClinVar variants (the sense gene’s biology, not this transcript’s)
• GTEx eGene: eQTL in 13 tissues, sQTL in 0 (q < 0.05)

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16000
Approved symbol	ST7-AS1
Name	ST7 antisense RNA 1
Location	7q31.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	ST7AS1
Ensembl gene	ENSG00000227199
Ensembl biotype	lncRNA
Entrez	93653
RNAcentral	URS000075E6C1 — lncRNA, 1908 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000456775

RefSeq mRNA: 0

Canonical transcript exons

ENST00000456775 — 1 exons

Exon	Start	End
ENSE00001634653	116952446	116954334

Expression profiles

Bgee: expression breadth ubiquitous, 159 present calls, max score 77.00.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.0944 / max 74.2322, expressed in 1313 samples.

Highest expression (Bgee): olfactory segment of nasal mucosa, colonic epithelium, lobe of thyroid gland, tibial artery, popliteal artery.

Genetic regulation across tissues (GTEx eQTL / sQTL)

ST7-AS1 is an eGene in GTEx v10 — its expression is genetically regulated (eQTL) in 13 tissues and its splicing (sQTL) in 0 (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant’s alternative allele.

13 significant tissue × QTL associations:

Tissue	QTL	q-value	Slope	Lead variant
Esophagus Muscularis	eqtl	8.6e-07	-0.70	7:116979549:A:G
Skin Sun Exposed Lower leg	eqtl	2.8e-05	-0.57	7:116979549:A:G
Adipose Subcutaneous	eqtl	1.3e-03	-0.40	7:116979549:A:G
Thyroid	eqtl	1.6e-03	-0.44	7:116952335:A:C
Breast Mammary Tissue	eqtl	2.8e-03	-0.39	7:117202734:A:C
Artery Aorta	eqtl	3.5e-03	-0.73	7:116979549:A:G
Artery Tibial	eqtl	3.9e-03	-0.30	7:116952335:A:C
Testis	eqtl	7.8e-03	-0.80	7:116954326:G:C
Colon Sigmoid	eqtl	1.1e-02	-0.56	7:116954326:G:C
Small Intestine Terminal Ileum	eqtl	1.4e-02	-0.60	7:117074260:G:A
Cells Cultured fibroblasts	eqtl	2.8e-02	-0.47	7:116954326:G:C
Brain Hippocampus	eqtl	3.2e-02	-2.35	7:116931340:G:A
Brain Cerebellum	eqtl	4.0e-02	+1.26	7:116498881:C:G

FANTOM5 promoters

1 alternative TSS:

