STEAP1B

Summary

STEAP1B (STEAP family member 1B, HGNC:41907) is a protein-coding gene on chromosome 7p15.3, encoding STEAP family member 1B (Q6NZ63).

Predicted to be located in membrane. Predicted to be active in endosome and plasma membrane.

Source: NCBI Gene 256227 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 48 total
• MANE Select transcript: NM_001382447

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41907
Approved symbol	STEAP1B
Name	STEAP family member 1B
Location	7p15.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000105889
Ensembl biotype	protein_coding
Entrez	256227

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 17 protein_coding, 4 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000404369, ENST00000406890, ENST00000414116, ENST00000424363, ENST00000439708, ENST00000442252, ENST00000483679, ENST00000649402, ENST00000650428, ENST00000678116, ENST00000906690, ENST00000915078, ENST00000915079, ENST00000915080, ENST00000915081, ENST00000915082, ENST00000915083, ENST00000915084, ENST00000915085, ENST00000915086, ENST00000915087, ENST00000957523

RefSeq mRNA: 3 — MANE Select: NM_001382447 NM_001164460, NM_001382447, NM_207342

CCDS: CCDS55094, CCDS56469, CCDS94065

Canonical transcript exons

ENST00000678116 — 5 exons

Exon	Start	End
ENSE00001558228	22419444	22419836
ENSE00003609177	22494772	22494886
ENSE00003689461	22493324	22493836
ENSE00003785908	22492565	22492729
ENSE00003908605	22500114	22500188

Expression profiles

Bgee: expression breadth ubiquitous, 173 present calls, max score 89.29.

FANTOM5 (CAGE): breadth broad, TPM avg 3.9972 / max 155.1186, expressed in 836 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
83067	3.7341	811
83086	0.2286	90
83066	0.2101	117
83077	0.0530	16

Top tissues by expression

281 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.29	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.34	gold quality
sural nerve	UBERON:0015488	78.96	gold quality
granulocyte	CL:0000094	74.08	gold quality
tibia	UBERON:0000979	73.18	gold quality
tibial nerve	UBERON:0001323	71.93	gold quality
right testis	UBERON:0004534	71.44	gold quality
mucosa of paranasal sinus	UBERON:0005030	71.36	gold quality
spleen	UBERON:0002106	70.93	gold quality
corpus callosum	UBERON:0002336	70.76	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	70.29	gold quality
left testis	UBERON:0004533	70.21	gold quality
hindlimb stylopod muscle	UBERON:0004252	70.10	gold quality
testis	UBERON:0000473	69.90	gold quality
prefrontal cortex	UBERON:0000451	68.24	gold quality
lymph node	UBERON:0000029	67.91	gold quality
spinal cord	UBERON:0002240	67.80	gold quality
medial globus pallidus	UBERON:0002477	66.89	silver quality
choroid plexus epithelium	UBERON:0003911	65.90	silver quality
putamen	UBERON:0001874	64.65	gold quality
cartilage tissue	UBERON:0002418	63.76	silver quality
vermiform appendix	UBERON:0001154	63.58	gold quality
caudate nucleus	UBERON:0001873	63.52	gold quality
frontal cortex	UBERON:0001870	63.28	gold quality
substantia nigra	UBERON:0002038	63.28	gold quality
oocyte	CL:0000023	63.20	gold quality
pigmented layer of retina	UBERON:0001782	63.18	gold quality
Brodmann (1909) area 9	UBERON:0013540	63.12	gold quality
omental fat pad	UBERON:0010414	62.86	gold quality
peritoneum	UBERON:0002358	62.80	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.36
E-MTAB-7037	no	109.44
E-GEOD-110499	no	49.80

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• STEAP1B transcripts have similar structural features to STEAP1, but may encode proteins with less transmembrane domains. STEAP1B2 transcript is also overexpressed on neoplastic prostate, making it worth to evaluate its potential as cancer biomarker (PMID:25053991)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Steap1	ENSMUSG00000015652
rattus_norvegicus	Steap1	ENSRNOG00000000017

Paralogs (4): STEAP3 (ENSG00000115107), STEAP4 (ENSG00000127954), STEAP2 (ENSG00000157214), STEAP1 (ENSG00000164647)

Protein

Protein identifiers

STEAP family member 1B — Q6NZ63 (reviewed: Q6NZ63)

