STX7

Summary

STX7 (syntaxin 7, HGNC:11442) is a protein-coding gene on chromosome 6q23.2, encoding Syntaxin-7 (O15400). May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles.

The protein encoded by this gene is a syntaxin family membrane receptor involved in vesicle transport. The encoded protein binds alpha-SNAP, an important regulator of transport vesicle fusion. Along with syntaxin 13, this protein plays a role in the ordered fusion of endosomes and lysosomes with the phagosome.

Source: NCBI Gene 8417 — RefSeq curated summary.

At a glance

• GWAS associations: 17
• Clinical variants (ClinVar): 48 total — 1 likely-pathogenic
• MANE Select transcript: NM_003569

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11442
Approved symbol	STX7
Name	syntaxin 7
Location	6q23.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000079950
Ensembl biotype	protein_coding
OMIM	603217
Entrez	8417

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 9 protein_coding, 1 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000367937, ENST00000367941, ENST00000448348, ENST00000475879, ENST00000862289, ENST00000862290, ENST00000862291, ENST00000862292, ENST00000862293, ENST00000942368, ENST00000942369

RefSeq mRNA: 4 — MANE Select: NM_003569 NM_001326578, NM_001326579, NM_001326580, NM_003569

CCDS: CCDS5153, CCDS87441

Canonical transcript exons

ENST00000367941 — 10 exons

Exon	Start	End
ENSE00000798744	132463993	132464075
ENSE00000798746	132469951	132470047
ENSE00001445973	132445867	132460850
ENSE00001750391	132468403	132468475
ENSE00001856918	132513007	132513116
ENSE00003501102	132503446	132503588
ENSE00003698784	132471463	132471600
ENSE00003699060	132472282	132472375
ENSE00003699492	132470574	132470626
ENSE00003700055	132475593	132475662

Expression profiles

Bgee: expression breadth ubiquitous, 293 present calls, max score 97.99.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 47.2144 / max 647.2784, expressed in 1821 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
75598	46.2267	1821
75597	0.9449	463
75599	0.0427	18

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	97.99	gold quality
endothelial cell	CL:0000115	97.91	gold quality
monocyte	CL:0000576	96.69	gold quality
mononuclear cell	CL:0000842	96.48	gold quality
tendon of biceps brachii	UBERON:0008188	96.42	gold quality
calcaneal tendon	UBERON:0003701	96.19	gold quality
leukocyte	CL:0000738	96.17	gold quality
middle temporal gyrus	UBERON:0002771	96.15	gold quality
tendon	UBERON:0000043	95.99	gold quality
ganglionic eminence	UBERON:0004023	95.54	gold quality
amniotic fluid	UBERON:0000173	95.27	gold quality
medial globus pallidus	UBERON:0002477	94.92	gold quality
renal glomerulus	UBERON:0000074	94.78	gold quality
secondary oocyte	CL:0000655	94.71	gold quality
metanephric glomerulus	UBERON:0004736	94.58	gold quality
corpus callosum	UBERON:0002336	94.54	gold quality
vermiform appendix	UBERON:0001154	94.42	gold quality
nephron tubule	UBERON:0001231	94.40	gold quality
gall bladder	UBERON:0002110	94.19	gold quality
lymph node	UBERON:0000029	93.86	gold quality
decidua	UBERON:0002450	93.75	gold quality
Brodmann (1909) area 23	UBERON:0013554	93.51	gold quality
globus pallidus	UBERON:0001875	93.45	gold quality
prefrontal cortex	UBERON:0000451	93.37	gold quality
tonsil	UBERON:0002372	93.18	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	93.18	gold quality
esophagus squamous epithelium	UBERON:0006920	93.07	gold quality
dorsal root ganglion	UBERON:0000044	92.94	gold quality
colonic epithelium	UBERON:0000397	92.92	gold quality
frontal pole	UBERON:0002795	92.65	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-CURD-122	yes	19.00
E-MTAB-6678	yes	4.47
E-MTAB-6075	no	365.62
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• syntaxin 7 has a role in the intracellular vacuolation induced by VacA (PMID:12730232)
• Results report that syntaxin 7, syntaxin 8, vti1b and VAMP8 physically and functionally interact with CFTR. (PMID:18570918)
• Palmitoylation-defective syntaxin 7 is selectively retained on the plasma membrane, suggesting that palmitoylation is important for intercompartmental transport of syntaxin 7. (PMID:18980942)
• The expression level of STX7 protein was inversely correlated to tumor stage, suggesting that decreased expression of STX7 is associated with more aggressive tumors. (PMID:19714869)
• data reveal the presence of syntaxin 7 in the membranes of exocytosis-prone granules and phagocytosis-related granules in human neutrophils, and therefore it might play a role in both exocytosis and phagocytosis in human neutrophils (PMID:20170677)
• Data suggest that accumulation of recycling T cell receptors at the immunological synapse is SNARE-dependent and that Stx7-mediated processing of recycling TCRs through endosomes is a prerequisite for the cytolytic function of cytotoxic T lymphocytes. (PMID:21438968)
• Syntaxin 7 contributes to breast cancer cell invasion by promoting invadopodia formation. (PMID:35762511)
• Syntaxin 7 modulates seizure activity in epilepsy. (PMID:37031804)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	stx7l	ENSDARG00000069208
mus_musculus	Stx7	ENSMUSG00000019998
rattus_norvegicus	Stx7	ENSRNOG00000015670
drosophila_melanogaster	Syx7	FBGN0267849
caenorhabditis_elegans	syx-7	WBGENE00009478

