STMN3

Summary

STMN3 (stathmin 3, HGNC:15926) is a protein-coding gene on chromosome 20q13.33, encoding Stathmin-3 (Q9NZ72). Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.

This gene encodes a protein which is a member of the stathmin protein family. Members of this protein family form a complex with tubulins at a ratio of 2 tubulins for each stathmin protein. Microtubules require the ordered assembly of alpha- and beta-tubulins, and formation of a complex with stathmin disrupts microtubule formation and function. A pseudogene of this gene is located on chromosome 22. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 50861 — RefSeq curated summary.

At a glance

• GWAS associations: 10
• Clinical variants (ClinVar): 26 total
• MANE Select transcript: NM_015894

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15926
Approved symbol	STMN3
Name	stathmin 3
Location	20q13.33
Locus type	gene with protein product
Status	Approved
Aliases	SCLIP
Ensembl gene	ENSG00000197457
Ensembl biotype	protein_coding
OMIM	608362
Entrez	50861

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 protein_coding

ENST00000370053, ENST00000540534, ENST00000631920, ENST00000632676, ENST00000634126, ENST00000860150, ENST00000860151, ENST00000940055, ENST00000953346

RefSeq mRNA: 2 — MANE Select: NM_015894 NM_001276310, NM_015894

CCDS: CCDS13529, CCDS63330

Canonical transcript exons

ENST00000370053 — 5 exons

Exon	Start	End
ENSE00001451631	63639712	63641397
ENSE00001451639	63653327	63653424
ENSE00001762902	63642108	63642299
ENSE00003685717	63644214	63644309
ENSE00003787918	63643756	63643931

Expression profiles

Bgee: expression breadth ubiquitous, 230 present calls, max score 99.59.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 59.7891 / max 1604.5738, expressed in 1571 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
188401	48.1160	1517
188402	6.6874	1195
188400	3.8332	1015
188396	0.3878	84
188395	0.2775	66
188404	0.2750	136
188403	0.1387	81
188394	0.0736	41

Top tissues by expression

279 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pons	UBERON:0000988	99.59	gold quality
right frontal lobe	UBERON:0002810	99.24	gold quality
middle temporal gyrus	UBERON:0002771	99.15	gold quality
Brodmann (1909) area 23	UBERON:0013554	99.15	gold quality
right hemisphere of cerebellum	UBERON:0014890	99.14	gold quality
lateral nuclear group of thalamus	UBERON:0002736	99.12	gold quality
endothelial cell	CL:0000115	99.07	gold quality
cerebellar hemisphere	UBERON:0002245	99.06	gold quality
cerebellar cortex	UBERON:0002129	99.05	gold quality
primary visual cortex	UBERON:0002436	99.00	gold quality
anterior cingulate cortex	UBERON:0009835	98.97	gold quality
superior vestibular nucleus	UBERON:0007227	98.95	gold quality
nucleus accumbens	UBERON:0001882	98.87	gold quality
entorhinal cortex	UBERON:0002728	98.80	gold quality
cingulate cortex	UBERON:0003027	98.77	gold quality
parietal lobe	UBERON:0001872	98.71	gold quality
cerebellar vermis	UBERON:0004720	98.67	gold quality
postcentral gyrus	UBERON:0002581	98.63	gold quality
temporal lobe	UBERON:0001871	98.50	gold quality
caudate nucleus	UBERON:0001873	98.41	gold quality
substantia nigra pars compacta	UBERON:0001965	98.41	gold quality
ventral tegmental area	UBERON:0002691	98.38	gold quality
lateral globus pallidus	UBERON:0002476	98.35	gold quality
amygdala	UBERON:0001876	98.31	gold quality
prefrontal cortex	UBERON:0000451	98.29	gold quality
dorsal root ganglion	UBERON:0000044	98.15	gold quality
cerebellum	UBERON:0002037	98.08	gold quality
substantia nigra pars reticulata	UBERON:0001966	97.91	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	97.89	gold quality
neocortex	UBERON:0001950	97.87	gold quality

Single-cell (SCXA)

Detected in 6 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-MTAB-7316	yes	14.64
E-HCAD-25	yes	9.41
E-HCAD-10	yes	4.93
E-ANND-3	yes	4.03
E-GEOD-36552	no	216.38
E-GEOD-110499	no	28.32

