STK40

Summary

STK40 (serine/threonine kinase 40, HGNC:21373) is a protein-coding gene on chromosome 1p34.3, encoding Serine/threonine-protein kinase 40 (Q8N2I9). May be a negative regulator of NF-kappa-B and p53-mediated gene transcription. It is a selective cancer dependency (DepMap: 11.0% of cell lines).

Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in regulation of MAPK cascade. Predicted to act upstream of or within several processes, including glycogen metabolic process; lung development; and respiratory system process. Located in cytosol and nucleoplasm.

Source: NCBI Gene 83931 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 77 total
• Cancer dependency (DepMap): dependent in 11.0% of screened cell lines
• MANE Select transcript: NM_001282547

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21373
Approved symbol	STK40
Name	serine/threonine kinase 40
Location	1p34.3
Locus type	gene with protein product
Status	Approved
Aliases	MGC4796, SgK495, SHIK
Ensembl gene	ENSG00000196182
Ensembl biotype	protein_coding
OMIM	609437
Entrez	83931

Gene structure

Transcript identifiers

Ensembl transcripts: 35 — 31 protein_coding, 4 protein_coding_CDS_not_defined

ENST00000359297, ENST00000373129, ENST00000373130, ENST00000373132, ENST00000460017, ENST00000460417, ENST00000473733, ENST00000482458, ENST00000852853, ENST00000852854, ENST00000852855, ENST00000852856, ENST00000852857, ENST00000852858, ENST00000852859, ENST00000852860, ENST00000852861, ENST00000852862, ENST00000852863, ENST00000852864, ENST00000852865, ENST00000852866, ENST00000852867, ENST00000852868, ENST00000936576, ENST00000956511, ENST00000956512, ENST00000956513, ENST00000956514, ENST00000956515, ENST00000956516, ENST00000956517, ENST00000956518, ENST00000956519, ENST00000956520

RefSeq mRNA: 3 — MANE Select: NM_001282547 NM_001282546, NM_001282547, NM_032017

CCDS: CCDS407, CCDS60089

Canonical transcript exons

ENST00000373132 — 11 exons

Exon	Start	End
ENSE00000000186	36339628	36341973
ENSE00000955892	36344120	36344264
ENSE00000955893	36343860	36343979
ENSE00001201134	36354364	36354416
ENSE00001201136	36355206	36355433
ENSE00001201162	36348700	36348815
ENSE00001281500	36385723	36385924
ENSE00001310889	36343364	36343448
ENSE00003512616	36358737	36358822
ENSE00003515013	36358239	36358382
ENSE00003684910	36361221	36361340

Expression profiles

Bgee: expression breadth ubiquitous, 217 present calls, max score 96.25.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 25.0407 / max 858.1368, expressed in 1812 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
11723	23.6895	1812
11721	0.7938	255
11722	0.3121	114
11720	0.1840	75
11719	0.0533	6
11718	0.0080	2

Top tissues by expression

239 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	96.25	gold quality
lower esophagus mucosa	UBERON:0035834	95.93	gold quality
muscle of leg	UBERON:0001383	95.81	gold quality
blood	UBERON:0000178	95.48	gold quality
hindlimb stylopod muscle	UBERON:0004252	95.02	gold quality
granulocyte	CL:0000094	94.82	gold quality
left testis	UBERON:0004533	94.12	gold quality
right testis	UBERON:0004534	93.85	gold quality
leukocyte	CL:0000738	93.78	gold quality
monocyte	CL:0000576	93.65	gold quality
lower esophagus	UBERON:0013473	93.40	gold quality
lower esophagus muscularis layer	UBERON:0035833	93.38	gold quality
apex of heart	UBERON:0002098	93.33	gold quality
right coronary artery	UBERON:0001625	93.27	gold quality
islet of Langerhans	UBERON:0000006	93.23	gold quality
popliteal artery	UBERON:0002250	92.97	gold quality
tibial artery	UBERON:0007610	92.96	gold quality
muscle layer of sigmoid colon	UBERON:0035805	92.69	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	92.69	gold quality
aorta	UBERON:0000947	92.56	gold quality
esophagus	UBERON:0001043	92.43	gold quality
amniotic fluid	UBERON:0000173	92.39	gold quality
testis	UBERON:0000473	92.18	gold quality
ascending aorta	UBERON:0001496	92.18	gold quality
thoracic aorta	UBERON:0001515	92.16	gold quality
heart left ventricle	UBERON:0002084	91.92	gold quality
esophagus mucosa	UBERON:0002469	91.82	gold quality
cardiac ventricle	UBERON:0002082	91.67	gold quality
right ovary	UBERON:0002118	91.62	gold quality
right atrium auricular region	UBERON:0006631	91.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	10.21