All UniProt accessions (4): Q6NZ63, A0A7I2V339, C9JE84, C9JL51

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Similarity. Belongs to the STEAP family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q6NZ63-1	1	yes
Q6NZ63-2	2

RefSeq proteins (3): NP_001157932, NP_001369376, NP_997225 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013130	Fe3_Rdtase_TM_dom	Domain
IPR051267	STEAP_metalloreductase	Family

Pfam: PF01794

UniProt features (11 total): transmembrane region 4, sequence variant 4, splice variant 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6NZ63-F1	84.29	0.71

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 49 (showing top): TCF4_Q5, RIGGI_EWING_SARCOMA_PROGENITOR_DN, LEF1_Q6, RICKMAN_HEAD_AND_NECK_CANCER_C, SMID_BREAST_CANCER_LUMINAL_B_DN, RATTENBACHER_BOUND_BY_CELF1, ATF2_S_UP.V1_UP, ATF2_UP.V1_UP, DCA_UP.V1_DN, TBK1.DF_UP, CBX5_TARGET_GENES, PHF21A_TARGET_GENES, TFEB_TARGET_GENES, ZMYM2_TARGET_GENES, ZNF146_TARGET_GENES

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (3): endosome (GO:0005768), plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1
endomembrane system	1
cytoplasmic vesicle	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

13 interactions, top by confidence:

A	B	Type	Score
STEAP1B	STEAP1	psi-mi:“MI:0915”(physical association)	0.590
TMBIM6	STEAP1B	psi-mi:“MI:0915”(physical association)	0.560
STEAP1B	FOXD4L6	psi-mi:“MI:0915”(physical association)	0.560
	NBAS	psi-mi:“MI:0914”(association)	0.350
	SHTN1	psi-mi:“MI:0914”(association)	0.350
	TMEM223	psi-mi:“MI:0914”(association)	0.350
TMBIM6	STEAP1B	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (10): STEAP1 (Affinity Capture-MS), STEAP1B (Affinity Capture-RNA), TMBIM6 (Two-hybrid), STEAP1B (Affinity Capture-MS), STEAP1B (Affinity Capture-MS), STEAP1B (Affinity Capture-MS), STEAP1B (Proximity Label-MS), STEAP1 (Affinity Capture-MS), STEAP1B (PCA), STEAP1B (PCA)

ESM2 similar proteins: A2AWR3, A2BFP5, F1QF89, O70536, P0C1Q3, P18537, Q1LWG4, Q4V8A1, Q4V8K1, Q502J0, Q53P98, Q5NVQ2, Q5R5C5, Q5RKL5, Q60457, Q61263, Q658P3, Q672J9, Q672K1, Q687X5, Q6AXF6, Q6INU7, Q6NZ63, Q6Q3F5, Q6T3U4, Q6ZNA5, Q71B07, Q7L5N7, Q7SXZ1, Q7Z3F1, Q810K3, Q8BYI6, Q8CI59, Q8CIR4, Q8IWX5, Q8K2C9, Q8K385, Q8R2R1, Q923B6, Q924V1

Diamond homologs: Q4V8K1, Q5RKL5, Q658P3, Q687X5, Q6NZ63, Q8BWB6, Q8CI59, Q8NFT2, Q923B6, Q9CWR7, Q9GL50, Q9UHE8, O29370

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

48 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	40
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1657 predictions. Top by Δscore:

Variant	Effect	Δscore
7:22492727:GACC:G	acceptor_loss	1.0000
7:22492734:C:T	acceptor_gain	1.0000
7:22492740:G:C	acceptor_gain	1.0000
7:22492740:G:GC	acceptor_gain	1.0000
7:22492744:A:C	acceptor_gain	1.0000
7:22493643:T:TA	donor_gain	1.0000
7:22493724:T:A	donor_gain	1.0000
7:22494766:TTTTA:T	donor_loss	1.0000
7:22494767:TTTA:T	donor_loss	1.0000
7:22494768:TTACC:T	donor_loss	1.0000
7:22494769:TAC:T	donor_loss	1.0000
7:22494770:A:C	donor_loss	1.0000
7:22494771:C:A	donor_loss	1.0000
7:22494887:CTGTA:C	acceptor_loss	1.0000
7:22500111:CACC:C	donor_loss	1.0000
7:22500112:AC:A	donor_gain	1.0000
7:22500112:ACCC:A	donor_loss	1.0000
7:22500113:CC:C	donor_gain	1.0000
7:22500113:CCCA:C	donor_gain	1.0000
7:22492563:A:AC	donor_loss	0.9900
7:22492605:A:AC	donor_gain	0.9900
7:22492606:C:CC	donor_gain	0.9900
7:22492725:TGGAC:T	acceptor_gain	0.9900
7:22492726:GGAC:G	acceptor_gain	0.9900
7:22492727:GAC:G	acceptor_gain	0.9900
7:22492728:AC:A	acceptor_gain	0.9900
7:22492729:CC:C	acceptor_gain	0.9900
7:22492730:C:CC	acceptor_gain	0.9900
7:22492734:C:CT	acceptor_gain	0.9900
7:22492735:A:T	acceptor_gain	0.9900

