STRIP1

Summary

STRIP1 (striatin interacting protein 1, HGNC:25916) is a protein-coding gene on chromosome 1p13.3, encoding Striatin-interacting protein 1 (Q5VSL9). Plays a role in the regulation of cell morphology and cytoskeletal organization. It is a selective cancer dependency (DepMap: 36.1% of cell lines).

This gene encodes a member of the striatin-interacting phosphatase and kinase complex, which is involved in localization of the Golgi body. The encoded protein participates in cytosketelal organization. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 85369 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 125 total
• Cancer dependency (DepMap): dependent in 36.1% of screened cell lines
• MANE Select transcript: NM_033088

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25916
Approved symbol	STRIP1
Name	striatin interacting protein 1
Location	1p13.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ14743, KIAA1761, FAR11A
Ensembl gene	ENSG00000143093
Ensembl biotype	protein_coding
OMIM	617918
Entrez	85369

Gene structure

Transcript identifiers

Ensembl transcripts: 20 — 13 protein_coding, 6 retained_intron, 1 nonsense_mediated_decay

ENST00000369795, ENST00000369796, ENST00000461054, ENST00000473429, ENST00000485775, ENST00000489059, ENST00000535003, ENST00000539541, ENST00000540970, ENST00000906338, ENST00000906339, ENST00000906340, ENST00000906341, ENST00000906342, ENST00000906343, ENST00000930842, ENST00000930843, ENST00000950691, ENST00000950692, ENST00000950693

RefSeq mRNA: 2 — MANE Select: NM_033088 NM_001270768, NM_033088

CCDS: CCDS30798, CCDS59197

Canonical transcript exons

ENST00000369795 — 21 exons

Exon	Start	End
ENSE00001850618	110034624	110034817
ENSE00003461663	110050956	110051060
ENSE00003463201	110047542	110047616
ENSE00003498567	110051683	110051887
ENSE00003508856	110044840	110044905
ENSE00003515653	110049460	110049560
ENSE00003535290	110041734	110041861
ENSE00003565721	110041536	110041642
ENSE00003590269	110040635	110040703
ENSE00003594631	110043639	110043856
ENSE00003602797	110046680	110046751
ENSE00003612165	110049112	110049238
ENSE00003620778	110050343	110050409
ENSE00003633825	110053665	110054641
ENSE00003635541	110045015	110045078
ENSE00003636515	110047772	110047869
ENSE00003643818	110043088	110043270
ENSE00003696781	110039172	110039306
ENSE00003697226	110038683	110038757
ENSE00003698529	110039395	110039515
ENSE00003700076	110037891	110037960

Expression profiles

Bgee: expression breadth ubiquitous, 236 present calls, max score 94.76.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 19.7221 / max 105.4209, expressed in 1809 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
4505	19.7221	1809

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	94.76	gold quality
ileal mucosa	UBERON:0000331	94.22	gold quality
pancreatic ductal cell	CL:0002079	94.21	gold quality
right hemisphere of cerebellum	UBERON:0014890	93.28	gold quality
cerebellar hemisphere	UBERON:0002245	92.92	gold quality
cerebellar cortex	UBERON:0002129	92.74	gold quality
granulocyte	CL:0000094	91.72	gold quality
cerebellum	UBERON:0002037	91.48	gold quality
ganglionic eminence	UBERON:0004023	91.35	gold quality
small intestine Peyer’s patch	UBERON:0003454	90.94	gold quality
body of uterus	UBERON:0009853	90.93	gold quality
bone marrow cell	CL:0002092	90.72	gold quality
right frontal lobe	UBERON:0002810	90.71	gold quality
adrenal tissue	UBERON:0018303	90.50	gold quality
ventricular zone	UBERON:0003053	90.46	gold quality
tibialis anterior	UBERON:0001385	90.33	gold quality
left ovary	UBERON:0002119	90.31	gold quality
stromal cell of endometrium	CL:0002255	90.28	gold quality
endocervix	UBERON:0000458	89.95	gold quality
right ovary	UBERON:0002118	89.89	gold quality
smooth muscle tissue	UBERON:0001135	89.81	gold quality
spleen	UBERON:0002106	89.73	gold quality
prefrontal cortex	UBERON:0000451	89.66	gold quality
germinal epithelium of ovary	UBERON:0001304	89.62	gold quality
middle temporal gyrus	UBERON:0002771	89.52	gold quality
left uterine tube	UBERON:0001303	89.50	gold quality
metanephros cortex	UBERON:0010533	89.30	gold quality
ectocervix	UBERON:0012249	89.12	gold quality
Brodmann (1909) area 9	UBERON:0013540	89.06	gold quality
skin of leg	UBERON:0001511	89.04	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.68

