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STARD10

gene
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Also known as NY-CO-28CGI-52PCTP2

Summary

STARD10 (StAR related lipid transfer domain containing 10, HGNC:10666) is a protein-coding gene on chromosome 11q13.4, encoding START domain-containing protein 10 (Q9Y365). May play metabolic roles in sperm maturation or fertilization.

Predicted to enable lipid binding activity. Predicted to be involved in lipid transport. Predicted to act upstream of or within bile acid secretion and positive regulation of peroxisome proliferator activated receptor signaling pathway. Located in cytosol.

Source: NCBI Gene 10809 — RefSeq curated summary.

At a glance

  • GWAS associations: 11
  • Clinical variants (ClinVar): 50 total
  • Druggable target: yes
  • MANE Select transcript: NM_006645

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:10666
Approved symbolSTARD10
NameStAR related lipid transfer domain containing 10
Location11q13.4
Locus typegene with protein product
StatusApproved
AliasesNY-CO-28, CGI-52, PCTP2
Ensembl geneENSG00000214530
Ensembl biotypeprotein_coding
OMIM617382
Entrez10809

Gene structure

Transcript identifiers

Ensembl transcripts: 52 — 47 protein_coding, 4 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000334805, ENST00000400925, ENST00000535054, ENST00000535075, ENST00000535267, ENST00000536290, ENST00000536377, ENST00000536728, ENST00000537351, ENST00000537947, ENST00000538009, ENST00000538437, ENST00000538536, ENST00000539138, ENST00000540587, ENST00000542989, ENST00000543089, ENST00000543304, ENST00000544767, ENST00000545082, ENST00000546314, ENST00000888238, ENST00000888239, ENST00000888240, ENST00000888241, ENST00000888242, ENST00000888243, ENST00000888244, ENST00000888245, ENST00000888246, ENST00000888247, ENST00000888248, ENST00000888249, ENST00000888250, ENST00000888251, ENST00000888252, ENST00000888253, ENST00000888254, ENST00000888255, ENST00000888256, ENST00000888257, ENST00000888258, ENST00000888259, ENST00000888260, ENST00000888261, ENST00000888262, ENST00000888263, ENST00000888264, ENST00000953907, ENST00000953908, ENST00000953909, ENST00000953910

RefSeq mRNA: 1 — MANE Select: NM_006645 NM_006645

CCDS: CCDS41688

Canonical transcript exons

ENST00000334805 — 7 exons

ExonStartEnd
ENSE000013390457275776772757884
ENSE000013390537275472972755142
ENSE000014319477279287572794047
ENSE000035669167275923472759381
ENSE000035911587275570172755753
ENSE000036083837278097572781294
ENSE000036910207275853072758633

Expression profiles

Bgee: expression breadth ubiquitous, 251 present calls, max score 99.55.

FANTOM5 (CAGE): breadth broad, TPM avg 0.6444 / max 49.6193, expressed in 309 samples.

FANTOM5 promoters (14 alternative TSS)

Promoter IDTPM avgSamples expressed
12120715.96471750
1212054.6926870
1212024.2962351
1212171.6513825
1212061.2298495
1212160.6929280
1212150.6444309
1212040.2271122
1212010.2146111
1212030.117067

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
right lobe of liverUBERON:000111499.55gold quality
mucosa of transverse colonUBERON:000499199.50gold quality
body of pancreasUBERON:000115099.22gold quality
left adrenal gland cortexUBERON:003582599.14gold quality
left testisUBERON:000453399.13gold quality
right testisUBERON:000453499.13gold quality
right adrenal gland cortexUBERON:003582799.05gold quality
left adrenal glandUBERON:000123499.00gold quality
adrenal cortexUBERON:000123598.99gold quality
right adrenal glandUBERON:000123398.98gold quality
rectumUBERON:000105298.80gold quality
olfactory segment of nasal mucosaUBERON:000538698.61gold quality
ileal mucosaUBERON:000033198.60gold quality
liverUBERON:000210798.49gold quality
adrenal glandUBERON:000236998.33gold quality
pancreasUBERON:000126498.16gold quality
apex of heartUBERON:000209898.13gold quality
minor salivary glandUBERON:000183097.88gold quality
transverse colonUBERON:000115797.76gold quality
body of stomachUBERON:000116197.76gold quality
islet of LangerhansUBERON:000000697.74gold quality
stomachUBERON:000094597.60gold quality
saliva-secreting glandUBERON:000104497.45gold quality
skin of legUBERON:000151197.42gold quality
skin of abdomenUBERON:000141697.39gold quality
nasal cavity epitheliumUBERON:000538497.38gold quality
left lobe of thyroid glandUBERON:000112097.31gold quality
pylorusUBERON:000116697.31gold quality
lower esophagus mucosaUBERON:003583497.23gold quality
right lobe of thyroid glandUBERON:000111997.22gold quality

