ST7L

Summary

ST7L (suppression of tumorigenicity 7 like, HGNC:18441) is a protein-coding gene on chromosome 1p13.2, encoding Suppressor of tumorigenicity 7 protein-like (Q8TDW4).

This gene was identified by its similarity to the ST7 tumor suppressor gene found in the chromosome 7q31 region. This gene is clustered in a tail-to-tail manner with the WNT2B gene in a chromosomal region known to be deleted and rearranged in a variety of cancers. Several transcript variants encoding many different isoforms have been described, but some have not been fully characterized.

Source: NCBI Gene 54879 — RefSeq curated summary.

At a glance

• GWAS associations: 32
• Clinical variants (ClinVar): 106 total
• MANE Select transcript: NM_017744

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18441
Approved symbol	ST7L
Name	suppression of tumorigenicity 7 like
Location	1p13.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ20284, STLR, ST7R, FAM4B
Ensembl gene	ENSG00000007341
Ensembl biotype	protein_coding
OMIM	617640
Entrez	54879

Gene structure

Transcript identifiers

Ensembl transcripts: 50 — 30 protein_coding, 18 protein_coding_CDS_not_defined, 2 nonsense_mediated_decay

ENST00000343210, ENST00000358039, ENST00000360743, ENST00000361846, ENST00000369664, ENST00000369666, ENST00000369669, ENST00000418497, ENST00000459630, ENST00000463235, ENST00000466360, ENST00000467335, ENST00000470519, ENST00000470683, ENST00000473206, ENST00000477332, ENST00000477682, ENST00000479436, ENST00000480988, ENST00000485753, ENST00000490067, ENST00000490715, ENST00000492274, ENST00000495109, ENST00000497235, ENST00000497457, ENST00000498197, ENST00000498383, ENST00000904302, ENST00000904303, ENST00000904304, ENST00000904305, ENST00000904306, ENST00000904307, ENST00000904308, ENST00000904309, ENST00000904310, ENST00000904311, ENST00000904312, ENST00000904313, ENST00000904314, ENST00000917580, ENST00000917581, ENST00000917582, ENST00000969281, ENST00000969282, ENST00000969283, ENST00000969284, ENST00000969285, ENST00000969286

RefSeq mRNA: 5 — MANE Select: NM_017744 NM_001308264, NM_017744, NM_138727, NM_138728, NM_138729

CCDS: CCDS76189, CCDS848, CCDS849, CCDS850, CCDS852

Canonical transcript exons

ENST00000358039 — 15 exons

Exon	Start	End
ENSE00002694629	112618909	112619141
ENSE00003483364	112610841	112611003
ENSE00003502022	112576986	112577088
ENSE00003508263	112591525	112591603
ENSE00003509790	112600794	112600848
ENSE00003514211	112555868	112556018
ENSE00003587823	112597971	112598086
ENSE00003611954	112581992	112582106
ENSE00003622850	112578345	112578417
ENSE00003642340	112582375	112582472
ENSE00003655548	112616813	112616895
ENSE00003666988	112550601	112550693
ENSE00003784206	112541951	112542090
ENSE00003789543	112583972	112584126
ENSE00003845725	112523514	112526111

Expression profiles

Bgee: expression breadth ubiquitous, 212 present calls, max score 96.25.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 18.5064 / max 156.1556, expressed in 1816 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
13860	15.9630	1803
13862	1.4115	344
13864	0.6371	298
13863	0.3904	177
13859	0.0660	23
13861	0.0283	9
13858	0.0101	6

Top tissues by expression

270 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	96.25	gold quality
male germ cell	CL:0000015	94.46	gold quality
right testis	UBERON:0004534	92.94	gold quality
left testis	UBERON:0004533	92.90	gold quality
calcaneal tendon	UBERON:0003701	91.42	gold quality
testis	UBERON:0000473	91.28	gold quality
colonic epithelium	UBERON:0000397	90.85	gold quality
adrenal tissue	UBERON:0018303	90.31	gold quality
ventricular zone	UBERON:0003053	89.84	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.30	gold quality
left ovary	UBERON:0002119	87.94	gold quality
body of pancreas	UBERON:0001150	87.71	gold quality
skin of abdomen	UBERON:0001416	87.65	gold quality
stromal cell of endometrium	CL:0002255	87.50	gold quality
lower esophagus mucosa	UBERON:0035834	87.26	gold quality
skin of leg	UBERON:0001511	87.19	gold quality
ectocervix	UBERON:0012249	87.10	gold quality
sural nerve	UBERON:0015488	87.02	gold quality
body of uterus	UBERON:0009853	86.94	gold quality
right ovary	UBERON:0002118	86.79	gold quality
endocervix	UBERON:0000458	86.65	gold quality
left lobe of thyroid gland	UBERON:0001120	86.48	gold quality
ganglionic eminence	UBERON:0004023	86.45	gold quality
buccal mucosa cell	CL:0002336	86.11	gold quality
adenohypophysis	UBERON:0002196	86.11	gold quality
ovary	UBERON:0000992	86.02	gold quality
popliteal artery	UBERON:0002250	86.01	gold quality
tibial artery	UBERON:0007610	86.01	gold quality
right lobe of thyroid gland	UBERON:0001119	86.00	gold quality
thyroid gland	UBERON:0002046	85.99	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

