STXBP5-AS1

Summary

STXBP5-AS1 (STXBP5 antisense RNA 1, HGNC:44183) is a long non-coding RNA gene on chromosome 6q24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44183
Approved symbol	STXBP5-AS1
Name	STXBP5 antisense RNA 1
Location	6q24.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000233452
Ensembl biotype	lncRNA
Entrez	729178
RNAcentral	URS000075A035 — lncRNA, 3082 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 103 — 103 lncRNA

ENST00000367477, ENST00000427394, ENST00000431143, ENST00000433308, ENST00000443712, ENST00000447072, ENST00000458125, ENST00000606831, ENST00000653106, ENST00000653851, ENST00000654318, ENST00000654921, ENST00000655055, ENST00000655172, ENST00000655759, ENST00000656581, ENST00000657036, ENST00000657117, ENST00000657550, ENST00000657809, ENST00000657865, ENST00000659980, ENST00000660323, ENST00000660355, ENST00000660983, ENST00000661216, ENST00000661610, ENST00000662560, ENST00000662679, ENST00000663694, ENST00000663777, ENST00000664859, ENST00000664872, ENST00000665150, ENST00000665382, ENST00000666487, ENST00000666827, ENST00000666983, ENST00000667141, ENST00000667163, ENST00000667404, ENST00000668874, ENST00000669025, ENST00000669305, ENST00000669474, ENST00000669549, ENST00000670235, ENST00000670722, ENST00000671556, ENST00000671674, ENST00000687020, ENST00000689518, ENST00000691632, ENST00000691719, ENST00000691838, ENST00000693082, ENST00000700849, ENST00000701219, ENST00000701304, ENST00000701439, ENST00000701446, ENST00000702296, ENST00000766195, ENST00000766196, ENST00000766197, ENST00000766198, ENST00000766199, ENST00000766200, ENST00000766201, ENST00000766202, ENST00000766203, ENST00000766204, ENST00000766205, ENST00000766206, ENST00000766207, ENST00000766208, ENST00000766209, ENST00000766210, ENST00000766211, ENST00000766212, ENST00000766213, ENST00000766214, ENST00000766215, ENST00000766216, ENST00000766217, ENST00000766218, ENST00000766219, ENST00000766220, ENST00000766221, ENST00000766222, ENST00000766224, ENST00000766225, ENST00000766226, ENST00000766227, ENST00000766228, ENST00000766229, ENST00000766230, ENST00000766231, ENST00000766232, ENST00000766233, ENST00000766234, ENST00000766235, ENST00000766236

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000367477 — 11 exons

Exon	Start	End
ENSE00001600838	146843114	146844712
ENSE00001603099	147119417	147119477
ENSE00001634364	147074805	147074847
ENSE00001640392	147173593	147173647
ENSE00001684261	147170013	147170083
ENSE00001699033	146860618	146860743
ENSE00001714430	147204413	147204614
ENSE00001743946	147173815	147173948
ENSE00001760076	146972045	146972070
ENSE00001776951	146850825	146851331
ENSE00001793013	147001441	147001543

Expression profiles

Bgee: expression breadth ubiquitous, 160 present calls, max score 88.10.

FANTOM5 (CAGE): breadth broad, TPM avg 3.3639 / max 143.5361, expressed in 770 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
76089	1.3374	451
76090	1.2980	484
76092	0.7285	116

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	88.10	gold quality
Brodmann (1909) area 9	UBERON:0013540	83.02	gold quality
right frontal lobe	UBERON:0002810	81.25	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.17	gold quality
prefrontal cortex	UBERON:0000451	80.58	gold quality
left testis	UBERON:0004533	80.51	gold quality
right testis	UBERON:0004534	80.08	gold quality
hypothalamus	UBERON:0001898	79.56	gold quality
anterior cingulate cortex	UBERON:0009835	78.99	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	77.78	gold quality
testis	UBERON:0000473	77.48	gold quality
monocyte	CL:0000576	77.43	gold quality
Brodmann (1909) area 23	UBERON:0013554	77.19	silver quality
bone marrow cell	CL:0002092	77.02	gold quality
primary visual cortex	UBERON:0002436	76.98	gold quality
leukocyte	CL:0000738	76.57	gold quality
islet of Langerhans	UBERON:0000006	76.33	gold quality
neocortex	UBERON:0001950	75.57	gold quality
frontal cortex	UBERON:0001870	75.27	gold quality
adenohypophysis	UBERON:0002196	74.67	gold quality
stromal cell of endometrium	CL:0002255	74.31	gold quality
pituitary gland	UBERON:0000007	74.11	gold quality
lower esophagus mucosa	UBERON:0035834	73.82	gold quality
rectum	UBERON:0001052	73.17	gold quality
adrenal tissue	UBERON:0018303	72.54	gold quality
small intestine Peyer’s patch	UBERON:0003454	71.90	gold quality
transverse colon	UBERON:0001157	71.68	gold quality
caudate nucleus	UBERON:0001873	71.59	gold quality
middle temporal gyrus	UBERON:0002771	71.56	gold quality
putamen	UBERON:0001874	71.51	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-HCAD-35	yes	63.16
E-ANND-3	no	7.46

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• we found a significant SNP-based heritability for self-rated Attention-deficit/hyperactivity disorder (ADHD). The top hit of the genome-wide meta-analysis (SNP rs12661753; p-value = 3.02 x 10(-7)) was present in the long non-coding RNA gene STXBP5-AS1. This association was also observed in a meta-analysis of childhood ADHD symptom scores in eight population-based pediatric cohorts (PMID:30659475)
• LncRNA STXBP5-AS1 suppresses stem cell-like properties of pancreatic cancer by epigenetically inhibiting neighboring androglobin gene expression. (PMID:33160411)
• Aberrant hypermethylation induced downregulation of antisense lncRNA STXBP5-AS1 and its sense gene STXBP5 correlate with tumorigenesis of glioma. (PMID:33965377)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.