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

36 targeting STMN3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-4525	99.94	64.38	675
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-579-3P	99.86	71.66	3628
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-664B-3P	99.84	71.65	3590
HSA-MIR-4319	99.76	69.83	2586
HSA-MIR-6763-5P	99.76	64.68	1767
HSA-MIR-92A-2-5P	99.75	67.01	2164
HSA-MIR-1255A	99.74	68.09	744
HSA-MIR-1255B-5P	99.74	68.16	741
HSA-MIR-4472	99.56	66.08	1478
HSA-MIR-4489	99.50	65.56	785
HSA-MIR-1275	99.47	67.90	2749
HSA-MIR-6722-3P	99.45	67.62	1919
HSA-MIR-302A-5P	99.39	68.21	1913
HSA-MIR-6853-3P	99.36	70.79	1558
HSA-MIR-4292	99.16	65.57	1767
HSA-MIR-6791-5P	99.16	65.92	1844
HSA-MIR-1909-3P	99.03	66.56	1662
HSA-MIR-6769B-5P	98.73	64.91	1092
HSA-MIR-6776-5P	98.54	67.43	1304
HSA-MIR-4305	97.94	68.63	533

Literature-anchored findings (GeneRIF, showing 8)

• The substantial expression of SCLIP in most tissues points out a novel function outside the nervous system and raises the possibility that its coexpression with stathmin could provide some degree of functional redundancy. (PMID:12676564)
• SCLIP and SCG10 were colocalized to the Golgi apparatus of chromaffin cells in vivo and shared localization with CHGA as it transited the Golgi. (PMID:18549247)
• Studies suggest that a STAT3-SCLIP interaction is required to preserve SCLIP stability and contributes to the maintenance of normal epithelial morphology. (PMID:19824884)
• Specific serine-proline phosphorylation and glycogen synthase kinase 3beta-directed subcellular targeting of stathmin 3/Sclip in neurons (PMID:22577147)
• We found that reduced expression and possibly posttranslational modification of SCLIP following paclitaxel treatment impaired the microtubule-destabilizing effect of SCLIP (PMID:23543364)
• STMN and SCG10 are similarly targeted by JNK but there are clear differences in JNK recognition and phosphorylation of the closely related family member, SCLIP. (PMID:24589734)
• Overexpression of ID1 in two different cell lines induced STMN3 and GSPT1 at the transcriptional level, while depletion of ID1 reduced their expression. (PMID:25028095)
• our findings demonstrate that SCLIP plays an important role in glioma pathology, and may represent a novel therapeutic strategy against human glioma. (PMID:25511414)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	stmn3	ENSDARG00000038465
mus_musculus	Stmn3	ENSMUSG00000027581
rattus_norvegicus	Stmn3	ENSRNOG00000013657
drosophila_melanogaster	stai	FBGN0266521

Paralogs (4): STMN4 (ENSG00000015592), STMN2 (ENSG00000104435), STMN1 (ENSG00000117632), STMND1 (ENSG00000230873)

Protein

Protein identifiers

Stathmin-3 — Q9NZ72 (reviewed: Q9NZ72)

Alternative names: SCG10-like protein

All UniProt accessions (3): A0A0J9YW36, A0A0J9YXY4, Q9NZ72

UniProt curated annotations — full annotation on UniProt →

Function. Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.

Subunit / interactions. Interacts with STAT3. Interacts with CLU (secreted form); this interaction may act as an important modulator during neuronal differentiation.

Subcellular location. Golgi apparatus. Cell projection. Growth cone. Axon. Cytoplasm. Cytosol.

Tissue specificity. Neuron specific.

Post-translational modifications. N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15.

Similarity. Belongs to the stathmin family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9NZ72-1	1	yes
Q9NZ72-2	2

RefSeq proteins (2): NP_001263239, NP_056978* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000956	Stathmin_fam	Family
IPR030514	Stathmin_CS	Conserved_site
IPR036002	Stathmin_sf	Homologous_superfamily

Pfam: PF00836

UniProt features (16 total): modified residue 7, lipid moiety-binding region 2, chain 1, domain 1, splice variant 1, sequence conflict 1, region of interest 1, coiled-coil region 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NZ72-F1	85.85	0.61

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (9): 73, 81, 22, 24, 50, 60, 65, 68, 72

