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STK32A

gene
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Also known as MGC22688YANK1

Summary

STK32A (serine/threonine kinase 32A, HGNC:28317) is a protein-coding gene on chromosome 5q32, encoding Serine/threonine-protein kinase 32A (Q8WU08).

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in plasma membrane.

Source: NCBI Gene 202374 — RefSeq curated summary.

At a glance

  • GWAS associations: 5
  • Clinical variants (ClinVar): 73 total
  • Druggable target: yes — 8 molecules with ChEMBL bioactivity
  • MANE Select transcript: NM_001112724

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:28317
Approved symbolSTK32A
Nameserine/threonine kinase 32A
Location5q32
Locus typegene with protein product
StatusApproved
AliasesMGC22688, YANK1
Ensembl geneENSG00000169302
Ensembl biotypeprotein_coding
OMIM621310
Entrez202374

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 6 retained_intron, 3 protein_coding, 1 nonsense_mediated_decay

ENST00000306304, ENST00000397936, ENST00000398523, ENST00000503384, ENST00000503975, ENST00000506091, ENST00000510953, ENST00000515832, ENST00000626951, ENST00000648628

RefSeq mRNA: 3 — MANE Select: NM_001112724 NM_001112724, NM_001287740, NM_145001

CCDS: CCDS47299, CCDS54931, CCDS75351

Canonical transcript exons

ENST00000397936 — 13 exons

ExonStartEnd
ENSE00001533450147383441147383505
ENSE00001533452147375090147375218
ENSE00002057341147383890147387855
ENSE00003506691147323898147324071
ENSE00003526815147239539147239686
ENSE00003532739147279247147279398
ENSE00003544570147343006147343043
ENSE00003599143147278124147278179
ENSE00003602055147373169147373294
ENSE00003609964147361517147361614
ENSE00003628208147370654147370770
ENSE00003668573147351065147351154
ENSE00003846187147235026147235199

Expression profiles

Bgee: expression breadth ubiquitous, 187 present calls, max score 83.04.

FANTOM5 (CAGE): breadth broad, TPM avg 2.3322 / max 146.3959, expressed in 473 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter IDTPM avgSamples expressed
592341.6928354
592380.3530151
592350.2071100
592330.079348

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
sural nerveUBERON:001548883.04gold quality
right adrenal gland cortexUBERON:003582782.72gold quality
left adrenal gland cortexUBERON:003582582.00gold quality
hypothalamusUBERON:000189881.97gold quality
left adrenal glandUBERON:000123481.88gold quality
right adrenal glandUBERON:000123381.27gold quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047380.81gold quality
adrenal cortexUBERON:000123579.64gold quality
tibial nerveUBERON:000132379.27gold quality
substantia nigraUBERON:000203878.97gold quality
tibiaUBERON:000097978.89gold quality
adrenal glandUBERON:000236978.36gold quality
descending thoracic aortaUBERON:000234577.59gold quality
right hemisphere of cerebellumUBERON:001489077.06gold quality
ascending aortaUBERON:000149676.94gold quality
thoracic aortaUBERON:000151576.78gold quality
midbrainUBERON:000189176.39gold quality
cerebellar hemisphereUBERON:000224576.35gold quality
cerebellar cortexUBERON:000212976.29gold quality
C1 segment of cervical spinal cordUBERON:000646976.03gold quality
cerebellumUBERON:000203775.67gold quality
adenohypophysisUBERON:000219675.26gold quality
medial globus pallidusUBERON:000247775.08gold quality
spinal cordUBERON:000224074.91gold quality
gall bladderUBERON:000211074.15gold quality
islet of LangerhansUBERON:000000673.70gold quality
calcaneal tendonUBERON:000370173.48gold quality
amygdalaUBERON:000187673.10gold quality
pituitary glandUBERON:000000772.91gold quality
primordial germ cell in gonadCL:0000670 ∩ UBERON:000099172.82gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

ExperimentMarker?Max mean expression
E-ENAD-20yes395.55
E-ANND-3yes5.46
E-MTAB-9543no1.22

