STT3A-AS1

Summary

STT3A-AS1 (STT3A antisense RNA 1, HGNC:44585) is a long non-coding RNA gene on chromosome 11q24.2.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 4 total

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44585
Approved symbol	STT3A-AS1
Name	STT3A antisense RNA 1
Location	11q24.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000254671
Entrez	105369550
RNAcentral	URS00008E39E6 — lncRNA, 434 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1506 / max 5.7102, expressed in 65 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
122996	0.1506	65

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

4 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	3
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000003307 (11:125569685 C>A,T), RS1000057998 (11:125593640 A>G), RS1000094518 (11:125584911 G>C), RS1000104956 (11:125577365 G>A), RS1000211018 (11:125580987 G>C), RS1000411184 (11:125581362 T>C), RS1000479018 (11:125567867 T>C), RS1000689960 (11:125569979 T>C), RS1000695480 (11:125582263 G>C,T), RS1000762710 (11:125590441 G>A,T), RS1000884697 (11:125582996 T>A), RS1001060698 (11:125592639 G>A,C), RS1001213750 (11:125579594 G>A,T), RS1001296656 (11:125568714 A>G,T), RS1001415596 (11:125568356 C>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST006979_235	Heel bone mineral density	2.000000e-10

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0009270	heel bone mineral density

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.