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): POU5F1

miRNA regulators (miRDB)

157 targeting STK40, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6798-5P	100.00	65.77	699
HSA-MIR-12118	100.00	65.88	1270
HSA-MIR-450A-1-3P	100.00	69.33	1837
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-3120-5P	100.00	65.56	965
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-6077	99.99	68.04	2299
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-3173-3P	99.98	66.49	1217
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-LET-7D-5P	99.96	71.76	1632
HSA-MIR-4458	99.96	71.64	1650
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 11.0% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 5)

• identification as a negative regulator of NF-kappaB- and p53-mediated gene transcription [SINK-homologous serine-threonine kinase] (PMID:13679039)
• STK40 binds the COP1 WD40 domain using a VPD/E motif in its C-terminal tail. (PMID:28089446)
• STK40 and LATS2 are conserved miR-31 target genes that have roles in regulation of keratinocyte growth and hair follicle biology (PMID:28419554)
• Construction and validation of a novel senescence-related risk score can help predict the prognosis and tumor microenvironment of gastric cancer patients and determine that STK40 can affect the ROS accumulation and proliferation ability of gastric cancer cells. (PMID:37915566)
• STK40 inhibits trophoblast fusion by mediating COP1 ubiquitination to degrade P57[Kip2]. (PMID:39304928)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	stk40	ENSDARG00000098135
mus_musculus	Stk40	ENSMUSG00000042608
rattus_norvegicus	Stk40	ENSRNOG00000025679
drosophila_melanogaster	trbl	FBGN0028978

Paralogs (3): TRIB2 (ENSG00000071575), TRIB3 (ENSG00000101255), TRIB1 (ENSG00000173334)

Protein

Protein identifiers

Serine/threonine-protein kinase 40 — Q8N2I9 (reviewed: Q8N2I9)

Alternative names: SINK-homologous serine/threonine-protein kinase, Sugen kinase 495

All UniProt accessions (1): Q8N2I9

UniProt curated annotations — full annotation on UniProt →

Function. May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.

Subcellular location. Nucleus. Cytoplasm.

Tissue specificity. Strongly expressed in heart, brain, placenta, lung, skeletal muscle, kidney, spleen, thymus, prostate, liver, pancreas, testis, ovary, small intestine, colon and peripheral blood leukocytes.

Similarity. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q8N2I9-1	1	yes
Q8N2I9-2	2
Q8N2I9-3	3
Q8N2I9-4	4

RefSeq proteins (3): NP_001269475, NP_001269476, NP_114406 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000719	Prot_kinase_dom	Domain
IPR008271	Ser/Thr_kinase_AS	Active_site
IPR011009	Kinase-like_dom_sf	Homologous_superfamily
IPR024104	Tribbles/Ser_Thr_kinase_40	Family
IPR024236	Ser/Thr_kinase_40	Family

Pfam: PF00069

Catalyzed reactions (Rhea), 2 shown:

• L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) (RHEA:17989)
• L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) (RHEA:46608)

UniProt features (42 total): helix 11, strand 10, splice variant 5, sequence variant 4, turn 3, sequence conflict 2, binding site 2, chain 1, domain 1, region of interest 1, compositionally biased region 1, active site 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
5L2Q	X-RAY DIFFRACTION	2.53

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N2I9-F1	78.26	0.57

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 196 (proton acceptor)