89 targeting ST7L, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-146A-5P	99.96	68.93	988
HSA-MIR-146B-5P	99.96	69.13	977
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-7153-5P	99.94	68.89	1006
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-302A-3P	99.89	71.23	1777
HSA-MIR-302B-3P	99.89	71.23	1777
HSA-MIR-302C-3P	99.89	71.20	1778
HSA-MIR-302D-3P	99.89	71.25	1777
HSA-MIR-424-5P	99.89	71.90	2641
HSA-MIR-6838-5P	99.89	71.94	2690
HSA-MIR-7162-3P	99.89	68.16	1682
HSA-MIR-12119	99.87	68.35	1653
HSA-MIR-369-3P	99.85	70.52	2264
HSA-MIR-373-3P	99.84	70.68	1668
HSA-MIR-520E-3P	99.84	70.55	1698

Literature-anchored findings (GeneRIF, showing 6)

• miR-24 is a direct regulator of ST7L. (PMID:23142218)
• This study revealed important roles of miR-23b and ST7L in progression of Hepatocellular carcinoma. (PMID:28518144)
• miR-378 functions as an onco-miRNA by directly downregulating ST7L mRNA and protein level. (PMID:28902356)
• Study found that miR-331-3p was significantly upregulated in tumor specimens of pancreatic cancer (PC) patients and cell lines. Downregulation of miR-331-3p inhibited PC cell proliferation and epithelial-mesenchymal transition-mediated metastasis in vitro. ST7L was identified as a novel target gene of miR-331-3p. Results demonstrate that miR-331-3p is a tumor-promoting microRNA and a promising biomarker for PC. (PMID:29850766)
• Suppression of the proliferation and invasion of breast cancer cells by ST7L occurs through inhibition of activation of Wnt/GSK-3beta/beta-catenin signalling. (PMID:31429477)
• MiR-331-3p Links to Drug Resistance of Pancreatic Cancer Cells by Activating WNT/beta-Catenin Signal via ST7L. (PMID:32924881)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	st7l	ENSDARG00000032603
mus_musculus	St7l	ENSMUSG00000045576
rattus_norvegicus	St7l	ENSRNOG00000014002
drosophila_melanogaster	CG3634	FBGN0037026
caenorhabditis_elegans		WBGENE00008686

Paralogs (1): ST7 (ENSG00000004866)

Protein

Protein identifiers

Suppressor of tumorigenicity 7 protein-like — Q8TDW4 (reviewed: Q8TDW4)

Alternative names: ST7-related protein

All UniProt accessions (3): Q8TDW4, H0Y7M0, Q5TEH7

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Similarity. Belongs to the ST7 family.

Isoforms (8)

UniProt ID	Names	Canonical?
Q8TDW4-1	1	yes
Q8TDW4-2	2
Q8TDW4-3	3
Q8TDW4-4	4
Q8TDW4-5	5
Q8TDW4-6	6
Q8TDW4-7	7
Q8TDW4-8	8

RefSeq proteins (5): NP_001295193, NP_060214, NP_620055, NP_620056, NP_620057 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007311	ST7	Family
IPR011990	TPR-like_helical_dom_sf	Homologous_superfamily

Pfam: PF04184

UniProt features (23 total): splice variant 10, sequence conflict 5, sequence variant 3, transmembrane region 2, chain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8TDW4-F1	80.12	0.50

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 154 (showing top): GSE18804_BRAIN_VS_COLON_TUMORAL_MACROPHAGE_UP, GOBP_NEGATIVE_REGULATION_OF_CELL_GROWTH, AAGCCAT_MIR135A_MIR135B, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GOBP_GROWTH, IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR, AAAYRNCTG_UNKNOWN, MODULE_256, TGIF_01, GATA2_01, RYTTCCTG_ETS2_B, ELK1_01, IK2_01, NERF_Q2, MODULE_47

