STRIP1

Summary

STRIP1 (striatin interacting protein 1, HGNC:25916) is a protein-coding gene on chromosome 1p13.3, encoding Striatin-interacting protein 1 (Q5VSL9). Plays a role in the regulation of cell morphology and cytoskeletal organization. It is a selective cancer dependency (DepMap: 36.1% of cell lines).

This gene encodes a member of the striatin-interacting phosphatase and kinase complex, which is involved in localization of the Golgi body. The encoded protein participates in cytosketelal organization. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 85369 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 125 total
• GTEx eGene: eQTL in 30 tissues, sQTL in 2 (q < 0.05)
• Cancer dependency (DepMap): dependent in 36.1% of screened cell lines
• Constraint (gnomAD): pLI 0.00 (LoF-tolerant), LOEUF 0.78 (unconstrained)
• MANE Select transcript: NM_033088
• Notable: 125 clinical variants but no curated precision-oncology (CIViC) evidence yet

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25916
Approved symbol	STRIP1
Name	striatin interacting protein 1
Location	1p13.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ14743, KIAA1761, FAR11A
Ensembl gene	ENSG00000143093
Ensembl biotype	protein_coding
OMIM	617918
Entrez	85369

Gene structure

Transcript identifiers

Ensembl transcripts: 38 — 17 nonsense_mediated_decay, 15 protein_coding, 6 retained_intron

MANE Select: ENST00000369795

Transcript support level (Ensembl TSL; 1 = fully mRNA-supported): TSL 1: 2, TSL 2: 4, TSL 3: 3

ENST00000369795, ENST00000369796, ENST00000461054, ENST00000473429, ENST00000485775, ENST00000489059, ENST00000535003, ENST00000539541, ENST00000540970, ENST00000906338, ENST00000906339, ENST00000906340, ENST00000906341, ENST00000906342, ENST00000906343, ENST00000930842, ENST00000930843, ENST00000950691, ENST00000950692, ENST00000950693, ENST00000997169, ENST00000997170, ENST00001044447, ENST00001044448, ENST00001044451, ENST00001044453, ENST00001044454, ENST00001044455, ENST00001044456, ENST00001044457, ENST00001044461, ENST00001071247, ENST00001071248, ENST00001071249, ENST00001071250, ENST00001071251, ENST00001071252, ENST00001143667

RefSeq mRNA: 2 — MANE Select: NM_033088 NM_001270768, NM_033088

CCDS: CCDS30798, CCDS59197

Canonical transcript exons

ENST00000369795 — 21 exons

Exon	Start	End
ENSE00001850618	110034624	110034817
ENSE00003461663	110050956	110051060
ENSE00003463201	110047542	110047616
ENSE00003498567	110051683	110051887
ENSE00003508856	110044840	110044905
ENSE00003515653	110049460	110049560
ENSE00003535290	110041734	110041861
ENSE00003565721	110041536	110041642
ENSE00003590269	110040635	110040703
ENSE00003594631	110043639	110043856
ENSE00003602797	110046680	110046751
ENSE00003612165	110049112	110049238
ENSE00003620778	110050343	110050409
ENSE00003635541	110045015	110045078
ENSE00003636515	110047772	110047869
ENSE00003643818	110043088	110043270
ENSE00003696781	110039172	110039306
ENSE00003697226	110038683	110038757
ENSE00003698529	110039395	110039515
ENSE00003700076	110037891	110037960
ENSE00004803382	110053665	110054641

Expression profiles

Bgee: expression breadth ubiquitous, 236 present calls, max score 94.76.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 19.7221 / max 105.4209, expressed in 1809 samples.

Highest expression (Bgee): cortical plate, ileal mucosa, pancreatic ductal cell, hemisphere of cerebellum, cerebellar hemisphere.

