STRAP

Summary

STRAP (serine/threonine kinase receptor associated protein, HGNC:30796) is a protein-coding gene on chromosome 12p12.3, encoding Serine-threonine kinase receptor-associated protein (Q9Y3F4). The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.

Enables RNA binding activity. Involved in maintenance of gastrointestinal epithelium and spliceosomal snRNP assembly. Acts upstream of with a positive effect on negative regulation of transforming growth factor beta receptor signaling pathway. Located in cytosol. Part of SMN complex. Implicated in adenocarcinoma; colorectal carcinoma; large cell carcinoma; lung carcinoma; and squamous cell neoplasm.

Source: NCBI Gene 11171 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 45 total
• Druggable target: yes
• MANE Select transcript: NM_007178

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30796
Approved symbol	STRAP
Name	serine/threonine kinase receptor associated protein
Location	12p12.3
Locus type	gene with protein product
Status	Approved
Aliases	UNRIP, pt-wd, MAWD
Ensembl gene	ENSG00000023734
Ensembl biotype	protein_coding
OMIM	605986
Entrez	11171

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 11 protein_coding, 2 retained_intron, 1 nonsense_mediated_decay

ENST00000025399, ENST00000419869, ENST00000536737, ENST00000538718, ENST00000539887, ENST00000541731, ENST00000888770, ENST00000888771, ENST00000927387, ENST00000927388, ENST00000927389, ENST00000927390, ENST00000927391, ENST00000956572

RefSeq mRNA: 1 — MANE Select: NM_007178 NM_007178

CCDS: CCDS8676

Canonical transcript exons

ENST00000419869 — 10 exons

Exon	Start	End
ENSE00000724091	15883541	15883676
ENSE00002297307	15882387	15882819
ENSE00003479597	15897882	15898018
ENSE00003494228	15894047	15894143
ENSE00003537668	15902917	15903478
ENSE00003596444	15900947	15901012
ENSE00003596910	15889928	15890009
ENSE00003602559	15899904	15900053
ENSE00003604550	15890597	15890669
ENSE00003694195	15895359	15895496

Expression profiles

Bgee: expression breadth ubiquitous, 305 present calls, max score 99.52.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 172.2765 / max 1290.3241, expressed in 1828 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
124503	167.9111	1828
124504	4.3072	1495
124502	0.0582	17

Top tissues by expression

305 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	99.52	gold quality
oocyte	CL:0000023	99.36	gold quality
corpus epididymis	UBERON:0004359	98.99	gold quality
pons	UBERON:0000988	98.81	gold quality
cauda epididymis	UBERON:0004360	98.81	gold quality
type B pancreatic cell	CL:0000169	98.72	gold quality
caput epididymis	UBERON:0004358	98.71	gold quality
adenohypophysis	UBERON:0002196	98.67	gold quality
embryo	UBERON:0000922	98.64	gold quality
ventricular zone	UBERON:0003053	98.59	gold quality
ganglionic eminence	UBERON:0004023	98.57	gold quality
cortical plate	UBERON:0005343	98.55	gold quality
adult organism	UBERON:0007023	98.51	gold quality
pituitary gland	UBERON:0000007	98.49	gold quality
Brodmann (1909) area 46	UBERON:0006483	98.49	gold quality
hypothalamus	UBERON:0001898	98.45	gold quality
amniotic fluid	UBERON:0000173	98.44	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	98.33	gold quality
lateral nuclear group of thalamus	UBERON:0002736	98.32	gold quality
germinal epithelium of ovary	UBERON:0001304	98.31	gold quality
substantia nigra pars compacta	UBERON:0001965	98.31	gold quality
lower lobe of lung	UBERON:0008949	98.30	gold quality
right frontal lobe	UBERON:0002810	98.29	gold quality
Brodmann (1909) area 9	UBERON:0013540	98.29	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	98.23	gold quality
gingiva	UBERON:0001828	98.20	gold quality
gingival epithelium	UBERON:0001949	98.20	gold quality
amygdala	UBERON:0001876	98.16	gold quality
substantia nigra pars reticulata	UBERON:0001966	98.16	gold quality
middle temporal gyrus	UBERON:0002771	98.12	gold quality

