STRADB

Summary

STRADB (STE20 related adaptor beta, HGNC:13205) is a protein-coding gene on chromosome 2q33.1, encoding STE20-related kinase adapter protein beta (Q9C0K7). Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1.

This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 55437 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 55 total — 1 pathogenic
• Druggable target: yes
• MANE Select transcript: NM_018571

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13205
Approved symbol	STRADB
Name	STE20 related adaptor beta
Location	2q33.1
Locus type	gene with protein product
Status	Approved
Aliases	STLK6, CALS-21, PAPK, ILPIPA, ILPIP
Ensembl gene	ENSG00000082146
Ensembl biotype	protein_coding
OMIM	607333
Entrez	55437

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 13 protein_coding, 4 retained_intron, 1 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000194530, ENST00000392249, ENST00000415688, ENST00000447698, ENST00000458269, ENST00000466770, ENST00000468123, ENST00000484098, ENST00000488196, ENST00000498648, ENST00000861982, ENST00000861983, ENST00000861984, ENST00000861985, ENST00000861986, ENST00000861987, ENST00000861988, ENST00000861989, ENST00000861990

RefSeq mRNA: 2 — MANE Select: NM_018571 NM_001206864, NM_018571

CCDS: CCDS2348, CCDS56161

Canonical transcript exons

ENST00000194530 — 12 exons

Exon	Start	End
ENSE00000784664	201478357	201478601
ENSE00000784666	201479489	201479531
ENSE00000934611	201458784	201458864
ENSE00000934612	201469953	201470052
ENSE00001172825	201480032	201480846
ENSE00001200786	201451740	201451938
ENSE00003509333	201478087	201478191
ENSE00003522169	201472955	201473076
ENSE00003649504	201477619	201477790
ENSE00003667257	201454746	201454852
ENSE00003676503	201474647	201474755
ENSE00003690883	201475619	201475742

Expression profiles

Bgee: expression breadth ubiquitous, 140 present calls, max score 97.67.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.5537 / max 924.9584, expressed in 1721 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
24680	11.5537	1721

Top tissues by expression

140 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	97.67	gold quality
right adrenal gland cortex	UBERON:0035827	97.01	gold quality
right adrenal gland	UBERON:0001233	96.75	gold quality
blood	UBERON:0000178	96.67	gold quality
left adrenal gland	UBERON:0001234	96.24	gold quality
gastrocnemius	UBERON:0001388	96.19	gold quality
muscle of leg	UBERON:0001383	96.03	gold quality
left adrenal gland cortex	UBERON:0035825	96.03	gold quality
skeletal muscle organ	UBERON:0014892	96.02	gold quality
hindlimb stylopod muscle	UBERON:0004252	95.89	gold quality
right lobe of liver	UBERON:0001114	95.87	gold quality
adrenal gland	UBERON:0002369	95.80	gold quality
skeletal muscle tissue	UBERON:0001134	95.57	gold quality
liver	UBERON:0002107	95.45	gold quality
duodenum	UBERON:0002114	95.28	gold quality
rectum	UBERON:0001052	95.05	gold quality
adult mammalian kidney	UBERON:0000082	95.00	gold quality
mucosa of transverse colon	UBERON:0004991	94.84	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	94.55	gold quality
kidney	UBERON:0002113	93.94	gold quality
cortical plate	UBERON:0005343	93.81	gold quality
bone element	UBERON:0001474	93.80	gold quality
bone marrow	UBERON:0002371	93.80	gold quality
heart left ventricle	UBERON:0002084	93.72	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	93.50	gold quality
monocyte	CL:0000576	93.46	gold quality
endometrium	UBERON:0001295	93.28	gold quality
bone marrow cell	CL:0002092	93.20	gold quality
body of pancreas	UBERON:0001150	93.16	gold quality
metanephros cortex	UBERON:0010533	93.12	gold quality

Single-cell (SCXA)

Detected in 12 experiment(s), a significant marker in 11.