Paralogs (12): STX1B (ENSG00000099365), STX4 (ENSG00000103496), STX1A (ENSG00000106089), STX2 (ENSG00000111450), STX12 (ENSG00000117758), STX16 (ENSG00000124222), STX11 (ENSG00000135604), STX17 (ENSG00000136874), STX5 (ENSG00000162236), STX3 (ENSG00000166900), TSNARE1 (ENSG00000171045), STX19 (ENSG00000178750)

Protein

Protein identifiers

Syntaxin-7 — O15400 (reviewed: O15400)

All UniProt accessions (2): O15400, B4DWC2

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.

Subunit / interactions. Forms a SNARE complex with VTI1B, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes. Interacts with VPS11, VPS16 and VPS18. Interacts with VPS33A. Interacts with TPC1.

Subcellular location. Early endosome membrane.

Tissue specificity. Highest expression is found in placenta followed by heart, skeletal muscle, kidney and brain. Low expression is found in pancreas, lung and liver.

Similarity. Belongs to the syntaxin family.

Isoforms (2)

UniProt ID	Names	Canonical?
O15400-1	1	yes
O15400-2	2

RefSeq proteins (4): NP_001313507, NP_001313508, NP_001313509, NP_003560* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000727	T_SNARE_dom	Domain
IPR006011	Syntaxin_N	Domain
IPR006012	Syntaxin/epimorphin_CS	Conserved_site
IPR010989	SNARE	Homologous_superfamily
IPR045242	Syntaxin	Family

Pfam: PF05739, PF14523

UniProt features (19 total): modified residue 9, topological domain 2, initiator methionine 1, chain 1, splice variant 1, sequence conflict 1, transmembrane region 1, domain 1, region of interest 1, coiled-coil region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O15400-F1	78.96	0.45

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (9): 45, 75, 79, 125, 126, 129, 205, 2, 4

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 291 (showing top): LIANG_HEMATOPOIESIS_STEM_CELL_NUMBER_SMALL_VS_HUGE_UP, GOBP_POSITIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, GOCC_VACUOLAR_MEMBRANE, GOCC_SECRETORY_GRANULE, GOBP_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE, GOBP_VESICLE_ORGANIZATION, GOBP_MEMBRANE_FUSION, GOBP_LEUKOCYTE_MEDIATED_CYTOTOXICITY, GOBP_VESICLE_MEDIATED_TRANSPORT, LHX3_01, CHX10_01, GOBP_LEUKOCYTE_MEDIATED_IMMUNITY, GOBP_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY, GOBP_MEMBRANE_DOCKING

GO Biological Process (9): positive regulation of T cell mediated cytotoxicity (GO:0001916), intracellular protein transport (GO:0006886), vesicle fusion (GO:0006906), obsolete vesicle docking (GO:0048278), organelle localization (GO:0051640), organelle assembly (GO:0070925), positive regulation of receptor localization to synapse (GO:1902685), regulation of protein localization to plasma membrane (GO:1903076), vesicle-mediated transport (GO:0016192)

GO Molecular Function (5): SNARE binding (GO:0000149), SNAP receptor activity (GO:0005484), chloride channel inhibitor activity (GO:0019869), syntaxin binding (GO:0019905), protein binding (GO:0005515)

