STK4-DT

Summary

STK4-DT (STK4 divergent transcript, HGNC:43811) is a long non-coding RNA gene on chromosome 20q13.12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43811
Approved symbol	STK4-DT
Name	STK4 divergent transcript
Location	20q13.12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000227477
Ensembl biotype	lncRNA
Entrez	100505826
RNAcentral	URS000075CC20 — lncRNA, 2129 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000434401, ENST00000445571, ENST00000698217

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000434401 — 3 exons

Exon	Start	End
ENSE00001625771	44963794	44965448
ENSE00001752258	44965562	44965685
ENSE00004110658	44966117	44966461

Expression profiles

Bgee: expression breadth ubiquitous, 157 present calls, max score 82.97.

Top tissues by expression

235 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	82.97	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.28	gold quality
epithelial cell of pancreas	CL:0000083	80.56	gold quality
upper arm skin	UBERON:0004263	76.97	gold quality
pancreatic ductal cell	CL:0002079	74.46	silver quality
vena cava	UBERON:0004087	74.43	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	73.96	gold quality
ganglionic eminence	UBERON:0004023	73.93	gold quality
oocyte	CL:0000023	72.11	silver quality
thymus	UBERON:0002370	71.61	gold quality
epithelium of mammary gland	UBERON:0003244	71.27	gold quality
mammary duct	UBERON:0001765	71.14	gold quality
ventral tegmental area	UBERON:0002691	71.05	gold quality
pharyngeal mucosa	UBERON:0000355	71.02	gold quality
cardia of stomach	UBERON:0001162	70.92	gold quality
body of tongue	UBERON:0011876	70.85	gold quality
nipple	UBERON:0002030	70.83	gold quality
trachea	UBERON:0003126	70.75	gold quality
superior surface of tongue	UBERON:0007371	70.67	gold quality
tongue	UBERON:0001723	70.62	gold quality
saphenous vein	UBERON:0007318	70.58	gold quality
pons	UBERON:0000988	70.30	gold quality
secondary oocyte	CL:0000655	70.24	gold quality
pericardium	UBERON:0002407	70.24	gold quality
substantia nigra pars reticulata	UBERON:0001966	70.14	gold quality
kidney epithelium	UBERON:0004819	70.14	gold quality
lateral globus pallidus	UBERON:0002476	70.02	gold quality
lateral nuclear group of thalamus	UBERON:0002736	69.98	gold quality
pylorus	UBERON:0001166	69.91	gold quality
substantia nigra pars compacta	UBERON:0001965	69.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.78

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA STK4 antisense RNA 1 (STK4-AS1) promoted osteosarcoma by inhibiting p53 expression. (PMID:35912730)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.