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

51 targeting STRIP1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-1184	99.99	68.19	1458
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-512-3P	99.97	67.35	1049
HSA-MIR-3682-5P	99.93	67.97	1163
HSA-MIR-548D-3P	99.87	70.67	4362
HSA-MIR-3941	99.86	70.54	2735
HSA-MIR-548BB-3P	99.86	70.58	4354
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-548AC	99.84	70.77	4351
HSA-MIR-548H-3P	99.84	70.80	4349
HSA-MIR-548Z	99.84	70.80	4349
HSA-MIR-4495	99.82	72.08	3080
HSA-MIR-1299	99.77	71.24	2389
HSA-MIR-6885-3P	99.75	70.36	3187
HSA-MIR-92A-2-5P	99.75	67.01	2164
HSA-MIR-4472	99.56	66.08	1478
HSA-MIR-516B-5P	99.56	66.33	1495
HSA-MIR-1275	99.47	67.90	2749
HSA-MIR-103A-1-5P	99.39	67.78	1545
HSA-MIR-103A-2-5P	99.39	67.72	1577
HSA-MIR-4292	99.16	65.57	1767

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 36.1% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 3)

• this study propose that the STRIPAK complex, FAM40A, FAM40B and STRN3, regulates the mode of cancer cell migration by controlling the activity of MST3 and 4, which locally coordinate the phosphorylation of ERM proteins and inhibit the dephosphorylation of MLC leading to increased actin-membrane linkage. (PMID:25531779)
• STRIP1 is required for mesenchymal cell migration and is enriched in cellular protrusions in mesenchymal migrating cells. (PMID:29203676)
• These results demonstrate the importance of the FAM40 proteins for endothelial cell physiology, and suggest that they act as part of the CCM3-containing STRIPAK complex. (PMID:30509168)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	strip1	ENSDARG00000074084
mus_musculus	Strip1	ENSMUSG00000014601
rattus_norvegicus	Strip1	ENSRNOG00000018293
drosophila_melanogaster	Strip	FBGN0035437
caenorhabditis_elegans		WBGENE00017349

Paralogs (1): STRIP2 (ENSG00000128578)

Protein

Protein identifiers

Striatin-interacting protein 1 — Q5VSL9 (reviewed: Q5VSL9)

Alternative names: Protein FAM40A

All UniProt accessions (1): Q5VSL9

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation.

Subunit / interactions. Part of the core of STRIPAK complexes composed of PP2A catalytic and scaffolding subunits, the striatins (PP2A regulatory subunits), the striatin-associated proteins MOB4, STRIP1 and STRIP2, PDCD10 and members of the STE20 kinases, such as STK24 and STK26. The STRIPAK complex can be extended by adapter proteins such as SLMAP:SIKE1, CTTNBP2 or CTTNBP2NL. Interacts with CDC42BPB. Interacts with CTTNBP2NL.

Subcellular location. Cytoplasm.