Single-cell (SCXA)

Detected in 6 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-HCAD-4	yes	19.68
E-HCAD-10	yes	16.94
E-MTAB-7249	no	37194.32
E-MTAB-6075	no	696.64
E-MTAB-7303	no	438.65
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): SMAD7, TP53

miRNA regulators (miRDB)

54 targeting STRAP, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-223-3P	99.99	70.14	1140
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-34C-5P	99.97	70.45	1577
HSA-MIR-449B-5P	99.97	70.26	1580
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-4778-3P	99.93	70.40	1818
HSA-MIR-10523-5P	99.91	69.22	2038
HSA-MIR-652-5P	99.91	67.49	505
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-6499-3P	99.90	66.38	1212
HSA-MIR-6715A-3P	99.83	68.05	1473
HSA-MIR-4659A-3P	99.80	72.62	4248
HSA-MIR-4659B-3P	99.80	72.62	4248
HSA-MIR-4645-3P	99.76	69.33	993
HSA-MIR-3059-5P	99.70	69.93	2491
HSA-MIR-6892-3P	99.68	66.40	1178
HSA-MIR-3177-5P	99.65	70.38	1174
HSA-MIR-1303	99.65	69.77	1662
HSA-MIR-549A-3P	99.54	68.17	825
HSA-MIR-12123	99.52	71.79	2990
HSA-MIR-642A-5P	99.51	65.10	1152
HSA-MIR-942-5P	99.41	68.40	1977
HSA-MIR-6719-3P	99.29	67.78	1387
HSA-MIR-664A-3P	99.22	71.08	2696
HSA-MIR-122B-3P	99.21	68.90	1333
HSA-MIR-21-3P	99.21	68.95	1312

Literature-anchored findings (GeneRIF, showing 27)