Single-cell (SCXA)

Detected in 7 experiment(s), a significant marker in 6.

ExperimentMarker?Max mean expression
E-CURD-114yes43.91
E-MTAB-6701yes40.77
E-GEOD-125970yes40.63
E-MTAB-8410yes15.43
E-HCAD-1yes7.95
E-MTAB-6142no85.15
E-ANND-3no0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

10 targeting STARD10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-4283100.0066.422097
HSA-MIR-345-3P99.8970.231421
HSA-MIR-444799.8567.812900
HSA-MIR-431999.7669.832586
HSA-MIR-447299.5666.081478
HSA-MIR-426098.7865.37848
HSA-MIR-1227-5P98.6565.321549
HSA-MIR-134-3P96.8366.221001
HSA-MIR-465495.8665.72751
HSA-MIR-63883.9364.4666

Literature-anchored findings (GeneRIF, showing 7)

  • Stard10 (Sdccag28) is much more highly transcribed in mouse cardiac atria than in cardiac ventricles. (PMID:14576202)
  • StarD10 interacts with phosphatidylcholine and phosphatidylethanolamine and preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position (PMID:15911624)
  • C-terminal StarD10 phosphorylation on serine 284 regulates its association with cellular membranes (PMID:17561512)
  • Data show that in multivariate analyses incorporating tumor size, tumor grade, lymph node status, ER, PR and HER2 status, low STARD10 expression was an independent predictor of death from breast cancer. (PMID:19676041)
  • StarD10 is required for normal insulin secretion, though its deletion enhances proinsulin processing. (PMID:28132686)
  • Hence, we provide a molecular explanation for acquired resistance to DTX that is caused by the miR-638 deficiency and subsequent STARD10 upregulation. In consequence, alteration of miR-638/STARD10 cascade may represent an attractive strategy in future adjuvant therapy along with DTX chemotherapy. (PMID:28412359)
  • Finding proved that STARD10 and ERBB2 positively regulate each other’s expression and function. (PMID:30611309)

Cross-species orthologs

4 orthologs

OrganismSymbolGene ID
danio_reriostard10ENSDARG00000097718
mus_musculusStard10ENSMUSG00000030688
rattus_norvegicusStard10ENSRNOG00000019491
caenorhabditis_elegansWBGENE00012127

Paralogs (2): STARD7 (ENSG00000084090), PCTP (ENSG00000141179)

Protein

Protein identifiers

START domain-containing protein 10 — Q9Y365 (reviewed: Q9Y365)

Alternative names: Antigen NY-CO-28, PCTP-like protein, Serologically defined colon cancer antigen 28, StAR-related lipid transfer protein 10

All UniProt accessions (15): Q9Y365, F5GWK5, F5GY07, F5GY11, F5GY42, F5H0V7, F5H1Z6, F5H3G8, F5H5A8, F5H8G1, F5H8H3, H0YFF3, H0YGA9, H0YGN8, H0YH17

UniProt curated annotations — full annotation on UniProt →

Function. May play metabolic roles in sperm maturation or fertilization. Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes.

Subcellular location. Cell projection. Cilium. Flagellum. Cytoplasm. Membrane.

Post-translational modifications. Phosphorylation at Ser-284 by CK2 negatively regulates lipid transfer activity, possibly by decreasing membrane association.

