STK11IP

Summary

STK11IP (serine/threonine kinase 11 interacting protein, HGNC:19184) is a protein-coding gene on chromosome 2q35, encoding Serine/threonine-protein kinase 11-interacting protein (Q8N1F8). May regulate STK11/LKB1 function by controlling its subcellular localization.

Enables protein kinase binding activity. Involved in protein localization. Located in cytoplasm and intracellular membrane-bounded organelle.

Source: NCBI Gene 114790 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 205 total
• MANE Select transcript: NM_052902

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19184
Approved symbol	STK11IP
Name	serine/threonine kinase 11 interacting protein
Location	2q35
Locus type	gene with protein product
Status	Approved
Aliases	LIP1, KIAA1898, LKB1IP, STK11IP1
Ensembl gene	ENSG00000144589
Ensembl biotype	protein_coding
OMIM	607172
Entrez	114790

Gene structure

Transcript identifiers

Ensembl transcripts: 26 — 15 protein_coding, 7 retained_intron, 2 nonsense_mediated_decay, 2 protein_coding_CDS_not_defined

ENST00000413891, ENST00000447191, ENST00000456857, ENST00000456909, ENST00000459692, ENST00000465230, ENST00000466648, ENST00000468584, ENST00000473899, ENST00000475396, ENST00000475843, ENST00000483319, ENST00000494777, ENST00000495941, ENST00000879649, ENST00000879650, ENST00000879651, ENST00000879652, ENST00000879653, ENST00000879654, ENST00000879655, ENST00000879656, ENST00000939311, ENST00000939312, ENST00000964335, ENST00000964336

RefSeq mRNA: 1 — MANE Select: NM_052902 NM_052902

CCDS: CCDS46521

Canonical transcript exons

ENST00000456909 — 25 exons

Exon	Start	End
ENSE00001461605	219616044	219616451
ENSE00001711385	219597857	219597923
ENSE00002356818	219611955	219612058
ENSE00002387596	219611604	219611834
ENSE00002415358	219615094	219615341
ENSE00002417904	219614476	219614546
ENSE00002425663	219613128	219613225
ENSE00003107623	219609363	219609540
ENSE00003460397	219614161	219614242
ENSE00003467019	219606476	219606517
ENSE00003510227	219613752	219613930
ENSE00003537785	219609097	219609213
ENSE00003541596	219602705	219602776
ENSE00003545281	219605956	219606059
ENSE00003554953	219605608	219605734
ENSE00003558977	219606712	219606858
ENSE00003571920	219606195	219606290
ENSE00003603489	219608047	219608430
ENSE00003608694	219607053	219607137
ENSE00003608784	219601988	219602083
ENSE00003615552	219598094	219598180
ENSE00003635082	219602468	219602575
ENSE00003655116	219608583	219608788
ENSE00003658740	219601235	219601440
ENSE00003678323	219601641	219601715

Expression profiles

Bgee: expression breadth ubiquitous, 215 present calls, max score 97.63.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 18.0861 / max 237.9970, expressed in 1810 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
25530	17.3619	1810
25531	0.6632	401
25534	0.0175	3
25533	0.0145	6
25532	0.0113	5
25537	0.0082	3
25536	0.0060	3
25535	0.0035	3

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	97.63	gold quality
left testis	UBERON:0004533	97.60	gold quality
right uterine tube	UBERON:0001302	96.67	gold quality
left ovary	UBERON:0002119	96.35	gold quality
right ovary	UBERON:0002118	96.18	gold quality
tibial nerve	UBERON:0001323	95.96	gold quality
adenohypophysis	UBERON:0002196	95.80	gold quality
right hemisphere of cerebellum	UBERON:0014890	95.22	gold quality
pituitary gland	UBERON:0000007	94.95	gold quality
granulocyte	CL:0000094	94.74	gold quality
testis	UBERON:0000473	94.73	gold quality
cerebellar hemisphere	UBERON:0002245	94.46	gold quality
cerebellar cortex	UBERON:0002129	94.23	gold quality
right lobe of thyroid gland	UBERON:0001119	93.56	gold quality
cerebellum	UBERON:0002037	92.72	gold quality
metanephros cortex	UBERON:0010533	92.67	gold quality
left lobe of thyroid gland	UBERON:0001120	92.53	gold quality
right adrenal gland	UBERON:0001233	91.88	gold quality
right frontal lobe	UBERON:0002810	91.78	gold quality
right adrenal gland cortex	UBERON:0035827	91.70	gold quality
apex of heart	UBERON:0002098	91.30	gold quality
body of uterus	UBERON:0009853	91.27	gold quality
thyroid gland	UBERON:0002046	91.25	gold quality
lower esophagus mucosa	UBERON:0035834	91.17	gold quality
spleen	UBERON:0002106	91.15	gold quality
ovary	UBERON:0000992	90.97	gold quality
left adrenal gland cortex	UBERON:0035825	90.96	gold quality
left adrenal gland	UBERON:0001234	90.82	gold quality
skin of abdomen	UBERON:0001416	90.80	gold quality
skin of leg	UBERON:0001511	90.72	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.35
E-GEOD-99795	no	36.36

