STARD7

Summary

STARD7 (StAR related lipid transfer domain containing 7, HGNC:18063) is a protein-coding gene on chromosome 2q11.2, encoding StAR-related lipid transfer protein 7, mitochondrial (Q9NQZ5). May play a protective role in mucosal tissues by preventing exaggerated allergic responses. It is a selective cancer dependency (DepMap: 36.0% of cell lines).

Predicted to enable molecular carrier activity. Predicted to be involved in ubiquinone biosynthetic process. Predicted to act upstream of or within several processes, including establishment of skin barrier; mucociliary clearance; and myeloid dendritic cell activation. Located in mitochondrion. Implicated in familial adult myoclonic epilepsy 2.

Source: NCBI Gene 56910 — RefSeq curated summary.

At a glance

• Gene–disease (curated): epilepsy, familial adult myoclonic, 2 (Limited, GenCC)
• GWAS associations: 1
• Clinical variants (ClinVar): 58 total — 2 pathogenic
• Phenotypes (HPO): 17
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 36.0% of screened cell lines
• MANE Select transcript: NM_020151

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18063
Approved symbol	STARD7
Name	StAR related lipid transfer domain containing 7
Location	2q11.2
Locus type	gene with protein product
Status	Approved
Aliases	GTT1
Ensembl gene	ENSG00000084090
Ensembl biotype	protein_coding
OMIM	616712
Entrez	56910

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 11 protein_coding, 3 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000337288, ENST00000443962, ENST00000462501, ENST00000479456, ENST00000488084, ENST00000495687, ENST00000869792, ENST00000869793, ENST00000869794, ENST00000869795, ENST00000869796, ENST00000914443, ENST00000914444, ENST00000914445, ENST00000949521

RefSeq mRNA: 2 — MANE Select: NM_020151 NM_001385622, NM_020151

CCDS: CCDS2017

Canonical transcript exons

ENST00000337288 — 8 exons

Exon	Start	End
ENSE00000540421	96193078	96193160
ENSE00000921755	96193242	96193352
ENSE00001817479	96184859	96186914
ENSE00001853520	96208145	96208827
ENSE00003614687	96195341	96195549
ENSE00003622057	96187217	96187301
ENSE00003643171	96194958	96195007
ENSE00003663624	96192369	96192468

Expression profiles

Bgee: expression breadth ubiquitous, 295 present calls, max score 99.61.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 76.8921 / max 576.1547, expressed in 1825 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
29722	39.7847	1821
29720	24.9506	1816
29721	5.6099	1721
29718	3.2444	1352
29723	2.3824	1332
29715	0.5654	314
29716	0.1882	93
29717	0.1665	41

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	99.61	gold quality
oocyte	CL:0000023	99.17	gold quality
medial globus pallidus	UBERON:0002477	99.00	gold quality
deltoid	UBERON:0001476	98.89	gold quality
tibialis anterior	UBERON:0001385	98.85	gold quality
globus pallidus	UBERON:0001875	98.81	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	98.75	gold quality
quadriceps femoris	UBERON:0001377	98.73	gold quality
vastus lateralis	UBERON:0001379	98.68	gold quality
cranial nerve II	UBERON:0000941	98.60	gold quality
choroid plexus epithelium	UBERON:0003911	98.58	gold quality
cerebellar vermis	UBERON:0004720	98.58	gold quality
heart right ventricle	UBERON:0002080	98.54	gold quality
body of tongue	UBERON:0011876	98.54	gold quality
skeletal muscle tissue	UBERON:0001134	98.53	gold quality
ileal mucosa	UBERON:0000331	98.50	gold quality
epithelium of nasopharynx	UBERON:0001951	98.49	gold quality
renal medulla	UBERON:0000362	98.48	gold quality
middle frontal gyrus	UBERON:0002702	98.48	gold quality
paraflocculus	UBERON:0005351	98.48	gold quality
tongue squamous epithelium	UBERON:0006919	98.48	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	98.46	gold quality
Brodmann (1909) area 46	UBERON:0006483	98.42	gold quality
visceral pleura	UBERON:0002401	98.40	gold quality
gluteal muscle	UBERON:0002000	98.37	gold quality
tongue	UBERON:0001723	98.36	gold quality
inferior vagus X ganglion	UBERON:0005363	98.36	gold quality
postcentral gyrus	UBERON:0002581	98.34	gold quality
left ventricle myocardium	UBERON:0006566	98.33	gold quality
parietal lobe	UBERON:0001872	98.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): CTNNB1, NR5A1, TCF7L2