Promoter ID	TPM avg	Samples expressed
85832	3.0944	1313

Top tissues by expression

showing 100 of 240 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	77.00	gold quality
colonic epithelium	UBERON:0000397	70.94	silver quality
left lobe of thyroid gland	UBERON:0001120	70.32	gold quality
tibial artery	UBERON:0007610	69.90	gold quality
popliteal artery	UBERON:0002250	69.85	gold quality
mucosa of stomach	UBERON:0001199	69.81	gold quality
right lobe of thyroid gland	UBERON:0001119	69.57	gold quality
thyroid gland	UBERON:0002046	69.01	gold quality
right lung	UBERON:0002167	68.87	gold quality
aorta	UBERON:0000947	68.49	gold quality
ventricular zone	UBERON:0003053	68.04	gold quality
islet of Langerhans	UBERON:0000006	67.88	gold quality
right coronary artery	UBERON:0001625	67.63	gold quality
stromal cell of endometrium	CL:0002255	67.53	gold quality
left uterine tube	UBERON:0001303	67.44	gold quality
descending thoracic aorta	UBERON:0002345	67.20	gold quality
thoracic aorta	UBERON:0001515	67.07	gold quality
adenohypophysis	UBERON:0002196	66.99	gold quality
ganglionic eminence	UBERON:0004023	66.91	gold quality
ascending aorta	UBERON:0001496	66.86	gold quality
left ovary	UBERON:0002119	66.51	gold quality
left coronary artery	UBERON:0001626	66.32	gold quality
monocyte	CL:0000576	65.64	gold quality
pituitary gland	UBERON:0000007	65.46	gold quality
cortical plate	UBERON:0005343	65.45	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.37	gold quality
lower esophagus	UBERON:0013473	65.30	gold quality
endocervix	UBERON:0000458	65.17	gold quality
left adrenal gland cortex	UBERON:0035825	65.16	gold quality
right ovary	UBERON:0002118	65.10	gold quality
coronary artery	UBERON:0001621	65.01	gold quality
body of uterus	UBERON:0009853	64.95	gold quality
leukocyte	CL:0000738	64.72	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.57	gold quality
apex of heart	UBERON:0002098	64.53	gold quality
right adrenal gland cortex	UBERON:0035827	64.35	gold quality
left adrenal gland	UBERON:0001234	64.20	gold quality
hindlimb stylopod muscle	UBERON:0004252	63.78	gold quality
right adrenal gland	UBERON:0001233	63.76	gold quality
ectocervix	UBERON:0012249	63.71	gold quality
bone marrow cell	CL:0002092	63.68	silver quality
subcutaneous adipose tissue	UBERON:0002190	63.66	gold quality
skin of leg	UBERON:0001511	63.56	gold quality
pancreas	UBERON:0001264	63.51	gold quality
nasal cavity mucosa	UBERON:0001826	63.30	gold quality
adrenal cortex	UBERON:0001235	63.26	gold quality
calcaneal tendon	UBERON:0003701	63.00	gold quality
metanephros cortex	UBERON:0010533	62.89	gold quality
muscle layer of sigmoid colon	UBERON:0035805	62.71	gold quality
smooth muscle tissue	UBERON:0001135	62.67	gold quality
ovary	UBERON:0000992	62.52	gold quality
gastrocnemius	UBERON:0001388	62.42	gold quality
muscle of leg	UBERON:0001383	62.34	gold quality
sural nerve	UBERON:0015488	62.33	silver quality
right uterine tube	UBERON:0001302	62.25	gold quality
adrenal gland	UBERON:0002369	62.13	gold quality
right atrium auricular region	UBERON:0006631	61.88	gold quality
body of pancreas	UBERON:0001150	61.58	gold quality
upper lobe of left lung	UBERON:0008952	61.57	gold quality
skin of abdomen	UBERON:0001416	61.36	gold quality
cardiac atrium	UBERON:0002081	61.33	gold quality
body of stomach	UBERON:0001161	61.26	gold quality
uterine cervix	UBERON:0000002	60.87	gold quality
tibial nerve	UBERON:0001323	60.84	gold quality
minor salivary gland	UBERON:0001830	60.51	gold quality
zone of skin	UBERON:0000014	60.42	gold quality
heart	UBERON:0000948	60.19	gold quality
vena cava	UBERON:0004087	60.12	gold quality
heart left ventricle	UBERON:0002084	60.10	gold quality
cerebellar cortex	UBERON:0002129	60.10	gold quality
adipose tissue	UBERON:0001013	60.07	gold quality
cortex of kidney	UBERON:0001225	60.06	gold quality
cerebellar hemisphere	UBERON:0002245	60.05	gold quality
upper lobe of lung	UBERON:0008948	59.76	gold quality
right hemisphere of cerebellum	UBERON:0014890	59.60	gold quality
cardiac ventricle	UBERON:0002082	59.43	gold quality
prefrontal cortex	UBERON:0000451	59.41	gold quality
esophagus	UBERON:0001043	59.20	gold quality
rectum	UBERON:0001052	58.94	gold quality
stomach	UBERON:0000945	58.91	gold quality
cerebellum	UBERON:0002037	58.75	gold quality
transverse colon	UBERON:0001157	58.66	gold quality
adult mammalian kidney	UBERON:0000082	58.60	gold quality
saliva-secreting gland	UBERON:0001044	58.42	gold quality
Brodmann (1909) area 9	UBERON:0013540	58.19	gold quality
hypothalamus	UBERON:0001898	58.13	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	58.10	gold quality
gall bladder	UBERON:0002110	58.08	gold quality
mouth mucosa	UBERON:0003729	57.88	gold quality
amygdala	UBERON:0001876	57.56	gold quality
prostate gland	UBERON:0002367	57.54	gold quality
small intestine Peyer’s patch	UBERON:0003454	57.46	gold quality
omental fat pad	UBERON:0010414	57.42	gold quality
anatomical system	UBERON:0000467	57.41	gold quality
colon	UBERON:0001155	57.41	gold quality
multicellular organism	UBERON:0000468	57.39	gold quality
material anatomical entity	UBERON:0000465	57.37	gold quality
peritoneum	UBERON:0002358	57.37	gold quality
adipose tissue of abdominal region	UBERON:0007808	57.33	gold quality
putamen	UBERON:0001874	57.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• ST7-AS1 might mediate its oncogenic effect by signaling through CARM1-Sox-2 axis to enhance Sox-2 self-association and transactivation activity. Collectively, we have unraveled a ST7-AS1/CARM1/Sox-2 signaling axis in laryngeal squamous cell carcinoma and may have created novel interconnections between noncoding RNAs and cancer development. (PMID:30853182)
• p53-targeted lncRNA ST7-AS1 acts as a tumour suppressor by interacting with PTBP1 to suppress the Wnt/beta-catenin signalling pathway in glioma. (PMID:33476649)
• CAF-derived midkine promotes EMT and cisplatin resistance by upregulating lncRNA ST7-AS1 in gastric cancer. (PMID:35588343)

