STK32C

Summary

STK32C (serine/threonine kinase 32C, HGNC:21332) is a protein-coding gene on chromosome 10q26.3, encoding Serine/threonine-protein kinase 32C (Q86UX6).

The protein encoded by this gene is a member of the serine/threonine protein kinase family. It is thought that this family member is functional in brain due to its high expression levels there. DNA methylation differences have been found in this gene in monozygotic twins that are discordant for adolescent depression. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 282974 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 79 total — 1 pathogenic
• Druggable target: yes — 1 molecules with ChEMBL bioactivity
• MANE Select transcript: NM_173575

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21332
Approved symbol	STK32C
Name	serine/threonine kinase 32C
Location	10q26.3
Locus type	gene with protein product
Status	Approved
Aliases	PKE, MGC23665, YANK3
Ensembl gene	ENSG00000165752
Ensembl biotype	protein_coding
OMIM	621308
Entrez	282974

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 8 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000298630, ENST00000368619, ENST00000368620, ENST00000368622, ENST00000456004, ENST00000462160, ENST00000858942, ENST00000916800, ENST00000956240

RefSeq mRNA: 6 — MANE Select: NM_173575 NM_001318878, NM_001318879, NM_001318880, NM_001318881, NM_001318883, NM_173575

CCDS: CCDS7666, CCDS81525, CCDS81526, CCDS81527

Canonical transcript exons

ENST00000298630 — 12 exons

Exon	Start	End
ENSE00001268023	132307572	132307950
ENSE00001610205	132225527	132225616
ENSE00001660695	132225233	132225336
ENSE00003350665	132222641	132222772
ENSE00003353212	132224407	132224523
ENSE00003373424	132226795	132226968
ENSE00003412781	132222861	132222986
ENSE00003423588	132225747	132225784
ENSE00003546748	132207492	132208151
ENSE00003627843	132209034	132209101
ENSE00003688899	132227977	132228128
ENSE00003692390	132245900	132245955

Expression profiles

Bgee: expression breadth ubiquitous, 198 present calls, max score 94.68.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.2279 / max 297.4962, expressed in 1798 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
112064	4.7037	1469
112066	4.3853	1657
112067	1.9921	1198
112063	0.8615	408
112068	0.2853	125

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	94.68	gold quality
left testis	UBERON:0004533	94.62	gold quality
anterior cingulate cortex	UBERON:0009835	93.56	gold quality
right frontal lobe	UBERON:0002810	93.30	gold quality
Brodmann (1909) area 9	UBERON:0013540	93.09	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	92.26	gold quality
prefrontal cortex	UBERON:0000451	92.05	gold quality
testis	UBERON:0000473	91.67	gold quality
caudate nucleus	UBERON:0001873	90.92	gold quality
amygdala	UBERON:0001876	90.91	gold quality
putamen	UBERON:0001874	90.75	gold quality
nucleus accumbens	UBERON:0001882	90.71	gold quality
neocortex	UBERON:0001950	90.46	gold quality
frontal cortex	UBERON:0001870	90.41	gold quality
pancreatic ductal cell	CL:0002079	90.34	silver quality
cerebral cortex	UBERON:0000956	89.26	gold quality
hypothalamus	UBERON:0001898	88.12	gold quality
forebrain	UBERON:0001890	88.11	gold quality
monocyte	CL:0000576	88.09	gold quality
leukocyte	CL:0000738	87.65	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	87.15	gold quality
middle temporal gyrus	UBERON:0002771	87.00	gold quality
brain	UBERON:0000955	86.84	gold quality
temporal lobe	UBERON:0001871	86.82	gold quality
Ammon’s horn	UBERON:0001954	86.72	gold quality
granulocyte	CL:0000094	85.26	gold quality
sperm	CL:0000019	85.21	silver quality
right hemisphere of cerebellum	UBERON:0014890	85.07	gold quality
spinal cord	UBERON:0002240	84.99	gold quality
left adrenal gland cortex	UBERON:0035825	84.92	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.29