Experiment	Marker?	Max mean expression
E-HCAD-4	yes	146.94
E-CURD-112	yes	56.62
E-HCAD-6	yes	42.08
E-MTAB-10042	yes	41.13
E-MTAB-9221	yes	21.22
E-MTAB-7316	yes	20.83
E-HCAD-9	yes	8.87
E-MTAB-9388	yes	7.73
E-HCAD-10	yes	7.02
E-MTAB-9467	yes	6.55
E-MTAB-9067	no	4.33
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

56 targeting STRADB, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-767-5P	99.95	70.85	993
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-424-5P	99.89	71.90	2641
HSA-MIR-6838-5P	99.89	71.94	2690
HSA-MIR-548E-5P	99.89	72.73	4486
HSA-MIR-9902	99.89	69.15	2250
HSA-MIR-6079	99.84	68.54	1170
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-26A-5P	99.78	73.52	2303
HSA-MIR-26B-5P	99.78	73.51	2305
HSA-MIR-577	99.78	69.13	2479
HSA-MIR-498-5P	99.76	69.64	1807
HSA-MIR-4446-5P	99.72	69.19	2544
HSA-MIR-1825	99.72	68.11	1089
HSA-MIR-4465	99.71	72.56	2096

Literature-anchored findings (GeneRIF, showing 1)

• a novel XIAP-interacting protein that acts as a co-factor enhancing XIAP-mediated activation of JNK1 and the caspase-independent protection of XIAP against apoptosis (PMID:12048196)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	STRADB	ENSDARG00000088225
mus_musculus	Stradb	ENSMUSG00000026027
rattus_norvegicus	Stradb	ENSRNOG00000010728

Paralogs (35): MAP3K14 (ENSG00000006062), MAP4K3 (ENSG00000011566), MAP4K5 (ENSG00000012983), MAP2K3 (ENSG00000034152), SLK (ENSG00000065613), MAP4K4 (ENSG00000071054), STK10 (ENSG00000072786), PAK3 (ENSG00000077264), MAP3K1 (ENSG00000095015), STK4 (ENSG00000101109), PAK5 (ENSG00000101349), STK24 (ENSG00000102572), STK3 (ENSG00000104375), MAP4K1 (ENSG00000104814), MAP3K8 (ENSG00000107968), MAP2K6 (ENSG00000108984), NEK4 (ENSG00000114904), STK25 (ENSG00000115694), NRK (ENSG00000123572), PAK4 (ENSG00000130669), STK26 (ENSG00000134602), TAOK3 (ENSG00000135090), PAK6 (ENSG00000137843), MINK1 (ENSG00000141503), PAK1 (ENSG00000149269), TAOK2 (ENSG00000149930), TNIK (ENSG00000154310), TAOK1 (ENSG00000160551), MAP4K2 (ENSG00000168067), OXSR1 (ENSG00000172939), MAP3K19 (ENSG00000176601), PAK2 (ENSG00000180370), SBK2 (ENSG00000187550), STK39 (ENSG00000198648), STRADA (ENSG00000266173)

Protein

Protein identifiers

STE20-related kinase adapter protein beta — Q9C0K7 (reviewed: Q9C0K7)

Alternative names: Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein, CALS-21, ILP-interacting protein, Pseudokinase ALS2CR2

All UniProt accessions (4): Q9C0K7, C9JSU7, F8WCQ7, H7C3S5

UniProt curated annotations — full annotation on UniProt →

Function. Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

Subunit / interactions. Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Interacts with BIRC4/XIAP. These two proteins are likely to coexist in a complex with TAK1, TRAF6, TAB1 and TAB2.

Subcellular location. Nucleus. Cytoplasm.

Tissue specificity. Highly expressed in heart, skeletal muscle, testis, liver and colon.

Domain organisation. The protein kinase domain is predicted to be catalytically inactive.

Similarity. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9C0K7-1	1, ILPIP-alpha	yes
Q9C0K7-2	2
Q9C0K7-3	3, ILPIP-beta

RefSeq proteins (2): NP_001193793, NP_061041* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000719	Prot_kinase_dom	Domain
IPR011009	Kinase-like_dom_sf	Homologous_superfamily
IPR047173	STRAD_A/B-like	Family

Pfam: PF00069

UniProt features (9 total): splice variant 3, binding site 2, sequence variant 2, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9C0K7-F1	74.39	0.52

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (2): 64–72; 89

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-380972	Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-162582	Signal Transduction
R-HSA-165159	MTOR signalling

MSigDB gene sets: 223 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_TUMORAL_MACROPHAGE_UP, GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, AP1_01, GOBP_REGULATION_OF_PHOSPHORYLATION, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, RORA1_01, AREB6_03, IVANOVA_HEMATOPOIESIS_MATURE_CELL, GOBP_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY, GOBP_REGULATION_OF_TRANSFERASE_ACTIVITY, TGACCTY_ERR1_Q2, GOBP_NUCLEAR_TRANSPORT, GOMF_KINASE_ACTIVATOR_ACTIVITY, GOBP_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY

GO Biological Process (6): cell morphogenesis (GO:0000902), protein export from nucleus (GO:0006611), JNK cascade (GO:0007254), activation of protein kinase activity (GO:0032147), negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001240), protein phosphorylation (GO:0006468)

GO Molecular Function (5): ATP binding (GO:0005524), protein serine/threonine kinase activator activity (GO:0043539), nucleotide binding (GO:0000166), protein kinase activity (GO:0004672), protein binding (GO:0005515)

GO Cellular Component (6): nucleus (GO:0005634), cytoplasm (GO:0005737), cytosol (GO:0005829), aggresome (GO:0016235), serine/threonine protein kinase complex (GO:1902554), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
MTOR signalling	1
Signal Transduction	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
anatomical structure morphogenesis	1
intracellular protein transport	1
nuclear export	1
MAPK cascade	1
positive regulation of protein kinase activity	1
extrinsic apoptotic signaling pathway in absence of ligand	1
negative regulation of signal transduction in absence of ligand	1
negative regulation of extrinsic apoptotic signaling pathway	1
regulation of extrinsic apoptotic signaling pathway in absence of ligand	1
phosphorylation	1
protein modification process	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
protein serine/threonine kinase activity	1
protein kinase activator activity	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
kinase activity	1
phosphotransferase activity, alcohol group as acceptor	1
catalytic activity, acting on a protein	1
binding	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cytoplasm	1
inclusion body	1
protein kinase complex	1

Protein interactions and networks

STRING

806 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
STRADB	CAB39	Q9Y376	976
STRADB	CAB39L	Q9H9S4	974
STRADB	TRAK2	O60296	908
STRADB	STK11	Q15831	839
STRADB	PAPOLG	Q9BWT3	585
STRADB	ALS2	Q96Q42	564
STRADB	MAP3K7	O43318	540
STRADB	DCAF12	Q5T6F0	507
STRADB	XIAP	P98170	496
STRADB	UBXN6	Q9BZV1	472
STRADB	EPB42	P16452	464
STRADB	ANKS3	Q6ZW76	439
STRADB	HACD4	Q5VWC8	427
STRADB	DYRK1B	Q9Y463	424
STRADB	COMMD1	Q8N668	423
STRADB	DIABLO	Q9NR28	423

IntAct

25 interactions, top by confidence:

A	B	Type	Score
STK11	STRADA	psi-mi:“MI:0914”(association)	0.960
STRADB	STK11	psi-mi:“MI:0403”(colocalization)	0.920
STRADB	STK11	psi-mi:“MI:0915”(physical association)	0.920
STK11	STRADB	psi-mi:“MI:0915”(physical association)	0.920
STK11	FKBP5	psi-mi:“MI:0914”(association)	0.910
CAB39	STRADB	psi-mi:“MI:0915”(physical association)	0.770
STRADB	CAB39	psi-mi:“MI:0403”(colocalization)	0.770
STRADB	CAB39	psi-mi:“MI:0915”(physical association)	0.770
STK11	HSP90AA1	psi-mi:“MI:0914”(association)	0.740
STK11	KDM4A	psi-mi:“MI:0914”(association)	0.640
PIP4K2A	AP3B1	psi-mi:“MI:0914”(association)	0.530
STRADB	TCP1	psi-mi:“MI:0914”(association)	0.530
Dlg4	STRADB	psi-mi:“MI:0407”(direct interaction)	0.440
STRADB	TIMM8A	psi-mi:“MI:0914”(association)	0.350
STK11	HK1	psi-mi:“MI:0914”(association)	0.350
STRADB	CREB1	psi-mi:“MI:0914”(association)	0.350
STRADB	GRB2	psi-mi:“MI:0915”(physical association)	0.000
TNIK	STRADB	psi-mi:“MI:0915”(physical association)	0.000
STRADB	CAB39	psi-mi:“MI:0915”(physical association)	0.000
CAB39	STRADB	psi-mi:“MI:0915”(physical association)	0.000
STRADB	NEB	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (51): STK11 (Affinity Capture-MS), CAB39 (Affinity Capture-MS), NBEA (Affinity Capture-MS), STRADB (Affinity Capture-MS), RPS6KA2 (Affinity Capture-MS), RPS6KA3 (Affinity Capture-MS), CCT6B (Affinity Capture-MS), CCT2 (Affinity Capture-MS), CCT3 (Affinity Capture-MS), CCT7 (Affinity Capture-MS), CAB39 (Two-hybrid), NEB (Two-hybrid), STRADB (Affinity Capture-Western), STRADB (Affinity Capture-Western), STRADB (Reconstituted Complex)