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

22 targeting STK32A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-548AW99.9972.573559
HSA-MIR-1468-3P99.9672.743797
HSA-MIR-450B-5P99.9271.483175
HSA-MIR-548AJ-5P99.7871.123085
HSA-MIR-548F-5P99.7871.023093
HSA-MIR-548G-5P99.7871.123085
HSA-MIR-548X-5P99.7871.123085
HSA-MIR-19A-5P99.3666.931675
HSA-MIR-19B-1-5P99.3667.071669
HSA-MIR-19B-2-5P99.3667.071669
HSA-MIR-2115-3P99.3169.682026
HSA-MIR-66199.0965.942062
HSA-MIR-939-3P98.9765.072347
HSA-MIR-361-5P98.9570.161340
HSA-MIR-374A-3P98.8767.821531
HSA-MIR-31-5P98.5868.351239
HSA-MIR-548AO-5P98.5569.571362
HSA-MIR-548AX98.5569.581362
HSA-MIR-1271-3P97.5664.85865
HSA-MIR-550A-3-5P97.5665.35823
HSA-MIR-550A-5P97.5665.35823
HSA-MIR-4800-3P88.4263.0735

Cross-species orthologs

8 orthologs

OrganismSymbolGene ID
mus_musculusStk32aENSMUSG00000039954
rattus_norvegicusStk32aENSRNOG00000027066
drosophila_melanogasterCG32944FBGN0052944
drosophila_melanogasterdopFBGN0267390
caenorhabditis_elegansWBGENE00002192
caenorhabditis_eleganswts-1WBGENE00007047
caenorhabditis_elegansWBGENE00010838
caenorhabditis_elegansWBGENE00011992

Paralogs (13): MAST4 (ENSG00000069020), MAST2 (ENSG00000086015), MAST3 (ENSG00000099308), SGK2 (ENSG00000101049), SGK3 (ENSG00000104205), DMPK (ENSG00000104936), MAST1 (ENSG00000105613), SGK1 (ENSG00000118515), MASTL (ENSG00000120539), LATS1 (ENSG00000131023), LATS2 (ENSG00000150457), STK32B (ENSG00000152953), STK32C (ENSG00000165752)

Protein

Protein identifiers

Serine/threonine-protein kinase 32A — Q8WU08 (reviewed: Q8WU08)

Alternative names: Yet another novel kinase 1

All UniProt accessions (3): Q8WU08, A0A3B3IS85, B7Z9H7

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Cell membrane.

Similarity. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Isoforms (3)

UniProt IDNamesCanonical?
Q8WU08-11yes
Q8WU08-22
Q8WU08-33

RefSeq proteins (3): NP_001106195, NP_001274669, NP_659438 (=MANE)

Domains & families (InterPro)

IDNameType
IPR000719Prot_kinase_domDomain
IPR008271Ser/Thr_kinase_ASActive_site
IPR011009Kinase-like_dom_sfHomologous_superfamily
IPR017441Protein_kinase_ATP_BSBinding_site

Pfam: PF00069

Catalyzed reactions (Rhea), 2 shown:

  • L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) (RHEA:17989)
  • L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) (RHEA:46608)

UniProt features (40 total): helix 16, strand 7, splice variant 4, sequence variant 3, binding site 2, initiator methionine 1, chain 1, mutagenesis site 1, turn 1, domain 1, region of interest 1, active site 1, lipid moiety-binding region 1

Structure

Experimental structures (PDB)

1 structures.

PDBMethodResolution (Å)
4FR4X-RAY DIFFRACTION2.29

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q8WU08-F187.610.68

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 146 (proton acceptor)

Ligand- & substrate-binding residues (2): 29–37; 52

Post-translational modifications (1): 2

Mutagenesis-validated functional residues (1):

PositionPhenotype
2localizes to cytoplasm.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 61 (showing top): TGACCTY_ERR1_Q2, TGACCTTG_SF1_Q6, chr5q32, GOMF_PROTEIN_KINASE_ACTIVITY, GOMF_KINASE_ACTIVITY, GOMF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY, GOMF_ADENYL_NUCLEOTIDE_BINDING, GOMF_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS, MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED, MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3, FOSTER_KDM1A_TARGETS_UP, ZNF618_TARGET_GENES, MIR1468_3P, MIR656_3P, MIR128_3P

GO Biological Process (2): intracellular signal transduction (GO:0035556), protein phosphorylation (GO:0006468)

GO Molecular Function (9): protein serine/threonine kinase activity (GO:0004674), ATP binding (GO:0005524), metal ion binding (GO:0046872), protein serine kinase activity (GO:0106310), nucleotide binding (GO:0000166), protein kinase activity (GO:0004672), protein binding (GO:0005515), kinase activity (GO:0016301), transferase activity (GO:0016740)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
protein kinase activity2
intracellular anatomical structure1
signal transduction1
phosphorylation1
protein modification process1
adenyl ribonucleotide binding1
purine ribonucleoside triphosphate binding1
cation binding1
nucleoside phosphate binding1
heterocyclic compound binding1
kinase activity1
phosphotransferase activity, alcohol group as acceptor1
catalytic activity, acting on a protein1
binding1
transferase activity, transferring phosphorus-containing groups1
catalytic activity1
membrane1
cell periphery1
cellular anatomical structure1