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

13 targeting STK32C, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6508-5P	99.92	70.67	2465
HSA-MIR-8067	99.86	69.59	2260
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-6766-5P	99.68	67.70	2325
HSA-MIR-5571-5P	99.49	66.99	1764
HSA-MIR-6081	99.48	66.07	1446
HSA-MIR-7854-3P	99.08	66.26	1117
HSA-MIR-3135B	98.61	65.33	1470
HSA-MIR-4290	98.51	65.17	907
HSA-MIR-4257	97.86	68.05	1190
HSA-MIR-4660	97.79	67.44	1328
HSA-MIR-517-5P	97.13	68.43	781
HSA-MIR-6784-5P	84.56	60.91	126

Literature-anchored findings (GeneRIF, showing 1)

• Silencing of STK32C inhibited the activity of the HMGB1 pathway and regulated the expression of key genes in this pathway. (PMID:30359551)

Cross-species orthologs

8 orthologs

Organism	Symbol	Gene ID
mus_musculus	Stk32c	ENSMUSG00000015981
rattus_norvegicus	Stk32c	ENSRNOG00000006962
drosophila_melanogaster	CG32944	FBGN0052944
drosophila_melanogaster	dop	FBGN0267390
caenorhabditis_elegans		WBGENE00002192
caenorhabditis_elegans	wts-1	WBGENE00007047
caenorhabditis_elegans		WBGENE00010838
caenorhabditis_elegans		WBGENE00011992

Paralogs (13): MAST4 (ENSG00000069020), MAST2 (ENSG00000086015), MAST3 (ENSG00000099308), SGK2 (ENSG00000101049), SGK3 (ENSG00000104205), DMPK (ENSG00000104936), MAST1 (ENSG00000105613), SGK1 (ENSG00000118515), MASTL (ENSG00000120539), LATS1 (ENSG00000131023), LATS2 (ENSG00000150457), STK32B (ENSG00000152953), STK32A (ENSG00000169302)

Protein

Protein identifiers

Serine/threonine-protein kinase 32C — Q86UX6 (reviewed: Q86UX6)

Alternative names: PKE, Yet another novel kinase 3

All UniProt accessions (5): A0A0A0MRK9, A0A140VJW0, Q86UX6, H0Y349, H0Y431

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q86UX6-1	1	yes
Q86UX6-2	2

RefSeq proteins (6): NP_001305807, NP_001305808, NP_001305809, NP_001305810, NP_001305812, NP_775846* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000719	Prot_kinase_dom	Domain
IPR008271	Ser/Thr_kinase_AS	Active_site
IPR011009	Kinase-like_dom_sf	Homologous_superfamily
IPR017441	Protein_kinase_ATP_BS	Binding_site

Pfam: PF00069

Catalyzed reactions (Rhea), 2 shown:

• L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) (RHEA:17989)
• L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) (RHEA:46608)

UniProt features (19 total): sequence variant 5, modified residue 3, region of interest 3, compositionally biased region 2, binding site 2, chain 1, domain 1, splice variant 1, active site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86UX6-F1	79.95	0.59

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 216 (proton acceptor)

Ligand- & substrate-binding residues (2): 99–107; 122

Post-translational modifications (3): 10, 15, 18

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 80 (showing top): TGACATY_UNKNOWN, GOMF_PROTEIN_KINASE_ACTIVITY, GOMF_KINASE_ACTIVITY, YKACATTT_UNKNOWN, GOMF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY, DODD_NASOPHARYNGEAL_CARCINOMA_DN, GOMF_ADENYL_NUCLEOTIDE_BINDING, HMGIY_Q6, GOMF_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS, MEISSNER_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3, MIKKELSEN_MCV6_HCP_WITH_H3K27ME3, MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3, DUAN_PRDM5_TARGETS, DACH1_TARGET_GENES, FOXJ2_TARGET_GENES

GO Biological Process (2): intracellular signal transduction (GO:0035556), protein phosphorylation (GO:0006468)

GO Molecular Function (9): protein serine/threonine kinase activity (GO:0004674), ATP binding (GO:0005524), metal ion binding (GO:0046872), protein serine kinase activity (GO:0106310), nucleotide binding (GO:0000166), protein kinase activity (GO:0004672), protein binding (GO:0005515), kinase activity (GO:0016301), transferase activity (GO:0016740)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein kinase activity	2
intracellular anatomical structure	1
signal transduction	1
phosphorylation	1
protein modification process	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
cation binding	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
kinase activity	1
phosphotransferase activity, alcohol group as acceptor	1
catalytic activity, acting on a protein	1
binding	1
transferase activity, transferring phosphorus-containing groups	1
catalytic activity	1

