STX12

Summary

STX12 (syntaxin 12, HGNC:11430) is a protein-coding gene on chromosome 1p35.3, encoding Syntaxin-12 (Q86Y82). SNARE promoting fusion of transport vesicles with target membranes.

Predicted to enable SNAP receptor activity and SNARE binding activity. Involved in autophagosome assembly; cholesterol efflux; and protein stabilization. Located in several cellular components, including BLOC-1 complex; phagocytic vesicle; and phagophore assembly site. Part of SNARE complex.

Source: NCBI Gene 23673 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 48 total
• MANE Select transcript: NM_177424

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11430
Approved symbol	STX12
Name	syntaxin 12
Location	1p35.3
Locus type	gene with protein product
Status	Approved
Aliases	STX13, STX14
Ensembl gene	ENSG00000117758
Ensembl biotype	protein_coding
OMIM	606892
Entrez	23673

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 7 protein_coding, 3 protein_coding_CDS_not_defined

ENST00000373943, ENST00000440806, ENST00000468761, ENST00000472285, ENST00000481874, ENST00000893600, ENST00000893601, ENST00000961041, ENST00000961042, ENST00000961043

RefSeq mRNA: 1 — MANE Select: NM_177424 NM_177424

CCDS: CCDS310

Canonical transcript exons

ENST00000373943 — 9 exons

Exon	Start	End
ENSE00000761741	27819650	27819732
ENSE00000866709	27801678	27801815
ENSE00001037463	27810246	27810289
ENSE00001153614	27773219	27773425
ENSE00001651718	27817851	27817923
ENSE00001814246	27822231	27824443
ENSE00003483126	27789562	27789631
ENSE00003571412	27793533	27793632
ENSE00003787731	27812163	27812268

Expression profiles

Bgee: expression breadth ubiquitous, 287 present calls, max score 97.54.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 58.6149 / max 399.7117, expressed in 1823 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
1746	58.6149	1823

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
middle temporal gyrus	UBERON:0002771	97.54	gold quality
corpus epididymis	UBERON:0004359	97.47	gold quality
Brodmann (1909) area 23	UBERON:0013554	97.31	gold quality
left lobe of thyroid gland	UBERON:0001120	97.08	gold quality
esophagus squamous epithelium	UBERON:0006920	97.03	gold quality
right lobe of thyroid gland	UBERON:0001119	96.88	gold quality
thyroid gland	UBERON:0002046	96.87	gold quality
lower lobe of lung	UBERON:0008949	96.53	gold quality
cauda epididymis	UBERON:0004360	96.46	gold quality
superior frontal gyrus	UBERON:0002661	96.42	gold quality
substantia nigra pars reticulata	UBERON:0001966	96.28	gold quality
Brodmann (1909) area 46	UBERON:0006483	96.25	gold quality
epithelium of esophagus	UBERON:0001976	96.24	gold quality
postcentral gyrus	UBERON:0002581	96.24	gold quality
substantia nigra pars compacta	UBERON:0001965	96.23	gold quality
entorhinal cortex	UBERON:0002728	96.18	gold quality
orbitofrontal cortex	UBERON:0004167	96.17	gold quality
cortical plate	UBERON:0005343	96.13	gold quality
endothelial cell	CL:0000115	96.07	gold quality
parietal lobe	UBERON:0001872	96.05	gold quality
right lung	UBERON:0002167	96.01	gold quality
pons	UBERON:0000988	95.95	gold quality
body of stomach	UBERON:0001161	95.89	gold quality
substantia nigra	UBERON:0002038	95.78	gold quality
squamous epithelium	UBERON:0006914	95.78	gold quality
midbrain	UBERON:0001891	95.74	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	95.73	gold quality
superior vestibular nucleus	UBERON:0007227	95.72	gold quality
spinal cord	UBERON:0002240	95.63	gold quality
subthalamic nucleus	UBERON:0001906	95.62	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-HCAD-13	yes	23.71
E-MTAB-11011	no	221.72
E-MTAB-6678	no	3.20
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

112 targeting STX12, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4425	100.00	67.59	1049
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-6744-5P	99.93	66.82	748
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-338-5P	99.92	72.34	2951