RefSeq proteins (1): NP_006636* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR002913START_lipid-bd_domDomain
IPR023393START-like_dom_sfHomologous_superfamily
IPR041951STARD10_STARTDomain
IPR051213START_lipid_transferFamily

Pfam: PF01852

UniProt features (29 total): strand 10, modified residue 8, helix 6, region of interest 2, chain 1, domain 1, turn 1

Structure

Experimental structures (PDB)

1 structures.

PDBMethodResolution (Å)
6SERX-RAY DIFFRACTION2.3

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q9Y365-F187.900.72

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (8): 284, 289, 1, 94, 197, 202, 253, 259

Function

Pathways and Gene Ontology

Reactome pathways

5 pathways

IDPathway
R-HSA-1483191Synthesis of PC
R-HSA-1430728Metabolism
R-HSA-1483206Glycerophospholipid biosynthesis
R-HSA-1483257Phospholipid metabolism
R-HSA-556833Metabolism of lipids

MSigDB gene sets: 193 (showing top): SHEPARD_CRASH_AND_BURN_MUTANT_UP, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN, chr11q13, GOLDRATH_ANTIGEN_RESPONSE, RICKMAN_METASTASIS_DN, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, YAMAZAKI_TCEB3_TARGETS_UP, MEDINA_SMARCA4_TARGETS, GOCC_CELL_CELL_JUNCTION, GOBP_LIPID_LOCALIZATION, CUI_TCF21_TARGETS_2_UP, HUANG_DASATINIB_RESISTANCE_DN, ZAMORA_NOS2_TARGETS_DN

GO Biological Process (1): lipid transport (GO:0006869)

GO Molecular Function (2): lipid binding (GO:0008289), protein binding (GO:0005515)

GO Cellular Component (8): cytosol (GO:0005829), microvillus (GO:0005902), membrane (GO:0016020), motile cilium (GO:0031514), intercellular canaliculus (GO:0046581), cytoplasm (GO:0005737), cilium (GO:0005929), cell projection (GO:0042995)

Reactome top-level categories

Rollup of top-4 pathways:

CategoryPathways
Glycerophospholipid biosynthesis1
Phospholipid metabolism1
Metabolism of lipids1
Metabolism1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
cellular anatomical structure4
binding2
transport1
lipid localization1
cytoplasm1
actin filament bundle1
actin-based cell projection1
cilium1
cell-cell junction1
intracellular anatomical structure1
intraciliary transport particle1
membrane-bounded organelle1
plasma membrane bounded cell projection1

Protein interactions and networks

STRING

570 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
STARD10STARP49675689
STARD10CERT1Q9Y5P4689
STARD10STARD5P59094682
STARD10STARD3Q14849643
STARD10PIRTP0C851628
STARD10ARAP1Q96P48606
STARD10STARD6P59095591
STARD10STARD9Q9P2P6556
STARD10STARD8Q92502537
STARD10STARD7Q9NQZ5524
STARD10STARD4Q96DR4488
STARD10ACOT12Q8WYK0476
STARD10PCTPQ9UKL6467
STARD10PLTPP55058451
STARD10NECTIN1Q15223439

IntAct

8 interactions, top by confidence:

ABTypeScore
STARD10PRMT6psi-mi:“MI:0915”(physical association)0.510
PRMT6STARD10psi-mi:“MI:0915”(physical association)0.510
STARD10TP53psi-mi:“MI:0915”(physical association)0.370
PLEKHA7PLEKHG3psi-mi:“MI:0914”(association)0.350
AGPSpsi-mi:“MI:0914”(association)0.350
PLEKHG3psi-mi:“MI:0914”(association)0.350
GOT1A2ML1psi-mi:“MI:0914”(association)0.350
MYO1Cpsi-mi:“MI:0914”(association)0.350

BioGRID (17): STARD10 (Two-hybrid), STARD10 (Affinity Capture-RNA), STARD10 (Proximity Label-MS), STARD10 (Affinity Capture-MS), STARD10 (Affinity Capture-MS), STARD10 (Co-fractionation), STARD10 (Co-fractionation), STARD10 (Affinity Capture-MS), STARD10 (Positive Genetic), STARD10 (Cross-Linking-MS (XL-MS)), STARD10 (Cross-Linking-MS (XL-MS)), STARD10 (Cross-Linking-MS (XL-MS)), STARD10 (Affinity Capture-MS), APP (Reconstituted Complex), STARD10 (Affinity Capture-MS)

