STARD4

Summary

STARD4 (StAR related lipid transfer domain containing 4, HGNC:18058) is a protein-coding gene on chromosome 5q22.1, encoding StAR-related lipid transfer protein 4 (Q96DR4). Involved in the intracellular transport of cholesterol.

Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD4 (Soccio et al., 2002 [PubMed 12011452]).

Source: NCBI Gene 134429 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 26 total
• MANE Select transcript: NM_139164

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18058
Approved symbol	STARD4
Name	StAR related lipid transfer domain containing 4
Location	5q22.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000164211
Ensembl biotype	protein_coding
OMIM	607049
Entrez	134429

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 12 protein_coding, 4 protein_coding_CDS_not_defined, 2 nonsense_mediated_decay, 1 retained_intron

ENST00000296632, ENST00000455172, ENST00000502322, ENST00000502931, ENST00000505803, ENST00000508215, ENST00000509887, ENST00000510346, ENST00000511137, ENST00000511436, ENST00000511569, ENST00000512160, ENST00000925892, ENST00000925893, ENST00000925894, ENST00000925895, ENST00000925896, ENST00000925897, ENST00000954329

RefSeq mRNA: 7 — MANE Select: NM_139164 NM_001308056, NM_001308057, NM_001308058, NM_001308059, NM_001308060, NM_001308061, NM_139164

CCDS: CCDS4104, CCDS78046

Canonical transcript exons

ENST00000296632 — 6 exons

Exon	Start	End
ENSE00001263084	111496033	111500106
ENSE00002080404	111512385	111512535
ENSE00003467152	111501962	111502088
ENSE00003494506	111501002	111501116
ENSE00003497181	111507329	111507442
ENSE00003590177	111506330	111506379

Expression profiles

Bgee: expression breadth ubiquitous, 221 present calls, max score 97.45.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 40.5075 / max 6108.2068, expressed in 1810 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
62917	33.5773	1801
62915	2.6999	1150
62916	1.8296	928
62918	1.5337	1009
62919	0.8670	104

Top tissues by expression

249 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	97.45	gold quality
ileal mucosa	UBERON:0000331	97.04	gold quality
jejunal mucosa	UBERON:0000399	91.94	gold quality
duodenum	UBERON:0002114	89.73	gold quality
right hemisphere of cerebellum	UBERON:0014890	88.57	gold quality
rectum	UBERON:0001052	88.17	gold quality
right lung	UBERON:0002167	88.14	gold quality
vermiform appendix	UBERON:0001154	88.06	gold quality
cerebellar cortex	UBERON:0002129	87.74	gold quality
cerebellar hemisphere	UBERON:0002245	87.71	gold quality
islet of Langerhans	UBERON:0000006	87.62	gold quality
upper lobe of left lung	UBERON:0008952	87.45	gold quality
cerebellum	UBERON:0002037	87.33	gold quality
upper lobe of lung	UBERON:0008948	87.23	gold quality
pancreatic ductal cell	CL:0002079	87.22	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	87.19	gold quality
prefrontal cortex	UBERON:0000451	86.91	gold quality
lung	UBERON:0002048	86.84	gold quality
ventricular zone	UBERON:0003053	86.70	gold quality
cerebellar vermis	UBERON:0004720	86.27	silver quality
pigmented layer of retina	UBERON:0001782	86.17	gold quality
spinal cord	UBERON:0002240	86.07	gold quality
Brodmann (1909) area 9	UBERON:0013540	85.90	gold quality
popliteal artery	UBERON:0002250	85.89	gold quality
tibial artery	UBERON:0007610	85.89	gold quality
placenta	UBERON:0001987	85.66	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	85.35	gold quality
embryo	UBERON:0000922	85.31	gold quality
ganglionic eminence	UBERON:0004023	85.31	gold quality
cartilage tissue	UBERON:0002418	85.26	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	12.18
E-GEOD-75140	no	251.69

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): ATF6, SREBF2

miRNA regulators (miRDB)