Literature-anchored findings (GeneRIF, showing 7)

• ABCA1 forms a complex with syntaxin 13 and flotillin-1, residing at the plasma membrane and in phagosomes that are partially located in raft microdomains (PMID:15469992)
• the importance of syntaxin-13 in the trafficking of matrix metalloproteinases during degradation of extracellular matrix substrates and subsequent cellular invasion (PMID:19910495)
• Data indicate that knockdown of syntaxin 13 (syx13) further increased the cellular toxicity caused by mutant CHMP2B (CHMP2BIntron5) expression. (PMID:24095276)
• The association of Src, EGFR and beta1 integrin is dependent upon membrane traffic that is mediated by syntaxin13 (officially known as STX12) and SNAP23. (PMID:24496451)
• STX13 acts as a fusion SNARE in melanosomal trafficking pathways. (PMID:26208634)
• A BLOC-1-AP-3 super-complex sorts a cis-SNARE complex into endosome-derived tubular transport carriers. (PMID:33886957)
• Syntaxin 12 and COMMD3 are new factors that function with VPS33B in the biogenesis of platelet alpha-granules. (PMID:34905616)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	stx12l	ENSDARG00000044605
danio_rerio	stx12	ENSDARG00000098813
mus_musculus	Stx12	ENSMUSG00000028879
rattus_norvegicus	Stx12	ENSRNOG00000011804
drosophila_melanogaster	Syx7	FBGN0267849
caenorhabditis_elegans	syx-7	WBGENE00009478

Paralogs (12): STX7 (ENSG00000079950), STX1B (ENSG00000099365), STX4 (ENSG00000103496), STX1A (ENSG00000106089), STX2 (ENSG00000111450), STX16 (ENSG00000124222), STX11 (ENSG00000135604), STX17 (ENSG00000136874), STX5 (ENSG00000162236), STX3 (ENSG00000166900), TSNARE1 (ENSG00000171045), STX19 (ENSG00000178750)

Protein

Protein identifiers

Syntaxin-12 — Q86Y82 (reviewed: Q86Y82)

All UniProt accessions (2): B1AJQ6, Q86Y82

UniProt curated annotations — full annotation on UniProt →

Function. SNARE promoting fusion of transport vesicles with target membranes. Together with SNARE STX6, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting.

Subunit / interactions. Interacts with NAPA and SNAP23. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A. Associates with the BLOC-1 complex. Interacts with BLOC1S6. Interacts with GRIPAP1. Forms a complex with GRIP1, GRIA2 and NSG1; controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. Interacts with NSG1. Interacts with TPC1. Interacts (via N-terminus) with VPS13B.

Subcellular location. Endosome membrane. Golgi apparatus membrane. Endomembrane system. Early endosome membrane. Recycling endosome membrane.

Similarity. Belongs to the syntaxin family.

RefSeq proteins (1): NP_803173* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000727	T_SNARE_dom	Domain
IPR006011	Syntaxin_N	Domain
IPR006012	Syntaxin/epimorphin_CS	Conserved_site
IPR010989	SNARE	Homologous_superfamily
IPR045242	Syntaxin	Family

Pfam: PF05739, PF14523

UniProt features (17 total): modified residue 5, helix 3, topological domain 2, initiator methionine 1, chain 1, sequence variant 1, strand 1, transmembrane region 1, domain 1, coiled-coil region 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
2DNX	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86Y82-F1	80.33	0.44

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (5): 218, 225, 2, 139, 142

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 245 (showing top): GSE45365_NK_CELL_VS_BCELL_UP, GCM_MAP4K4, GOBP_VACUOLE_ORGANIZATION, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, GOBP_VESICLE_ORGANIZATION, TTTGTAG_MIR520D, GOBP_MEMBRANE_FUSION, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GOBP_VESICLE_MEDIATED_TRANSPORT, GGGTGGRR_PAX4_03, GOBP_MACROAUTOPHAGY, GOBP_MEMBRANE_DOCKING, GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT, GOBP_CHOLESTEROL_EFFLUX, RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN

GO Biological Process (10): autophagosome assembly (GO:0000045), intracellular protein transport (GO:0006886), vesicle fusion (GO:0006906), endocytic recycling (GO:0032456), cholesterol efflux (GO:0033344), obsolete vesicle docking (GO:0048278), protein stabilization (GO:0050821), protein transport (GO:0015031), vesicle-mediated transport (GO:0016192), regulation of biological quality (GO:0065008)

GO Molecular Function (3): SNARE binding (GO:0000149), SNAP receptor activity (GO:0005484), protein binding (GO:0005515)

GO Cellular Component (20): Golgi membrane (GO:0000139), phagophore assembly site (GO:0000407), nucleoplasm (GO:0005654), Golgi apparatus (GO:0005794), synaptic vesicle (GO:0008021), endomembrane system (GO:0012505), synaptic vesicle membrane (GO:0030672), SNARE complex (GO:0031201), early endosome membrane (GO:0031901), vesicle (GO:0031982), membrane raft (GO:0045121), phagocytic vesicle (GO:0045335), recycling endosome (GO:0055037), recycling endosome membrane (GO:0055038), postsynaptic recycling endosome (GO:0098837), endosome (GO:0005768), endosome membrane (GO:0010008), membrane (GO:0016020), BLOC-1 complex (GO:0031083), cytoplasmic vesicle (GO:0031410)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	4
cellular anatomical structure	4
intracellular protein localization	2
transport	2
bounding membrane of organelle	2
endomembrane system	2
endosome membrane	2
endosome	2
recycling endosome	2
Atg12 activating enzyme activity	1
protein-phosphatidylethanolamide deconjugating activity	1
Atg12 conjugating enzyme activity	1
Atg12 ligase activity	1
organelle assembly	1
Atg1/ULK1 kinase complex assembly	1
autophagosome organization	1
protein transport	1
intracellular transport	1
vesicle organization	1
vesicle-mediated transport	1
organelle membrane fusion	1
endosomal transport	1
vesicle-mediated transport to the plasma membrane	1
cholesterol transport	1
regulation of protein stability	1
establishment of protein localization	1
cellular process	1
biological regulation	1
protein binding	1
protein-macromolecule adaptor activity	1
membrane fusion	1
fusogenic activity	1
binding	1
Golgi apparatus	1
nuclear lumen	1
intracellular membrane-bounded organelle	1
exocytic vesicle	1
presynapse	1
vacuole	1
plasma membrane	1

Protein interactions and networks

STRING

1712 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
STX12	STX8	Q9UNK0	936
STX12	BLOC1S6	Q9UL45	858
STX12	STX6	O43752	821
STX12	VPS33A	Q96AX1	814
STX12	VPS33B	Q9H267	792
STX12	VTI1A	Q96AJ9	792
STX12	VAMP4	O75379	781
STX12	VIPAS39	Q9H9C1	773
STX12	VAMP7	P51809	769
STX12	SNAP23	O00161	758
STX12	VAMP8	Q9BV40	751
STX12	VAMP3	Q15836	738
STX12	RAB11A	P24410	677
STX12	VAMP2	P19065	671
STX12	STX11	O75558	641

IntAct

269 interactions, top by confidence:

A	B	Type	Score
STX12	SNAP29	psi-mi:“MI:0915”(physical association)	0.880
SNAP29	STX12	psi-mi:“MI:0915”(physical association)	0.880
STX12	STX4	psi-mi:“MI:0915”(physical association)	0.870
STX4	STX12	psi-mi:“MI:0915”(physical association)	0.870
STX12	DTX2	psi-mi:“MI:0915”(physical association)	0.780
DTX2	STX12	psi-mi:“MI:0915”(physical association)	0.780
NAPA	SNAP23	psi-mi:“MI:0914”(association)	0.780
STX12	SNAP47	psi-mi:“MI:0915”(physical association)	0.740
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
TRDN	TMEM223	psi-mi:“MI:0914”(association)	0.640
STX12	TIMMDC1	psi-mi:“MI:0915”(physical association)	0.560
STX12	TMEM14B	psi-mi:“MI:0915”(physical association)	0.560
STX12	PLPPR2	psi-mi:“MI:0915”(physical association)	0.560
STX12	BCL2L13	psi-mi:“MI:0915”(physical association)	0.560
STX1A	STX12	psi-mi:“MI:0915”(physical association)	0.560
STX12	KASH5	psi-mi:“MI:0915”(physical association)	0.560
STX2	STX12	psi-mi:“MI:0915”(physical association)	0.560
	STX12	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (469): STX12 (Two-hybrid), STX12 (Two-hybrid), DTX2 (Two-hybrid), STX12 (Affinity Capture-RNA), STX12 (Affinity Capture-MS), STX12 (Affinity Capture-MS), STX12 (Affinity Capture-MS), EIF2B5 (Affinity Capture-MS), RNF13 (Affinity Capture-MS), KIAA1467 (Affinity Capture-MS), YKT6 (Affinity Capture-MS), EIF2B1 (Affinity Capture-MS), BNIP1 (Affinity Capture-MS), EIF2B4 (Affinity Capture-MS), GOLGA2 (Affinity Capture-MS)