Genetic regulation across tissues (GTEx eQTL / sQTL)

STRIP1 is an eGene in GTEx v10 — its expression is genetically regulated (eQTL) in 30 tissues and its splicing (sQTL) in 2 (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant’s alternative allele.

showing 20 of 32 significant tissue × QTL associations:

Tissue	QTL	q-value	Slope	Lead variant
Testis	eqtl	1.2e-23	+1.61	1:110042975:C:T
Thyroid	eqtl	1.2e-14	+0.27	1:110090022:A:G
Nerve Tibial	eqtl	5.4e-10	+0.21	1:110066666:T:G
Whole Blood	eqtl	2.2e-08	-0.15	1:109988373:G:C
Muscle Skeletal	eqtl	2.5e-08	+0.15	1:110037593:G:A
Esophagus Muscularis	eqtl	4.3e-08	+0.14	1:110037593:G:A
Skin Not Sun Exposed Suprapubic	eqtl	4.0e-06	+0.13	1:110090022:A:G
Adipose Subcutaneous	eqtl	9.6e-06	+0.16	1:109998355:T:C
Breast Mammary Tissue	eqtl	1.0e-05	-0.21	1:109988373:G:C
Esophagus Gastroesophageal Junction	eqtl	1.2e-05	+0.15	1:110037593:G:A
Lung	eqtl	1.3e-05	-0.15	1:110034040:G:A
Skin Sun Exposed Lower leg	eqtl	1.9e-05	+0.13	1:110021192:G:A
Esophagus Mucosa	eqtl	2.6e-05	+0.13	1:110037593:G:A
Colon Transverse	eqtl	8.2e-05	-0.15	1:109988373:G:C
Brain Cortex	eqtl	3.2e-04	-0.14	1:110034040:G:A
Adipose Visceral Omentum	eqtl	5.2e-04	+0.16	1:110008588:AT:A
Spleen	eqtl	1.5e-03	+0.27	1:110008588:AT:A
Cells EBV-transformed lymphocytes	eqtl	2.0e-03	+0.61	1:110069272:C:T
Cells Cultured fibroblasts	eqtl	4.4e-03	+0.42	1:110489262:G:A
Artery Tibial	eqtl	5.2e-03	+0.13	1:110008588:AT:A

FANTOM5 promoters

1 alternative TSS:

Promoter ID	TPM avg	Samples expressed
4505	19.7221	1809

Top tissues by expression

showing 100 of 250 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	94.76	gold quality
ileal mucosa	UBERON:0000331	94.22	gold quality
pancreatic ductal cell	CL:0002079	94.21	gold quality
right hemisphere of cerebellum	UBERON:0014890	93.28	gold quality
cerebellar hemisphere	UBERON:0002245	92.92	gold quality
cerebellar cortex	UBERON:0002129	92.74	gold quality
granulocyte	CL:0000094	91.72	gold quality
cerebellum	UBERON:0002037	91.48	gold quality
ganglionic eminence	UBERON:0004023	91.35	gold quality
small intestine Peyer’s patch	UBERON:0003454	90.94	gold quality
body of uterus	UBERON:0009853	90.93	gold quality
bone marrow cell	CL:0002092	90.72	gold quality
right frontal lobe	UBERON:0002810	90.71	gold quality
adrenal tissue	UBERON:0018303	90.50	gold quality
ventricular zone	UBERON:0003053	90.46	gold quality
tibialis anterior	UBERON:0001385	90.33	gold quality
left ovary	UBERON:0002119	90.31	gold quality
stromal cell of endometrium	CL:0002255	90.28	gold quality
endocervix	UBERON:0000458	89.95	gold quality
right ovary	UBERON:0002118	89.89	gold quality
smooth muscle tissue	UBERON:0001135	89.81	gold quality
spleen	UBERON:0002106	89.73	gold quality
prefrontal cortex	UBERON:0000451	89.66	gold quality
germinal epithelium of ovary	UBERON:0001304	89.62	gold quality
middle temporal gyrus	UBERON:0002771	89.52	gold quality
left uterine tube	UBERON:0001303	89.50	gold quality
metanephros cortex	UBERON:0010533	89.30	gold quality
ectocervix	UBERON:0012249	89.12	gold quality
Brodmann (1909) area 9	UBERON:0013540	89.06	gold quality
skin of leg	UBERON:0001511	89.04	gold quality
left testis	UBERON:0004533	88.96	gold quality
small intestine	UBERON:0002108	88.92	gold quality
adenohypophysis	UBERON:0002196	88.87	gold quality
gingival epithelium	UBERON:0001949	88.81	gold quality
right adrenal gland cortex	UBERON:0035827	88.79	gold quality
transverse colon	UBERON:0001157	88.77	gold quality
right lobe of thyroid gland	UBERON:0001119	88.76	gold quality
skin of abdomen	UBERON:0001416	88.76	gold quality
right testis	UBERON:0004534	88.74	gold quality
right uterine tube	UBERON:0001302	88.64	gold quality
muscle layer of sigmoid colon	UBERON:0035805	88.63	gold quality
lower esophagus	UBERON:0013473	88.62	gold quality
lower esophagus muscularis layer	UBERON:0035833	88.62	gold quality
pituitary gland	UBERON:0000007	88.61	gold quality
left lobe of thyroid gland	UBERON:0001120	88.60	gold quality
right adrenal gland	UBERON:0001233	88.59	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	88.56	gold quality
tibial nerve	UBERON:0001323	88.52	gold quality
apex of heart	UBERON:0002098	88.52	gold quality
anterior cingulate cortex	UBERON:0009835	88.37	gold quality
minor salivary gland	UBERON:0001830	88.30	gold quality
popliteal artery	UBERON:0002250	88.25	gold quality
tibial artery	UBERON:0007610	88.25	gold quality
left adrenal gland	UBERON:0001234	88.19	gold quality
right coronary artery	UBERON:0001625	88.11	gold quality
endothelial cell	CL:0000115	88.10	silver quality
left adrenal gland cortex	UBERON:0035825	87.99	gold quality
descending thoracic aorta	UBERON:0002345	87.97	gold quality
aorta	UBERON:0000947	87.95	gold quality
primary visual cortex	UBERON:0002436	87.94	gold quality
ovary	UBERON:0000992	87.93	gold quality
esophagus	UBERON:0001043	87.91	gold quality
neocortex	UBERON:0001950	87.90	gold quality
thoracic aorta	UBERON:0001515	87.84	gold quality
ascending aorta	UBERON:0001496	87.76	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	87.74	gold quality
Brodmann (1909) area 23	UBERON:0013554	87.73	gold quality
body of stomach	UBERON:0001161	87.71	gold quality
rectum	UBERON:0001052	87.65	gold quality
frontal cortex	UBERON:0001870	87.60	gold quality
body of pancreas	UBERON:0001150	87.57	gold quality
esophagus mucosa	UBERON:0002469	87.57	gold quality
mucosa of stomach	UBERON:0001199	87.51	gold quality
upper lobe of left lung	UBERON:0008952	87.49	gold quality
left coronary artery	UBERON:0001626	87.43	gold quality
thyroid gland	UBERON:0002046	87.42	gold quality
adrenal gland	UBERON:0002369	87.37	gold quality
vermiform appendix	UBERON:0001154	87.25	gold quality
testis	UBERON:0000473	87.13	gold quality
gall bladder	UBERON:0002110	87.01	gold quality
mouth mucosa	UBERON:0003729	86.99	gold quality
islet of Langerhans	UBERON:0000006	86.85	gold quality
zone of skin	UBERON:0000014	86.84	gold quality
omental fat pad	UBERON:0010414	86.83	gold quality
leukocyte	CL:0000738	86.80	gold quality
peritoneum	UBERON:0002358	86.78	gold quality
hypothalamus	UBERON:0001898	86.69	gold quality
uterine cervix	UBERON:0000002	86.65	gold quality
sural nerve	UBERON:0015488	86.64	gold quality
pancreas	UBERON:0001264	86.63	gold quality
monocyte	CL:0000576	86.60	gold quality
stomach	UBERON:0000945	86.51	gold quality
vagina	UBERON:0000996	86.50	gold quality
adrenal cortex	UBERON:0001235	86.49	gold quality
intestine	UBERON:0000160	86.35	gold quality
coronary artery	UBERON:0001621	86.28	gold quality
cerebral cortex	UBERON:0000956	86.24	gold quality
upper lobe of lung	UBERON:0008948	86.23	gold quality
right lung	UBERON:0002167	86.10	gold quality
right atrium auricular region	UBERON:0006631	86.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.68