Similarity. Belongs to the STRIP family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q5VSL9-1	1	yes
Q5VSL9-2	2
Q5VSL9-3	3
Q5VSL9-4	4

RefSeq proteins (2): NP_001257697, NP_149079* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR012486	Far11/STRP_N	Domain
IPR021819	Far11/STRP_C	Domain
IPR040185	Far11/STRP	Family

Pfam: PF07923, PF11882

UniProt features (68 total): helix 33, splice variant 7, strand 6, modified residue 5, compositionally biased region 5, region of interest 3, mutagenesis site 3, sequence conflict 2, turn 2, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
7K36	ELECTRON MICROSCOPY	3.3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5VSL9-F1	81.27	0.57

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (5): 59, 335, 339, 788, 1

Mutagenesis-validated functional residues (3):

Position	Phenotype
131–134	decreased formation of stripak core complex.
427	decreased interaction with other stripak core complex components. decreased inhibition of hippo signaling.
744	decreased interaction with other stripak core complex components. decreased inhibition of hippo signaling.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 142 (showing top): RNGTGGGC_UNKNOWN, GOBP_REGULATION_OF_CELL_MORPHOGENESIS, GOBP_HIPPO_SIGNALING, GOMF_GTPASE_BINDING, GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, ATF3_Q6, TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P, YY1_01, GOBP_CORTICAL_CYTOSKELETON_ORGANIZATION, AR_Q2, TGGAAA_NFAT_Q4_01, YATGNWAAT_OCT_C, GOMF_KINASE_BINDING, GOBP_REGULATION_OF_HIPPO_SIGNALING, GOBP_NEGATIVE_REGULATION_OF_HIPPO_SIGNALING

GO Biological Process (4): cytoskeleton organization (GO:0007010), regulation of cell morphogenesis (GO:0022604), cortical actin cytoskeleton organization (GO:0030866), negative regulation of hippo signaling (GO:0035331)

GO Molecular Function (4): protein kinase binding (GO:0019901), protein-macromolecule adaptor activity (GO:0030674), small GTPase binding (GO:0031267), protein binding (GO:0005515)

GO Cellular Component (5): nucleus (GO:0005634), cytosol (GO:0005829), extracellular exosome (GO:0070062), FAR/SIN/STRIPAK complex (GO:0090443), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
organelle organization	1
cell morphogenesis	1
regulation of anatomical structure morphogenesis	1
actin cytoskeleton organization	1
cortical cytoskeleton organization	1
hippo signaling	1
regulation of hippo signaling	1
negative regulation of intracellular signal transduction	1
kinase binding	1
protein binding	1
molecular adaptor activity	1
GTPase binding	1
binding	1
intracellular membrane-bounded organelle	1
cytoplasm	1
extracellular vesicle	1
protein-containing complex	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

864 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
STRIP1	MOB4	Q9Y3A3	990
STRIP1	PPP2CA	P05323	967
STRIP1	PDCD10	Q9BUL8	956
STRIP1	STRN	O43815	955
STRIP1	PPP2R1A	P30153	939
STRIP1	STK26	Q9P289	924
STRIP1	STK25	O00506	899
STRIP1	SLMAP	Q14BN4	870
STRIP1	CTTNBP2NL	Q9P2B4	864
STRIP1	STRN3	Q13033	852
STRIP1	STRN4	Q9NRL3	834
STRIP1	STK24	Q9Y6E0	806
STRIP1	CTTNBP2	Q8WZ74	778
STRIP1	SIKE1	Q9BRV8	763
STRIP1	MAP4K2	Q12851	722

IntAct

149 interactions, top by confidence:

A	B	Type	Score
PPP2R1A	PPP2CA	psi-mi:“MI:0914”(association)	0.990
PDCD10	STK25	psi-mi:“MI:0914”(association)	0.980
STRN3	PPP2R1A	psi-mi:“MI:0914”(association)	0.920
STRIP1	PPP2CA	psi-mi:“MI:0915”(physical association)	0.900
STK25	STRN	psi-mi:“MI:0914”(association)	0.900
STK24	STK25	psi-mi:“MI:0914”(association)	0.890
PPP2R1A	STRN	psi-mi:“MI:0914”(association)	0.880
PPP2R1A	STRN	psi-mi:“MI:2364”(proximity)	0.880
STRN3	STK25	psi-mi:“MI:0914”(association)	0.880
CTTNBP2NL	STK25	psi-mi:“MI:0914”(association)	0.880
STRN3	STRN	psi-mi:“MI:0914”(association)	0.880
STRN3	STRN	psi-mi:“MI:2364”(proximity)	0.880
STRIP1	PPP2CB	psi-mi:“MI:0915”(physical association)	0.870
STK24	STRN	psi-mi:“MI:0914”(association)	0.870
STRIP1	PPP2CB	psi-mi:“MI:0914”(association)	0.870
STK26	STRN	psi-mi:“MI:0914”(association)	0.860
PRDM14	CBFA2T2	psi-mi:“MI:0914”(association)	0.860
PPP2CA	STRN	psi-mi:“MI:0914”(association)	0.840