ESM2 similar proteins: G3V7P1, O08522, O14662, O15400, O22151, O43752, O49377, O60499, O64791, O70257, O70439, O70480, O75379, O88384, O88630, O88983, O95249, P58200, Q08851, Q08DB5, Q13190, Q2KIU0, Q2TBU3, Q32L97, Q3T075, Q3ZBT5, Q5R602, Q5R6Q2, Q5RBL6, Q5RBW6, Q5RF94, Q5SRX1, Q5ZL19, Q62931, Q63635, Q86Y82, Q8BVI5, Q8K1E0, Q944A9, Q946Y7

Diamond homologs: A8WVD0, G3V7P1, O14662, O15400, O16000, O35526, O64791, O65359, O70257, O70439, O94651, P32850, P32851, P32854, P32856, P50279, P61264, P61265, P61266, P61267, P61268, P70452, P91409, Q00262, Q08144, Q08849, Q08850, Q12846, Q13277, Q16623, Q16932, Q24547, Q3SWZ3, Q3ZBT5, Q42374, Q54JY7, Q54X86, Q5R4L2, Q5R602, Q5RBW6

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 128 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Retrograde transport at the Trans-Golgi-Network	11	27.8×	5e-11
Intra-Golgi traffic	6	17.9×	5e-05
trans-Golgi Network Vesicle Budding	6	17.5×	5e-05
NCAM signaling for neurite out-growth	5	15.6×	5e-04
Golgi Associated Vesicle Biogenesis	5	11.5×	1e-03
COPII-mediated vesicle transport	6	11.2×	5e-04
Intra-Golgi and retrograde Golgi-to-ER traffic	9	10.8×	1e-05
ER-Phagosome pathway	6	8.9×	1e-03

GO biological processes:

GO term	Partners	Fold	FDR
obsolete vesicle docking	7	45.8×	2e-08
vesicle fusion	8	41.1×	5e-09
synaptic vesicle priming	5	34.3×	2e-05
membrane fusion	5	26.7×	8e-05
exocytosis	14	18.2×	3e-11
mitophagy	6	16.3×	1e-04
autophagosome maturation	5	15.0×	1e-03
retrograde transport, endosome to Golgi	8	14.1×	1e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

48 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	33
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1262 predictions. Top by Δscore:

Variant	Effect	Δscore
1:27773422:GCCA:G	donor_gain	1.0000
1:27773426:G:GG	donor_gain	1.0000
1:27789560:A:AG	acceptor_gain	1.0000
1:27789561:G:GG	acceptor_gain	1.0000
1:27789632:G:GG	donor_gain	1.0000
1:27801675:TA:T	acceptor_loss	1.0000
1:27801676:A:AG	acceptor_gain	1.0000
1:27801677:G:GG	acceptor_gain	1.0000
1:27801677:GC:G	acceptor_gain	1.0000
1:27801778:A:T	donor_gain	1.0000
1:27801816:G:GG	donor_gain	1.0000
1:27812161:A:AG	acceptor_gain	1.0000
1:27812162:G:GA	acceptor_gain	1.0000
1:27812162:GCC:G	acceptor_gain	1.0000
1:27812162:GCCAT:G	acceptor_gain	1.0000
1:27812267:AG:A	donor_loss	1.0000
1:27812270:T:A	donor_loss	1.0000
1:27817845:CCTTA:C	acceptor_loss	1.0000
1:27817847:TTA:T	acceptor_loss	1.0000
1:27817848:TA:T	acceptor_loss	1.0000
1:27817849:A:AG	acceptor_gain	1.0000
1:27817850:G:GA	acceptor_gain	1.0000
1:27817850:GGCT:G	acceptor_gain	1.0000
1:27817924:G:GG	donor_gain	1.0000
1:27819645:TGCA:T	acceptor_loss	1.0000
1:27819646:GCA:G	acceptor_loss	1.0000
1:27819647:CAG:C	acceptor_loss	1.0000
1:27819648:A:AG	acceptor_gain	1.0000
1:27819648:AG:A	acceptor_loss	1.0000
1:27819649:G:GC	acceptor_gain	1.0000

AlphaMissense

1821 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:27812264:T:C	L191P	1.000
1:27801706:T:C	L106P	0.999
1:27817851:G:C	A193P	0.999
1:27817876:T:A	I201K	0.999
1:27817878:T:C	F202L	0.999
1:27817880:T:A	F202L	0.999
1:27817880:T:G	F202L	0.999
1:27817890:G:C	A206P	0.999
1:27819661:G:C	A221P	0.999
1:27819697:G:C	A233P	0.999
1:27819718:G:C	A240P	0.999
1:27793565:C:A	A74D	0.998
1:27793586:T:C	L81P	0.998
1:27801726:G:C	A113P	0.998
1:27817888:T:C	L205S	0.998
1:27819656:T:A	I219K	0.998
1:27789631:T:C	L63P	0.997
1:27793564:G:C	A74P	0.997
1:27793573:A:C	T77P	0.997
1:27801703:G:C	R105P	0.997
1:27801751:A:C	Q121P	0.997
1:27812251:G:C	A187P	0.997
1:27817867:T:A	V198D	0.997
1:27817876:T:C	I201T	0.997
1:27819676:T:C	S226P	0.997
1:27801718:T:C	F110S	0.996
1:27812243:G:T	R184I	0.996
1:27817876:T:G	I201R	0.996
1:27817888:T:G	L205W	0.996
1:27817911:G:T	G213C	0.996

dbSNP variants (sampled 300 via entrez): RS1000021133 (1:27777212 C>T), RS1000058975 (1:27776086 A>C), RS1000191154 (1:27816034 C>G,T), RS1000216018 (1:27795394 C>T), RS1000419991 (1:27790951 A>C), RS1000502832 (1:27794254 T>A), RS1000534042 (1:27794012 T>A), RS1000586540 (1:27824824 TCAC>T), RS1000658186 (1:27794586 T>C), RS1000662812 (1:27787908 A>G), RS1000680076 (1:27824576 TAGAG>T), RS1000708187 (1:27804547 C>G,T), RS1000815761 (1:27807597 A>G), RS1000866450 (1:27807809 A>G), RS1000882438 (1:27786091 A>G)

Disease associations

OMIM: gene MIM:606892 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

48 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases abundance, affects methylation	3
Arsenic	affects methylation, decreases expression, increases abundance	2
Tobacco Smoke Pollution	affects expression, increases expression	2
aristolochic acid I	increases expression	1
FR900359	increases phosphorylation	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	affects cotreatment, increases expression	1
methylselenic acid	increases expression	1
pyrogallol 1,3-dimethyl ether	affects cotreatment, affects localization, increases expression	1
trichostatin A	affects expression	1
potassium chromate(VI)	decreases expression	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
K 7174	increases expression	1
ICG 001	decreases expression	1
bisphenol B	increases expression	1
ON 01910	increases expression	1
jinfukang	decreases expression	1
bisphenol AF	increases expression	1
Bortezomib	increases expression	1
Acetaminophen	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Atrazine	decreases expression	1
Benzo(a)pyrene	affects methylation	1
Caffeine	decreases phosphorylation	1
Demecolcine	increases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Dimethyl Sulfoxide	increases expression	1
Ethyl Methanesulfonate	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.