ESM2 similar proteins: O15530, O54863, O70444, O94768, P06803, P11309, P26794, P37023, P57078, P58750, P80203, P92958, P97343, P97756, Q03142, Q20443, Q38997, Q3SZW1, Q5RAN0, Q5RCY1, Q61288, Q62070, Q63285, Q7TNJ7, Q852Q2, Q86V86, Q8BG48, Q8BZ25, Q8C1R0, Q8K4T3, Q8TAS1, Q8VBY2, Q91822, Q91VB2, Q91XS8, Q95LJ0, Q96LW2, Q96PF2, Q9BXA7, Q9C0K7

Diamond homologs: A0A1D6E0S8, B4E2M5, C0LGL9, F1M5M3, F1MJR8, P0C0T2, P9WI62, P9WI63, Q0CL79, Q0D4B2, Q16584, Q1ZXD6, Q4WHP3, Q54XZ5, Q66HA1, Q68DC2, Q6CVA2, Q6GQX6, Q75DK7, Q7EZ44, Q7M6U3, Q7TYY6, Q7Z6K4, Q80XI6, Q8IWB6, Q8K4B2, Q91ZA8, Q9C0K7, Q9J4Z6, Q9UU77, A0A509AKL0, A5K0N4, G5ECN5, O23304, O34507, O43930, O54784, O61122, O74426, O88764

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

55 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	38
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
1456057	NC_000002.11:g.(?201943606)(204824322_?)del	Pathogenic

SpliceAI

3773 predictions. Top by Δscore:

Variant	Effect	Δscore
2:201389309:T:TA	donor_gain	1.0000
2:201389324:C:A	donor_gain	1.0000
2:201389799:A:AC	donor_gain	1.0000
2:201389800:C:CT	donor_gain	1.0000
2:201389800:CT:C	donor_gain	1.0000
2:201389800:CTT:C	donor_gain	1.0000
2:201389800:CTTTT:C	donor_gain	1.0000
2:201392903:GCTT:G	donor_loss	1.0000
2:201392904:CTTA:C	donor_loss	1.0000
2:201392906:TACCC:T	donor_loss	1.0000
2:201392907:A:AC	donor_gain	1.0000
2:201392907:AC:A	donor_gain	1.0000
2:201392907:ACC:A	donor_gain	1.0000
2:201392907:ACCC:A	donor_gain	1.0000
2:201392908:C:A	donor_loss	1.0000
2:201392908:C:CC	donor_gain	1.0000
2:201392908:CC:C	donor_gain	1.0000
2:201392908:CCC:C	donor_gain	1.0000
2:201392908:CCCC:C	donor_gain	1.0000
2:201392908:CCCCA:C	donor_gain	1.0000
2:201393042:TGCAG:T	acceptor_gain	1.0000
2:201393043:GCAG:G	acceptor_gain	1.0000
2:201393044:CAG:C	acceptor_gain	1.0000
2:201393044:CAGC:C	acceptor_gain	1.0000
2:201393045:AG:A	acceptor_gain	1.0000
2:201393045:AGCTA:A	acceptor_loss	1.0000
2:201393046:GC:G	acceptor_loss	1.0000
2:201393047:C:CC	acceptor_gain	1.0000
2:201393048:T:G	acceptor_loss	1.0000
2:201394792:CATTA:C	donor_loss	1.0000

AlphaMissense

2730 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:201477764:T:A	W232R	0.999
2:201477764:T:C	W232R	0.999
2:201477770:A:C	S234R	0.999
2:201477772:T:A	S234R	0.999
2:201477772:T:G	S234R	0.999
2:201478115:A:T	D250V	0.999
2:201478129:G:T	G255W	0.999
2:201478130:G:A	G255E	0.999
2:201478601:G:C	R357T	0.999
2:201478601:G:T	R357M	0.999
2:201479489:G:C	R357S	0.999
2:201479489:G:T	R357S	0.999
2:201478114:G:C	D250H	0.998
2:201478114:G:T	D250Y	0.998
2:201478115:A:C	D250A	0.998
2:201478115:A:G	D250G	0.998
2:201478123:A:C	S253R	0.998
2:201478125:T:A	S253R	0.998
2:201478125:T:G	S253R	0.998
2:201478129:G:A	G255R	0.998
2:201478129:G:C	G255R	0.998
2:201478138:G:C	A258P	0.998
2:201478576:T:C	C349R	0.998
2:201478578:T:G	C349W	0.998
2:201475688:T:C	L165P	0.997
2:201477771:G:T	S234I	0.997
2:201478120:T:G	Y252D	0.997
2:201478127:T:A	V254D	0.997
2:201478148:T:C	L261S	0.997
2:201472990:G:C	A77P	0.996