BioGRID (209): STRIP1 (Affinity Capture-RNA), STRIP1 (Affinity Capture-RNA), STRIP1 (Affinity Capture-RNA), STRIP1 (Affinity Capture-RNA), STRIP1 (Affinity Capture-MS), STRIP1 (Affinity Capture-MS), STRIP1 (Affinity Capture-MS), STRIP1 (Affinity Capture-MS), STRIP1 (Affinity Capture-MS), STRIP1 (Affinity Capture-MS), STRIP1 (Affinity Capture-MS), SLMAP (Co-fractionation), STRIP1 (Affinity Capture-MS), STRIP1 (Affinity Capture-MS), STRIP1 (Affinity Capture-MS)

ESM2 similar proteins: A0A4X1TB62, A4VCH4, G3V7Q0, O14795, O35841, O43237, O70585, P23116, P48553, Q0P5J8, Q14152, Q15542, Q1JU68, Q3TLI0, Q3UHE1, Q4R5P6, Q5R660, Q5R7S4, Q5R7U7, Q5RE09, Q5RE70, Q5VSL9, Q5XI83, Q658Y4, Q68E01, Q6IQ26, Q6PAL8, Q6PDL0, Q6TEP1, Q6WKZ8, Q7SYD9, Q7TPD0, Q8BIK4, Q8BWQ6, Q8C079, Q8C092, Q8C9H6, Q8CBY8, Q8IWV8, Q8K400

Diamond homologs: Q0P5J8, Q5R7S4, Q5VSL9, Q803T2, Q8C079, Q8C9H6, Q9GLZ5, Q9ULQ0, Q54IL2

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 109 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Degradation of beta-catenin by the destruction complex	7	20.2×	2e-05
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	6	11.7×	1e-03
EML4 and NUDC in mitotic spindle formation	6	9.3×	1e-03
Separation of Sister Chromatids	9	9.1×	8e-05
Resolution of Sister Chromatid Cohesion	6	8.7×	1e-03
Mitotic Prometaphase	7	8.1×	1e-03
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	5	8.1×	5e-03
RHO GTPases Activate Formins	6	7.8×	2e-03

GO biological processes:

GO term	Partners	Fold	FDR
negative regulation of hippo signaling	7	51.7×	3e-08
regulation of MAPK cascade	5	24.0×	3e-04
protein autophosphorylation	9	13.8×	6e-06
protein phosphorylation	10	7.2×	3e-04
intracellular signal transduction	12	4.8×	9e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

125 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	95
Likely benign	1
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

3866 predictions. Top by Δscore:

Variant	Effect	Δscore
1:110034813:CAGAG:C	donor_loss	1.0000
1:110034815:GAG:G	donor_gain	1.0000
1:110034816:AGG:A	donor_loss	1.0000
1:110034817:GGTC:G	donor_loss	1.0000
1:110038757:GGTG:G	donor_loss	1.0000
1:110038758:G:GG	donor_gain	1.0000
1:110038758:GTG:G	donor_loss	1.0000
1:110038759:T:A	donor_loss	1.0000
1:110039162:T:TA	acceptor_gain	1.0000
1:110039167:T:TA	acceptor_gain	1.0000
1:110039170:A:AG	acceptor_gain	1.0000
1:110039170:AGT:A	acceptor_gain	1.0000
1:110039171:G:GT	acceptor_gain	1.0000
1:110039171:GT:G	acceptor_gain	1.0000
1:110039171:GTG:G	acceptor_gain	1.0000
1:110039171:GTGA:G	acceptor_gain	1.0000
1:110039171:GTGAC:G	acceptor_gain	1.0000
1:110039246:G:GT	donor_gain	1.0000
1:110039260:G:GT	donor_gain	1.0000
1:110039306:GGTAT:G	donor_gain	1.0000
1:110039512:TAGA:T	donor_gain	1.0000
1:110039514:GA:G	donor_gain	1.0000
1:110039516:G:GG	donor_gain	1.0000
1:110040559:ATT:A	acceptor_gain	1.0000
1:110040561:T:A	acceptor_gain	1.0000
1:110040600:T:TA	acceptor_gain	1.0000
1:110041638:GCTGG:G	donor_gain	1.0000
1:110041639:C:G	donor_gain	1.0000
1:110041732:A:AG	acceptor_gain	1.0000
1:110041733:G:GG	acceptor_gain	1.0000