Protein interactions and networks

STRING

940 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
STK32ADPYSL3Q14195651
STK32AJAKMIP2Q96AA8479
STK32ARABGGTAQ92696474
STK32ASTAC2Q6ZMT1472
STK32AGPR149Q86SP6461
STK32APLEKHG1Q9ULL1455
STK32ARUNX2Q13950453
STK32AARHGAP25P42331449
STK32AFAM131CQ96AQ9433
STK32ACCER2I3L3R5433
STK32ADOCK5Q9H7D0425
STK32AGULP1Q9UBP9414
STK32AING2Q9H160412
STK32AVARS1P26640410
STK32APPP2R2BQ00005410

IntAct

3 interactions, top by confidence:

ABTypeScore
CDKL3psi-mi:“MI:0914”(association)0.350
STK32AHSP90AA1psi-mi:“MI:0914”(association)0.350

BioGRID (19): STK32A (Synthetic Growth Defect), CST7 (Affinity Capture-MS), STK32A (Two-hybrid), STK32A (Affinity Capture-MS), HSP90AA1 (Affinity Capture-MS), HSP90AB1 (Affinity Capture-MS), TCP1 (Affinity Capture-MS), CCT6A (Affinity Capture-MS), CCT5 (Affinity Capture-MS), CCT3 (Affinity Capture-MS), CCT8 (Affinity Capture-MS), CCT4 (Affinity Capture-MS), CCT2 (Affinity Capture-MS), PRKCE (Affinity Capture-MS), FKBP5 (Affinity Capture-MS)

ESM2 similar proteins: A2VDV2, A8XJL7, O13310, O75582, O97627, P00518, P07934, P13286, P18652, P18653, P18654, P21146, P23443, P26817, P26818, P26819, P35626, P51812, P54645, P67998, P67999, Q09639, Q12706, Q15208, Q21734, Q2L6W9, Q2LZZ7, Q39030, Q3UYH7, Q54IH8, Q5F3L1, Q5R4K3, Q5R8M1, Q64682, Q6PFQ0, Q6TGC6, Q6TJY3, Q7TPS0, Q7TSE6, Q8BGW6

Diamond homologs: A0A078CGE6, A1A5Q6, A2QHV0, A4K2M3, A4K2P5, A4K2Q5, A4K2S1, A4K2T0, A4K2W5, A4K2Y1, B0WAU8, B3DL84, B3NKK1, B4IMC3, B4J3F1, B4KYX8, B4LDJ6, B4MXR8, B4NSS9, D3ZHP7, F1M7Y5, F4HPN2, F4HYG2, F4IRW0, F4J6F6, F4JBP3, F4JY37, J9W0G9, O22042, O54748, O61122, O64629, O74426, O75011, P0C8M8, P18652, P23647, P34102, P38692, P41743

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

73 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance65
Likely benign0
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2949 predictions. Top by Δscore:

VariantEffectΔscore
5:147239683:GATG:Gdonor_gain1.0000
5:147278122:A:AGacceptor_gain1.0000
5:147278123:G:GAacceptor_gain1.0000
5:147278123:GTC:Gacceptor_gain1.0000
5:147278123:GTCA:Gacceptor_gain1.0000
5:147278123:GTCAA:Gacceptor_gain1.0000
5:147279396:GTG:Gdonor_gain1.0000
5:147279399:G:Adonor_loss1.0000
5:147279400:TGA:Tdonor_loss1.0000
5:147279401:GAG:Gdonor_loss1.0000
5:147323890:A:AGacceptor_gain1.0000
5:147323891:A:Gacceptor_gain1.0000
5:147323896:A:AGacceptor_gain1.0000
5:147323896:AG:Aacceptor_gain1.0000
5:147323897:G:GAacceptor_gain1.0000
5:147323897:GG:Gacceptor_gain1.0000
5:147323897:GGT:Gacceptor_gain1.0000
5:147323897:GGTA:Gacceptor_gain1.0000
5:147323897:GGTAT:Gacceptor_gain1.0000
5:147348838:C:Gdonor_gain1.0000
5:147351061:GCA:Gacceptor_loss1.0000
5:147351063:A:ATacceptor_loss1.0000
5:147351063:AG:Aacceptor_gain1.0000
5:147351063:AGG:Aacceptor_gain1.0000
5:147351064:GG:Gacceptor_gain1.0000
5:147351064:GGG:Gacceptor_gain1.0000
5:147351064:GGGC:Gacceptor_gain1.0000
5:147361621:T:TAdonor_gain1.0000
5:147361622:A:AAdonor_gain1.0000
5:147370652:A:Gacceptor_gain1.0000