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 36.0% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 15)

• the apparent occurrence of an unusual TG 3’ splice site in intron 1 is discussed (PMID:17672918)
• Beta-catenin and TCF4 activate the human StarD7 gene interacting with its promoter region through Wnt/beta-catenin signalling. (PMID:19679347)
• These results suggest that StarD7 facilitates the delivery of phosphatidylcholine to mitochondria in non-vesicular system. (PMID:20042613)
• The SF-1 and beta-catenin pathway convergence on StarD7 expression may have important implications in the phospholipid uptake and transport, contributing to the normal trophoblast development. (PMID:21622533)
• StarD7 behaves as a fusogenic protein in model and cell membrane bilayers. (PMID:22063720)
• StarD7 modulates ABCG2 multidrug transporter level, cell migration, proliferation, and biochemical and morphological differentiation marker expression in a human trophoblast cell model. (PMID:22952907)
• MFSD2B, CCL20 and STAT1, or STARD7 and ZNF512 genes may be risk or protect factors in prognosis of ADC; HTR2B, DPP4, and TGFBRAP1 genes may be risk factors in prognosis of SQC. (PMID:27301951)
• The results indicate that StarD7 contributes to the modulation of cellular redox homeostasis. (PMID:27554972)
• this study demonstrated that StarD7, a non-vesicular carrier of PC, is anchored onto the OMM via its N-terminal TM domain. (PMID:28821867)
• PARL preserves mitochondrial membrane homeostasis via STARD7 processing and is emerging as a critical regulator of protein localization between mitochondria and the cytosol (PMID:29301859)
• The data point at StarD7 as a candidate effector protein by which ceramides may exert part of their mitochondria-mediated cytotoxic effects. (PMID:29343537)
• An ATTTC expansion in the first intron of STARD7 segregated with Familial Adult Myoclonic Epilepsy (FAME2, OMIM: 607876)in 158 typically affected individuals. Expression of STARD7 mRNA and protein abundance was not altered in fibroblast cell lines derived from individuals with FAME2 ATTTC repeat expansions. (PMID:31664034)
• Familial Adult Myoclonic Epilepsy type 2 is caused by an expansion of an ATTTC pentamer within the first intron of STARD7. (PMID:31664034)
• The phosphatidylcholine transfer protein StarD7 is important for myogenic differentiation in mouse myoblast C2C12 cells and human primary skeletal myoblasts. (PMID:32071354)
• Role of the lipid transport protein StarD7 in mitochondrial dynamics. (PMID:34416390)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	stard7	ENSDARG00000074858
mus_musculus	Stard7	ENSMUSG00000027367
rattus_norvegicus	Stard7	ENSRNOG00000013479
drosophila_melanogaster	CG6565	FBGN0032513
caenorhabditis_elegans		WBGENE00007386

Paralogs (2): PCTP (ENSG00000141179), STARD10 (ENSG00000214530)

Protein

Protein identifiers

StAR-related lipid transfer protein 7, mitochondrial — Q9NQZ5 (reviewed: Q9NQZ5)

Alternative names: Gestational trophoblastic tumor protein 1, START domain-containing protein 7

All UniProt accessions (2): Q9NQZ5, C9JTD3

UniProt curated annotations — full annotation on UniProt →

Function. May play a protective role in mucosal tissues by preventing exaggerated allergic responses.