Ligand- & substrate-binding residues (2): 41–49; 66

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 265 (showing top): GOBP_RESPIRATORY_GASEOUS_EXCHANGE_BY_RESPIRATORY_SYSTEM, MYOGENIN_Q6, PEREZ_TP63_TARGETS, GOBP_GROWTH, GOBP_LUNG_MORPHOGENESIS, GOBP_RESPIRATORY_SYSTEM_PROCESS, GOBP_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY, CEBP_Q2, GOBP_ANIMAL_ORGAN_MORPHOGENESIS, HEN1_01, chr1p34, GOBP_MULTICELLULAR_ORGANISM_GROWTH, GOBP_CARBOHYDRATE_METABOLIC_PROCESS, TGANTCA_AP1_C, LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN

GO Biological Process (10): respiratory system process (GO:0003016), glycogen metabolic process (GO:0005977), regulation of gene expression (GO:0010468), multicellular organism growth (GO:0035264), negative regulation of apoptotic process (GO:0043066), regulation of MAPK cascade (GO:0043408), lung alveolus development (GO:0048286), lung morphogenesis (GO:0060425), protein phosphorylation (GO:0006468), lung development (GO:0030324)

GO Molecular Function (8): protein serine/threonine kinase activity (GO:0004674), ATP binding (GO:0005524), protein serine kinase activity (GO:0106310), nucleotide binding (GO:0000166), protein kinase activity (GO:0004672), protein binding (GO:0005515), kinase activity (GO:0016301), transferase activity (GO:0016740)

GO Cellular Component (4): nucleoplasm (GO:0005654), cytosol (GO:0005829), nucleus (GO:0005634), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
lung development	2
protein kinase activity	2
system process	1
respiratory gaseous exchange by respiratory system	1
energy reserve metabolic process	1
glucan metabolic process	1
gene expression	1
regulation of macromolecule biosynthetic process	1
multicellular organismal process	1
developmental growth	1
apoptotic process	1
regulation of apoptotic process	1
negative regulation of programmed cell death	1
MAPK cascade	1
regulation of intracellular signal transduction	1
anatomical structure development	1
animal organ morphogenesis	1
phosphorylation	1
protein modification process	1
respiratory tube development	1
animal organ development	1
respiratory system development	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
kinase activity	1
phosphotransferase activity, alcohol group as acceptor	1
catalytic activity, acting on a protein	1
binding	1
transferase activity, transferring phosphorus-containing groups	1
catalytic activity	1
nuclear lumen	1
cytoplasm	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1381 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
STK40	RIBC2	Q9H4K1	490
STK40	PPP6C	O00743	473
STK40	RCN2	Q14257	464
STK40	OSCP1	Q8WVF1	432
STK40	MRPS15	P82914	427
STK40	VAC14	Q08AM6	416
STK40	STRADA	Q7RTN6	401
STK40	KPNA6	O60684	398
STK40	PSMD3	O43242	390
STK40	MAST2	Q6P0Q8	389
STK40	USP33	Q8TEY7	389
STK40	VRK3	Q8IV63	389
STK40	DNAJB4	Q9UDY4	387
STK40	CTC1	Q2NKJ3	383
STK40	PDIK1L	Q8N165	381

IntAct

60 interactions, top by confidence:

A	B	Type	Score
FOS	JUN	psi-mi:“MI:0914”(association)	0.980
FOSL2	JUN	psi-mi:“MI:0914”(association)	0.930
ATF6	ATF6	psi-mi:“MI:0914”(association)	0.790
STK40	TRIB1	psi-mi:“MI:0915”(physical association)	0.740
FOSB	JUN	psi-mi:“MI:0914”(association)	0.690
TRIB3	STK40	psi-mi:“MI:0914”(association)	0.640
STK40	SLIRP	psi-mi:“MI:0915”(physical association)	0.560
TRIB2	POTEF	psi-mi:“MI:0914”(association)	0.530
ZNF397	ZNF197	psi-mi:“MI:0914”(association)	0.530
FOSL2	ZZEF1	psi-mi:“MI:0914”(association)	0.530
ETV5	DET1	psi-mi:“MI:0914”(association)	0.530
FOS	YEATS4	psi-mi:“MI:0914”(association)	0.530
DET1	UBE2E1	psi-mi:“MI:0914”(association)	0.530
NFIL3	STK40	psi-mi:“MI:0914”(association)	0.530
STK40	COP1	psi-mi:“MI:0914”(association)	0.530
TRIB2	UBE2E1	psi-mi:“MI:0914”(association)	0.530
Ogn	STK40	psi-mi:“MI:0407”(direct interaction)	0.440
STK40	LRRK2	psi-mi:“MI:0407”(direct interaction)	0.440
Ufl1	PRSS1	psi-mi:“MI:0914”(association)	0.350
FOS	TRAPPC13	psi-mi:“MI:0914”(association)	0.350
JUN		psi-mi:“MI:0914”(association)	0.350
SNX11	CHEK1	psi-mi:“MI:0914”(association)	0.350
JUNB	PPP1R12A	psi-mi:“MI:0914”(association)	0.350