177 targeting STARD4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-LET-7A-3P	100.00	74.03	3932
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-4775	99.98	75.00	6394
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790

Literature-anchored findings (GeneRIF, showing 16)

• StarD4 is regulated by sterols via SREBP-2, and StarD5 is activated by ER stress cholesterol metabolism; they serve different functions (PMID:15760897)
• Induction of STARD4 depended on both transcription factor ATF6 and an ERSE-like element in its promoter. (PMID:16579971)
• StarD4 plays an important role as a directional cholesterol transporter in the maintenance of cellular cholesterol homeostasis (PMID:18403318)
• StarD4-accelerated 7 alpha-OOH transfer to mitochondria resulted in greater susceptibility to free radical lipid peroxidation and loss of membrane potential than in a non-StarD4 control. (PMID:20059974)
• Study provide strong evidence for StarD4 as a highly regulated, non-vesicular, directional, intracellular transporter of cholesterol which plays a key role in the maintenance of intracellular cholesterol homeostasis. (PMID:21767660)
• cholesterol transport mediated by STARD4 is an important component of the cholesterol homeostasis regulatory machinery (PMID:21900492)
• The data indicate a role for STARD4 in nonvesicular transport of cholesterol from the plasma membrane and the endocytic recycling compartment to the endoplasmic reticulum and perhaps other intracellular compartments as well. (PMID:23033213)
• Studies show the 3 steroidogenic acute regulatory-related lipid transfer (START) domain proteins StarD4, StarD5 and StarD6 have a similar lipid binding pocket specific for sterols (cholesterol in particular), but differing regulation and localization. (PMID:24440759)
• This study shows that nonvesicular sterol transport mechanisms and STARD4 in particular account for a large fraction of sterol transport between the plasma membrane and the ERC. (PMID:28209730)
• STARD4 has a conserved alpha-helix/beta-grip fold with a deep hydrophobic pocket.STARD4 binds sterol in the pocket and transport sterol between liposomes. Sterol binding requires a conformational change to form a complementary pocket. (PMID:31607485)
• Knockdown of STARD4, a sterol transporter, leads to large changes in the lipidome. STARD4-KD cells also have large changes in their mRNA profile. There is an increase in cellular cholesterol, including in late endosomes. These results indicate that STARD4 plays important roles in lipid homeostasis. (PMID:31917335)
• STARD4 promotes breast cancer cell malignancy. (PMID:33125124)
• [Steroidogenic acute regulatory protein-related lipid transfer 4 (StarD4) promotes breast cancer cell proliferation and its mechanism]. (PMID:34970895)
• SREBF2-STARD4 axis confers sorafenib resistance in hepatocellular carcinoma by regulating mitochondrial cholesterol homeostasis. (PMID:35642354)
• Membrane specificity of the human cholesterol transfer protein STARD4. (PMID:38615744)
• Differential regulation of STARD1, STARD4 and STARD6 in the human ovary. (PMID:38829257)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	stard4	ENSDARG00000102477
mus_musculus	Stard4	ENSMUSG00000024378
rattus_norvegicus	Stard4	ENSRNOG00000020468
drosophila_melanogaster	Start1	FBGN0035028
caenorhabditis_elegans		WBGENE00010505
caenorhabditis_elegans		WBGENE00017826

Paralogs (5): STARD3NL (ENSG00000010270), STARD3 (ENSG00000131748), STAR (ENSG00000147465), STARD5 (ENSG00000172345), STARD6 (ENSG00000174448)

Protein

Protein identifiers

StAR-related lipid transfer protein 4 — Q96DR4 (reviewed: Q96DR4)

Alternative names: START domain-containing protein 4

All UniProt accessions (3): D6RDM5, D6REN7, Q96DR4

UniProt curated annotations — full annotation on UniProt →

Function. Involved in the intracellular transport of cholesterol. Binds cholesterol or other sterols.