• unrip functions in the pathway of small nuclear ribonucleoproteins biogenesis (PMID:15848170)
• biochemical evidence for the existence of another, yet atypical, SMN complex component, termed unr-interacting protein (unrip) (PMID:16159890)
• STRAP acts as an intermediate signaling molecule linking between the phosphatidylinositol 3-kinase/PDK1 and the TGF-beta signaling pathways (PMID:16251192)
• Gemin8 has an essential role in the proper structural organization of the SMN complex and the involvement of the heteromeric subunit containing Gemin6, Gemin7, Gemin8, and Unrip in the recruitment of Sm proteins to the snRNP assembly pathway (PMID:17023415)
• the direct interaction of NM23-H1 and STRAP is important for the regulation of TGF-beta-dependent biological activity as well as NM23-H1 activity (PMID:17314099)
• These results indicate that upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. (PMID:17316412)
• an interplay between PPM1G and unrip determine compartment-specific phosphorylation patterns, localization, and function of the SMN complex (PMID:17984321)
• Strap regulation reflects the coordinated interplay between different DNA damage-activated protein kinases, ATM and Chk2 (Checkpoint kinase 2), where phosphorylation by each kinase provides a distinct functional consequence on the activity of Strap. (PMID:18833288)
• STRAP can act as a negative regulator of ASK1. (PMID:19880523)
• gonucleotide pulldown identified STRAP (serine/threonine kinase receptor-associated protein) as a further protein recruited to the MMP28 promoter and acting functionally with Sp1. (PMID:20144149)
• B-MYB acts as a positive regulator of STRAP (PMID:21148321)
• STRAP protein decreases ubiquitination of intracellular domain of Notch3 and may help to stabilize it. (PMID:21502811)
• both of the TPR and OB-fold domains localize to the chromatin of p53 target genes and exhibit intrinsic regulatory activity necessary for the Strap-dependent p53 response (PMID:22362889)
• Coexpression of MAWBP and MAWD inhibited epithelial mesenchymal transformation, and EMT-aided malignant cell progression was suppressed in gastric cancer. (PMID:23687415)
• Data indicate serine-threonine kinase receptor-associated protein (STRAP) as a novel regulator of the coordinated translation of collagen alpha1(I) and alpha2(I) mRNAs. (PMID:23918805)
• Strap augments the apoptotic effects of mitochondrial p53. (PMID:25168243)
• STRAP inhibits the transactivation function of Sp1 either by directly blocking its DNA binding domain or destabilizing Sp1 protein through ubiquitin-proteasome pathway in cell cycle G1 phase. (PMID:25483064)
• MAWD and MAWBP were downregulated and associated with the differentiation grade in GC tissues. (PMID:26373288)
• these results suggest that STRAP increases invasion and metastasis of colorectal cancer partly through inhibiting ubiquitin-dependent degradation of beta-catenin and promoting Wnt/beta-catenin signaling (PMID:26910283)
• Findings illuminated a novel STRAP-NOTCH1-HES1 molecular axis as a CSC regulator in colorectal cancer. (PMID:28827371)
• STRAP plays an inhibitory role in hepatocellular carcinoma via regulating PTEN expression.STRAP is down-regulated in the hepatocellular carcinoma tissues. (PMID:29283497)
• Study found that STRAP and MELK were overexpressed and highly phosphorylated in samples form colorectal adenocarcinoma patients and their expression were significantly correlated with tumor stages. (PMID:29783958)
• Strap associates with Csde1 and affects expression of select Csde1-bound transcripts (PMID:30138317)
• Results show that the increased STRAP protein levels observed in HCC provide growth advantage among others by enhancing Wnt/beta-catenin signaling. (PMID:30257989)
• SIRT7 Deacetylates STRAP to Regulate p53 Activity and Stability. (PMID:32527012)
• Serine-threonine Kinase Receptor-Associated Protein is a Critical Mediator of APC Mutation-Induced Intestinal Tumorigenesis Through a Feed-Forward Mechanism. (PMID:34520730)
• Serine-Threonine Kinase Receptor Associate Protein (STRAP) confers an aggressive phenotype in neuroblastoma via regulation of Focal Adhesion Kinase (FAK). (PMID:35272839)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	strap	ENSDARG00000007405
mus_musculus	Strap	ENSMUSG00000030224
rattus_norvegicus	Strap	ENSRNOG00000007134
drosophila_melanogaster	wmd	FBGN0034876

Protein

Protein identifiers

Serine-threonine kinase receptor-associated protein — Q9Y3F4 (reviewed: Q9Y3F4)

Alternative names: MAP activator with WD repeats, UNR-interacting protein, WD-40 repeat protein PT-WD

All UniProt accessions (3): Q9Y3F4, F5H1G1, H0YH33

UniProt curated annotations — full annotation on UniProt →

Function. The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.

Subunit / interactions. Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Associates with the SMN complex in the cytoplasm but not in the nucleus. Interacts with GEMIN6; the interaction is direct. Interacts with GEMIN7; the interaction is direct. Interacts with CSDE1/UNR and MAWBP. Interacts with PDPK1. Interacts with TRIM48.

Subcellular location. Cytoplasm. Nucleus.

Similarity. Belongs to the WD repeat STRAP family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9Y3F4-1	1	yes
Q9Y3F4-2	2

RefSeq proteins (1): NP_009109* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR020472	WD40_PAC1	Repeat
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily

Pfam: PF00400

UniProt features (15 total): repeat 7, modified residue 3, sequence conflict 3, chain 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y3F4-F1	89.75	0.84

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 338, 312, 335

Function

Pathways and Gene Ontology

Reactome pathways

6 pathways

ID	Pathway
R-HSA-2173788	Downregulation of TGF-beta receptor signaling
R-HSA-9764790	Positive Regulation of CDH1 Gene Transcription
R-HSA-162582	Signal Transduction
R-HSA-170834	Signaling by TGF-beta Receptor Complex
R-HSA-2173789	TGF-beta receptor signaling activates SMADs
R-HSA-9006936	Signaling by TGFB family members