GO Biological Process (1): negative regulation of cell growth (GO:0030308)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of cell growth	1
cell growth	1
negative regulation of growth	1
negative regulation of cellular process	1
binding	1
cellular anatomical structure	1

Protein interactions and networks

STRING

448 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ST7L	FXYD2	P54710	444
ST7L	AKT1	P31749	441
ST7L	TAOK2	Q9UL54	433
ST7L	TSPYL2	Q9H2G4	377
ST7L	BCLAF1	Q9NYF8	341
ST7L	FIGN	Q5HY92	340
ST7L	TP73	O15350	329
ST7L	SPDL1	Q96EA4	324
ST7L	TEX261	Q6UWH6	316
ST7L	TTC16	Q8NEE8	316
ST7L	WNT2B	Q93097	307
ST7L	CAPZA1	P52907	301
ST7L	TLR2	O60603	295
ST7L	HOXD13	P35453	271
ST7L	BPIFB3	P59826	257

IntAct

35 interactions, top by confidence:

A	B	Type	Score
KIR3DL2	METTL15	psi-mi:“MI:0914”(association)	0.530
MCOLN3	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
KCNS3	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
ZNRF4	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
PCDHB7	C2CD2L	psi-mi:“MI:0914”(association)	0.530
CHRND	TPST2	psi-mi:“MI:0914”(association)	0.530
RNF170	ERLIN1	psi-mi:“MI:0914”(association)	0.530
ST7L	MACO1	psi-mi:“MI:0914”(association)	0.530
KCNA2	TMEM129	psi-mi:“MI:0914”(association)	0.350
TTMP	TMEM223	psi-mi:“MI:0914”(association)	0.350
TTYH1	TMEM223	psi-mi:“MI:0914”(association)	0.350
SIDT2	KLRG2	psi-mi:“MI:0914”(association)	0.350
PCDHB6	KLRG2	psi-mi:“MI:0914”(association)	0.350
PCDHGB4	FAM171A2	psi-mi:“MI:0914”(association)	0.350
RXFP1	UPK3BL1	psi-mi:“MI:0914”(association)	0.350
SCAP	UPK3BL1	psi-mi:“MI:0914”(association)	0.350
PCDHGC4		psi-mi:“MI:0914”(association)	0.350
SLC39A8	GOLIM4	psi-mi:“MI:0914”(association)	0.350
PCDHB11	SDCBP	psi-mi:“MI:0914”(association)	0.350
MARCHF4	C2CD2L	psi-mi:“MI:0914”(association)	0.350
PTCHD3	ABCD4	psi-mi:“MI:0914”(association)	0.350
MS4A15	ABCD4	psi-mi:“MI:0914”(association)	0.350
SLC17A2	ABCD4	psi-mi:“MI:0914”(association)	0.350
ABCA2	ABCD4	psi-mi:“MI:0914”(association)	0.350
OR10H2	ABCD4	psi-mi:“MI:0914”(association)	0.350
SLC4A8	ABCC4	psi-mi:“MI:0914”(association)	0.350
LRRN2	TRIM13	psi-mi:“MI:0914”(association)	0.350
GABRA6	HMGCR	psi-mi:“MI:0914”(association)	0.350
RNF5	ZFTRAF1	psi-mi:“MI:0914”(association)	0.350
IL17RB	ATP1A3	psi-mi:“MI:0914”(association)	0.350

BioGRID (64): ST7L (Affinity Capture-MS), ST7L (Affinity Capture-MS), ST7L (Affinity Capture-MS), ST7L (Affinity Capture-MS), ST7L (Affinity Capture-MS), ST7L (Affinity Capture-MS), ST7L (Affinity Capture-MS), ST7L (Affinity Capture-MS), ST7L (Affinity Capture-MS), ST7L (Affinity Capture-MS), ST7L (Affinity Capture-MS), ST7L (Affinity Capture-MS), ST7L (Affinity Capture-MS), ST7L (Affinity Capture-MS), ST7L (Affinity Capture-MS)

ESM2 similar proteins: A0M8S0, A0M8T1, A0M8U1, A3KN28, A4D7R9, A9JRA0, P70398, Q00PJ0, Q07DV5, Q07DW9, Q07DX8, Q07DY8, Q07E08, Q07E45, Q09YH4, Q09YI5, Q09YJ7, Q09YK8, Q09YN2, Q108U3, Q148V7, Q1RLU8, Q2IBA8, Q2IBD0, Q2IBE0, Q2IBE8, Q2PG42, Q2QL86, Q2QLA6, Q2QLB7, Q2QLD7, Q2QLE8, Q2QLG2, Q5R660, Q5R8N4, Q5XI83, Q68FW3, Q7Z3J2, Q86X10, Q8BWQ6