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 219 (showing top): GOBP_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING, GOBP_CYTOPLASMIC_MICROTUBULE_ORGANIZATION, GOBP_REGULATION_OF_MICROTUBULE_BASED_PROCESS, STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, GOZGIT_ESR1_TARGETS_DN, GOBP_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION, GOBP_NEUROGENESIS, GOBP_NEGATIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION, GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION, MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_DN, GOBP_REGULATION_OF_CELL_PROJECTION_ORGANIZATION, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1, GOBP_IN_UTERO_EMBRYONIC_DEVELOPMENT, GOBP_MICROTUBULE_DEPOLYMERIZATION

GO Biological Process (9): blastocyst hatching (GO:0001835), microtubule depolymerization (GO:0007019), nervous system development (GO:0007399), negative regulation of neuron projection development (GO:0010977), regulation of microtubule polymerization or depolymerization (GO:0031110), cytoplasmic microtubule organization (GO:0031122), neuron projection development (GO:0031175), negative regulation of Rac protein signal transduction (GO:0035021), regulation of cytoskeleton organization (GO:0051493)

GO Molecular Function (3): tubulin binding (GO:0015631), protein domain specific binding (GO:0019904), protein binding (GO:0005515)

GO Cellular Component (7): cytoplasm (GO:0005737), Golgi apparatus (GO:0005794), cytosol (GO:0005829), growth cone (GO:0030426), neuron projection (GO:0043005), axon (GO:0030424), cell projection (GO:0042995)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
microtubule polymerization or depolymerization	2
supramolecular fiber organization	2
cytoplasm	2
blastocyst development	1
hatching	1
protein depolymerization	1
system development	1
regulation of neuron projection development	1
neuron projection development	1
negative regulation of cell projection organization	1
regulation of microtubule cytoskeleton organization	1
microtubule cytoskeleton organization	1
neuron development	1
plasma membrane bounded cell projection organization	1
Rac protein signal transduction	1
regulation of Rac protein signal transduction	1
negative regulation of small GTPase mediated signal transduction	1
cytoskeleton organization	1
regulation of organelle organization	1
cytoskeletal protein binding	1
protein binding	1
binding	1
intracellular anatomical structure	1
endomembrane system	1
intracellular membrane-bounded organelle	1
site of polarized growth	1
distal axon	1
plasma membrane bounded cell projection	1
neuron projection	1

Protein interactions and networks

STRING

1980 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
STMN3	ZGPAT	Q8N5A5	523
STMN3	GMEB2	Q9UKD1	515
STMN3	C2orf80	Q0P641	498
STMN3	ARFRP1	Q13795	472
STMN3	LIME1	Q9H400	431
STMN3	FNDC11	Q9BVV2	418
STMN3	SLC2A4RG	Q9NR83	385
STMN3	GNG3	P29798	380
STMN3	RTEL1	Q9NZ71	374
STMN3	HOXA2	O43364	372
STMN3	LRPAP1	P30533	370
STMN3	TMEM239	Q8WW34	360
STMN3	ARPC3	O15145	352
STMN3	SV2A	Q7L0J3	351
STMN3	SLC1A2	P43004	350

IntAct

94 interactions, top by confidence:

A	B	Type	Score
UBA7	ISG15	psi-mi:“MI:0914”(association)	0.890
PKN1	STMN3	psi-mi:“MI:0915”(physical association)	0.560
CTNNA3	STMN3	psi-mi:“MI:0915”(physical association)	0.560
ENKD1	STMN3	psi-mi:“MI:0915”(physical association)	0.560
KRT34	STMN3	psi-mi:“MI:0915”(physical association)	0.560
MIPOL1	STMN3	psi-mi:“MI:0915”(physical association)	0.560
STMN3	CTNNA3	psi-mi:“MI:0915”(physical association)	0.560
CARD9	STMN3	psi-mi:“MI:0915”(physical association)	0.560
HGS	STMN3	psi-mi:“MI:0915”(physical association)	0.560
STMN3	ANKRD11	psi-mi:“MI:0915”(physical association)	0.560
SMARCD1	STMN3	psi-mi:“MI:0915”(physical association)	0.560
TRIM69	STMN3	psi-mi:“MI:0915”(physical association)	0.560
TXLNB	STMN3	psi-mi:“MI:0915”(physical association)	0.560
KAT5	STMN3	psi-mi:“MI:0915”(physical association)	0.560
POLR1C	STMN3	psi-mi:“MI:0915”(physical association)	0.560
GPANK1	STMN3	psi-mi:“MI:0915”(physical association)	0.560
KIFC3	STMN3	psi-mi:“MI:0915”(physical association)	0.560
AIRIM	STMN3	psi-mi:“MI:0915”(physical association)	0.560
PLEKHA7	STMN3	psi-mi:“MI:0915”(physical association)	0.560
ZNF76	STMN3	psi-mi:“MI:0915”(physical association)	0.560
MKRN3	STMN3	psi-mi:“MI:0915”(physical association)	0.560
EXOC8	STMN3	psi-mi:“MI:0915”(physical association)	0.560
P4HA3	STMN3	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (48): STMN3 (Two-hybrid), TRPC5 (Reconstituted Complex), STMN3 (Affinity Capture-RNA), STMN3 (Two-hybrid), STMN3 (Two-hybrid), STMN3 (Two-hybrid), STMN3 (Two-hybrid), STMN3 (Two-hybrid), STMN3 (Two-hybrid), STMN3 (Two-hybrid), STMN3 (Two-hybrid), STMN3 (Two-hybrid), STMN3 (Two-hybrid), STMN3 (Two-hybrid), STMN3 (Two-hybrid)