BioGRID (102): STK40 (Affinity Capture-RNA), STK40 (Affinity Capture-MS), STK40 (Affinity Capture-MS), STK40 (Affinity Capture-MS), STK40 (Affinity Capture-MS), STK40 (Affinity Capture-MS), STK40 (Affinity Capture-MS), RFWD2 (Affinity Capture-MS), TRIB1 (Affinity Capture-MS), STK40 (Affinity Capture-MS), STK40 (Affinity Capture-MS), STK40 (Co-fractionation), STK40 (Affinity Capture-MS), STK40 (Affinity Capture-MS), STK40 (Affinity Capture-MS)

ESM2 similar proteins: A2AJ88, B3MRI9, B3NY03, B4H3U8, B4IL64, B4JLX2, B4L535, B4M709, B4N1W9, B4Q0P3, B5DKS8, D3ZEF4, O08703, O08962, O35219, O54853, P25848, P59111, P97414, Q02331, Q12809, Q14999, Q17QV9, Q21534, Q3TRM4, Q5BK26, Q5R667, Q5RCJ3, Q5RDS0, Q5TEA3, Q67E00, Q67E01, Q6CF18, Q6ZV29, Q7TNL3, Q7TT23, Q8IY17, Q8N2I9, Q8RY24, Q8VE73

Diamond homologs: A2X6X1, A5A7I8, A8WRV1, F1MH24, F1SPM8, F4I4F2, G5ECQ3, O13839, O14976, O34507, O43066, O75716, O77676, O88697, P00516, P00517, P05130, P05132, P0C1X8, P0C605, P17157, P17612, P17948, P25321, P31374, P32023, P33981, P34100, P34331, P35761, P35916, P35917, P35969, P38070, P38080, P40494, P53767, P53974, P54119, P57760

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
STK40	“down-regulates quantity by destabilization”	CEBPB	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 55 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
NGF-stimulated transcription	6	51.9×	3e-07

GO biological processes:

GO term	Partners	Fold	FDR
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	6	26.3×	5e-05
response to xenobiotic stimulus	6	8.6×	5e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

77 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	55
Likely benign	5
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

2124 predictions. Top by Δscore:

Variant	Effect	Δscore
1:36341969:TTCGC:T	acceptor_gain	1.0000
1:36341970:TCGC:T	acceptor_gain	1.0000
1:36341971:CGC:C	acceptor_gain	1.0000
1:36341971:CGCC:C	acceptor_gain	1.0000
1:36341974:C:CC	acceptor_gain	1.0000
1:36341975:T:C	acceptor_gain	1.0000
1:36341976:T:C	acceptor_gain	1.0000
1:36341976:T:TC	acceptor_gain	1.0000
1:36341982:C:CT	acceptor_gain	1.0000
1:36341983:G:T	acceptor_gain	1.0000
1:36341990:G:C	acceptor_gain	1.0000
1:36341990:G:GC	acceptor_gain	1.0000
1:36343362:ACCT:A	donor_gain	1.0000
1:36343363:CCTC:C	donor_gain	1.0000
1:36343445:CTGC:C	acceptor_gain	1.0000
1:36343449:C:CC	acceptor_gain	1.0000
1:36343855:CTTA:C	donor_loss	1.0000
1:36343856:TTACC:T	donor_loss	1.0000
1:36343857:TAC:T	donor_loss	1.0000
1:36343858:A:AC	donor_gain	1.0000
1:36343858:AC:A	donor_gain	1.0000
1:36343859:C:CG	donor_gain	1.0000
1:36343859:CC:C	donor_gain	1.0000
1:36343859:CCA:C	donor_gain	1.0000
1:36343859:CCAT:C	donor_gain	1.0000
1:36343859:CCATG:C	donor_gain	1.0000
1:36343975:CATCC:C	acceptor_gain	1.0000
1:36343977:TCC:T	acceptor_gain	1.0000
1:36343978:CC:C	acceptor_gain	1.0000
1:36343978:CCC:C	acceptor_gain	1.0000