GO Cellular Component (20): immunological synapse (GO:0001772), lysosome (GO:0005764), lysosomal membrane (GO:0005765), endosome (GO:0005768), early endosome (GO:0005769), late endosome (GO:0005770), plasma membrane (GO:0005886), synaptic vesicle (GO:0008021), endomembrane system (GO:0012505), endocytic vesicle (GO:0030139), SNARE complex (GO:0031201), early endosome membrane (GO:0031901), vesicle (GO:0031982), azurophil granule (GO:0042582), perinuclear region of cytoplasm (GO:0048471), recycling endosome (GO:0055037), extracellular exosome (GO:0070062), tertiary granule (GO:0070820), membrane (GO:0016020), secretory vesicle (GO:0099503)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
cytoplasmic vesicle	3
endosome	3
plasma membrane	2
cytoplasm	2
secretory granule	2
positive regulation of leukocyte mediated cytotoxicity	1
T cell mediated cytotoxicity	1
regulation of T cell mediated cytotoxicity	1
positive regulation of T cell mediated immunity	1
intracellular protein localization	1
protein transport	1
intracellular transport	1
vesicle organization	1
vesicle-mediated transport	1
organelle membrane fusion	1
localization	1
organelle organization	1
cellular component assembly	1
positive regulation of biological process	1
receptor localization to synapse	1
regulation of receptor localization to synapse	1
protein localization to plasma membrane	1
regulation of protein localization to cell periphery	1
regulation of protein localization to membrane	1
transport	1
cellular process	1
protein binding	1
protein-macromolecule adaptor activity	1
membrane fusion	1
fusogenic activity	1
chloride channel activity	1
ion channel inhibitor activity	1
chloride channel regulator activity	1
SNARE binding	1
binding	1
lytic vacuole	1
lysosome	1
lytic vacuole membrane	1
endomembrane system	1

Protein interactions and networks

STRING

1814 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
STX7	STX8	Q9UNK0	999
STX7	VAMP8	Q9BV40	998
STX7	VAMP7	P51809	997
STX7	VTI1B	Q9UEU0	997
STX7	SNAP29	O95721	991
STX7	YKT6	O15498	990
STX7	STX6	O43752	949
STX7	SNAP23	O00161	891
STX7	MOXD1	Q6UVY6	859
STX7	VPS33A	Q96AX1	836
STX7	TAAR5	O14804	833
STX7	VAMP3	Q15836	787
STX7	STX17	P56962	766
STX7	NAPA	P54920	760
STX7	BET1	O15155	758

IntAct

269 interactions, top by confidence:

A	B	Type	Score
STX7	STX4	psi-mi:“MI:0915”(physical association)	0.830
STX4	STX7	psi-mi:“MI:0915”(physical association)	0.830
STX7	LSMEM2	psi-mi:“MI:0915”(physical association)	0.740
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
VAMP8	STX7	psi-mi:“MI:0915”(physical association)	0.670
TMPRSS2	STX7	psi-mi:“MI:0915”(physical association)	0.600
STX7	HSD17B13	psi-mi:“MI:0915”(physical association)	0.560
STX7	REEP1	psi-mi:“MI:0915”(physical association)	0.560
STX7	ELOVL5	psi-mi:“MI:0915”(physical association)	0.560
STX7	AQP6	psi-mi:“MI:0915”(physical association)	0.560
STX7	CYBRD1	psi-mi:“MI:0915”(physical association)	0.560
STX7	JAGN1	psi-mi:“MI:0915”(physical association)	0.560
STX7	EBP	psi-mi:“MI:0915”(physical association)	0.560
STX7	RETREG3	psi-mi:“MI:0915”(physical association)	0.560
STX7	ANKS6	psi-mi:“MI:0915”(physical association)	0.560
STX7	STX2	psi-mi:“MI:0915”(physical association)	0.560
STX7	STX1A	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (954): STX7 (Two-hybrid), STX7 (Affinity Capture-MS), STX7 (Affinity Capture-Western), STX7 (Affinity Capture-Western), STX7 (Affinity Capture-Western), STX7 (Affinity Capture-Western), STX7 (Affinity Capture-MS), STX7 (Affinity Capture-MS), YKT6 (Affinity Capture-MS), GOLGA2 (Affinity Capture-MS), ZNF101 (Affinity Capture-MS), ZKSCAN1 (Affinity Capture-MS), VPS45 (Affinity Capture-MS), NAPA (Affinity Capture-MS), STX4 (Affinity Capture-MS)