MSigDB gene sets: 196 (showing top): GOBP_DIGESTION, GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, PAL_PRMT5_TARGETS_UP, MODULE_151, GOBP_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME, MORF_UBE2I, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, DARWICHE_SKIN_TUMOR_PROMOTER_DN, DARWICHE_PAPILLOMA_RISK_LOW_DN, DARWICHE_PAPILLOMA_RISK_HIGH_DN, DARWICHE_SQUAMOUS_CELL_CARCINOMA_DN, MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP, REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS

GO Biological Process (12): negative regulation of transcription by RNA polymerase II (GO:0000122), alternative mRNA splicing, via spliceosome (GO:0000380), spliceosomal snRNP assembly (GO:0000387), neuron differentiation (GO:0030182), maintenance of gastrointestinal epithelium (GO:0030277), negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512), retinoic acid catabolic process (GO:0034653), retinoic acid receptor signaling pathway (GO:0048384), mRNA splicing, via spliceosome (GO:0000398), mRNA processing (GO:0006397), RNA splicing (GO:0008380), protein-RNA complex assembly (GO:0022618)

GO Molecular Function (5): RNA binding (GO:0003723), mRNA binding (GO:0003729), signaling receptor binding (GO:0005102), U2 snRNP binding (GO:1990447), protein binding (GO:0005515)

GO Cellular Component (5): nucleus (GO:0005634), cytoplasm (GO:0005737), cytosol (GO:0005829), SMN complex (GO:0032797), SMN-Sm protein complex (GO:0034719)

Reactome top-level categories

Rollup of top-5 pathways:

Category	Pathways
TGF-beta receptor signaling activates SMADs	1
Regulation of CDH1 Gene Transcription	1
Signaling by TGFB family members	1
Signaling by TGF-beta Receptor Complex	1
Signal Transduction	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
mRNA splicing, via spliceosome	2
RNA processing	2
cellular anatomical structure	2
cytoplasm	2
Sm-like protein family complex	2
regulation of transcription by RNA polymerase II	1
transcription by RNA polymerase II	1
negative regulation of DNA-templated transcription	1
protein-RNA complex assembly	1
cell differentiation	1
generation of neurons	1
epithelial structure maintenance	1
digestive system process	1
transforming growth factor beta receptor signaling pathway	1
regulation of transforming growth factor beta receptor signaling pathway	1
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	1
diterpenoid catabolic process	1
fat-soluble vitamin catabolic process	1
retinoic acid metabolic process	1
monocarboxylic acid catabolic process	1
hormone-mediated signaling pathway	1
nuclear receptor-mediated signaling pathway	1
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	1
mRNA processing	1
mRNA metabolic process	1
ribonucleoprotein complex biogenesis	1
protein-containing complex assembly	1
protein-RNA complex organization	1
nucleic acid binding	1
RNA binding	1
protein binding	1
snRNP binding	1
binding	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
SMN-Sm protein complex	1
SMN complex	1

Protein interactions and networks

STRING

1452 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
STRAP	GEMIN2	O14893	998
STRAP	PBLD	P30039	981
STRAP	GEMIN7	Q9H840	974
STRAP	GEMIN6	Q8WXD5	964
STRAP	CSDE1	O75534	941
STRAP	SMN1	Q16637	886
STRAP	GEMIN5	Q8TEQ6	881
STRAP	DDX20	Q9UHI6	879
STRAP	GEMIN8	Q9NWZ8	862
STRAP	SMAD7	O15105	847
STRAP	NME1	P15531	813
STRAP	TBK1	Q9UHD2	681
STRAP	IRF3	Q14653	681
STRAP	LARP6	Q9BRS8	618
STRAP	GEMIN4	P57678	609

IntAct

200 interactions, top by confidence:

A	B	Type	Score
SMN1	GEMIN2	psi-mi:“MI:0914”(association)	0.960
STRAP	GEMIN6	psi-mi:“MI:0407”(direct interaction)	0.760
GEMIN7	STRAP	psi-mi:“MI:0407”(direct interaction)	0.760
STRAP	GEMIN7	psi-mi:“MI:0407”(direct interaction)	0.760
CDK2AP1	MTA2	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
SNRPD2	GEMIN2	psi-mi:“MI:0914”(association)	0.710
STRAP	NME1	psi-mi:“MI:0915”(physical association)	0.670
NME1	STRAP	psi-mi:“MI:0915”(physical association)	0.670
STRAP	NME1	psi-mi:“MI:0403”(colocalization)	0.670
STRAP	NME1	psi-mi:“MI:0407”(direct interaction)	0.670
HTT	STRAP	psi-mi:“MI:0915”(physical association)	0.670
SNRNP70	GEMIN2	psi-mi:“MI:0914”(association)	0.640
CFTR	HAX1	psi-mi:“MI:0914”(association)	0.610

BioGRID (415): STRAP (Affinity Capture-MS), STRAP (Affinity Capture-RNA), STRAP (Affinity Capture-RNA), STRAP (Affinity Capture-MS), STRAP (Affinity Capture-MS), SMAD3 (Phenotypic Suppression), STRAP (Phenotypic Suppression), STRAP (Affinity Capture-MS), STRAP (Affinity Capture-Western), CTPS1 (Co-fractionation), PLCG1 (Co-fractionation), UBA6 (Co-fractionation), STRAP (Affinity Capture-MS), STRAP (Affinity Capture-MS), STRAP (Affinity Capture-MS)

ESM2 similar proteins: A4QNE6, B0BNA7, B5FZ19, O43172, O74184, Q13347, Q29RH4, Q29RZ9, Q38884, Q3KPT3, Q3MHE2, Q3UGF1, Q4R571, Q53HC9, Q561Y0, Q5E959, Q5E966, Q5M7F6, Q5M8I4, Q5MNZ6, Q5NVD0, Q5PPK9, Q5R7W0, Q5XIG8, Q5XJP1, Q5ZL16, Q5ZL33, Q640T2, Q66J51, Q68F45, Q6DUZ9, Q6H8D5, Q6H8D6, Q7ZUW6, Q8BGF3, Q8K0G5, Q8NEZ3, Q8VE80, Q91VM3, Q96J01

Diamond homologs: A1CTE6, A1DMI8, A2QVV2, B0Y7H6, B8N4F5, D9N129, P16649, P56094, Q08274, Q09019, Q0CKB1, Q10437, Q2HJH6, Q2UM42, Q4WN25, Q5RF51, Q5XIG8, Q6ZMW3, Q8TBZ3, Q96DI7, Q9P4R5, Q9VBC4, Q9Y3F4, Q9Z1Z2, O22469, Q5ZL33, A0A223GEB2, A0CH87, A0DB19, A1D3F5, A5D7H2, A5DWF4, A6H603, A6NE52, A6QX61, A6RRD4, A6ZZZ8, A8XYW9, B0XAF3, B0XQ42

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
SMAD7	up-regulates	STRAP	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 180 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Metabolism of non-coding RNA	7	34.7×	1e-07
snRNP Assembly	14	23.1×	4e-13
SARS-CoV-2 modulates host translation machinery	13	22.7×	3e-12
mRNA Splicing - Minor Pathway	6	10.5×	1e-03
mRNA Splicing	12	10.3×	3e-07
RNA Polymerase II Transcription Termination	6	10.3×	1e-03
Processing of Capped Intron-Containing Pre-mRNA	13	8.3×	8e-07
mRNA Polyadenylation	11	7.5×	2e-05

GO biological processes:

GO term	Partners	Fold	FDR
spliceosomal snRNP assembly	15	55.9×	2e-20
U2-type prespliceosome assembly	6	24.0×	5e-05
spliceosomal complex assembly	5	19.3×	1e-03
circadian rhythm	7	11.0×	9e-04
mRNA splicing, via spliceosome	15	8.8×	1e-07
negative regulation of translation	7	8.8×	3e-03
positive regulation of protein ubiquitination	6	8.2×	8e-03
protein phosphorylation	10	4.4×	9e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

45 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	23
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