HPA expression

RNA tissue specificity: Low tissue specificity

showing 60 of 80 HPA tissues / cells by nTPM:

Tissue / cell	Axis	nTPM	Protein (IHC)
Frontal cortex	tissue	43.0
Cerebral cortex	tissue	35.5	medium
Motor cortex	tissue	35.5
Prefrontal cortex	tissue	33.1
Somatosensory cortex	tissue	31.4
Retrosplenial and cingulate cortex	tissue	31.1
Cerebellum	tissue	30.6	medium
Insular cortex	tissue	29.6
Retrosplenial cortex	tissue	29.2
Locus coeruleus	tissue	29.0
Occipital cortex	tissue	28.4
Hippocampal formation	tissue	28.2
Entorhinal cortex	tissue	28.2
Pons	tissue	27.8
Thalamus	tissue	27.0
Temporal cortex	tissue	26.9
Hypothalamus	tissue	26.3
Postcentral gyrus	tissue	25.9
Midbrain	tissue	25.6
Superior colliculi	tissue	24.0
Periaqueductal gray	tissue	24.0
Medulla oblongata	tissue	23.2
Substantia nigra	tissue	22.4
Amygdala	tissue	21.7
Bone marrow	tissue	21.3	low
Hippocampus	tissue	21.0	low
Septum	tissue	20.3
Parathyroid gland	tissue	20.0	low
Spinal cord	tissue	19.8
Caudate putamen	tissue	18.8
Choroid plexus	tissue	17.8
Spleen	tissue	17.8	low
Ovary	tissue	17.6	not detected
Corpus callosum	tissue	16.9
Smooth muscle	tissue	16.8	low
Endometrium 1	tissue	16.8	low
Ventral forebrain	tissue	16.7
Testis	tissue	16.5	medium
Skin 1	tissue	15.9	low
Placenta	tissue	15.6	medium
Olfactory bulb	tissue	15.3
Thymus	tissue	15.1
Pituitary gland	tissue	15.0
Basal ganglia	tissue	14.9	low
Small intestine	tissue	14.9	medium
Epididymis	tissue	14.7	medium
Lymph node	tissue	14.6	not detected
Fallopian tube	tissue	14.6	medium
Tonsil	tissue	14.4	low
Vagina	tissue	14.2	medium
Putamen	tissue	14.1
Nucleus accumbens	tissue	14.0
Esophagus	tissue	13.3	low
Seminal vesicle	tissue	13.0	low
Skeletal muscle	tissue	13.0	medium
Tongue	tissue	12.8
Rectum	tissue	12.6	medium
Duodenum	tissue	12.3	medium
Urinary bladder	tissue	12.2	low
Cervix	tissue	12.1	medium

Brain sub-regions (HPA Brain Atlas): detected in 192; highest nTPM — Habenula (35.6), Medial dorsal thalamic nucleus (29.2), Perirhinal gyrus (29.1), Olfactory area (28.3), Dorsal hippocampus (27.9).