ESM2 similar proteins: A8WVD0, O15400, O16000, O35526, O70257, O70439, P32850, P32851, P32856, P32867, P39926, P50279, P61264, P61265, P61266, P61267, P61268, P70452, Q00262, Q08849, Q08850, Q0VCI2, Q12846, Q13277, Q16623, Q16932, Q20024, Q24547, Q3SWZ3, Q3ZBT5, Q42374, Q59YF0, Q5R4L2, Q5R602, Q5TX47, Q64704, Q7XIE2, Q8N4C7, Q8R1Q0, Q8VZU2

Diamond homologs: A8WVD0, G3V7P1, O14662, O15400, O16000, O35526, O64791, O65359, O70257, O70439, O94651, P32850, P32851, P32854, P32856, P50279, P61264, P61265, P61266, P61267, P61268, P70452, P91409, Q00262, Q08144, Q08849, Q08850, Q12846, Q13277, Q16623, Q16932, Q24547, Q3SWZ3, Q3ZBT5, Q42374, Q54JY7, Q54X86, Q5R4L2, Q5R602, Q5RBW6

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 98 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
trans-Golgi Network Vesicle Budding	7	29.1×	1e-06
Retrograde transport at the Trans-Golgi-Network	5	18.0×	4e-04
ER-Phagosome pathway	5	10.6×	1e-03
COPI-mediated anterograde transport	5	9.0×	2e-03
Membrane Trafficking	8	4.9×	2e-03
Vesicle-mediated transport	8	4.6×	2e-03
Neutrophil degranulation	10	3.8×	2e-03

GO biological processes:

GO term	Partners	Fold	FDR
exocytosis	10	18.7×	7e-08
intracellular protein transport	9	7.2×	6e-04
protein transport	10	5.4×	9e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

48 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	32
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
218904	NM_003569.3(STX7):c.159A>C (p.Gln53His)	Likely pathogenic

SpliceAI

1864 predictions. Top by Δscore:

Variant	Effect	Δscore
6:132463990:TACCT:T	donor_loss	1.0000
6:132463991:A:AC	donor_gain	1.0000
6:132463991:A:AT	donor_loss	1.0000
6:132463992:C:A	donor_loss	1.0000
6:132463992:C:CC	donor_gain	1.0000
6:132464072:CTAT:C	acceptor_gain	1.0000
6:132464073:TAT:T	acceptor_gain	1.0000
6:132464074:AT:A	acceptor_gain	1.0000
6:132464076:C:CC	acceptor_gain	1.0000
6:132464077:T:C	acceptor_loss	1.0000
6:132464078:G:C	acceptor_gain	1.0000
6:132464083:A:AC	acceptor_gain	1.0000
6:132464083:A:C	acceptor_gain	1.0000
6:132469949:A:AC	donor_gain	1.0000
6:132469950:C:CC	donor_gain	1.0000
6:132469950:CTT:C	donor_gain	1.0000
6:132469952:T:TA	donor_gain	1.0000
6:132469959:G:A	donor_gain	1.0000
6:132470043:TTTGG:T	acceptor_gain	1.0000
6:132470048:C:CC	acceptor_gain	1.0000
6:132471455:ATACT:A	donor_loss	1.0000
6:132471456:TACTT:T	donor_loss	1.0000
6:132471460:TACAG:T	donor_gain	1.0000
6:132471461:A:AC	donor_gain	1.0000
6:132471461:ACAGA:A	donor_gain	1.0000
6:132471462:C:CC	donor_gain	1.0000
6:132471462:CA:C	donor_gain	1.0000
6:132471462:CAG:C	donor_gain	1.0000
6:132471462:CAGA:C	donor_gain	1.0000
6:132471462:CAGAC:C	donor_gain	1.0000