ESM2 similar proteins: A0A088MLT8, A2AQ19, A4FV29, A4IFK9, B3KU38, O14795, O70166, O93388, O95983, P21818, P31395, P50751, P54227, P55821, P63042, P63043, Q09001, Q09002, Q09004, Q09006, Q2KJ58, Q32L68, Q4KUS2, Q4R4N5, Q5F3L9, Q5FVJ5, Q5PSV4, Q5R4C5, Q5R562, Q5R8C6, Q5RAD5, Q62768, Q6GQB5, Q8IVM0, Q8IW50, Q8TBN0, Q8VDV3, Q90987, Q92541, Q93045

Diamond homologs: A4IFK9, A9YWH3, O70166, O93388, P13668, P16949, P21818, P31395, P54227, P55821, P63042, P63043, Q09001, Q09002, Q09004, Q09005, Q09006, Q3T0C7, Q4R4N5, Q4R712, Q5R4C5, Q5R8C6, Q6DUB7, Q90987, Q93045, Q9H169, Q9JHU6, Q9NZ72

SIGNOR signaling

6 interactions.

A	Effect	B	Mechanism
GSK3B	“up-regulates activity”	STMN3	phosphorylation
GSK3A	“up-regulates activity”	STMN3	phosphorylation
CDK5	unknown	STMN3	phosphorylation
MAPK1	unknown	STMN3	phosphorylation
STMN3	“down-regulates quantity by destabilization”	Microtubule_polimerization	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

26 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	22
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

793 predictions. Top by Δscore:

Variant	Effect	Δscore
20:63643749:T:TA	donor_gain	1.0000
20:63643758:T:TA	donor_gain	1.0000
20:63643927:CATGT:C	acceptor_gain	1.0000
20:63643929:TGT:T	acceptor_gain	1.0000
20:63643930:GT:G	acceptor_gain	1.0000
20:63643931:TC:T	acceptor_loss	1.0000
20:63643932:C:CC	acceptor_gain	1.0000
20:63644212:AC:A	donor_gain	1.0000
20:63644212:ACC:A	donor_gain	1.0000
20:63644212:ACCC:A	donor_gain	1.0000
20:63644213:CC:C	donor_gain	1.0000
20:63644213:CCC:C	donor_gain	1.0000
20:63644213:CCCC:C	donor_gain	1.0000
20:63644305:GTAGG:G	acceptor_gain	1.0000
20:63644306:TAGG:T	acceptor_gain	1.0000
20:63644310:C:CC	acceptor_gain	1.0000
20:63642296:GCGT:G	acceptor_gain	0.9900
20:63642297:CGT:C	acceptor_gain	0.9900
20:63642297:CGTC:C	acceptor_gain	0.9900
20:63642300:C:CC	acceptor_gain	0.9900
20:63642300:C:CG	acceptor_loss	0.9900
20:63643928:ATGT:A	acceptor_gain	0.9900
20:63644207:CACT:C	donor_loss	0.9900
20:63644208:ACTC:A	donor_loss	0.9900
20:63644209:CTCA:C	donor_loss	0.9900
20:63644210:TCAC:T	donor_loss	0.9900
20:63644211:C:CG	donor_loss	0.9900
20:63644212:A:AC	donor_gain	0.9900
20:63644212:A:C	donor_loss	0.9900
20:63644213:C:A	donor_loss	0.9900