AlphaMissense

1740 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:22493452:A:G	W138R	0.975
7:22493452:A:T	W138R	0.975
7:22492577:A:C	F231L	0.959
7:22492577:A:T	F231L	0.959
7:22492579:A:G	F231L	0.959
7:22493471:A:C	F131L	0.958
7:22493471:A:T	F131L	0.958
7:22493473:A:G	F131L	0.958
7:22493417:A:C	S149R	0.953
7:22493417:A:T	S149R	0.953
7:22493419:T:G	S149R	0.953
7:22493710:A:G	W52R	0.952
7:22493710:A:T	W52R	0.952
7:22492677:T:A	E198V	0.946
7:22493438:T:A	R142S	0.941
7:22493438:T:G	R142S	0.941
7:22492687:A:G	W195R	0.939
7:22492687:A:T	W195R	0.939
7:22493435:C:A	K143N	0.936
7:22493435:C:G	K143N	0.936
7:22492703:C:A	W189C	0.913
7:22492703:C:G	W189C	0.913
7:22492685:C:A	W195C	0.909
7:22492685:C:G	W195C	0.909
7:22492586:C:A	W228C	0.906
7:22492586:C:G	W228C	0.906
7:22492677:T:G	E198A	0.902
7:22493448:A:G	M139T	0.902
7:22493708:C:A	W52C	0.902
7:22493708:C:G	W52C	0.902

dbSNP variants (sampled 300 via entrez): RS1000045886 (7:22439207 G>A,T), RS1000108286 (7:22433005 C>T), RS1000127201 (7:22439865 C>T), RS1000134058 (7:22451390 A>G), RS1000141129 (7:22458715 T>C), RS1000287630 (7:22483485 G>C), RS1000293097 (7:22468093 G>A), RS1000324649 (7:22500081 A>G), RS1000375908 (7:22438965 T>C), RS1000412240 (7:22469423 T>C), RS1000462192 (7:22429366 T>C), RS1000468262 (7:22421058 G>A), RS1000488686 (7:22500799 C>CCCGAGTAGCTGGGAT), RS1000495942 (7:22451746 G>A), RS1000529234 (7:22455870 G>A,C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST003542_181	Night sleep phenotypes	3.000000e-06
GCST010307_5	Urinary albumin excretion	1.000000e-10

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004285	albuminuria

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases expression, affects expression, affects cotreatment	7
Benzo(a)pyrene	affects methylation, increases expression, increases methylation	3
sodium arsenite	affects methylation, affects cotreatment, increases abundance, increases expression	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Aflatoxin B1	affects methylation, decreases methylation	2
p-Chloromercuribenzoic Acid	affects cotreatment, increases expression	2
TL8-506	affects cotreatment, increases expression	1
2,5,2’,5’-tetrachlorobiphenyl	decreases expression	1
trichostatin A	increases expression	1
manganese chloride	increases abundance, increases expression, affects cotreatment	1
entinostat	increases expression	1
monomethylarsonous acid	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
ICG 001	increases expression	1
dorsomorphin	increases expression, affects cotreatment	1
theaflavin-3,3’-digallate	affects expression	1
Dasatinib	decreases expression	1
Temozolomide	decreases expression	1
Vorinostat	increases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Diethylhexyl Phthalate	increases expression	1
Endosulfan	decreases expression	1
Manganese	increases abundance, increases expression, affects cotreatment	1
Oxygen	decreases expression	1
Poly I-C	affects cotreatment, increases expression	1
Silicon Dioxide	increases expression	1
Triclosan	decreases expression	1
Asbestos, Serpentine	decreases methylation	1
Tungsten Compounds	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.