AlphaMissense

1729 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:132464028:C:G	A220P	0.999
6:132464049:C:G	A213P	0.999
6:132464064:C:G	A208P	0.999
6:132469955:A:G	L178P	0.999
6:132471519:C:G	A111P	0.999
6:132471548:A:G	L101P	0.999
6:132464007:C:G	A227P	0.998
6:132464015:A:G	L224P	0.998
6:132464069:A:T	I206K	0.998
6:132468475:C:G	A180P	0.998
6:132471516:C:G	A112P	0.998
6:132472343:G:T	A63D	0.998
6:132468446:A:C	F189L	0.997
6:132468446:A:T	F189L	0.997
6:132468448:A:G	F189L	0.997
6:132464069:A:C	I206R	0.996
6:132471560:A:G	F97S	0.996
6:132471575:C:G	R92P	0.996
6:132472335:T:G	T66P	0.996
6:132472344:C:G	A63P	0.996
6:132472346:A:G	L62P	0.996
6:132468438:A:G	L192S	0.995
6:132468450:A:T	I188K	0.995
6:132472334:G:T	T66K	0.995
6:132464004:C:G	A228P	0.994
6:132471527:T:G	Q108P	0.994
6:132472334:G:C	T66R	0.994
6:132464036:A:T	V217D	0.993
6:132468405:A:T	I203K	0.993
6:132471536:T:G	Q105P	0.993

dbSNP variants (sampled 300 via entrez): RS1000006324 (6:132473023 G>A), RS1000006471 (6:132471108 C>G), RS1000153264 (6:132474222 T>C,G), RS1000154141 (6:132513051 C>T), RS1000174429 (6:132483118 G>A), RS1000181478 (6:132504444 G>C), RS1000205121 (6:132456419 G>A), RS1000306471 (6:132488695 G>C), RS1000359589 (6:132494705 C>G,T), RS1000422172 (6:132488966 C>T), RS1000428395 (6:132460160 T>C), RS1000492281 (6:132510806 G>A,T), RS1000497199 (6:132464497 G>T), RS1000604018 (6:132509041 C>A,G,T), RS1000642966 (6:132458035 A>T)

Disease associations

OMIM: gene MIM:603217 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

17 associations (top):

Study	Trait	p-value
GCST004611_67	High light scatter reticulocyte count	7.000000e-10
GCST004612_26	High light scatter reticulocyte percentage of red cells	2.000000e-09
GCST004619_84	Reticulocyte fraction of red cells	3.000000e-09
GCST004621_106	Red cell distribution width	5.000000e-13
GCST004622_198	Reticulocyte count	2.000000e-09
GCST011739_3	Cutaneous leishmaniasis	6.000000e-06
GCST90002385_167	High light scatter reticulocyte count	5.000000e-30
GCST90002386_113	High light scatter reticulocyte percentage of red cells	5.000000e-29
GCST90002387_291	Immature fraction of reticulocytes	5.000000e-12
GCST90002397_481	Mean spheric corpuscular volume	8.000000e-12
GCST90002404_271	Red cell distribution width	1.000000e-23
GCST90002405_207	Reticulocyte count	1.000000e-28
GCST90002406_226	Reticulocyte fraction of red cells	5.000000e-27
GCST90020024_58	A body shape index	2.000000e-08
GCST90020025_533	Waist-to-hip ratio adjusted for BMI	2.000000e-08
GCST90020027_1052	Waist-hip index	7.000000e-09
GCST90020029_1445	Waist circumference adjusted for body mass index	3.000000e-09

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0007986	reticulocyte count
EFO:0009188	Red cell distribution width
EFO:0007789	BMI-adjusted waist circumference
EFO:0007788	BMI-adjusted waist-hip ratio

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

50 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases methylation, increases expression	4
sodium arsenite	decreases expression, increases expression	3
bisphenol A	decreases expression, increases expression	2
GSK-J4	increases expression	1
FR900359	affects phosphorylation	1
bisphenol F	increases expression	1
dicrotophos	decreases expression	1
decabromobiphenyl ether	decreases expression	1
trichostatin A	affects expression	1
tetrabromobisphenol A	decreases expression	1
perfluorooctanoic acid	increases expression	1
manganese chloride	increases abundance, increases expression	1
ochratoxin A	decreases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, decreases expression	1
ciglitazone	affects binding, increases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
di-n-butylphosphoric acid	affects expression	1
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	affects expression, affects reaction	1
K 7174	increases expression	1
bisphenol B	increases expression	1
abrine	decreases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
pentabrominated diphenyl ether 100	decreases expression	1
hexabrominated diphenyl ether 153	decreases expression	1
(+)-JQ1 compound	increases expression	1
bisphenol AF	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Air Pollutants, Occupational	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.