Subcellular location. Mitochondrion.

Tissue specificity. Expressed in nasal epithelial cells. Down-regulated in nasal epithelial cells in patients experiencing an asthma exacerbation as compared to stable asthmatics and healthy controls.

Post-translational modifications. Proteolytically cleaved by PARL.

RefSeq proteins (2): NP_001372551, NP_064536* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002913	START_lipid-bd_dom	Domain
IPR023393	START-like_dom_sf	Homologous_superfamily
IPR041949	START_STARD7	Domain
IPR051213	START_lipid_transfer	Family

Pfam: PF01852

UniProt features (9 total): region of interest 2, transit peptide 1, chain 1, domain 1, coiled-coil region 1, site 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NQZ5-F1	75.69	0.39

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 77–78 (cleavage; by parl)

Function

Pathways and Gene Ontology

Reactome pathways

10 pathways

ID	Pathway
R-HSA-1483191	Synthesis of PC
R-HSA-2142789	Ubiquinol biosynthesis
R-HSA-9837999	Mitochondrial protein degradation
R-HSA-1430728	Metabolism
R-HSA-1483206	Glycerophospholipid biosynthesis
R-HSA-1483257	Phospholipid metabolism
R-HSA-196854	Metabolism of vitamins and cofactors
R-HSA-392499	Metabolism of proteins
R-HSA-556833	Metabolism of lipids
R-HSA-8978934	Metabolism of cofactors

MSigDB gene sets: 293 (showing top): GOBP_EPITHELIUM_DEVELOPMENT, GOBP_RESPIRATORY_GASEOUS_EXCHANGE_BY_RESPIRATORY_SYSTEM, MORF_SMC1L1, GOBP_INFLAMMATORY_RESPONSE, MORF_UBE2I, MORF_HDAC1, MORF_UBE2N, MORF_RAD21, MORF_CDK2, GOBP_RESPIRATORY_SYSTEM_PROCESS, MORF_HDAC2, GOBP_KETONE_METABOLIC_PROCESS, PUJANA_CHEK2_PCC_NETWORK, MORF_TERF1, GTGCCTT_MIR506

GO Biological Process (7): myeloid dendritic cell activation (GO:0001773), ubiquinone biosynthetic process (GO:0006744), inflammatory response (GO:0006954), type 2 immune response (GO:0042092), establishment of skin barrier (GO:0061436), mucociliary clearance (GO:0120197), intermembrane lipid transfer (GO:0120009)

GO Molecular Function (4): lipid binding (GO:0008289), lipid transfer activity (GO:0120013), molecular carrier activity (GO:0140104), protein binding (GO:0005515)

GO Cellular Component (4): extracellular region (GO:0005576), mitochondrion (GO:0005739), mitochondrial outer membrane (GO:0005741), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-7 pathways:

Category	Pathways
Metabolism	2
Glycerophospholipid biosynthesis	1
Metabolism of cofactors	1
Metabolism of proteins	1
Phospholipid metabolism	1
Metabolism of lipids	1
Metabolism of vitamins and cofactors	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	3
cellular anatomical structure	2
myeloid leukocyte activation	1
ubiquinone metabolic process	1
quinone biosynthetic process	1
defense response	1
immune response	1
skin epidermis development	1
respiratory system process	1
epithelial cilium movement involved in extracellular fluid movement	1
lipid transport	1
membrane organization	1
transporter activity	1
lipid carrier activity	1
intermembrane lipid transfer	1
molecular_function	1
cytoplasm	1
intracellular membrane-bounded organelle	1
mitochondrial membrane	1
organelle outer membrane	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1074 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
STARD7	SAMD12	Q8N8I0	758
STARD7	CERT1	Q9Y5P4	689
STARD7	STAR	P49675	666
STARD7	MARCHF6	O60337	649
STARD7	YEATS2	Q9ULM3	649
STARD7	RAPGEF2	Q9Y4G8	645
STARD7	STARD5	P59094	645
STARD7	STARD3	Q14849	627
STARD7	TRIAP1	O43715	557
STARD7	PRELID1	Q9Y255	553
STARD7	STARD8	Q92502	551
STARD7	STARD10	Q9Y365	524
STARD7	PRELID3B	Q9Y3B1	480
STARD7	STARD4	Q96DR4	478
STARD7	ACOT12	Q8WYK0	476