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

Targeting STRIP1 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific).

showing 30 of 51 miRNAs:

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-1184	99.99	68.19	1458
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-512-3P	99.97	67.35	1049
HSA-MIR-3682-5P	99.93	67.97	1163
HSA-MIR-548D-3P	99.87	70.67	4362
HSA-MIR-3941	99.86	70.54	2735
HSA-MIR-548BB-3P	99.86	70.58	4354
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-548AC	99.84	70.77	4351
HSA-MIR-548H-3P	99.84	70.80	4349
HSA-MIR-548Z	99.84	70.80	4349
HSA-MIR-4495	99.82	72.08	3080
HSA-MIR-1299	99.77	71.24	2389
HSA-MIR-6885-3P	99.75	70.36	3187
HSA-MIR-92A-2-5P	99.75	67.01	2164
HSA-MIR-4472	99.56	66.08	1478
HSA-MIR-516B-5P	99.56	66.33	1495
HSA-MIR-1275	99.47	67.90	2749
HSA-MIR-103A-1-5P	99.39	67.78	1545
HSA-MIR-103A-2-5P	99.39	67.72	1577
HSA-MIR-4292	99.16	65.57	1767

Functional genomics

gnomAD constraint: pLI 2.15e-12, LOEUF 0.783, missense Z 2.37 — population loss-of-function intolerance (pLI ≥ 0.9 = LoF-intolerant; lower LOEUF = more constrained). gnomAD

Regional missense constraint (gnomAD)

ENST00000369795 splits into 2 regions with different missense tolerance; 0 are missense-constrained. Missense variants in a constrained region (low observed/expected) are more likely to be pathogenic. gnomAD

Region (GRCh38)	Missense obs / exp	o/e	Constrained
1:110,034,638–110,034,802	107 / 85.1	1.26	no
1:110,034,803–110,053,909	750 / 989.8	0.76	no
DepMap (CRISPR cell-line fitness): dependent in 36.1% of screened cell lines.

Most-dependent cell lines (DepMap gene-effect, lower = stronger; ≤ −0.5 shown): RERF-GC-1B (-1.847), NCI-H1568 (-1.576), SU-DHL-10 (-1.556), HUP-T4 (-1.46), EFO-21 (-1.456), OVISE (-1.446), G-402 (-1.441), JHOS-2 (-1.397), JHH-1 (-1.376), RERF-LC-Sq1 (-1.248), OE21 (-1.233), NB-4 (-1.226), EM-2 (-1.181), TEN (-1.15), EPLC-272H (-1.146).

Literature-anchored findings (GeneRIF, showing 3)

• this study propose that the STRIPAK complex, FAM40A, FAM40B and STRN3, regulates the mode of cancer cell migration by controlling the activity of MST3 and 4, which locally coordinate the phosphorylation of ERM proteins and inhibit the dephosphorylation of MLC leading to increased actin-membrane linkage. (PMID:25531779)
• STRIP1 is required for mesenchymal cell migration and is enriched in cellular protrusions in mesenchymal migrating cells. (PMID:29203676)
• These results demonstrate the importance of the FAM40 proteins for endothelial cell physiology, and suggest that they act as part of the CCM3-containing STRIPAK complex. (PMID:30509168)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	strip1	ENSDARG00000074084
mus_musculus	Strip1	ENSMUSG00000014601
rattus_norvegicus	Strip1	ENSRNOG00000018293
drosophila_melanogaster	Strip	FBGN0035437
caenorhabditis_elegans		WBGENE00017349

Paralogs (1): STRIP2 (ENSG00000128578)

Mouse-model phenotypes

Observed phenotypes of the mouse ortholog (MGI:2443884) from MGI (Alliance of Genome Resources) — knockout/mutant phenotypes, ranked by annotation count. 9 distinct phenotype terms.

Mouse phenotype (MP)	Records
abnormal mesoderm development	1
abnormal primitive streak morphology	1
embryonic growth retardation	1
cardia bifida	1
embryonic lethality, complete penetrance	1
abnormal head fold morphology	1
decreased fibroblast cell migration	1
embryonic-extraembryonic boundary constriction	1
short rostral-caudal axis	1

Additional cross-species homologs

Sequence homologs in species beyond Ensembl Compara’s model organisms, by Diamond local protein alignment (% sequence identity; best hit per species). Lower-identity rows are more distant homologs. The matched accessions’ gene symbols aren’t in biobtree yet, so each row shows the UniProt accession.

Organism	UniProt	Identity	Method
Macaca fascicularis	Q9GLZ5	99.2%	Diamond
Pongo abelii	Q5R7S4	99.0%	Diamond
Bos taurus	Q0P5J8	98.7%	Diamond

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
SLC6A17-AS1	ncRNA	105378897
UBL4B	protein-coding	164153
ALX3	protein-coding	257
SLC6A17	protein-coding	388662
LINC01397	ncRNA	104355139
AHCYL1	protein-coding	10768
CSF1	protein-coding	1435
LINC01768	ncRNA	107985167

Protein

Protein identifiers

Striatin-interacting protein 1 — Q5VSL9 (reviewed: Q5VSL9)

Alternative names: Protein FAM40A

All UniProt accessions (1): Q5VSL9

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation.

Subunit / interactions. Part of the core of STRIPAK complexes composed of PP2A catalytic and scaffolding subunits, the striatins (PP2A regulatory subunits), the striatin-associated proteins MOB4, STRIP1 and STRIP2, PDCD10 and members of the STE20 kinases, such as STK24 and STK26. The STRIPAK complex can be extended by adapter proteins such as SLMAP:SIKE1, CTTNBP2 or CTTNBP2NL. Interacts with CDC42BPB. Interacts with CTTNBP2NL.

Subcellular location. Cytoplasm.

Similarity. Belongs to the STRIP family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q5VSL9-1	1	yes
Q5VSL9-2	2
Q5VSL9-3	3
Q5VSL9-4	4

RefSeq proteins (2): NP_001257697, NP_149079* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR012486	Far11/STRP_N	Domain
IPR021819	Far11/STRP_C	Domain
IPR040185	Far11/STRP	Family

Pfam: PF07923, PF11882

UniProt features (68 total): helix 34, splice variant 7, modified residue 5, strand 5, compositionally biased region 5, region of interest 3, mutagenesis site 3, sequence conflict 2, turn 2, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

1 structures by resolution:

PDB	Title	Method	Resolution (Å)
7K36	Cryo-EM structure of STRIPAK complex	ELECTRON MICROSCOPY	3.3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5VSL9-F1	81.27	0.57

Human Protein Atlas

Protein class: Predicted intracellular proteins

Protein evidence: Evidence at protein level

Subcellular location (HPA, imaging): cytosol

Antibody reliability (HPA): IH approved · IF supported

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (5)

Type	Positions
Phosphoserine	59, 335, 339, 788
N-acetylmethionine	1

Mutagenesis-validated functional residues (3)

Position	Phenotype
131–134	decreased formation of stripak core complex.
427	decreased interaction with other stripak core complex components. decreased inhibition of hippo signaling.
744	decreased interaction with other stripak core complex components. decreased inhibition of hippo signaling.

Function

Pathways and Gene Ontology

Reactome pathways

0 curated (TAS) of 0; 0 disease pathways. Curated-first; evidence = TAS (manually curated) vs IEA (electronic inference).

MSigDB gene sets: 142 (showing top): RNGTGGGC_UNKNOWN, GOBP_REGULATION_OF_CELL_MORPHOGENESIS, GOBP_HIPPO_SIGNALING, GOMF_GTPASE_BINDING, GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, ATF3_Q6, TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P, YY1_01, GOBP_CORTICAL_CYTOSKELETON_ORGANIZATION, AR_Q2, TGGAAA_NFAT_Q4_01, YATGNWAAT_OCT_C, GOMF_KINASE_BINDING, GOBP_REGULATION_OF_HIPPO_SIGNALING, GOBP_NEGATIVE_REGULATION_OF_HIPPO_SIGNALING

GO Biological Process (3): cytoskeleton organization (GO:0007010), regulation of hippo signaling (GO:0035330), negative regulation of hippo signaling (GO:0035331)

GO Molecular Function (4): protein kinase binding (GO:0019901), protein-macromolecule adaptor activity (GO:0030674), small GTPase binding (GO:0031267), protein binding (GO:0005515)

GO Cellular Component (5): nucleus (GO:0005634), cytosol (GO:0005829), extracellular exosome (GO:0070062), FAR/SIP/STRIPAK complex (GO:0090443), cytoplasm (GO:0005737)

GO top-level categories

16 GO namespaces:

Category	Terms
hippo signaling	2
cellular anatomical structure	2
organelle organization	1
regulation of intracellular signal transduction	1
regulation of hippo signaling	1
negative regulation of intracellular signal transduction	1
kinase binding	1
protein binding	1
molecular adaptor activity	1
GTPase binding	1
binding	1
intracellular membrane-bounded organelle	1
cytoplasm	1
extracellular vesicle	1
protein-containing complex	1
intracellular anatomical structure	1

Experimentally-supported GO annotations

GO terms backed by direct experimental evidence (ECO experimental codes) — 6 of 12 annotations. The rest are phylogenetic / computational / electronic (IEA).

6 experimentally-supported GO terms:

GO term	NS	Evidence
negative regulation of hippo signaling	BP	direct assay
FAR/SIP/STRIPAK complex	CC	direct assay
cytosol	CC	direct assay
extracellular exosome	CC	high-throughput assay
nucleus	CC	direct assay
protein-macromolecule adaptor activity	MF	direct assay

Protein interactions and networks

STRING

showing 15 of 646 interactions by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
STRIP1	MOB4	Q9Y3A3	823
STRIP1	STRN	O43815	800
STRIP1	SIKE1	Q9BRV8	770
STRIP1	STRN3	Q13033	767
STRIP1	SLMAP	Q14BN4	764
STRIP1	STRN4	Q9NRL3	724
STRIP1	CTTNBP2NL	Q9P2B4	711
STRIP1	STK26	Q9P289	700
STRIP1	STK25	O00506	693
STRIP1	PDCD10	Q9BUL8	689
STRIP1	PPP2R1A	P30153	628
STRIP1	STK24	Q9Y6E0	602
STRIP1	FGFR1OP2	Q9NVK5	601
STRIP1	PPP2CA	P05323	598
STRIP1	MAP4K2	Q12851	572

IntAct

Human interaction partners of STRIP1 in IntAct, one row per partner (best MIscore; records = supporting IntAct interaction records).

10 partners by confidence:

Partner	Interaction type	MIscore	Records
PPP2CA	physical association	0.900	1
PPP2CB	association	0.870	2
STK25	association	0.840	1
STRN	physical association	0.770	1
STK24	physical association	0.740	1
STK26	physical association	0.710	1
CTTNBP2NL	physical association	0.690	1
TRAF3IP3	physical association	0.620	1
TRPT1	association	0.350	2
ENDOD1	association	0.350	1

BioGRID (210 interactions; top human partners by supporting records): PPP2R1A (Affinity Capture-MS; 9 records), PPP2CB (Affinity Capture-MS; 8 records), STRN (Affinity Capture-MS; 8 records), STRN3 (Affinity Capture-MS; 8 records), PPP2CA (Affinity Capture-MS; 7 records), STK25 (Affinity Capture-MS; 6 records), CTTNBP2NL (Affinity Capture-MS; 5 records), MOB4 (Affinity Capture-MS; 5 records), SLMAP (Affinity Capture-MS; 5 records), STK26 (Affinity Capture-MS; 5 records), MINK1 (Reconstituted Complex; 4 records), PDCD10 (Affinity Capture-MS; 4 records), SIKE1 (Affinity Capture-MS; 4 records), STK24 (Affinity Capture-MS; 4 records), TRAF3IP3 (Affinity Capture-MS; 4 records)

Protein complexes (CORUM) (1)

Experimentally-characterized complexes this protein is a subunit of (★ = the complex contains a known drug target).