Diamond homologs: A0M8S0, A0M8T1, A0M8U1, A3KN28, A4D7R9, A7S641, A8X0L4, A9JRA0, Q00PJ0, Q07DV5, Q07DW9, Q07DX8, Q07DY8, Q07E08, Q07E45, Q09YH4, Q09YI5, Q09YJ7, Q09YK8, Q09YN2, Q108U3, Q19337, Q1RLU8, Q2IBA8, Q2IBD0, Q2IBE0, Q2IBE8, Q2M146, Q2PG42, Q2QL86, Q2QLA6, Q2QLB7, Q2QLD7, Q2QLE8, Q2QLG2, Q68FW3, Q8K4P7, Q8TDW4, Q90YH8, Q99M96

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 52 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
SLC-mediated transmembrane transport	5	9.0×	9e-03
Transport of small molecules	10	7.6×	5e-05

GO biological processes:

GO term	Partners	Fold	FDR
transmembrane transport	5	21.1×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

106 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	64
Likely benign	18
Benign	5

Top pathogenic / likely-pathogenic (0)

SpliceAI

2869 predictions. Top by Δscore:

Variant	Effect	Δscore
1:112555866:A:AC	donor_gain	1.0000
1:112555866:ACTG:A	donor_gain	1.0000
1:112555867:C:CC	donor_gain	1.0000
1:112555867:CTGC:C	donor_gain	1.0000
1:112576984:A:AC	donor_gain	1.0000
1:112576985:C:CT	donor_gain	1.0000
1:112576985:CTT:C	donor_gain	1.0000
1:112578343:A:AC	donor_gain	1.0000
1:112578344:C:CC	donor_gain	1.0000
1:112578344:CTTTT:C	donor_gain	1.0000
1:112582103:TCAA:T	acceptor_gain	1.0000
1:112582104:CAA:C	acceptor_gain	1.0000
1:112582104:CAAC:C	acceptor_gain	1.0000
1:112582107:C:CC	acceptor_gain	1.0000
1:112582114:T:TC	acceptor_gain	1.0000
1:112582374:CAT:C	donor_gain	1.0000
1:112582374:CATCT:C	donor_gain	1.0000
1:112583970:A:AC	donor_gain	1.0000
1:112583971:C:CC	donor_gain	1.0000
1:112583971:CT:C	donor_gain	1.0000
1:112583975:G:C	donor_gain	1.0000
1:112584124:CAG:C	acceptor_gain	1.0000
1:112591523:A:AC	donor_gain	1.0000
1:112591524:C:CC	donor_gain	1.0000
1:112598087:C:CC	acceptor_gain	1.0000
1:112598093:C:CT	acceptor_gain	1.0000
1:112598094:A:T	acceptor_gain	1.0000
1:112619023:C:CA	donor_gain	1.0000
1:112619035:G:C	donor_gain	1.0000
1:112619880:GAAG:G	donor_gain	1.0000

AlphaMissense

3718 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:112555919:A:G	W449R	1.000
1:112555919:A:T	W449R	1.000
1:112576993:A:T	V413D	1.000
1:112555888:A:G	L459S	0.999
1:112555891:A:G	L458P	0.999
1:112555917:C:A	W449C	0.999
1:112555917:C:G	W449C	0.999
1:112555918:C:G	W449S	0.999
1:112555956:A:C	S436R	0.999
1:112555956:A:T	S436R	0.999
1:112555958:T:G	S436R	0.999
1:112556014:A:G	L417S	0.999
1:112577001:A:C	N410K	0.999
1:112577001:A:T	N410K	0.999
1:112577014:G:T	A406D	0.999
1:112577015:C:G	A406P	0.999
1:112577027:C:G	A402P	0.999
1:112578372:A:G	L372P	0.999
1:112578375:G:T	A371E	0.999
1:112582057:A:G	L335P	0.999
1:112591589:A:G	W213R	0.999
1:112591589:A:T	W213R	0.999
1:112598036:A:G	L186P	0.999
1:112600829:G:C	N157K	0.999
1:112600829:G:T	N157K	0.999
1:112556018:A:C	Y416D	0.998
1:112556018:A:G	Y416H	0.998
1:112577004:A:C	F409L	0.998
1:112577004:A:T	F409L	0.998
1:112577006:A:G	F409L	0.998

dbSNP variants (sampled 300 via entrez): RS1000008870 (1:112534251 G>A), RS1000039184 (1:112589829 A>T), RS1000049579 (1:112545784 T>C), RS1000054693 (1:112592612 A>G), RS1000086745 (1:112586566 T>C), RS1000106643 (1:112592237 T>TA), RS1000118637 (1:112542178 A>T), RS1000137429 (1:112618272 T>A,C), RS1000195744 (1:112594401 G>A), RS1000244867 (1:112571820 C>A), RS1000258703 (1:112601331 C>T), RS1000297858 (1:112572280 A>C), RS1000317741 (1:112549008 T>C), RS1000335172 (1:112585221 C>T), RS1000389606 (1:112562419 G>A)