IntAct

54 interactions, top by confidence:

A	B	Type	Score
NDUFAF5	NDUFAF8	psi-mi:“MI:0914”(association)	0.750
PRELID1	TRIAP1	psi-mi:“MI:0914”(association)	0.730
RCC1L	NME6	psi-mi:“MI:0914”(association)	0.720
LYRM4	NDUFAB1	psi-mi:“MI:0914”(association)	0.640
PIGM	STARD7	psi-mi:“MI:0915”(physical association)	0.590
PRKCA	DUSP11	psi-mi:“MI:0914”(association)	0.530
GLTP	AMD1	psi-mi:“MI:0914”(association)	0.530
NAT2	STARD7	psi-mi:“MI:0914”(association)	0.530
APOOL	MTX2	psi-mi:“MI:0914”(association)	0.530
STARD7	TLE5	psi-mi:“MI:0914”(association)	0.530
HOGA1	STARD7	psi-mi:“MI:0915”(physical association)	0.500
HOGA1	STARD7	psi-mi:“MI:0914”(association)	0.500
STARD7	H2BC9	psi-mi:“MI:0915”(physical association)	0.400
STARD7	ECE1	psi-mi:“MI:0915”(physical association)	0.370
ECE1	STARD7	psi-mi:“MI:0915”(physical association)	0.370
PB2		psi-mi:“MI:0914”(association)	0.350
AGFG2	AGFG1	psi-mi:“MI:0914”(association)	0.350
STARD7	TLE3	psi-mi:“MI:0914”(association)	0.350
CCDC91	CCDC102A	psi-mi:“MI:0914”(association)	0.350
CHCHD10	TIMM44	psi-mi:“MI:0914”(association)	0.350
IVD	ETFA	psi-mi:“MI:0914”(association)	0.350
AFG1L	SLC25A6	psi-mi:“MI:0914”(association)	0.350

BioGRID (56): STARD7 (Affinity Capture-MS), KIAA0907 (Affinity Capture-MS), TLE1 (Affinity Capture-MS), TLE3 (Affinity Capture-MS), STARD7 (Affinity Capture-MS), STARD7 (Affinity Capture-MS), STARD7 (Affinity Capture-MS), STARD7 (Affinity Capture-MS), STARD7 (Affinity Capture-MS), STARD7 (Affinity Capture-MS), STARD7 (Affinity Capture-MS), STARD7 (Affinity Capture-MS), STARD7 (Affinity Capture-MS), STARD7 (Affinity Capture-MS), STARD7 (Affinity Capture-MS)

ESM2 similar proteins: A1A4M6, A5GFX0, A5PJU6, O46689, O88736, P49675, P51557, P53808, P59095, P59096, P70114, P79245, P97826, Q28918, Q28996, Q3U1V6, Q4R5S9, Q58DB0, Q5BKH5, Q5IH13, Q5IH14, Q5R8P9, Q64421, Q6GM21, Q6IQS6, Q6NTS7, Q6P9U4, Q6TMK8, Q8R1R3, Q8VE85, Q8WYK0, Q90673, Q90ZB9, Q94E75, Q96DR4, Q96N28, Q99JV5, Q99NB7, Q9CYY7, Q9DBK0