2300 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:15882730:T:A	L8H	1.000
12:15882730:T:C	L8P	1.000
12:15882735:T:C	C10R	1.000
12:15882736:G:A	C10Y	1.000
12:15882737:C:G	C10W	1.000
12:15882741:G:C	G12R	1.000
12:15882741:G:T	G12C	1.000
12:15882742:G:A	G12D	1.000
12:15882742:G:T	G12V	1.000
12:15882744:C:A	H13N	1.000
12:15882744:C:G	H13D	1.000
12:15882744:C:T	H13Y	1.000
12:15882745:A:G	H13R	1.000
12:15882746:C:A	H13Q	1.000
12:15882746:C:G	H13Q	1.000
12:15882751:G:C	R15P	1.000
12:15882753:C:A	P16T	1.000
12:15882753:C:T	P16S	1.000
12:15882754:C:A	P16H	1.000
12:15882754:C:G	P16R	1.000
12:15882754:C:T	P16L	1.000
12:15882757:T:A	V17E	1.000
12:15882766:T:G	L20W	1.000
12:15882771:T:C	F22L	1.000
12:15882773:C:A	F22L	1.000
12:15882773:C:G	F22L	1.000
12:15882774:A:C	S23R	1.000
12:15882776:T:A	S23R	1.000
12:15882776:T:G	S23R	1.000
12:15882807:A:C	S34R	1.000

dbSNP variants (sampled 300 via entrez): RS1000018911 (12:15882158 G>A), RS1000082506 (12:15881985 A>G), RS1000121931 (12:15902824 A>G,T), RS1000125332 (12:15888169 G>A), RS1000169718 (12:15900310 T>A), RS1000305573 (12:15903281 T>A,G), RS1000543586 (12:15886121 A>T), RS1000658261 (12:15886331 C>T), RS1000732277 (12:15881244 A>G), RS1000911564 (12:15898516 T>C), RS1000917264 (12:15892520 C>G), RS1000918817 (12:15898415 C>T), RS1001095673 (12:15881021 C>A,T), RS1001105969 (12:15891953 A>C), RS1001513173 (12:15896966 A>C)

Disease associations

OMIM: gene MIM:605986 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067330 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

4 potent at pChembl≥5 of 4 total, top 4 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
7.75	Kd	17.7	nM	CHEMBL5653589
7.75	ED50	17.7	nM	CHEMBL5653589
6.64	Kd	231.2	nM	CHEMBL3752910
6.64	ED50	231.2	nM	CHEMBL3752910

PubChem BioAssay actives

2 with measured affinity, of 4 total; 2 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149517: Binding affinity to human STRAP incubated for 45 mins by Kinobead based pull down assay	kd	0.0177	uM
4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149517: Binding affinity to human STRAP incubated for 45 mins by Kinobead based pull down assay	kd	0.2312	uM

CTD chemical–gene interactions

37 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases methylation, affects expression, decreases expression	4
Tobacco Smoke Pollution	affects expression, increases expression	2
aristolochic acid I	increases expression	1
FR900359	increases phosphorylation	1
bisphenol F	increases expression	1
moringin	increases expression	1
TAK-243	increases sumoylation	1
deoxynivalenol	increases expression	1
trichostatin A	increases expression	1
sodium arsenite	decreases expression	1
tetrabromobisphenol A	decreases expression	1
2-bromopalmitate	decreases reaction, increases abundance, increases palmitoylation	1
perfluorooctanoic acid	decreases expression	1
ochratoxin A	increases expression	1
chloropicrin	increases expression	1
bisphenol B	increases expression	1
bisphenol S	increases expression	1
bisphenol AF	increases expression	1
Arsenic Trioxide	increases expression	1
Vorinostat	decreases expression	1
Acetaminophen	decreases expression	1
Air Pollutants, Occupational	affects expression	1
Benztropine	decreases expression	1
Cadmium	decreases reaction, increases abundance, increases palmitoylation	1
Cannabidiol	increases expression	1
Clozapine	decreases expression	1
Doxorubicin	affects expression	1
Enzyme Inhibitors	increases O-linked glycosylation, decreases activity	1
Ivermectin	decreases expression	1
Phthalic Acids	increases methylation	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652559	Binding	Binding affinity to human STRAP incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B3II	Abcam HEK293T STRAP KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.