Isoforms (2)

UniProt ID	Names	Canonical?
Q96DR4-1	1	yes
Q96DR4-2	2

RefSeq proteins (7): NP_001294985, NP_001294986, NP_001294987, NP_001294988, NP_001294989, NP_001294990, NP_631903* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002913	START_lipid-bd_dom	Domain
IPR023393	START-like_dom_sf	Homologous_superfamily
IPR042555	StarD4	Family

Pfam: PF01852

Catalyzed reactions (Rhea), 1 shown:

• cholesterol(in) = cholesterol(out) (RHEA:39747)

UniProt features (20 total): strand 11, helix 5, chain 1, domain 1, turn 1, splice variant 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
6L1M	X-RAY DIFFRACTION	1.7
6L1D	X-RAY DIFFRACTION	1.95

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96DR4-F1	96.03	0.96

Function

Pathways and Gene Ontology

Reactome pathways

5 pathways

ID	Pathway
R-HSA-196108	Pregnenolone biosynthesis
R-HSA-1430728	Metabolism
R-HSA-196071	Metabolism of steroid hormones
R-HSA-556833	Metabolism of lipids
R-HSA-8957322	Metabolism of steroids

MSigDB gene sets: 276 (showing top): RNGTGGGC_UNKNOWN, MODULE_97, CCAWYNNGAAR_UNKNOWN, MENSE_HYPOXIA_UP, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, MODULE_182, GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS, GOBP_KETONE_METABOLIC_PROCESS, GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS, MOLENAAR_TARGETS_OF_CCND1_AND_CDK4_UP, GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT, GOBP_BILE_ACID_BIOSYNTHETIC_PROCESS, GOBP_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS, GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS

GO Biological Process (6): cholesterol transport involved in cholesterol storage (GO:0010879), intracellular cholesterol transport (GO:0032367), cholesterol import (GO:0070508), positive regulation of bile acid biosynthetic process (GO:0070859), positive regulation of cholesterol metabolic process (GO:0090205), lipid transport (GO:0006869)

GO Molecular Function (4): cholesterol binding (GO:0015485), cholesterol transfer activity (GO:0120020), protein binding (GO:0005515), lipid binding (GO:0008289)

GO Cellular Component (4): cytoplasm (GO:0005737), endoplasmic reticulum (GO:0005783), cytosol (GO:0005829), cytoplasmic vesicle (GO:0031410)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
Metabolism of steroid hormones	1
Metabolism of steroids	1
Metabolism	1
Metabolism of lipids	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cholesterol transport	3
cytoplasm	3
intracellular anatomical structure	2
positive regulation of small molecule metabolic process	2
binding	2
cellular anatomical structure	2
lipid transport involved in lipid storage	1
cholesterol storage	1
intracellular sterol transport	1
bile acid biosynthetic process	1
positive regulation of steroid biosynthetic process	1
regulation of bile acid biosynthetic process	1
cholesterol metabolic process	1
positive regulation of steroid metabolic process	1
regulation of cholesterol metabolic process	1
transport	1
lipid localization	1
sterol binding	1
alcohol binding	1
cholesterol binding	1
sterol transfer activity	1
endomembrane system	1
intracellular membrane-bounded organelle	1
intracellular vesicle	1

Protein interactions and networks

STRING

586 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
STARD4	PCTP	Q9UKL6	940
STARD4	SREBF1	P36956	656
STARD4	CERT1	Q9Y5P4	647
STARD4	NR1H3	Q13133	568
STARD4	STARD3	Q14849	557
STARD4	HMGCS1	Q01581	525
STARD4	OSBP	P22059	499
STARD4	NPC1	O15118	488
STARD4	STARD10	Q9Y365	488
STARD4	SREBF2	Q12772	480
STARD4	STARD7	Q9NQZ5	478
STARD4	MSMO1	Q15800	475
STARD4	DGLUCY	Q7Z3D6	469
STARD4	HMGCR	P04035	466
STARD4	SQLE	Q14534	463

IntAct

19 interactions, top by confidence:

A	B	Type	Score
ARL6IP1	STARD4	psi-mi:“MI:0915”(physical association)	0.560
CCHCR1	STARD4	psi-mi:“MI:0915”(physical association)	0.560
AGTRAP	STARD4	psi-mi:“MI:0915”(physical association)	0.560
GDAP1	STARD4	psi-mi:“MI:0915”(physical association)	0.560
STARD4	MTIF3	psi-mi:“MI:0915”(physical association)	0.560
SYP	STARD4	psi-mi:“MI:0915”(physical association)	0.560
STARD4	AGTRAP	psi-mi:“MI:0915”(physical association)	0.000
STARD4	ARL6IP1	psi-mi:“MI:0915”(physical association)	0.000
STARD4	CCHCR1	psi-mi:“MI:0915”(physical association)	0.000
STARD4	GDAP1	psi-mi:“MI:0915”(physical association)	0.000
STARD4	SYP	psi-mi:“MI:0915”(physical association)	0.000
STARD4	MTIF3	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (8): STARD4 (Two-hybrid), STARD4 (Two-hybrid), STARD4 (Two-hybrid), ARL6IP1 (Two-hybrid), AGTRAP (Two-hybrid), CCHCR1 (Two-hybrid), STARD4 (Affinity Capture-RNA), STARD4 (Affinity Capture-RNA)

ESM2 similar proteins: A1A4M6, A5GFX0, A5PJU6, O46689, O88736, P49675, P51557, P53808, P59095, P59096, P70114, P79245, P97826, Q28918, Q28996, Q3U1V6, Q4R5S9, Q58DB0, Q5BKH5, Q5IH13, Q5IH14, Q5R8P9, Q64421, Q6GM21, Q6IQS6, Q6NTS7, Q6P9U4, Q6TMK8, Q8R1R3, Q8VE85, Q8WYK0, Q90673, Q90ZB9, Q94E75, Q96DR4, Q96N28, Q99JV5, Q99NB7, Q9CYY7, Q9DBK0

Diamond homologs: A1A4M6, P59095, P59096, Q5R8P9, Q96DR4, Q99JV5, Q9EPQ7, Q9NSY2, Q61542

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

26 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	23
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1104 predictions. Top by Δscore:

Variant	Effect	Δscore
5:111501112:CAATT:C	acceptor_gain	1.0000
5:111501113:AATT:A	acceptor_gain	1.0000
5:111501114:ATTC:A	acceptor_loss	1.0000
5:111501115:TT:T	acceptor_gain	1.0000
5:111501115:TTCT:T	acceptor_loss	1.0000
5:111501116:TCTG:T	acceptor_loss	1.0000
5:111501117:C:CC	acceptor_gain	1.0000
5:111501117:C:T	acceptor_loss	1.0000
5:111501118:T:C	acceptor_loss	1.0000
5:111501957:GATAC:G	donor_loss	1.0000
5:111501958:ATACC:A	donor_loss	1.0000
5:111501959:TACC:T	donor_loss	1.0000
5:111501960:A:T	donor_loss	1.0000
5:111501961:C:G	donor_loss	1.0000
5:111502089:C:CC	acceptor_gain	1.0000
5:111506328:A:AC	donor_gain	1.0000
5:111506329:C:CC	donor_gain	1.0000
5:111499860:C:CT	donor_gain	0.9900
5:111499861:T:TT	donor_gain	0.9900
5:111499932:G:A	donor_gain	0.9900
5:111501019:T:TA	donor_gain	0.9900
5:111501114:ATT:A	acceptor_gain	0.9900
5:111501961:CCT:C	donor_gain	0.9900
5:111501963:T:TA	donor_gain	0.9900
5:111502084:TGTAG:T	acceptor_gain	0.9900
5:111502086:TAG:T	acceptor_gain	0.9900
5:111502087:AG:A	acceptor_gain	0.9900
5:111502088:GC:G	acceptor_loss	0.9900
5:111502089:C:T	acceptor_loss	0.9900
5:111502090:T:A	acceptor_loss	0.9900