Cross-species orthologs

0 orthologs

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
ST7-OT4	ncRNA	338069
ST7	protein-coding	7982
CAPZA2	protein-coding	830
ST7-AS2	ncRNA	93654
ST7-OT3	ncRNA	93655
MIR6132	ncRNA	102466616
MET	protein-coding	4233

Protein

Non-coding RNA — no protein product.

Function

Gene-set membership (MSigDB)

This non-coding RNA is a member of 33 curated MSigDB gene sets — regulatory-target and signature collections that include it (it has no protein-based pathway / GO / interaction data).

RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN, chr7q31, WINNEPENNINCKX_MELANOMA_METASTASIS_DN, ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP, CREB3L4_TARGET_GENES, DIDO1_TARGET_GENES, GSE14000_UNSTIM_VS_4H_LPS_DC_DN, BLANCO_MELO_BRONCHIAL_EPITHELIAL_CELLS_INFLUENZA_A_DEL_NS1_INFECTION_UP, GSE15659_NAIVE_VS_PTPRC_NEG_CD4_TCELL_DN, GSE15659_NAIVE_CD4_TCELL_VS_RESTING_TREG_DN, GSE15659_NAIVE_CD4_TCELL_VS_NONSUPPRESSIVE_TCELL_DN, GSE15659_NAIVE_CD4_TCELL_VS_ACTIVATED_TREG_DN, GSE15659_CD45RA_NEG_CD4_TCELL_VS_RESTING_TREG_DN, GSE15659_CD45RA_NEG_CD4_TCELL_VS_NONSUPPRESSIVE_TCELL_DN, GSE15659_CD45RA_NEG_CD4_TCELL_VS_ACTIVATED_TREG_DN, GSE15659_RESTING_TREG_VS_NONSUPPRESSIVE_TCELL_DN, GSE15659_RESTING_VS_ACTIVATED_TREG_DN, ZNF250_TARGET_GENES, ZBED5_TARGET_GENES, ZNF318_TARGET_GENES, SS18_SSX1_FUSION_UNIPROT_Q8IZH1_UNREVIEWED_TARGET_GENES, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_48H_ACT_CD4_TCELL_UP, GSE18791_CTRL_VS_NEWCASTLE_VIRUS_DC_12H_DN, GSE18791_CTRL_VS_NEWCASTLE_VIRUS_DC_16H_DN, GSE2706_UNSTIM_VS_2H_LPS_AND_R848_DC_DN, GSE1740_MCSF_VS_MCSF_AND_IFNG_DAY2_DERIVED_MACROPHAGE_WITH_IFNA_STIM_DN, GSE1740_MCSF_VS_MCSF_AND_IFNG_DAY2_DERIVED_MACROPHAGE_UP, GSE9960_HEALTHY_VS_GRAM_POS_SEPSIS_PBMC_DN, ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP, GSE21927_UNTREATED_VS_GMCSF_IL6_TREATED_BONE_MARROW_UP, GSE25088_WT_VS_STAT6_KO_MACROPHAGE_UP, ZHOU_INFLAMMATORY_RESPONSE_LPS_UP, GSE45365_WT_VS_IFNAR_KO_BCELL_MCMV_INFECTION_DN

ncRNA interactions

Experimentally supported non-coding-RNA interaction partners (NPInter).

showing 60 of 72 interaction partners:

Partner	Partner type	Level	Source
hsa-miR-106a-3p	miRNA	RNA-RNA	Literature mining
IGF2BP1	protein	RNA-Protein	High-throughput data
WDR33	protein	RNA-Protein	High-throughput data
IGF2P1	protein	RNA-Protein	High-throughput data
hnRNPA2B1	protein	RNA-Protein	High-throughput data
FUS	protein	RNA-Protein	High-throughput data
BCCIP	protein	RNA-Protein	ENCODE
BUD13	protein	RNA-Protein	ENCODE
CSTF2	protein	RNA-Protein	ENCODE
CSTF2T	protein	RNA-Protein	ENCODE
DDX3X	protein	RNA-Protein	ENCODE
DGCR8	protein	RNA-Protein	ENCODE
EIF3D	protein	RNA-Protein	ENCODE
FAM120A	protein	RNA-Protein	ENCODE
FAKD2	protein	RNA-Protein	ENCODE
FKBP4	protein	RNA-Protein	ENCODE
GRWD1	protein	RNA-Protein	ENCODE
HNRNPUL1	protein	RNA-Protein	ENCODE
hnRNPM	protein	RNA-Protein	ENCODE
HNRNPU	protein	RNA-Protein	ENCODE
IF2B1	protein	RNA-Protein	ENCODE
IGF2BP3	protein	RNA-Protein	ENCODE;GSE78507
NCBP2	protein	RNA-Protein	ENCODE
NKRF	protein	RNA-Protein	ENCODE
PCBP2	protein	RNA-Protein	ENCODE
PPIG	protein	RNA-Protein	ENCODE
PRPF8	protein	RNA-Protein	ENCODE
PTBP1	protein	RNA-Protein	ENCODE
RBM15	protein	RNA-Protein	ENCODE
RBM5	protein	RNA-Protein	ENCODE
TAF15	protein	RNA-Protein	ENCODE
RNC	protein	RNA-Protein	ENCODE
HNRNPA1	protein	RNA-Protein	ENCODE
RPB7	protein	RNA-Protein	ENCODE
PSF	protein	RNA-Protein	ENCODE;GSE90650
SFRS1	protein	RNA-Protein	ENCODE
TIA1	protein	RNA-Protein	ENCODE
U2AF1	protein	RNA-Protein	ENCODE
UCHL5	protein	RNA-Protein	ENCODE
XRCC6	protein	RNA-Protein	ENCODE
XRN2	protein	RNA-Protein	ENCODE
ZC11A	protein	RNA-Protein	ENCODE
EWSR1	protein	RNA-Protein	ENCODE
EXOS5	protein	RNA-Protein	ENCODE
FUBP2	protein	RNA-Protein	ENCODE
GEMI5	protein	RNA-Protein	ENCODE
IF2B2	protein	RNA-Protein	ENCODE
LARP4	protein	RNA-Protein	ENCODE
LSM11	protein	RNA-Protein	ENCODE
METAP2	protein	RNA-Protein	ENCODE
DBHS	protein	RNA-Protein	ENCODE;GSE90650
PAPD1	protein	RNA-Protein	ENCODE
SLTM	protein	RNA-Protein	ENCODE
SFRS7	protein	RNA-Protein	ENCODE
T2FA	protein	RNA-Protein	ENCODE
YBOX3	protein	RNA-Protein	ENCODE
ZNF622	protein	RNA-Protein	ENCODE
ZRAB2	protein	RNA-Protein	ENCODE
QKI	protein	RNA-Protein	GSE111188
MOV10	protein	RNA-Protein	GSE70061

Disease & clinical

ncRNA disease associations

Curated non-coding-RNA → disease associations (LncRNADisease, HMDD) — these are RNA-level associations for this gene, not the positional variant data omitted above.

5 ncRNA–disease associations:

Disease	Causal?	Validated by
Breast Neoplasms	No	qRT-PCR
Squamous Cell Carcinoma of Head and Neck	Yes	FISH, Luciferase Report Assay, Migration Assay
Adenocarcinoma of Lung	Yes	Western Blot, Wound Healing Assay, qRT-PCR, MTT, Transwell Assay
Glioma	Yes	In Vivo Experiment, RNA Pull-Down, ChIP, Western Blot, ISH, Transfection, qPCR, CCK8, FISH, RIP, IF, Luciferase Report Assay, H&E Staining, IHC, EdU Staining, Transwell Assay
Thyroid Cancer, Papillary	Yes	CCK8, qRT-PCR, Luciferase Report Assay, Colony Formation Assay

Drugs & pharmacology

ncRNA–drug associations

Curated non-coding-RNA → drug associations (drug response / resistance / target).

2 ncRNA–drug associations:

Drug	Relation	Effect	Condition
Panobinostat	drug_target	down-regulated	“cell line (SK-NEP-1, G401)”
Radioactivity Iodine	drug_resistance	sensitive	tissue