AlphaMissense

1173 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
20:63643885:G:C	F54L	0.999
20:63643885:G:T	F54L	0.999
20:63643887:A:G	F54L	0.999
20:63642146:C:G	A149P	0.998
20:63642184:A:G	L136P	0.998
20:63643759:C:A	R96S	0.998
20:63643759:C:G	R96S	0.998
20:63643763:C:G	R95P	0.998
20:63641375:C:G	R169P	0.997
20:63642118:A:G	L158P	0.997
20:63643773:C:G	A92P	0.997
20:63643886:A:G	F54S	0.997
20:63642121:C:G	R157P	0.996
20:63642134:C:G	A153P	0.996
20:63642151:C:G	R147P	0.996
20:63642197:C:G	A132P	0.996
20:63643880:A:T	V56D	0.996
20:63643895:C:T	G51D	0.996
20:63642130:A:G	L154P	0.995
20:63642139:A:G	L151P	0.995
20:63642259:C:G	R111P	0.995
20:63643760:C:G	R96T	0.995
20:63644265:A:G	C22R	0.994
20:63641376:G:T	R169S	0.993
20:63643874:A:G	L58P	0.993
20:63644259:A:G	C24R	0.993
20:63641388:C:G	A165P	0.992
20:63642230:C:G	A121P	0.992
20:63642269:C:G	A108P	0.992
20:63642271:A:G	L107P	0.992

dbSNP variants (sampled 300 via entrez): RS1000121665 (20:63639726 G>A), RS1000320928 (20:63653432 A>G), RS1000440240 (20:63651561 G>A,C), RS1000567247 (20:63644729 A>T), RS1000619377 (20:63649803 T>A,C,G), RS1000720345 (20:63650065 T>A), RS1000915752 (20:63646079 C>T), RS1000970154 (20:63652610 G>A), RS1001131006 (20:63639350 C>A,G), RS1001397739 (20:63655384 T>C), RS1001540286 (20:63650579 A>C,G), RS1001616076 (20:63647115 C>T), RS1001838230 (20:63649336 C>T), RS1001949441 (20:63649686 A>G), RS1002111843 (20:63655288 CAT>C)

Disease associations

OMIM: gene MIM:608362 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

10 associations (top):

Study	Trait	p-value
GCST000964_24	Ulcerative colitis	2.000000e-10
GCST001942_22	Prostate cancer	4.000000e-16
GCST004131_34	Inflammatory bowel disease	3.000000e-26
GCST004132_110	Crohn’s disease	3.000000e-13
GCST004133_15	Ulcerative colitis	9.000000e-17
GCST007563_15	Allergic disease (asthma, hay fever or eczema)	3.000000e-08
GCST007564_6	Asthma or allergic disease (pleiotropy)	3.000000e-10
GCST009856_12	Leukocyte telomere length	6.000000e-14
GCST010002_71	Refractive error	1.000000e-14
GCST90002390_678	Mean corpuscular hemoglobin	1.000000e-15

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004527	mean corpuscular hemoglobin

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

39 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases expression, increases methylation	4
sodium arsenite	decreases expression, increases expression	3
Tobacco Smoke Pollution	decreases expression	2
Cyclosporine	decreases expression	2
Particulate Matter	increases abundance, affects cotreatment, decreases expression	2
pirinixic acid	affects binding, decreases expression, increases activity	1
bisphenol A	affects expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
butyraldehyde	increases expression	1
tobacco tar	decreases expression	1
pentanal	increases expression	1
CGP 52608	affects binding, increases reaction	1
jinfukang	increases expression, affects cotreatment	1
NSC 689534	decreases expression, affects binding	1
Temozolomide	increases expression	1
Sunitinib	decreases expression	1
Acetaminophen	affects expression	1
Air Pollutants	decreases expression, increases abundance	1
Arsenic	affects methylation	1
Atrazine	decreases expression	1
Benzo(a)pyrene	increases methylation, decreases methylation	1
Cisplatin	increases expression, affects cotreatment	1
Copper	decreases expression, affects binding	1
Cyclophosphamide	increases expression	1
Dactinomycin	increases expression	1
Doxorubicin	decreases expression	1
Estradiol	decreases expression, affects cotreatment	1
Gasoline	affects cotreatment, decreases expression, increases abundance	1
Glucose	decreases expression	1
Methyl Methanesulfonate	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.