AlphaMissense

1355 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:111501051:A:C	F116L	0.998
5:111501051:A:T	F116L	0.998
5:111501053:A:G	F116L	0.998
5:111499938:G:T	A189D	0.996
5:111500041:A:G	W155R	0.996
5:111500041:A:T	W155R	0.996
5:111501057:T:A	R114S	0.996
5:111501057:T:G	R114S	0.996
5:111502009:A:G	W79R	0.996
5:111502009:A:T	W79R	0.996
5:111507349:A:G	W29R	0.996
5:111507349:A:T	W29R	0.996
5:111500043:C:T	G154D	0.995
5:111500099:A:C	S135R	0.995
5:111500099:A:T	S135R	0.995
5:111500101:T:G	S135R	0.995
5:111501052:A:G	F116S	0.994
5:111501067:A:T	I111N	0.994
5:111502007:C:A	W79C	0.994
5:111502007:C:G	W79C	0.994
5:111502018:G:T	R76S	0.994
5:111500061:C:T	G148E	0.993
5:111502006:C:G	D80H	0.993
5:111501047:C:G	D118H	0.992
5:111501052:A:C	F116C	0.992
5:111501058:C:G	R114T	0.992
5:111502005:T:G	D80A	0.992
5:111499939:C:G	A189P	0.991
5:111502005:T:A	D80V	0.991
5:111499990:A:C	Y172D	0.990

dbSNP variants (sampled 300 via entrez): RS1000181162 (5:111502580 G>C), RS1000232732 (5:111505809 A>C,G), RS1000365692 (5:111498021 A>G,T), RS1000735976 (5:111496640 C>G,T), RS1000842576 (5:111499756 G>A), RS1000872074 (5:111506396 A>C), RS1001106205 (5:111496317 A>G), RS1001241321 (5:111499664 CAGAGTG>C), RS1001399677 (5:111500013 G>C), RS1001477641 (5:111505859 A>G), RS1001487845 (5:111509804 G>A), RS1001678502 (5:111512685 A>C), RS1001772245 (5:111499672 G>A,C), RS1001886607 (5:111504642 A>T), RS1002093855 (5:111511942 G>C)

Disease associations

OMIM: gene MIM:607049 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST002541_14	Menarche (age at onset)	3.000000e-10
GCST002875_171	Diisocyanate-induced asthma	2.000000e-06
GCST007507_8	Benign prostatic hyperplasia and lower urinary tract symptoms	4.000000e-12
GCST009798_4	Asthma	1.000000e-14
GCST009798_60	Asthma	1.000000e-44
GCST010320_81	PR interval	3.000000e-09
GCST010321_2	PR interval	5.000000e-09

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0004703	age at menarche
EFO:0006995	response to diisocyanate
EFO:0008008	lower urinary tract symptom
EFO:0004462	PR interval

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

55 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects cotreatment, decreases expression, increases abundance, increases expression	3
methylmercuric chloride	decreases expression	2
Resveratrol	increases expression, affects cotreatment	2
Arsenic Trioxide	affects cotreatment, decreases expression	2
Arsenic	affects methylation, affects cotreatment, decreases expression, increases abundance	2
Valproic Acid	decreases expression, decreases methylation	2
aristolochic acid I	decreases expression	1
6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	increases expression	1
triphenyl phosphate	affects expression	1
propionaldehyde	increases expression	1
trichostatin A	affects expression	1
dodecyldimethylamine oxide	increases expression	1
beta-lapachone	decreases expression	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
cupric chloride	decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression	1
dinophysistoxin 1	decreases expression	1
yessotoxin	increases expression	1
perfluorooctane sulfonic acid	decreases expression	1
CGP 52608	affects binding, increases reaction	1
perfluoro-n-nonanoic acid	decreases expression	1
monomethylarsonous acid	decreases expression	1
azaspiracid	increases expression	1
ICG 001	decreases expression	1
abrine	decreases expression	1
jinfukang	affects cotreatment, increases expression	1
PP242	decreases expression	1
Dasatinib	affects cotreatment, decreases expression	1
Decitabine	decreases expression, decreases reaction	1
Air Pollutants	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.