AlphaMissense

2680 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
5:147278139:T:CF23S1.000
5:147278160:G:AG30E1.000
5:147278165:G:CG32R1.000
5:147278171:T:AF34I1.000
5:147278171:T:CF34L1.000
5:147278173:T:AF34L1.000
5:147278173:T:GF34L1.000
5:147278174:G:AG35R1.000
5:147278174:G:CG35R1.000
5:147278174:G:TG35W1.000
5:147278175:G:AG35E1.000
5:147278175:G:TG35V1.000
5:147279287:C:AA50E1.000
5:147279292:A:CK52Q1.000
5:147279292:A:GK52E1.000
5:147279294:G:CK52N1.000
5:147279294:G:TK52N1.000
5:147279306:A:CK56N1.000
5:147279306:A:TK56N1.000
5:147323905:T:CF90L1.000
5:147323907:C:AF90L1.000
5:147323907:C:GF90L1.000
5:147343008:A:CD146A1.000
5:147343008:A:TD146V1.000
5:147351082:G:CD164H1.000
5:147351083:A:CD164A1.000
5:147351083:A:GD164G1.000
5:147351083:A:TD164V1.000
5:147351084:T:AD164E1.000
5:147351084:T:GD164E1.000

dbSNP variants (sampled 300 via entrez): RS1000026849 (5:147321337 C>T), RS1000054251 (5:147240365 A>G), RS1000065445 (5:147325519 T>C), RS1000066855 (5:147305342 C>A,G,T), RS1000070910 (5:147234506 G>T), RS1000095579 (5:147239316 T>C), RS1000101867 (5:147283534 G>A), RS1000103907 (5:147245861 C>G,T), RS1000104536 (5:147298262 T>C), RS1000135429 (5:147277821 T>C), RS1000162362 (5:147379755 T>C), RS1000183667 (5:147251836 G>A), RS1000185465 (5:147234831 G>C), RS1000208574 (5:147315307 A>T), RS1000216315 (5:147252085 T>C)

Disease associations

OMIM: gene MIM:621310 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

StudyTraitp-value
GCST003542_162Night sleep phenotypes7.000000e-06
GCST008759_50Intake of total sugars4.000000e-07
GCST009218_12Lateral ventricle temporal horn volume5.000000e-06
GCST010397_73Gut microbiota (bacterial taxa, rank normal transformation method)5.000000e-06
GCST011494_25Daytime nap6.000000e-26

EFO canonical traits (3, from GWAS)

EFO IDTrait name
EFO:0010158sugar consumption measurement
EFO:0007874gut microbiome measurement
EFO:0007828daytime rest measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6150 (SINGLE PROTEIN)

Molecules with ChEMBL bioactivity

8 molecules (phase ≥1), by development phase (incl. off-target/promiscuous compounds). Patent mentions across the top 20 by phase: 94,834 (via chembl_molecule»patent_compound — counts attach to the compound, not the gene–compound relationship, so off-target/promiscuous molecules can dominate).

MoleculeNamePhasePatents
CHEMBL24828VANDETANIB442,230
CHEMBL288441BOSUTINIB412,255
CHEMBL608533MIDOSTAURIN47,259
CHEMBL223360LINIFANIB33,925
CHEMBL428690ALVOCIDIB327,781
CHEMBL603469LESTAURTINIB3
CHEMBL475251R-4062762
CHEMBL1908397KW-24491622

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: enzyme — YANK family

ChEMBL bioactivities

18 potent at pChembl≥5 of 18 total, top 18 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChemblTypeValueUnitMolecule
7.89Kd13nMTAE-684
7.89Kd13nMSTAUROSPORINE
6.19Kd640nMLINIFANIB
6.16Kd690nMCHEMBL1241674
6.00IC501000nMTP-030-1
6.00IC501000nMTP-030-2
6.00IC501000nMTP-030n
5.89Kd1300nMSB-203580
5.81Kd1544nMCHEMBL4465866
5.76Kd1749nMCHEMBL4576489
5.75Kd1800nMBOSUTINIB
5.68Kd2100nMLESTAURTINIB
5.64Kd2300nMR-406
5.62Kd2400nMMIDOSTAURIN
5.60Kd2500nMCHEMBL386051
5.36Kd4400nMKW-2449
5.30Kd5000nMVANDETANIB
5.26Kd5500nMALVOCIDIB