Protein interactions and networks

STRING

832 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
STK32C	MCF2L	O15068	503
STK32C	LRRC8B	Q6P9F7	486
STK32C	CCDC144A	A2RUR9	384
STK32C	LMTK2	Q8IWU2	339
STK32C	INPP5A	Q14642	335
STK32C	CEP170B	Q9Y4F5	332
STK32C	ZNF329	Q86UD4	326
STK32C	YIPF1	Q9Y548	315
STK32C	CCDC33	Q8N5R6	309
STK32C	PPP1R21	Q6ZMI0	300
STK32C	MFSD11	O43934	295
STK32C	TMUB2	Q71RG4	295
STK32C	FAM110A	Q9BQ89	295
STK32C	NME8	Q8N427	294
STK32C	NUP210L	Q5VU65	290

IntAct

15 interactions, top by confidence:

A	B	Type	Score
HGS	STK32C	psi-mi:“MI:0915”(physical association)	0.560
STK32C	HSP90AB1	psi-mi:“MI:0915”(physical association)	0.560
STK32C	FDFT1	psi-mi:“MI:0914”(association)	0.530
YWHAE	STK32C	psi-mi:“MI:0915”(physical association)	0.400
SFN	STK32C	psi-mi:“MI:0915”(physical association)	0.400
STK32C	SHANK3	psi-mi:“MI:0915”(physical association)	0.370
STK32C	ILVBL	psi-mi:“MI:0914”(association)	0.350
PHF10	NVL	psi-mi:“MI:0914”(association)	0.350
STK32C	HAUS5	psi-mi:“MI:0914”(association)	0.350
RPRM	STK32C	psi-mi:“MI:0915”(physical association)	0.000
HGS	STK32C	psi-mi:“MI:0915”(physical association)	0.000
STK32C	GRB2	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (95): HSP90AA5P (Affinity Capture-MS), HSP90AA4P (Affinity Capture-MS), FDFT1 (Affinity Capture-MS), CDC37 (Affinity Capture-MS), MCM5 (Affinity Capture-MS), HSP90AA5P (Affinity Capture-MS), HSP90AA4P (Affinity Capture-MS), STK32C (Affinity Capture-RNA), HGS (Two-hybrid), STK32C (Two-hybrid), HSP90AA4P (Affinity Capture-MS), FDFT1 (Affinity Capture-MS), HSP90AA5P (Affinity Capture-MS), HAUS3 (Affinity Capture-MS), IQGAP3 (Affinity Capture-MS)

ESM2 similar proteins: A5PKJ4, B2DD29, B8Y466, O14976, O43781, O54781, O60307, O70551, O88831, P0C865, P33279, P78362, P97756, Q13164, Q20443, Q3U214, Q3V016, Q4R6S5, Q4R8E0, Q4V793, Q4V8A3, Q5RD27, Q5RJI5, Q641K5, Q84M93, Q86UX6, Q8C078, Q8CIP4, Q8N5S9, Q8NE63, Q8QZV4, Q8TD08, Q8TDC3, Q8VBY2, Q8WP28, Q922Y0, Q96L34, Q96RR4, Q96SB4, Q99KY4

Diamond homologs: A1Z9X0, A2VDZ4, A7MB74, A8XJQ6, A8XNJ6, B2GUY1, B4IMC3, B4NSS9, F1M7Y5, F4HPN2, F4JY37, J9W0G9, M3TYT0, O00141, O15530, O55173, O70291, O74426, O75116, O77819, P05130, P09216, P10666, P10830, P11792, P12370, P13678, P16054, P18654, P23298, P25341, P26818, P28178, P28327, P32866, P34099, P34102, P34103, P34885, P36582

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

79 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	59
Likely benign	4
Benign	5

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
1077185	Single allele	Pathogenic

SpliceAI

3919 predictions. Top by Δscore:

Variant	Effect	Δscore
10:132209029:CTCA:C	donor_gain	1.0000
10:132209031:CA:C	donor_loss	1.0000
10:132209032:A:AC	donor_gain	1.0000
10:132209033:C:CT	donor_gain	1.0000
10:132209033:CT:C	donor_gain	1.0000
10:132209033:CTTTT:C	donor_gain	1.0000
10:132209097:TTCTC:T	acceptor_gain	1.0000
10:132209099:CTC:C	acceptor_gain	1.0000
10:132209100:TC:T	acceptor_gain	1.0000
10:132209101:CC:C	acceptor_gain	1.0000
10:132209101:CCTGT:C	acceptor_loss	1.0000
10:132209102:C:CC	acceptor_gain	1.0000
10:132209103:T:G	acceptor_loss	1.0000
10:132222640:CGGA:C	donor_gain	1.0000
10:132222773:C:CC	acceptor_gain	1.0000
10:132222859:A:AC	donor_gain	1.0000
10:132222860:C:CC	donor_gain	1.0000
10:132222860:CG:C	donor_gain	1.0000
10:132222983:GGAG:G	acceptor_gain	1.0000
10:132222986:GC:G	acceptor_loss	1.0000
10:132222987:C:CC	acceptor_gain	1.0000
10:132222987:CTG:C	acceptor_loss	1.0000
10:132222988:T:A	acceptor_loss	1.0000
10:132224401:GCTCA:G	donor_loss	1.0000
10:132224402:CTCA:C	donor_loss	1.0000
10:132224403:TCA:T	donor_loss	1.0000
10:132224406:C:CG	donor_loss	1.0000
10:132224522:CT:C	acceptor_gain	1.0000
10:132225617:C:CC	acceptor_gain	1.0000
10:132226792:CACC:C	donor_loss	1.0000

AlphaMissense

3213 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:132222726:A:C	I389S	1.000
10:132222726:A:G	I389T	1.000
10:132222726:A:T	I389N	1.000
10:132222735:T:A	E386V	1.000
10:132222738:A:G	L385P	1.000
10:132222738:A:T	L385Q	1.000
10:132225265:C:A	G282W	1.000
10:132225274:A:G	W279R	1.000
10:132225274:A:T	W279R	1.000
10:132225541:G:A	T253I	1.000
10:132225544:C:T	G252D	1.000
10:132225586:G:T	A238D	1.000
10:132225591:G:C	N236K	1.000
10:132225591:G:T	N236K	1.000
10:132225597:G:C	D234E	1.000
10:132225597:G:T	D234E	1.000
10:132225598:T:A	D234V	1.000
10:132225598:T:C	D234G	1.000
10:132225598:T:G	D234A	1.000
10:132225599:C:G	D234H	1.000
10:132225616:C:T	G228E	1.000
10:132225761:A:G	L223P	1.000
10:132225766:G:C	N221K	1.000
10:132225766:G:T	N221K	1.000
10:132225775:C:A	K218N	1.000
10:132225775:C:G	K218N	1.000
10:132225777:T:C	K218E	1.000
10:132225781:A:C	D216E	1.000
10:132225781:A:T	D216E	1.000
10:132225782:T:A	D216V	1.000

dbSNP variants (sampled 300 via entrez): RS1000012358 (10:132331176 G>A), RS1000015664 (10:132236556 C>A), RS1000031320 (10:132216243 T>C), RS1000045057 (10:132330810 TA>T,TAA), RS1000065733 (10:132321055 A>G), RS1000088634 (10:132211226 G>A), RS1000128260 (10:132270116 C>G,T), RS1000170700 (10:132244309 C>T), RS1000200533 (10:132232823 G>A,C), RS1000218795 (10:132231179 G>C,T), RS1000249009 (10:132236860 G>A,T), RS1000249321 (10:132297264 T>A,C), RS1000249892 (10:132207882 C>T), RS1000290184 (10:132211738 T>C), RS1000297768 (10:132236731 C>A,T)

Disease associations

OMIM: gene MIM:621308 | disease phenotypes: MIM:609625

GenCC curated gene-disease

Mondo (1): distal 10q deletion syndrome (MONDO:0012315)