Disease associations

OMIM: gene MIM:617640 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

32 associations (top):

Study	Trait	p-value
GCST001072_3	Blood pressure	8.000000e-06
GCST001074_5	Blood pressure	1.000000e-08
GCST003074_3	Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging)	2.000000e-07
GCST003273_2	Diastolic blood pressure	6.000000e-07
GCST003273_5	Diastolic blood pressure	7.000000e-08
GCST004599_247	Mean platelet volume	2.000000e-13
GCST004607_203	Plateletcrit	5.000000e-12
GCST004616_111	Platelet distribution width	9.000000e-31
GCST004776_10	Systolic blood pressure	2.000000e-07
GCST004777_46	Diastolic blood pressure	2.000000e-08
GCST006166_6	Diastolic blood pressure x alcohol consumption interaction (2df test)	1.000000e-19
GCST006167_6	Mean arterial pressure x alcohol consumption interaction (2df test)	5.000000e-10
GCST006231_13	Mean arterial pressure	3.000000e-07
GCST006258_50	Diastolic blood pressure	9.000000e-10
GCST006259_26	Systolic blood pressure	1.000000e-12
GCST006394_30	Intraocular pressure	3.000000e-11
GCST007294_13	Body fat distribution (trunk fat ratio)	9.000000e-19
GCST007294_32	Body fat distribution (trunk fat ratio)	1.000000e-08
GCST007295_163	Body fat distribution (leg fat ratio)	8.000000e-07
GCST007295_7	Body fat distribution (leg fat ratio)	7.000000e-16
GCST009725_41	Intraocular pressure	2.000000e-11
GCST010696_10	Cortical thickness (min-P)	6.000000e-41
GCST010697_23	Cortical surface area (min-P)	1.000000e-08
GCST010698_26	Subcortical volume (min-P)	2.000000e-08
GCST010699_12	Brain morphology (min-P)	2.000000e-10
GCST010700_13	Cortical thickness (MOSTest)	8.000000e-13
GCST010701_138	Cortical surface area (MOSTest)	9.000000e-10
GCST010702_169	Subcortical volume (MOSTest)	2.000000e-17
GCST010703_263	Brain morphology (MOSTest)	3.000000e-13
GCST90002401_352	Platelet distribution width	1.000000e-91

EFO canonical traits (13, from GWAS)

EFO ID	Trait name
EFO:0006335	systolic blood pressure
EFO:0006336	diastolic blood pressure
EFO:0007707	cerebral amyloid deposition measurement
EFO:0007985	platelet crit
EFO:0007984	platelet component distribution width
EFO:0004329	alcohol drinking
EFO:0006340	mean arterial pressure
EFO:0004695	intraocular pressure measurement
EFO:0004341	body fat distribution
EFO:0004346	neuroimaging measurement
EFO:0004840	cortical thickness
EFO:0004736	aspartate aminotransferase measurement
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression, increases expression, increases methylation	7
Phenylmercuric Acetate	affects cotreatment, increases expression, decreases expression	2
alpha-pinene	affects cotreatment, increases expression, increases abundance	1
bisphenol A	increases expression	1
trichostatin A	decreases expression	1
sodium arsenite	decreases expression	1
methacrylaldehyde	increases abundance, affects cotreatment, increases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
cylindrospermopsin	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression, decreases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, increases expression, decreases expression	1
Acrolein	increases abundance, affects cotreatment, increases expression	1
Air Pollutants	increases abundance, increases expression, affects cotreatment	1
Arsenic	affects methylation	1
Doxorubicin	decreases expression	1
Lead	increases expression	1
Nickel	decreases expression	1
Ozone	increases expression, increases abundance, affects cotreatment	1
Quercetin	increases expression	1
Tretinoin	increases expression	1
Urethane	decreases expression	1
Cyclosporine	increases expression	1
Gold Compounds	increases expression	1
Antirheumatic Agents	increases expression	1
Cadmium Chloride	decreases expression	1
Copper Sulfate	decreases expression	1
Volatile Organic Compounds	affects cotreatment, increases expression	1
Magnetite Nanoparticles	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.