ST8SIA6-AS1

Summary

ST8SIA6-AS1 (ST8SIA6 antisense RNA 1, HGNC:44880) is a long non-coding RNA gene on chromosome 10p12.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44880
Approved symbol	ST8SIA6-AS1
Name	ST8SIA6 antisense RNA 1
Location	10p12.33
Locus type	RNA, long non-coding
Status	Approved
Aliases	APAL
Ensembl gene	ENSG00000204832
Ensembl biotype	lncRNA
Entrez	100128098
RNAcentral	URS000075A563 — lncRNA, 574 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 18 lncRNA

ENST00000377597, ENST00000451190, ENST00000451225, ENST00000457649, ENST00000657045, ENST00000790852, ENST00000790853, ENST00000790854, ENST00000790855, ENST00000790856, ENST00000790857, ENST00000790858, ENST00000790859, ENST00000790860, ENST00000790861, ENST00000790862, ENST00000790863, ENST00000790864

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000377597 — 4 exons

Exon	Start	End
ENSE00001474492	17399105	17399202
ENSE00002041024	17386951	17387075
ENSE00003485372	17407968	17408244
ENSE00003601007	17409321	17410631

Expression profiles

Bgee: expression breadth ubiquitous, 157 present calls, max score 82.13.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.7135 / max 60.3126, expressed in 125 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
104084	0.6002	110
104086	0.0416	17
104085	0.0301	19
104083	0.0239	13
205741	0.0176	8

Top tissues by expression

251 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
placenta	UBERON:0001987	82.13	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.06	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.89	gold quality
ganglionic eminence	UBERON:0004023	80.76	gold quality
left testis	UBERON:0004533	77.55	gold quality
right testis	UBERON:0004534	77.03	gold quality
testis	UBERON:0000473	76.28	gold quality
ventricular zone	UBERON:0003053	75.02	gold quality
sperm	CL:0000019	73.99	gold quality
cortical plate	UBERON:0005343	72.73	gold quality
endothelial cell	CL:0000115	72.44	gold quality
bone marrow cell	CL:0002092	72.24	silver quality
colonic epithelium	UBERON:0000397	71.28	silver quality
tibial nerve	UBERON:0001323	69.79	gold quality
oocyte	CL:0000023	67.02	silver quality
tibialis anterior	UBERON:0001385	66.21	silver quality
parotid gland	UBERON:0001831	66.13	gold quality
buccal mucosa cell	CL:0002336	64.58	gold quality
thymus	UBERON:0002370	63.50	silver quality
upper arm skin	UBERON:0004263	63.21	gold quality
vena cava	UBERON:0004087	63.20	gold quality
secondary oocyte	CL:0000655	63.19	gold quality
deltoid	UBERON:0001476	63.19	gold quality
cardia of stomach	UBERON:0001162	62.84	gold quality
hindlimb stylopod muscle	UBERON:0004252	62.57	gold quality
cerebellar vermis	UBERON:0004720	62.54	gold quality
ventral tegmental area	UBERON:0002691	62.28	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	62.25	gold quality
right atrium auricular region	UBERON:0006631	62.21	gold quality
substantia nigra pars reticulata	UBERON:0001966	62.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.79

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• The Role of APAL/ST8SIA6-AS1 lncRNA in PLK1 Activation and Mitotic Catastrophe of Tumor Cells. (PMID:31286138)
• LncRNA ST8SIA6-AS1 promotes proliferation, migration and invasion in breast cancer through the p38 MAPK signalling pathway. (PMID:31784750)
• LncRNA ST8SIA6-AS1 promotes colorectal cancer cell proliferation, migration and invasion by regulating the miR-5195/PCBP2 axis. (PMID:32373956)
• ST8SIA6-AS1 promotes hepatocellular carcinoma by absorbing miR-5195-3p to regulate HOXB6. (PMID:32420798)
• LncRNA ST8SIA6-AS1 promotes hepatocellular carcinoma progression by regulating MAGEA3 and DCAF4L2 expression. (PMID:33012505)
• Long noncoding RNA ST8SIA6AS1 promotes the migration and invasion of hypoxiatreated hepatocellular carcinoma cells through the miR338/MEPCE axis. (PMID:33416148)
• LncRNA ST8SIA6-AS1 facilitates hepatocellular carcinoma progression by governing miR-651-5p/TM4SF4 axis. (PMID:35946523)
• ST8SIA6-AS1 contributes to hepatocellular carcinoma progression by targeting miR-142-3p/HMGA1 axis. (PMID:36635290)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.