PubChem BioAssay actives

15 with measured affinity, of 128 total; 15 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

CompoundAssayTypeValueUnit
5-chloro-2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine624821: Binding constant for YANK1 kinase domainkd0.0130uM
(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one624821: Binding constant for YANK1 kinase domainkd0.0130uM
1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea624821: Binding constant for YANK1 kinase domainkd0.6400uM
2-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol624821: Binding constant for YANK1 kinase domainkd0.6900uM
4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine624821: Binding constant for YANK1 kinase domainkd1.3000uM
3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)-N-[2-[2-[2-[2-[[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]propanamide1526220: Binding affinity to recombinant full-length N-terminal His-FLAG-tagged STK32A (unknown origin) expressed in baculovirus infected Sf9 insect cells incubated for 1 hr by TR-FRET assaykd1.5440uM
3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)-N-[2-[2-[2-[2-[[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-methylamino]ethoxy]ethoxy]ethoxy]ethyl]propanamide1526220: Binding affinity to recombinant full-length N-terminal His-FLAG-tagged STK32A (unknown origin) expressed in baculovirus infected Sf9 insect cells incubated for 1 hr by TR-FRET assaykd1.7490uM
Bosutinib624821: Binding constant for YANK1 kinase domainkd1.8000uM
(15S,16S,18R)-16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaen-3-one624821: Binding constant for YANK1 kinase domainkd2.1000uM
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one624821: Binding constant for YANK1 kinase domainkd2.3000uM
Midostaurin624821: Binding constant for YANK1 kinase domainkd2.4000uM
6-(2,6-dichlorophenyl)-8-methyl-2-(3-methylsulfanylanilino)pyrido[2,3-d]pyrimidin-7-one624821: Binding constant for YANK1 kinase domainkd2.5000uM
[4-[(E)-2-(1H-indazol-3-yl)ethenyl]phenyl]-piperazin-1-ylmethanone624821: Binding constant for YANK1 kinase domainkd4.4000uM
Vandetanib624821: Binding constant for YANK1 kinase domainkd5.0000uM
2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one624821: Binding constant for YANK1 kinase domainkd5.5000uM

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

ChemicalActions (top 5)PubMed papers
Valproic Acidaffects cotreatment, decreases expression, increases expression5
trichostatin Adecreases expression, affects cotreatment3
Benzo(a)pyrenedecreases expression, increases expression, increases methylation3
sodium arseniteincreases expression2
mercuric bromidedecreases expression, affects cotreatment2
entinostatdecreases expression, affects cotreatment2
Vorinostataffects cotreatment, decreases expression2
Panobinostataffects cotreatment, decreases expression2
Nickeldecreases expression2
Phenylmercuric Acetateaffects cotreatment, decreases expression2
Tobacco Smoke Pollutiondecreases expression, increases methylation2
p-Chloromercuribenzoic Aciddecreases expression, affects cotreatment2
methylmercuric chloridedecreases expression1
caffeic aciddecreases expression, affects cotreatment1
perfluoro-n-nonanoic acidincreases expression1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamideaffects cotreatment, decreases expression1
belinostatdecreases expression1
dorsomorphinaffects cotreatment, decreases expression1
bisphenol Sdecreases methylation1
NSC 689534affects binding, increases expression1
Zoledronic Aciddecreases expression1
Troglitazoneincreases expression1
Acetaminophenincreases expression1
Copperaffects binding, increases expression1
Diethylhexyl Phthalatedecreases expression1
N-Nitrosopyrrolidineincreases expression1
Cyclosporineincreases expression1
Thapsigarginaffects cotreatment, decreases expression1
Acrylamideincreases expression1

ChEMBL screening assays

85 unique, capped per target: 85 binding

Representative assays (with source publication via chembl_document):

Assay IDTypeDescriptionSource paper
CHEMBL1045672BindingBinding affinity to YANK1 assessed as percentage of kinase remaining bound to the bead at 1 uM by T7 phage display based binding assayStructure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4). — J Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 79

This page pulls from 79 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_assaychembl_documentchembl_moleculechembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgtopdb_interactiongwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpatent_compoundpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomerefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot