STRN3

Summary

STRN3 (striatin 3, HGNC:15720) is a protein-coding gene on chromosome 14q12, encoding Striatin-3 (Q13033). Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes.

Enables armadillo repeat domain binding activity; enzyme binding activity; and protein-macromolecule adaptor activity. Involved in negative regulation of hippo signaling; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus; nucleoplasm; and plasma membrane. Part of FAR/SIN/STRIPAK complex.

Source: NCBI Gene 29966 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 101 total
• MANE Select transcript: NM_001083893

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15720
Approved symbol	STRN3
Name	striatin 3
Location	14q12
Locus type	gene with protein product
Status	Approved
Aliases	SG2NA, PPP2R6B, S/G2NA
Ensembl gene	ENSG00000196792
Ensembl biotype	protein_coding
OMIM	614766
Entrez	29966

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 12 protein_coding, 1 protein_coding_CDS_not_defined, 1 retained_intron, 1 nonsense_mediated_decay

ENST00000355683, ENST00000357479, ENST00000366206, ENST00000554124, ENST00000554991, ENST00000555152, ENST00000555358, ENST00000556577, ENST00000937939, ENST00000964546, ENST00000964547, ENST00000964548, ENST00000964549, ENST00000964550, ENST00000964551

RefSeq mRNA: 2 — MANE Select: NM_001083893 NM_001083893, NM_014574

CCDS: CCDS41938, CCDS9641

Canonical transcript exons

ENST00000357479 — 18 exons

Exon	Start	End
ENSE00001366972	30947090	30947263
ENSE00001367141	30955620	30955693
ENSE00001373638	30936495	30936624
ENSE00001373653	30950863	30950944
ENSE00001375130	30935163	30935304
ENSE00001429532	30918966	30919106
ENSE00001432633	30929201	30929311
ENSE00001847082	31025904	31026379
ENSE00002494759	30893804	30895580
ENSE00003461486	30956139	30956242
ENSE00003480010	30911777	30911824
ENSE00003500181	30912007	30912182
ENSE00003550807	30902536	30902643
ENSE00003555138	30906877	30907044
ENSE00003588671	30905418	30905558
ENSE00003633185	30895662	30895748
ENSE00003637476	30911041	30911162
ENSE00003790719	30913524	30913657

Expression profiles

Bgee: expression breadth ubiquitous, 288 present calls, max score 98.17.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 15.7006 / max 130.7316, expressed in 1802 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
142725	13.4813	1790
142726	2.2193	1226

Top tissues by expression

294 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	98.17	gold quality
colonic epithelium	UBERON:0000397	96.92	gold quality
biceps brachii	UBERON:0001507	94.18	gold quality
sural nerve	UBERON:0015488	94.12	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	93.72	gold quality
blood vessel layer	UBERON:0004797	93.69	gold quality
adrenal tissue	UBERON:0018303	92.79	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	92.69	gold quality
muscle of leg	UBERON:0001383	91.84	gold quality
cauda epididymis	UBERON:0004360	91.81	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	91.79	gold quality
gastrocnemius	UBERON:0001388	91.70	gold quality
hindlimb stylopod muscle	UBERON:0004252	91.51	gold quality
muscle organ	UBERON:0001630	91.22	gold quality
stromal cell of endometrium	CL:0002255	90.84	gold quality
tibialis anterior	UBERON:0001385	90.71	gold quality
ventricular zone	UBERON:0003053	90.58	gold quality
skeletal muscle tissue	UBERON:0001134	90.23	gold quality
oocyte	CL:0000023	89.63	gold quality
cortical plate	UBERON:0005343	89.44	gold quality
vastus lateralis	UBERON:0001379	89.02	gold quality
quadriceps femoris	UBERON:0001377	88.98	gold quality
corpus epididymis	UBERON:0004359	88.90	gold quality
smooth muscle tissue	UBERON:0001135	88.74	gold quality
ganglionic eminence	UBERON:0004023	88.68	gold quality
epithelium of nasopharynx	UBERON:0001951	88.63	gold quality
muscle tissue	UBERON:0002385	88.60	gold quality
deltoid	UBERON:0001476	88.55	gold quality
caput epididymis	UBERON:0004358	88.23	gold quality
popliteal artery	UBERON:0002250	88.10	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	10.12
E-MTAB-6379	no	299.80

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

172 targeting STRN3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-3134	100.00	66.43	777
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-34C-5P	99.97	70.45	1577
HSA-MIR-449B-5P	99.97	70.26	1580
HSA-MIR-3065-5P	99.97	71.56	3281

Literature-anchored findings (GeneRIF, showing 10)

• STRN3 (rs2273171)is associated with single nucleotide polymorphisms in Korean patients, either non-segmental or segmental type. (PMID:23678272)
• This result combined with a number of biophysical analyses provide evidence that the coiled coil domain of striatin 3 and the PP2A A subunit form a stable core complex with a 2:2 stoichiometry (PMID:24550388)
• The structure and protein-binding domains of the SG2NA protein variants have been described. (PMID:25015106)
• this study propose that the STRIPAK complex, FAM40A, FAM40B and STRN3, regulates the mode of cancer cell migration by controlling the activity of MST3 and 4, which locally coordinate the phosphorylation of ERM proteins and inhibit the dephosphorylation of MLC leading to increased actin-membrane linkage. (PMID:25531779)
• results demonstrate that XBP1 mRNA splicing plays an important role in maintaining the function of bone marrow-derived macrophages and provide new insight into the study and treatment of atherosclerosis (PMID:26022125)
• we detected novel and related STRN-NTRK3 and STRN3-NTRK3 fusions in 2 fibrosarcomas that occurred in the bone and soft tissue of young adult patients (PMID:30520818)
• Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer. (PMID:32589942)
• The profile of expression of the scaffold protein SG2NA(s) differs between cancer types and its interactome in normal vis-a-vis breast tumor tissues suggests its wide roles in regulating multiple cellular pathways. (PMID:35230605)
• Phosphorylation of Influenza A Virus Matrix Protein 1 at Threonine 108 Controls Its Multimerization State and Functional Association with the STRIPAK Complex. (PMID:36602306)
• STRN3 promotes tumour growth in hepatocellular carcinoma by inhibiting the hippo pathway. (PMID:38429901)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	strn3	ENSDARG00000001729
mus_musculus	Strn3	ENSMUSG00000020954
rattus_norvegicus	Strn3	ENSRNOG00000060335

Paralogs (2): STRN4 (ENSG00000090372), STRN (ENSG00000115808)

Protein

Protein identifiers

Striatin-3 — Q13033 (reviewed: Q13033)

Alternative names: Cell cycle autoantigen SG2NA, S/G2 antigen

All UniProt accessions (5): Q13033, G3V340, G3V3G7, H0YJT2, H0YJZ4

UniProt curated annotations — full annotation on UniProt →

Function. Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation.

Subunit / interactions. Tetramerizes. Part of the core of STRIPAK complexes composed of PP2A catalytic and scaffolding subunits, the striatins (PP2A regulatory subunits), the striatin-associated proteins MOB4, STRIP1 and STRIP2, PDCD10 and members of the STE20 kinases, such as STK24 and STK26. The STRIPAK complex can be extended by adapter proteins such as SLMAP:SIKE1 or CTTNBP2NL. Interacts with CDC42BPB.

Subcellular location. Cytoplasm. Membrane.

Similarity. Belongs to the WD repeat striatin family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q13033-1	Beta	yes
Q13033-2	Alpha

RefSeq proteins (2): NP_001077362, NP_055389 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR013258	Striatin_N	Domain
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR019775	WD40_repeat_CS	Conserved_site
IPR020472	WD40_PAC1	Repeat
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily
IPR051488	WD_repeat_striatin	Family

Pfam: PF00400, PF08232

UniProt features (69 total): strand 33, modified residue 7, repeat 6, region of interest 5, compositionally biased region 5, mutagenesis site 3, helix 3, turn 2, chain 1, coiled-coil region 1, splice variant 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

4 structures.

PDB	Method	Resolution (Å)
6AKL	X-RAY DIFFRACTION	1.75
4N6J	X-RAY DIFFRACTION	2
7K36	ELECTRON MICROSCOPY	3.3
6IUR	X-RAY DIFFRACTION	3.33

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q13033-F1	68.65	0.40

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (7): 1, 150, 202, 214, 229, 257, 335

Mutagenesis-validated functional residues (3):

Position	Phenotype
176–185	loss of stripak complex formation.
179–186	loss of stripak complex formation.
530	decreased interaction with other components of stripak core complex.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 274 (showing top): TGGTGCT_MIR29A_MIR29B_MIR29C, GOBP_RESPONSE_TO_ESTRADIOL, GOBP_CELLULAR_RESPONSE_TO_LIPID, GCANCTGNY_MYOD_Q6, GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY, GOBP_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY, GOBP_HIPPO_SIGNALING, GOMF_GTPASE_BINDING, GGGTGGRR_PAX4_03, AAAYRNCTG_UNKNOWN, GGCNKCCATNK_UNKNOWN, chr14q12, GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, GOBP_HORMONE_MEDIATED_SIGNALING_PATHWAY, WATANABE_COLON_CANCER_MSI_VS_MSS_UP

GO Biological Process (6): negative regulation of transcription by RNA polymerase II (GO:0000122), response to estradiol (GO:0032355), negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147), negative regulation of hippo signaling (GO:0035331), negative regulation of DNA-templated transcription (GO:0045892), positive regulation of transcription by RNA polymerase II (GO:0045944)

GO Molecular Function (8): calmodulin binding (GO:0005516), protein kinase binding (GO:0019901), protein-macromolecule adaptor activity (GO:0030674), small GTPase binding (GO:0031267), protein-containing complex binding (GO:0044877), protein phosphatase 2A binding (GO:0051721), armadillo repeat domain binding (GO:0070016), protein binding (GO:0005515)

GO Cellular Component (11): nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), Golgi apparatus (GO:0005794), plasma membrane (GO:0005886), dendrite (GO:0030425), protein-containing complex (GO:0032991), neuronal cell body (GO:0043025), FAR/SIN/STRIPAK complex (GO:0090443), postsynapse (GO:0098794), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
regulation of transcription by RNA polymerase II	2
transcription by RNA polymerase II	2
protein binding	2
binding	2
intracellular membrane-bounded organelle	2
negative regulation of DNA-templated transcription	1
response to lipid	1
response to oxygen-containing compound	1
estrogen receptor signaling pathway	1
negative regulation of intracellular steroid hormone receptor signaling pathway	1
regulation of intracellular estrogen receptor signaling pathway	1
hippo signaling	1
regulation of hippo signaling	1
negative regulation of intracellular signal transduction	1
DNA-templated transcription	1
regulation of DNA-templated transcription	1
negative regulation of RNA biosynthetic process	1
positive regulation of DNA-templated transcription	1
kinase binding	1
molecular adaptor activity	1
GTPase binding	1
protein phosphatase binding	1
protein domain specific binding	1
nuclear lumen	1
intracellular anatomical structure	1
cytoplasm	1
endomembrane system	1
membrane	1
cell periphery	1
neuron projection	1
dendritic tree	1
cellular_component	1
somatodendritic compartment	1
cell body	1
protein-containing complex	1
synapse	1

Protein interactions and networks

STRING

822 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
STRN3	CTTNBP2NL	Q9P2B4	877
STRN3	STRIP1	Q5VSL9	852
STRN3	STRIP2	Q9ULQ0	812
STRN3	PPP2CA	P05323	792
STRN3	MOB4	Q9Y3A3	790
STRN3	SLMAP	Q14BN4	761
STRN3	STK26	Q9P289	738
STRN3	PPP2R1A	P30153	722
STRN3	PDCD10	Q9BUL8	718
STRN3	CTTNBP2	Q8WZ74	711
STRN3	PARK7	Q99497	702
STRN3	STK25	O00506	691
STRN3	STRN	O43815	635
STRN3	SIKE1	Q9BRV8	589
STRN3	FHOD3	Q2V2M9	556

IntAct

164 interactions, top by confidence:

A	B	Type	Score
PPP2R1A	PPP2CA	psi-mi:“MI:0914”(association)	0.990
PDCD10	STK25	psi-mi:“MI:0914”(association)	0.980
STRN3	PPP2R1A	psi-mi:“MI:0914”(association)	0.920
STK25	STRN	psi-mi:“MI:0914”(association)	0.900
STK24	STK25	psi-mi:“MI:0914”(association)	0.890
PPP2R1A	STRN	psi-mi:“MI:0914”(association)	0.880
PPP2R1A	STRN	psi-mi:“MI:2364”(proximity)	0.880
STRN3	STRN	psi-mi:“MI:0915”(physical association)	0.880
STRN	STRN3	psi-mi:“MI:0915”(physical association)	0.880
STRN3	STK25	psi-mi:“MI:0914”(association)	0.880
CTTNBP2NL	STK25	psi-mi:“MI:0914”(association)	0.880
STRN3	STRN	psi-mi:“MI:0914”(association)	0.880
STRN3	STRN	psi-mi:“MI:2364”(proximity)	0.880
STK24	STRN	psi-mi:“MI:0914”(association)	0.870
STK26	STRN	psi-mi:“MI:0915”(physical association)	0.860
STK26	STRN	psi-mi:“MI:0914”(association)	0.860

BioGRID (342): STRN3 (Affinity Capture-MS), STRN3 (Affinity Capture-MS), STRN3 (Affinity Capture-MS), STRN3 (Affinity Capture-MS), STRN3 (Affinity Capture-MS), STRN3 (Affinity Capture-MS), STRN3 (Affinity Capture-MS), STRN3 (Affinity Capture-MS), STRN3 (Affinity Capture-MS), STRN3 (Affinity Capture-MS), STRN3 (Affinity Capture-MS), STRN3 (Affinity Capture-MS), PPP2R1B (Affinity Capture-MS), COL4A5 (Affinity Capture-MS), CTTNBP2NL (Affinity Capture-MS)

ESM2 similar proteins: A0A8C0TYJ0, A0A8I5ZNK2, A5D7H2, O55047, O88506, O94806, O95747, P00535, P11273, P32298, P34947, P43249, P49137, Q08CW1, Q12959, Q13033, Q15139, Q15700, Q16644, Q1ECX4, Q28C55, Q3SYZ2, Q3UMW7, Q5PYH5, Q5PYH6, Q5R372, Q5R495, Q5RCW6, Q5XIS9, Q62101, Q62696, Q62833, Q63622, Q66H84, Q6P9R2, Q811D0, Q863I2, Q86UE8, Q8BZ03, Q8C0V0

Diamond homologs: A1C7E4, A1CBP8, A1CUD6, A1DDL6, A1DHW6, A1DP19, A2QCU8, A2R3Z3, A3LNI7, A4RJV3, A5D7H2, A7EKM8, B0XM00, B0XTS1, B2VWG7, B6GZA1, B6Q4Z5, B6QC06, B6QC56, B8M0Q1, B8M7Q5, B8NGT5, C0S902, C1GB49, C5FP68, C5GVJ9, C5JD40, D1ZEM6, D4AM37, D4D8P3, L7N1X6, O43815, O55106, P0DL28, P39014, P58404, P58405, P70483, P87053, Q00659

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 113 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
RAF activation	6	31.5×	5e-06
Cyclin A/B1/B2 associated events during G2/M transition	5	24.1×	6e-05
Regulation of TP53 Degradation	5	22.9×	6e-05
Degradation of beta-catenin by the destruction complex	6	16.2×	6e-05
Interferon Signaling	6	11.3×	3e-04
PKR-mediated signaling	5	11.0×	1e-03
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	6	10.9×	3e-04
MAPK1/MAPK3 signaling	5	10.3×	2e-03

GO biological processes:

GO term	Partners	Fold	FDR
negative regulation of hippo signaling	7	51.2×	3e-08
regulation of MAPK cascade	5	23.7×	4e-04
neuron projection morphogenesis	5	14.4×	3e-03
protein autophosphorylation	9	13.6×	7e-06
protein phosphorylation	10	7.1×	3e-04
intracellular signal transduction	11	4.4×	4e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

101 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	77
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

4547 predictions. Top by Δscore:

Variant	Effect	Δscore
14:30895577:TGGC:T	acceptor_gain	1.0000
14:30895579:GCCTG:G	acceptor_loss	1.0000
14:30895581:C:CA	acceptor_loss	1.0000
14:30895581:C:CC	acceptor_gain	1.0000
14:30895660:A:AC	donor_gain	1.0000
14:30895660:ACTT:A	donor_gain	1.0000
14:30895661:C:CC	donor_gain	1.0000
14:30895661:CTT:C	donor_gain	1.0000
14:30895661:CTTC:C	donor_gain	1.0000
14:30895663:T:TA	donor_gain	1.0000
14:30902530:GCTTA:G	donor_loss	1.0000
14:30902531:CTTAC:C	donor_loss	1.0000
14:30902532:TTACC:T	donor_loss	1.0000
14:30902533:TAC:T	donor_loss	1.0000
14:30902534:A:AC	donor_gain	1.0000
14:30902534:A:AT	donor_loss	1.0000
14:30902534:AC:A	donor_gain	1.0000
14:30902534:ACC:A	donor_gain	1.0000
14:30902535:C:A	donor_loss	1.0000
14:30902535:C:CC	donor_gain	1.0000
14:30902535:CC:C	donor_gain	1.0000
14:30902535:CCC:C	donor_gain	1.0000
14:30902535:CCCG:C	donor_gain	1.0000
14:30902535:CCCGT:C	donor_gain	1.0000
14:30902639:TAAAC:T	acceptor_gain	1.0000
14:30902640:AAAC:A	acceptor_gain	1.0000
14:30902642:AC:A	acceptor_gain	1.0000
14:30902643:CC:C	acceptor_gain	1.0000
14:30902644:C:CC	acceptor_gain	1.0000
14:30902644:CTG:C	acceptor_loss	1.0000

AlphaMissense

5214 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
14:30895436:T:A	D790V	1.000
14:30895437:C:G	D790H	1.000
14:30895442:C:T	G788E	1.000
14:30895447:A:C	S786R	1.000
14:30895447:A:T	S786R	1.000
14:30895449:T:G	S786R	1.000
14:30895451:G:T	A785D	1.000
14:30895510:T:A	R765S	1.000
14:30895510:T:G	R765S	1.000
14:30895511:C:A	R765I	1.000
14:30895511:C:G	R765T	1.000
14:30895515:G:C	H764D	1.000
14:30895527:C:T	E760K	1.000
14:30895534:A:C	C757W	1.000
14:30895535:C:T	C757Y	1.000
14:30895536:A:G	C757R	1.000
14:30895555:C:A	W750C	1.000
14:30895555:C:G	W750C	1.000
14:30895556:C:G	W750S	1.000
14:30895557:A:G	W750R	1.000
14:30895557:A:T	W750R	1.000
14:30895561:T:A	R748S	1.000
14:30895561:T:G	R748S	1.000
14:30895562:C:G	R748T	1.000
14:30895574:T:A	D744V	1.000
14:30895574:T:G	D744A	1.000
14:30895575:C:G	D744H	1.000
14:30895667:G:A	S740F	1.000
14:30895709:A:T	V726D	1.000
14:30895720:G:C	H722Q	1.000

dbSNP variants (sampled 300 via entrez): RS1000023802 (14:30908162 T>C), RS1000029579 (14:30989442 C>T), RS1000031470 (14:31027427 C>T), RS1000058163 (14:30907873 T>A), RS1000141564 (14:31001977 CAACATGG>C), RS1000158250 (14:30902426 T>A), RS1000167794 (14:31012593 A>T), RS1000190339 (14:31020142 C>T), RS1000198450 (14:30966991 G>A), RS1000222552 (14:30973262 T>C), RS1000223107 (14:31006804 A>C), RS1000275896 (14:30926634 T>C), RS1000299788 (14:30919939 T>C,G), RS1000309046 (14:30914168 C>A,T), RS1000314203 (14:30972898 A>G)

Disease associations

OMIM: gene MIM:614766 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST010703_231	Brain morphology (MOSTest)	1.000000e-12
GCST90002395_167	Mean platelet volume	2.000000e-30
GCST90002402_228	Platelet count	6.000000e-12

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004346	neuroimaging measurement
EFO:0004309	platelet count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

45 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects expression, decreases expression	2
perfluorooctane sulfonic acid	decreases expression	2
Resveratrol	affects cotreatment, decreases expression, increases expression	2
Benzo(a)pyrene	affects methylation, increases methylation	2
Valproic Acid	decreases expression	2
FR900359	increases phosphorylation	1
dicrotophos	decreases expression	1
2,4,6-tribromophenol	decreases expression	1
testosterone enanthate	affects expression	1
sodium arsenate	decreases expression	1
decabromobiphenyl ether	decreases expression	1
beta-lapachone	decreases expression	1
arsenite	decreases reaction, affects binding	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
sodium arsenite	affects expression	1
tetrabromobisphenol A	decreases expression	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, decreases expression	1
coumarin	decreases phosphorylation	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
monomethylarsonous acid	affects expression	1
dimethylarsinous acid	affects expression	1
abrine	increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
pentabrominated diphenyl ether 100	decreases expression	1
jinfukang	decreases expression	1
bisphenol AF	increases expression	1
Arsenic Trioxide	increases expression	1
Leflunomide	increases expression	1
Acetaminophen	decreases expression	1

Cellosaurus cell lines

4 cell lines: 4 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_TR03	HAP1 STRN3 (-) 1	Cancer cell line	Male
CVCL_TR04	HAP1 STRN3 (-) 2	Cancer cell line	Male
CVCL_TR05	HAP1 STRN3 (-) 3	Cancer cell line	Male
CVCL_TR06	HAP1 STRN3 (-) 4	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.