Orphanet (1): Distal deletion 10q syndrome (Orphanet:96148)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST006460_9	Bronchopulmonary dysplasia in preterm infants	3.000000e-06
GCST007325_259	General risk tolerance (MTAG)	3.000000e-09
GCST007325_9	General risk tolerance (MTAG)	7.000000e-09
GCST008181_10	Spontaneous preterm birth without premature rupture of membranes	7.000000e-06
GCST009082_1	Pneumococcal meningitis x streptococcus pneumoniae genotype cluster interaction	1.000000e-08

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0008579	risk-taking behaviour
EFO:0006917	spontaneous preterm birth
EFO:0010271	bacterial pathogen genotype measurement

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
C567182	Chromosome 10q26 Deletion Syndrome (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5405 (SINGLE PROTEIN)

Molecules with ChEMBL bioactivity

1 molecules (phase ≥1), by development phase (incl. off-target/promiscuous compounds).

Molecule	Name	Phase	Patents
CHEMBL603469	LESTAURTINIB	3

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: enzyme — YANK family

ChEMBL bioactivities

12 potent at pChembl≥5 of 12 total, top 11 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
7.26	Kd	55	nM	TAE-684
6.86	IC50	139	nM	STAUROSPORINE
6.79	IC50	162	nM	STAUROSPORINE
6.51	Kd	310	nM	STAUROSPORINE
6.49	Kd	326	nM	CHEMBL4576489
6.49	IC50	325	nM	STAUROSPORINE
6.35	Kd	448	nM	CHEMBL4465866
6.00	IC50	1000	nM	TP-030-1
6.00	IC50	1000	nM	TP-030-2
6.00	IC50	1000	nM	TP-030n
5.10	Kd	8000	nM	LESTAURTINIB

PubChem BioAssay actives

9 with measured affinity, of 262 total; 5 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
5-chloro-2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine	624734: Binding constant for YANK3 kinase domain	kd	0.0550	uM
(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one	1715156: Inhibition of human STK32C using MBP as substrate by [gamma-33P]-ATP assay	ic50	0.1390	uM
3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)-N-[2-[2-[2-[2-[[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-methylamino]ethoxy]ethoxy]ethoxy]ethyl]propanamide	1526275: Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged STK32C (unknown origin) (66 to 486 residues) expressed in baculovirus infected Sf9 insect cells incubated for 1 hr by TR-FRET assay	kd	0.3260	uM
3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)-N-[2-[2-[2-[2-[[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]propanamide	1526275: Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged STK32C (unknown origin) (66 to 486 residues) expressed in baculovirus infected Sf9 insect cells incubated for 1 hr by TR-FRET assay	kd	0.4480	uM
(15S,16S,18R)-16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaen-3-one	624734: Binding constant for YANK3 kinase domain	kd	8.0000	uM

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases expression, increases methylation	3
trichostatin A	affects cotreatment, decreases expression, affects expression	2
Valproic Acid	affects expression, increases methylation	2
bisphenol A	affects cotreatment, increases methylation, decreases methylation	1
beta-lapachone	decreases expression	1
sodium arsenite	decreases expression	1
butyraldehyde	increases expression	1
benzo(e)pyrene	increases methylation, decreases methylation	1
aflatoxin B2	decreases methylation, increases methylation	1
avobenzone	increases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	decreases expression, affects cotreatment	1
bisphenol S	decreases methylation	1
jinfukang	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Caffeine	decreases phosphorylation	1
Diethylhexyl Phthalate	decreases expression	1
Estradiol	increases expression	1
Methapyrilene	decreases methylation, increases methylation	1
Smoke	decreases expression	1
Urethane	increases expression	1
Aflatoxin B1	increases methylation	1
Asbestos, Serpentine	increases methylation	1
Asbestos, Crocidolite	increases methylation	1
Cadmium Chloride	increases expression	1
Okadaic Acid	increases expression	1
Acrylamide	increases expression	1

ChEMBL screening assays

148 unique, capped per target: 148 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL1043385	Binding	Binding affinity to human YANK3 at 500 nM by cell-based competition binding assay relative to control in presence of DTT	Staurosporine tethered peptide ligands that target cAMP-dependent protein kinase (PKA): optimization and selectivity profiling. — Bioorg Med Chem

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_TQ88	HAP1 STK32C (-) 1	Cancer cell line	Male
CVCL_TQ89	HAP1 STK32C (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.