AlphaMissense

2855 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:36343912:G:T	R318S	1.000
1:36343932:A:G	L311P	1.000
1:36343935:A:G	L310P	1.000
1:36343944:A:T	I307N	1.000
1:36344147:A:C	I286S	1.000
1:36344147:A:G	I286T	1.000
1:36344147:A:T	I286N	1.000
1:36344148:T:A	I286F	1.000
1:36344155:G:C	F283L	1.000
1:36344155:G:T	F283L	1.000
1:36344156:A:G	F283S	1.000
1:36344157:A:C	F283V	1.000
1:36344157:A:G	F283L	1.000
1:36344159:A:G	L282P	1.000
1:36344159:A:T	L282H	1.000
1:36344182:G:C	F274L	1.000
1:36344182:G:T	F274L	1.000
1:36344183:A:C	F274C	1.000
1:36344183:A:G	F274S	1.000
1:36344184:A:C	F274V	1.000
1:36344184:A:G	F274L	1.000
1:36344184:A:T	F274I	1.000
1:36344186:G:C	P273R	1.000
1:36344186:G:T	P273H	1.000
1:36344187:G:A	P273S	1.000
1:36344187:G:T	P273T	1.000
1:36344188:G:C	F272L	1.000
1:36344188:G:T	F272L	1.000
1:36344189:A:C	F272C	1.000
1:36344189:A:G	F272S	1.000

dbSNP variants (sampled 300 via entrez): RS1000000046 (1:36363692 G>A,T), RS1000126281 (1:36340985 C>A), RS1000132124 (1:36377467 A>C,T), RS1000289634 (1:36368992 T>A,C), RS1000427288 (1:36386272 G>A), RS1000483559 (1:36342466 A>C,G), RS1000498770 (1:36380599 G>A,C), RS1000558766 (1:36342207 CAG>C), RS1000929891 (1:36359134 T>C), RS1001014279 (1:36375594 C>T), RS1001059302 (1:36386579 C>G), RS1001087790 (1:36375911 A>C), RS1001166235 (1:36363062 C>T), RS1001246000 (1:36356715 T>A,G), RS1001402478 (1:36365078 G>A,C)

Disease associations

OMIM: gene MIM:609437 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST90002398_48	Neutrophil count	1.000000e-09

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004833	neutrophil count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: enzyme — CAMK-unique family

CTD chemical–gene interactions

40 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cyclosporine	increases expression	3
sodium arsenite	affects cotreatment, increases abundance, increases expression	2
potassium chromate(VI)	increases expression, affects cotreatment, decreases expression	2
Arsenic	affects methylation, affects cotreatment, increases abundance, increases expression	2
methylmercuric chloride	increases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	affects expression	1
beta-lapachone	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
hydroquinone	increases expression	1
beta-methylcholine	affects expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
chromium hexavalent ion	affects expression	1
CGP 52608	affects binding, increases reaction	1
entinostat	decreases expression	1
abrine	increases expression	1
PCI 5002	affects cotreatment, increases expression	1
NSC668394	increases expression	1
Temozolomide	decreases expression	1
Sunitinib	increases expression	1
Zoledronic Acid	decreases expression	1
Acetaminophen	increases expression	1
Air Pollutants	affects expression, increases abundance	1
Benzene	increases expression	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Carbamazepine	affects expression	1
Doxorubicin	decreases expression	1
Manganese	affects cotreatment, increases abundance, increases expression	1
Ozone	affects expression, increases abundance	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2HS	Abcam HeLa STK40 KO	Cancer cell line	Female
CVCL_TQ97	HAP1 STK40 (-)	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.