AlphaMissense

5533 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:110043840:T:A	W424R	1.000
1:110043840:T:C	W424R	1.000
1:110043842:G:C	W424C	1.000
1:110043842:G:T	W424C	1.000
1:110043851:G:C	K427N	1.000
1:110043851:G:T	K427N	1.000
1:110044859:T:C	F436L	1.000
1:110044860:T:C	F436S	1.000
1:110044860:T:G	F436C	1.000
1:110044861:C:A	F436L	1.000
1:110044861:C:G	F436L	1.000
1:110044863:T:A	L437H	1.000
1:110044863:T:C	L437P	1.000
1:110044874:C:A	R441S	1.000
1:110044874:C:G	R441G	1.000
1:110044875:G:C	R441P	1.000
1:110044880:A:G	K443E	1.000
1:110044883:T:C	F444L	1.000
1:110044884:T:C	F444S	1.000
1:110044884:T:G	F444C	1.000
1:110044885:T:A	F444L	1.000
1:110044885:T:G	F444L	1.000
1:110045034:G:A	G458R	1.000
1:110045034:G:C	G458R	1.000
1:110045034:G:T	G458W	1.000
1:110045035:G:A	G458E	1.000
1:110045038:T:A	L459Q	1.000
1:110045038:T:C	L459P	1.000
1:110045038:T:G	L459R	1.000
1:110045040:C:A	P460T	1.000

dbSNP variants (sampled 300 via entrez): RS1000115039 (1:110034329 G>A), RS1000143465 (1:110032287 G>C), RS1000182198 (1:110049656 G>A,C), RS1000364380 (1:110040102 G>A), RS1000381441 (1:110050047 T>G), RS1000411943 (1:110032674 G>T), RS1000903468 (1:110039384 C>T), RS1000927428 (1:110045703 G>A), RS1000933477 (1:110050188 T>C), RS1000966507 (1:110038584 G>A), RS1001002517 (1:110034094 T>C), RS1001105750 (1:110032624 A>C), RS1001322279 (1:110047037 G>A,C), RS1001385836 (1:110051318 T>G), RS1001531083 (1:110041454 T>G)

Disease associations

OMIM: gene MIM:617918 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST001524_21	Visceral adipose tissue/subcutaneous adipose tissue ratio	2.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004767	visceral:subcutaneous adipose tissue ratio

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	increases expression	1
FR900359	affects phosphorylation	1
bisphenol F	increases expression	1
pirinixic acid	increases expression, affects binding, increases activity	1
bisphenol A	affects cotreatment, increases methylation, decreases methylation	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
sodium arsenite	decreases expression	1
CGP 52608	increases reaction, affects binding	1
K 7174	increases expression	1
abrine	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Air Pollutants	decreases expression, increases abundance	1
Benzo(a)pyrene	increases methylation	1
Caffeine	increases phosphorylation	1
Doxorubicin	affects expression	1
Ivermectin	decreases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Smoke	decreases expression	1
Tretinoin	increases expression	1
Valproic Acid	affects expression	1
Cyclosporine	increases expression	1
Acrylamide	decreases expression	1
Particulate Matter	increases abundance, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.