1 complexes by size:

Complex	Subunits	Members
STRIPAK complex	11	PPP2CA, PPP2R1A, STRIP1, STRN, CTTNBP2NL, GOLGA2, MOB4, STK26, STRN3, STRN4, PDCD10

Disease & clinical

Genetic variants

Variant evidence for STRIP1: 125 ClinVar records (0 pathogenic / likely pathogenic); 1 GWAS association.

ClinVar

125 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	95
Likely benign	1
Benign	3

SpliceAI

Top 10 splice-impact sites by Δscore (adjacent positions with the same effect merged into one range; 29 predictions of 1,852):

Position(s)	Effect	Δscore	Sites
1:110034818	donor_loss	1.0000
1:110038758–110038759	donor_loss	1.0000	5
1:110039170–110039171	acceptor_loss	1.0000	6
1:110040561	acceptor_gain	1.0000
1:110040600	acceptor_gain	1.0000
1:110041639	donor_gain	1.0000
1:110043078	acceptor_gain	1.0000
1:110043086–110043087	acceptor_loss	1.0000	5
1:110043630–110043631	acceptor_gain	1.0000	2
1:110043637–110043638	acceptor_loss	1.0000	6

AlphaMissense

3,139 missense substitutions predicted likely pathogenic (of 5,533 scored), across 647 residues. Top 20 hotspot residues, ranked by the number of likely-pathogenic substitutions (of those reachable by a single-nucleotide change), then by mean score:

Residue	Likely-pathogenic substitutions	Mean am_pathogenicity	Max am_pathogenicity
M733	9	0.995	1.000
M687	9	0.993	1.000
M688	9	0.987	1.000
M553	9	0.968	0.999
M736	9	0.918	1.000
M331	9	0.904	0.996
M269	9	0.866	0.995
F692	8	0.999	1.000
H745	8	0.999	1.000
D749	8	0.999	1.000
D750	8	0.999	1.000
D763	8	0.998	1.000
D566	8	0.997	0.999
F606	8	0.996	1.000
N608	8	0.994	1.000
N732	8	0.994	1.000
F813	8	0.992	0.999
D452	8	0.990	0.998
D796	8	0.989	0.998
D547	8	0.988	0.999

HPA cancer prognostics

RNA cancer specificity: Low cancer specificity

Human Protein Atlas survival analysis — favorable = higher expression predicts better survival.

3 prognostic cancer types:

Cancer	Prognostic	p-value
Glioblastoma Multiforme (validation)	favorable	2.46e-06
Kidney Renal Clear Cell Carcinoma (validation)	favorable	0.000407
Liver Hepatocellular Carcinoma (TCGA)	unfavorable	0.000695

Disease associations

OMIM: gene MIM:617918 | disease phenotypes:

GWAS associations

1 associations:

Study	Trait	p-value
GCST001524_21	Visceral adipose tissue/subcutaneous adipose tissue ratio	2e-6

EFO canonical traits (from GWAS)

1 canonical traits:

EFO ID	Trait name
EFO:0004767	visceral:subcutaneous adipose tissue ratio

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (CPIC guideline: no)

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	increases expression	1
FR900359	affects phosphorylation	1
bisphenol F	increases expression	1
pirinixic acid	increases expression, affects binding, increases activity	1
bisphenol A	affects cotreatment, increases methylation, decreases methylation	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
sodium arsenite	decreases expression	1
CGP 52608	increases reaction, affects binding	1
K 7174	increases expression	1
abrine	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Air Pollutants	decreases expression, increases abundance	1
Benzo(a)pyrene	increases methylation	1
Caffeine	increases phosphorylation	1
Doxorubicin	affects expression	1
Ivermectin	decreases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Smoke	decreases expression	1
Tretinoin	increases expression	1
Valproic Acid	affects expression	1
Cyclosporine	increases expression	1
Acrylamide	decreases expression	1
Particulate Matter	increases abundance, decreases expression	1

Clinical trials (associated diseases)

Via MONDO — disease-level, not drug-specific.