Diamond homologs: P02720, P53808, P53809, Q8R1R3, Q9NQZ5, Q9UKL6, Q01277, Q54N86

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 58 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial protein import	6	22.4×	3e-05
Respiratory electron transport	9	19.0×	2e-07
Complex I biogenesis	5	18.4×	3e-04
Aerobic respiration and respiratory electron transport	7	13.8×	4e-05

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrion organization	5	14.1×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

58 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	2
Likely pathogenic	0
Uncertain significance	45
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (2)

Variant ID	HGVS	Classification
635132	NM_020151.3(STARD7):c.291-1572_291-1518ATTTT[376]ATTTC[274]	Pathogenic
694447	NC_000002.12:g.96197067AAAAT[(n)]/AAATG[(n)]	Pathogenic

SpliceAI

1200 predictions. Top by Δscore:

Variant	Effect	Δscore
2:96186910:CATGC:C	acceptor_gain	1.0000
2:96186912:TGC:T	acceptor_gain	1.0000
2:96186913:GCC:G	acceptor_loss	1.0000
2:96186914:CCTG:C	acceptor_loss	1.0000
2:96186915:C:CC	acceptor_gain	1.0000
2:96187211:ACTT:A	donor_loss	1.0000
2:96187212:CTT:C	donor_loss	1.0000
2:96187214:TAC:T	donor_loss	1.0000
2:96187215:ACCAC:A	donor_loss	1.0000
2:96187216:C:CA	donor_loss	1.0000
2:96187216:CCA:C	donor_gain	1.0000
2:96187297:CCATT:C	acceptor_gain	1.0000
2:96187298:CATT:C	acceptor_gain	1.0000
2:96187298:CATTC:C	acceptor_gain	1.0000
2:96187300:TT:T	acceptor_gain	1.0000
2:96187302:C:CC	acceptor_gain	1.0000
2:96192364:CTCA:C	donor_loss	1.0000
2:96192365:TCAC:T	donor_loss	1.0000
2:96192366:CACCT:C	donor_loss	1.0000
2:96192367:A:AT	donor_loss	1.0000
2:96192368:C:CA	donor_loss	1.0000
2:96192368:CCT:C	donor_gain	1.0000
2:96192464:CAGCA:C	acceptor_gain	1.0000
2:96192465:AGCA:A	acceptor_gain	1.0000
2:96192466:GCA:G	acceptor_gain	1.0000
2:96192466:GCAC:G	acceptor_loss	1.0000
2:96192467:CA:C	acceptor_gain	1.0000
2:96192467:CAC:C	acceptor_gain	1.0000
2:96192469:C:CC	acceptor_gain	1.0000
2:96192472:G:C	acceptor_gain	1.0000

AlphaMissense

2422 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:96186890:A:G	L318P	1.000
2:96186901:G:C	F314L	1.000
2:96186901:G:T	F314L	1.000
2:96186903:A:G	F314L	1.000
2:96187282:A:G	L288P	1.000
2:96187297:C:T	G283D	1.000
2:96192394:A:T	I273N	1.000
2:96192407:A:G	S269P	1.000
2:96193082:A:G	S247P	1.000
2:96193123:C:G	R233P	1.000
2:96193126:C:G	R232P	1.000
2:96193259:A:G	W215R	1.000
2:96193259:A:T	W215R	1.000
2:96193324:T:A	D193V	1.000
2:96193326:C:A	W192C	1.000
2:96193326:C:G	W192C	1.000
2:96193327:C:G	W192S	1.000
2:96193328:A:G	W192R	1.000
2:96193328:A:T	W192R	1.000
2:96193335:T:A	R189S	1.000
2:96193335:T:G	R189S	1.000
2:96193336:C:A	R189I	1.000
2:96193336:C:G	R189T	1.000
2:96195001:C:T	G169E	1.000
2:96195343:C:G	R166P	1.000
2:96186881:G:T	A321D	0.999
2:96186882:C:G	A321P	0.999
2:96186888:G:C	H319D	0.999
2:96186899:A:G	L315P	0.999
2:96186902:A:C	F314C	0.999