ESM2 similar proteins: A0A0B4J1F4, A2AIG8, A7Z026, B0BNL6, B2RYF1, D4ABL6, E9PV86, O35393, O54804, O73884, O75078, O75864, P20417, P29067, P32120, P32121, P35790, P35821, P51467, Q00961, Q01098, Q01134, Q14957, Q5E9H2, Q5RCR4, Q642A6, Q6AZB0, Q6DN14, Q6IA17, Q8BHT7, Q8BKR5, Q8CIW5, Q8N431, Q8N5I2, Q8N5X7, Q8NBA8, Q8NCT1, Q8R2Z5, Q91YI4, Q92546

Diamond homologs: Q9JMD3, Q9Y365

SIGNOR signaling

1 interactions.

AEffectBMechanism
CSNK2A1down-regulatesSTARD10phosphorylation

Disease & clinical

Clinical variants and AI predictions

ClinVar

50 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance41
Likely benign0
Benign1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1232 predictions. Top by Δscore:

VariantEffectΔscore
11:72757762:CTCAC:Cdonor_loss1.0000
11:72757763:TCACC:Tdonor_loss1.0000
11:72757765:A:Cdonor_loss1.0000
11:72757880:TATTT:Tacceptor_gain1.0000
11:72757881:ATTT:Aacceptor_gain1.0000
11:72757882:TTT:Tacceptor_gain1.0000
11:72757883:TT:Tacceptor_gain1.0000
11:72757885:C:CCacceptor_gain1.0000
11:72757886:T:Gacceptor_loss1.0000
11:72758528:A:ACdonor_gain1.0000
11:72758529:C:CCdonor_gain1.0000
11:72758529:CGGG:Cdonor_gain1.0000
11:72758629:CCTCC:Cacceptor_gain1.0000
11:72758630:CTCC:Cacceptor_gain1.0000
11:72758630:CTCCC:Cacceptor_gain1.0000
11:72758631:TCCC:Tacceptor_loss1.0000
11:72758631:TCCCT:Tacceptor_gain1.0000
11:72758632:CC:Cacceptor_gain1.0000
11:72758633:CC:Cacceptor_gain1.0000
11:72758633:CCTG:Cacceptor_loss1.0000
11:72759222:ACG:Adonor_gain1.0000
11:72759223:CGC:Cdonor_gain1.0000
11:72759230:TCA:Tdonor_loss1.0000
11:72759231:CACAG:Cdonor_loss1.0000
11:72759232:A:ACdonor_gain1.0000
11:72759232:ACAGG:Adonor_loss1.0000
11:72759233:C:CAdonor_gain1.0000
11:72759233:CA:Cdonor_gain1.0000
11:72759233:CAG:Cdonor_gain1.0000
11:72759233:CAGG:Cdonor_gain1.0000

AlphaMissense

1908 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
11:72755067:A:GW236R1.000
11:72755067:A:TW236R1.000
11:72757835:C:TG170D1.000
11:72757853:G:TA164D1.000
11:72757859:A:TV162D1.000
11:72758540:A:TV150D1.000
11:72758583:A:GW136R1.000
11:72758583:A:TW136R1.000
11:72758588:C:GR134P1.000
11:72758603:T:AD129V1.000
11:72758604:C:GD129H1.000
11:72758606:C:GR128P1.000
11:72758607:G:TR128S1.000
11:72759302:T:AD96V1.000
11:72759303:C:GD96H1.000
11:72759304:C:AW95C1.000
11:72759304:C:GW95C1.000
11:72759305:C:GW95S1.000
11:72759306:A:GW95R1.000
11:72759306:A:TW95R1.000
11:72759314:C:GR92P1.000
11:72759315:G:TR92S1.000
11:72759318:A:CY91D1.000
11:72755065:C:AW236C0.999
11:72755065:C:GW236C0.999
11:72755095:T:AK226N0.999
11:72755095:T:GK226N0.999
11:72755098:C:AW225C0.999
11:72755098:C:GW225C0.999
11:72755100:A:GW225R0.999