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

20 targeting STK11IP, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-106A-5P	99.90	73.94	2683
HSA-MIR-17-5P	99.89	73.83	2665
HSA-MIR-106B-5P	99.88	74.72	2795
HSA-MIR-20A-5P	99.88	74.76	2769
HSA-MIR-20B-5P	99.88	74.01	2621
HSA-MIR-519D-3P	99.88	73.97	2607
HSA-MIR-526B-3P	99.88	74.06	2587
HSA-MIR-93-5P	99.88	73.98	2606
HSA-MIR-4261	99.59	70.30	3415
HSA-MIR-147B-5P	99.45	70.62	2432
HSA-MIR-4251	99.40	69.19	3363
HSA-MIR-544B	99.18	67.41	1632
HSA-MIR-4324	99.04	70.14	1569
HSA-MIR-6873-5P	98.45	66.14	1417
HSA-MIR-665	97.60	65.64	1781
HSA-MIR-4685-3P	97.55	67.35	1255
HSA-MIR-4287	97.55	67.24	1247
HSA-MIR-3918	96.13	64.65	1300
HSA-MIR-571	95.38	66.54	671

Literature-anchored findings (GeneRIF, showing 3)

• observations provide complete information about the pattern and levels of LKB1 & p-acetyl-CoA carboxylase immunostaining in normal tissues and in lung tumors, and highlight the special relevance of abnormalities of the LKB1 pathway in lung adenocarcinoma (PMID:17521700)
• LKB1 and LIP1 provide negative control of TGFbeta signaling. (PMID:20974850)
• LKB1IP promotes pathological cardiac hypertrophy by targeting PTEN/Akt signalling pathway. (PMID:33486894)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	stk11ip	ENSDARG00000070122
mus_musculus	Stk11ip	ENSMUSG00000026213
rattus_norvegicus	Stk11ip	ENSRNOG00000020107
drosophila_melanogaster	CG9044	FBGN0031752

Paralogs (1): NISCH (ENSG00000010322)

Protein

Protein identifiers

Serine/threonine-protein kinase 11-interacting protein — Q8N1F8 (reviewed: Q8N1F8)

Alternative names: LKB1-interacting protein 1

All UniProt accessions (5): Q8N1F8, E7ERV2, H7C236, H7C2J7, M0QYE5

UniProt curated annotations — full annotation on UniProt →

Function. May regulate STK11/LKB1 function by controlling its subcellular localization.

Subunit / interactions. Found in a ternary complex composed of STK11/LKB1, STK11IP and SMAD4. Interacts with STK11/LKB1 and SMAD4.

Subcellular location. Cytoplasm.

Similarity. Belongs to the STK11IP family.

RefSeq proteins (1): NP_443134* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001611	Leu-rich_rpt	Repeat
IPR031782	LIP1_N	Domain
IPR032675	LRR_dom_sf	Homologous_superfamily
IPR057288	PH_PLEKHM2	Domain
IPR057292	PH_S11IP	Domain
IPR057676	PH_S11IP_C	Domain

Pfam: PF15904, PF23142, PF25357, PF25624

UniProt features (34 total): repeat 8, modified residue 8, compositionally biased region 7, sequence variant 5, region of interest 4, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N1F8-F1	68.89	0.23

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (8): 387, 389, 392, 470, 599, 761, 773, 777

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-6798695	Neutrophil degranulation
R-HSA-168249	Innate Immune System
R-HSA-168256	Immune System

MSigDB gene sets: 0 (showing top):

GO Biological Process (1): intracellular protein localization (GO:0008104)

GO Molecular Function (2): protein kinase binding (GO:0019901), protein binding (GO:0005515)

GO Cellular Component (4): extracellular region (GO:0005576), cytoplasm (GO:0005737), lysosomal membrane (GO:0005765), azurophil granule lumen (GO:0035578)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Innate Immune System	1
Immune System	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
macromolecule localization	1
kinase binding	1
binding	1
intracellular anatomical structure	1
lysosome	1
lytic vacuole membrane	1
vacuolar lumen	1
secretory granule lumen	1
azurophil granule	1