dbSNP variants (sampled 300 via entrez): RS1000072413 (2:96203793 T>C), RS1000179463 (2:96209214 C>T), RS1000190977 (2:96201659 A>G), RS1000286581 (2:96196784 T>A,C), RS1000292372 (2:96196626 T>C), RS1000668517 (2:96209163 T>G), RS1000719027 (2:96209521 A>C), RS1000758801 (2:96184892 C>T), RS1000871984 (2:96190244 A>C), RS1001076979 (2:96205304 G>A), RS1001235350 (2:96192052 G>A), RS1001638064 (2:96202983 T>C), RS1001807817 (2:96184379 C>T), RS1002023902 (2:96203970 A>C), RS1002054992 (2:96204192 G>A)

Disease associations

OMIM: gene MIM:616712 | disease phenotypes: MIM:607876

GenCC curated gene-disease

Disease	Classification	Inheritance
epilepsy, familial adult myoclonic, 2	Limited	Autosomal dominant

Mondo (1): epilepsy, familial adult myoclonic, 2 (MONDO:0011930)

Orphanet (1): Familial adult myoclonic epilepsy (Orphanet:86814)

HPO phenotypes

17 total (17 of 17 shown, HPO-id order):

HPO	Term
HP:0000006	Autosomal dominant inheritance
HP:0000643	Blepharospasm
HP:0000726	Dementia
HP:0001249	Intellectual disability
HP:0001251	Ataxia
HP:0001312	Giant somatosensory evoked potentials
HP:0001326	EEG with irregular generalized spike and wave complexes
HP:0001336	Myoclonus
HP:0001337	Tremor
HP:0001340	Enhancement of the C-reflex
HP:0001351	Jerk-locked premyoclonus spikes
HP:0002069	Bilateral tonic-clonic seizure
HP:0002076	Migraine
HP:0003581	Adult onset
HP:0003680	Nonprogressive
HP:0010852	EEG with photoparoxysmal response
HP:0100543	Cognitive impairment

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST001776_1	Cardiac Troponin-T levels	8.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0005043	cardiac troponin T measurement

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
C564313	Epilepsy, Myoclonic, Benign Adult Familial, Type 2 (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL3399912 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

31 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
cobaltous chloride	increases expression	2
Air Pollutants	decreases expression, increases abundance	2
Smoke	decreases expression, increases abundance	2
bisphenol F	affects cotreatment, increases expression	1
triphenyl phosphate	affects expression	1
sodium arsenite	increases expression	1
di-n-butylphosphoric acid	affects expression	1
K 7174	decreases expression	1
erucylphospho-N,N,N-trimethylpropylammonium	decreases expression	1
ICG 001	decreases expression	1
abrine	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Sunitinib	increases expression	1
Leflunomide	decreases expression	1
Acetaminophen	affects response to substance	1
Ethanol	decreases expression, increases expression	1
Arsenic	affects methylation	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Dexamethasone	increases expression, affects cotreatment	1
Estradiol	affects expression	1
Fluorouracil	affects expression	1
Indomethacin	affects cotreatment, increases expression	1
Ivermectin	increases expression	1
Thiram	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Valproic Acid	increases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, increases expression	1
Lithium Chloride	decreases activity, increases expression	1
Sodium Selenite	increases expression	1
Cadmium Chloride	increases expression	1

ChEMBL screening assays

3 unique, capped per target: 3 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL3405666	Binding	Binding affinity to His-tagged human recombinant START domain-containing protein 7 containing CERT START domain expressed in Escherichia coli assessed as bound fluorescent ceramide probe level TALON metal affinity resin at 200 pmol incubate	The CERT antagonist HPA-12: first practical synthesis and individual binding evaluation of the four stereoisomers. — Bioorg Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.