dbSNP variants (sampled 300 via entrez): RS1000024933 (11:72755537 C>T), RS1000045807 (11:72762753 G>T), RS1000186800 (11:72755757 T>A), RS1000269491 (11:72761395 A>G), RS1000345065 (11:72775320 C>T), RS1000385083 (11:72767714 G>A), RS1000475415 (11:72774103 G>A), RS1000506596 (11:72782503 C>G), RS1000543219 (11:72772285 G>A), RS1000551992 (11:72757719 T>G), RS1000553927 (11:72778213 G>A), RS1000606399 (11:72778653 G>A), RS1000686322 (11:72795418 C>G), RS1000687517 (11:72765845 G>A), RS1000802019 (11:72793865 G>A)

Disease associations

OMIM: gene MIM:617382 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

11 associations (top):

StudyTraitp-value
GCST002094_8Crohn’s disease7.000000e-09
GCST002691_1Alloimmunization response to red blood cell transfusion in sickle cell anemia7.000000e-07
GCST004575_4Acute insulin response4.000000e-06
GCST004599_23Mean platelet volume7.000000e-15
GCST007614_55C-reactive protein levels5.000000e-09
GCST008151_97Waist circumference1.000000e-06
GCST008160_99Waist circumference1.000000e-06
GCST008161_57Waist circumference adjusted for body mass index5.000000e-06
GCST90002397_532Mean spheric corpuscular volume2.000000e-09
GCST90011898_4Alanine aminotransferase levels5.000000e-12
GCST90013405_101Liver enzyme levels (alanine transaminase)3.000000e-22

EFO canonical traits (5, from GWAS)

EFO IDTrait name
EFO:0006802response to red blood cell transfusion
EFO:0006804alloimmunization
EFO:0006831acute insulin response measurement
EFO:0004458C-reactive protein measurement
EFO:0007789BMI-adjusted waist circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4523506 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

54 total (human), top 30 by PubMed support.

ChemicalActions (top 5)PubMed papers
bisphenol Aaffects expression, decreases expression, increases expression4
sodium arseniteaffects acetylation, affects methylation, decreases expression, increases expression3
Acetaminophendecreases expression, increases expression3
Cyclosporinedecreases expression3
Benzo(a)pyrenedecreases expression, decreases methylation2
Silicon Dioxidedecreases expression, decreases methylation2
Valproic Acidaffects cotreatment, increases expression2
aristolochic acid Iincreases expression1
FR900359affects phosphorylation1
2,4,6-tribromophenoldecreases expression1
triphenyl phosphateaffects expression1
trichostatin Aaffects expression1
beta-lapachonedecreases expression, increases expression1
sulforaphanedecreases expression1
tris(1,3-dichloro-2-propyl)phosphatedecreases expression1
CGP 52608affects binding, increases reaction1
monomethylarsonous acidaffects acetylation, affects methylation1
K 7174decreases expression1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamideincreases expression, affects cotreatment1
ICG 001affects expression1
14-deoxy-11,12-didehydroandrographolidedecreases expression1
abrineincreases expression1
2,2’,4,4’-tetrabromodiphenyl etherdecreases expression1
dorsomorphinaffects cotreatment, increases expression1
pentabrominated diphenyl ether 100increases expression1
hexabrominated diphenyl ether 153increases expression1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic aciddecreases expression1
Sunitinibincreases expression1
Vorinostatincreases expression1
Norethindrone Acetateaffects cotreatment, increases expression1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay IDTypeDescriptionSource paper
CHEMBL4482715BindingInhibition of StarD10 (unknown origin) using NBD-PC and donor and acceptor small unilamellar vesicles by fluorescence quench assayPhosphatidylcholine transfer protein inhibitors

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

  • Disease cohort memberships (association, not causation — diseases whose associated-gene cohort lists this gene; a subset are also under Associated diseases): Crohn disease

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.2
BioBTree
v2.0.2

Sources 78

This page pulls from 78 datasets indexed by BioBTree:

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