Protein interactions and networks

STRING

856 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
STK11IP	STK11	Q15831	878
STK11IP	SMAD4	Q13485	719
STK11IP	STRADA	Q7RTN6	665
STK11IP	CAB39	Q9Y376	520
STK11IP	NRDE2	Q9H7Z3	498
STK11IP	TAGLN	Q01995	493
STK11IP	TBC1D10B	Q4KMP7	476
STK11IP	NEDD9	Q14511	470
STK11IP	DNAJC14	Q6Y2X3	434
STK11IP	ARSA	P15289	432
STK11IP	STK25	O00506	429
STK11IP	GOLGA2	Q08379	429
STK11IP	CD24	P25063	426
STK11IP	CTNND1	O60716	424
STK11IP	VEGFC	P49767	423

IntAct

60 interactions, top by confidence:

A	B	Type	Score
COMMD1	VPS26C	psi-mi:“MI:0914”(association)	0.730
LRRC32	SMPD2	psi-mi:“MI:0914”(association)	0.640
BCL7C	ARID1A	psi-mi:“MI:0914”(association)	0.640
COMTD1	IFRD1	psi-mi:“MI:0914”(association)	0.530
VASN	AP3B1	psi-mi:“MI:0914”(association)	0.530
LINGO2	GAPDHS	psi-mi:“MI:0914”(association)	0.530
SLC15A4	PGRMC1	psi-mi:“MI:0914”(association)	0.530
UBE2DNL	STK11IP	psi-mi:“MI:0915”(physical association)	0.370
STK11IP	SMAD4	psi-mi:“MI:0915”(physical association)	0.370
Papss1	TCOF1	psi-mi:“MI:0914”(association)	0.350
MAPK8		psi-mi:“MI:0914”(association)	0.350
HSCB	RBP5	psi-mi:“MI:0914”(association)	0.350
KERA	VWA8	psi-mi:“MI:0914”(association)	0.350
BCL7C	DPF1	psi-mi:“MI:0914”(association)	0.350
TLR2	ACVR2A	psi-mi:“MI:0914”(association)	0.350
	BTAF1	psi-mi:“MI:0914”(association)	0.350
	FAM20B	psi-mi:“MI:0914”(association)	0.350
M	TM9SF1	psi-mi:“MI:0914”(association)	0.350
Npc1	ESYT2	psi-mi:“MI:0914”(association)	0.350
TMEM106B	STX7	psi-mi:“MI:0914”(association)	0.350
MGARP	BTAF1	psi-mi:“MI:0914”(association)	0.350
TLR1	LRP6	psi-mi:“MI:0914”(association)	0.350
COMTD1	TARS3	psi-mi:“MI:0914”(association)	0.350

BioGRID (108): STK11IP (Affinity Capture-MS), STK11IP (Affinity Capture-MS), STK11IP (Affinity Capture-MS), STK11IP (Affinity Capture-MS), STK11IP (Affinity Capture-MS), STK11IP (Affinity Capture-MS), STK11IP (Affinity Capture-MS), STK11IP (Affinity Capture-MS), STK11IP (Affinity Capture-MS), STK11IP (Affinity Capture-MS), STK11IP (Affinity Capture-MS), STK11IP (Affinity Capture-MS), STK11IP (Affinity Capture-MS), STK11IP (Affinity Capture-MS), STK11IP (Affinity Capture-RNA)

ESM2 similar proteins: A0A0G2JXN2, A2AWP8, O88842, O95267, P29590, P52734, P98174, Q1LY10, Q29RM4, Q2TBA3, Q3TAA7, Q3U0J8, Q3UTZ3, Q496Y0, Q4VX76, Q568M3, Q58D15, Q5BIM1, Q5JSP0, Q5R5M3, Q5R5T1, Q5REJ9, Q5W0U4, Q68FF6, Q69Z89, Q69ZK0, Q6PFY8, Q7TNM2, Q7Z4K8, Q7Z5H3, Q7Z6J4, Q80V85, Q8BY35, Q8BZ52, Q8C190, Q8N1F8, Q8TCU6, Q8WVR3, Q96JH8, Q99N48

Diamond homologs: Q3TAA7, Q5F479, Q6IRN0, Q6P4K6, Q8N1F8, A3KPW7, A5A779, O93829, O94412, Q00618, Q08602, Q55DQ4, Q5EA80, Q5NVK5, Q92696, Q9JHK4

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 83 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
toll-like receptor signaling pathway	6	48.1×	1e-06

Disease & clinical

Clinical variants and AI predictions

ClinVar

205 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	161
Likely benign	19
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

4371 predictions. Top by Δscore:

Variant	Effect	Δscore
2:219598176:GTCCG:G	donor_gain	1.0000
2:219598178:CCGG:C	donor_loss	1.0000
2:219598181:G:C	donor_loss	1.0000
2:219598182:T:G	donor_loss	1.0000
2:219601637:TCAGC:T	acceptor_loss	1.0000
2:219601638:CAGC:C	acceptor_loss	1.0000
2:219601639:AGCT:A	acceptor_gain	1.0000
2:219601640:GCTG:G	acceptor_gain	1.0000
2:219601713:G:GT	donor_gain	1.0000
2:219602461:T:TA	acceptor_gain	1.0000
2:219602462:GCTCA:G	acceptor_loss	1.0000
2:219602466:A:AG	acceptor_gain	1.0000
2:219602466:AG:A	acceptor_gain	1.0000
2:219602467:G:GG	acceptor_gain	1.0000
2:219602467:GG:G	acceptor_gain	1.0000
2:219602467:GGA:G	acceptor_gain	1.0000
2:219602467:GGAGC:G	acceptor_gain	1.0000
2:219602572:CCTGG:C	donor_loss	1.0000
2:219602574:TGG:T	donor_loss	1.0000
2:219602576:G:C	donor_loss	1.0000
2:219602576:G:GG	donor_gain	1.0000
2:219602577:TGAG:T	donor_loss	1.0000
2:219605594:T:A	acceptor_gain	1.0000
2:219605597:A:AG	acceptor_gain	1.0000
2:219605598:C:G	acceptor_gain	1.0000
2:219605602:T:A	acceptor_gain	1.0000
2:219605605:CAGG:C	acceptor_loss	1.0000
2:219605606:A:AG	acceptor_gain	1.0000
2:219605606:AG:A	acceptor_gain	1.0000
2:219605607:G:A	acceptor_gain	1.0000

AlphaMissense

6949 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:219601348:T:C	F59L	0.997
2:219601350:T:A	F59L	0.997
2:219601350:T:G	F59L	0.997
2:219601436:T:A	L88H	0.997
2:219601702:T:A	L110H	0.997
2:219602513:T:A	W162R	0.997
2:219602513:T:C	W162R	0.997
2:219601436:T:C	L88P	0.996
2:219601693:T:C	F107S	0.995
2:219601711:T:C	L113P	0.995
2:219601989:T:A	L115H	0.995
2:219601989:T:C	L115P	0.995
2:219602538:T:C	F170S	0.995
2:219602548:T:A	N173K	0.995
2:219602548:T:G	N173K	0.995
2:219601412:A:T	D80V	0.994
2:219601418:T:C	L82P	0.994
2:219601692:T:C	F107L	0.994
2:219601694:C:A	F107L	0.994
2:219601694:C:G	F107L	0.994
2:219616140:T:C	F1072L	0.994
2:219616142:T:A	F1072L	0.994
2:219616142:T:G	F1072L	0.994
2:219601402:T:C	F77L	0.993
2:219601403:T:C	F77S	0.993
2:219601404:T:A	F77L	0.993
2:219601404:T:G	F77L	0.993
2:219602547:A:T	N173I	0.993
2:219602746:T:A	N196K	0.993
2:219602746:T:G	N196K	0.993

dbSNP variants (sampled 300 via entrez): RS1000273638 (2:219610051 A>G,T), RS1000275226 (2:219600254 C>T), RS1000311597 (2:219613264 T>A,C,G), RS1000410457 (2:219608525 A>G), RS1000448610 (2:219612335 A>G), RS1000490289 (2:219605259 T>TA), RS1000609578 (2:219598785 G>A), RS1000680507 (2:219614434 A>C), RS1000737058 (2:219604978 TGC>T), RS1000783622 (2:219611196 C>T), RS1000898724 (2:219610892 G>A), RS1001129387 (2:219602149 G>A,T), RS1001197546 (2:219605499 G>A), RS1001243929 (2:219601867 C>T), RS1001342506 (2:219606229 CT>C)

Disease associations

OMIM: gene MIM:607172 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cisplatin	affects expression, decreases expression	2
GSK-J4	increases expression	1
FR900359	affects phosphorylation	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
sodium arsenite	increases abundance, increases expression	1
coumarin	decreases phosphorylation	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
abrine	increases expression	1
Decitabine	affects expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Air Pollutants	affects cotreatment, increases abundance, increases oxidation	1
Arsenic	increases abundance, increases expression	1
Caffeine	decreases phosphorylation	1
Carcinogens	decreases expression	1
Doxorubicin	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Ozone	affects cotreatment, increases oxidation, increases abundance	1
Smoke	decreases expression	1
Valproic Acid	decreases expression	1
Aflatoxin B1	increases methylation	1
Cadmium Chloride	increases expression	1
Volatile Organic Compounds	affects cotreatment, increases oxidation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.