dbSNP variants (sampled 300 via entrez): RS1000025372 (2:201450448 C>T), RS1000153306 (2:201476101 T>A), RS1000237405 (2:201454608 T>A), RS1000247126 (2:201479355 C>G), RS1000503364 (2:201460902 T>G), RS1000572375 (2:201462744 T>C), RS1000879809 (2:201457292 C>T), RS1000980488 (2:201468859 C>A,T), RS1001005233 (2:201464852 A>C), RS1001632119 (2:201461904 A>G), RS1001709776 (2:201478933 T>C), RS1001742197 (2:201454281 A>G), RS1001895256 (2:201459881 C>A), RS1002114950 (2:201453237 G>C), RS1002168513 (2:201464158 G>A)

Disease associations

OMIM: gene MIM:607333 | disease phenotypes: MIM:614424, MIM:607271, MIM:607594, MIM:616100

GenCC curated gene-disease

Mondo (4): Joubert syndrome 14 (MONDO:0013745), autoimmune lymphoproliferative syndrome type 2B (MONDO:0011804), immunodeficiency, common variable, 1 (MONDO:0011864), autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency (MONDO:0014493)

Orphanet (4): OBSOLETE: Common variable immunodeficiency (Orphanet:1572), Autoimmune lymphoproliferative syndrome-recurrent viral infections due to CASP8 deficiency (Orphanet:275517), Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency (Orphanet:436159), Late-onset combined immunodeficiency due to ICOS deficiency (Orphanet:695183)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4105756 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: enzyme — STLK subfamily

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	increases expression, affects expression, increases abundance, decreases expression	3
Cadmium Chloride	decreases expression, increases abundance	2
Particulate Matter	decreases expression, increases abundance, increases expression	2
aristolochic acid I	decreases expression	1
methylmercuric chloride	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
CGP 52608	affects binding, increases reaction	1
K 7174	decreases expression	1
ICG 001	increases expression	1
abrine	decreases expression	1
jinfukang	affects cotreatment, increases expression	1
Temozolomide	decreases expression	1
Sunitinib	increases expression	1
Leflunomide	decreases expression	1
Benzo(a)pyrene	affects methylation	1
Cadmium	decreases expression, increases abundance	1
Caffeine	decreases phosphorylation	1
Cannabidiol	decreases expression	1
Cisplatin	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Hydrogen Peroxide	increases expression	1
Ozone	affects expression, increases abundance	1
Thiram	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Tretinoin	decreases expression	1
Aflatoxin B1	decreases methylation	1
Okadaic Acid	decreases expression	1
Copper Sulfate	decreases expression	1

ChEMBL screening assays

20 unique, capped per target: 20 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4034498	Binding	Inhibition of STLK6 Lysine 1 labelling site (unknown origin) at 10 uM	Developing DYRK inhibitors derived from the meridianins as a means of increasing levels of NFAT in the nucleus. — Bioorg Med Chem Lett

Cellosaurus cell lines

4 cell lines: 3 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B3IH	Abcam HEK293T STRADB KO	Transformed cell line	Female
CVCL_TR00	HAP1 STRADB (-) 1	Cancer cell line	Male
CVCL_TR01	HAP1 STRADB (-) 2	Cancer cell line	Male
CVCL_TR02	HAP1 STRADB (-) 3	Cancer cell line	Male

Clinical trials (associated diseases)

3 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT05235438	PHASE1	UNKNOWN	Safety and Toxicity Study of IMM27M in Patients With Advanced Solid Tumor
NCT04377867	Not specified	UNKNOWN	New Biomarkers for Diagnosis and Follow-up of Patients With LRBA or CTLA4 Deficiencies
NCT05040256	Not specified	COMPLETED	Neurologic and Immunologic Characteristics of CTLA-4 and LRBA Hereditary Deficiency