SUGP1

Summary

SUGP1 (SURP and G-patch domain containing 1, HGNC:18643) is a protein-coding gene on chromosome 19p13.11, encoding SURP and G-patch domain-containing protein 1 (Q8IWZ8). Plays a role in pre-mRNA splicing. It is a selective cancer dependency (DepMap: 88.4% of cell lines).

SF4 is a member of the SURP family of splicing factors.

Source: NCBI Gene 57794 — RefSeq curated summary.

At a glance

• GWAS associations: 37
• Clinical variants (ClinVar): 110 total
• Cancer dependency (DepMap): dependent in 88.4% of screened cell lines
• MANE Select transcript: NM_172231

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18643
Approved symbol	SUGP1
Name	SURP and G-patch domain containing 1
Location	19p13.11
Locus type	gene with protein product
Status	Approved
Aliases	F23858, DKFZp434E2216, RBP
Ensembl gene	ENSG00000105705
Ensembl biotype	protein_coding
OMIM	607992
Entrez	57794

Gene structure

Transcript identifiers

Ensembl transcripts: 25 — 12 protein_coding, 6 nonsense_mediated_decay, 4 retained_intron, 3 protein_coding_CDS_not_defined

ENST00000247001, ENST00000535070, ENST00000585444, ENST00000585763, ENST00000586387, ENST00000587119, ENST00000587716, ENST00000588580, ENST00000588731, ENST00000589144, ENST00000590439, ENST00000591007, ENST00000591350, ENST00000592188, ENST00000606725, ENST00000859768, ENST00000859769, ENST00000859770, ENST00000859771, ENST00000859772, ENST00000859773, ENST00000940551, ENST00000940552, ENST00000940553, ENST00000970039

RefSeq mRNA: 1 — MANE Select: NM_172231 NM_172231

CCDS: CCDS12399

Canonical transcript exons

ENST00000247001 — 14 exons

Exon	Start	End
ENSE00003481906	19276033	19276674
ENSE00003495904	19276947	19277076
ENSE00003564708	19320463	19320509
ENSE00003571981	19296989	19297344
ENSE00003574777	19302265	19302388
ENSE00003585861	19303724	19303847
ENSE00003599070	19279213	19279390
ENSE00003633176	19277734	19277879
ENSE00003634654	19280185	19280291
ENSE00003637318	19278690	19278796
ENSE00003679580	19316422	19316593
ENSE00003707713	19303348	19303448
ENSE00003708907	19305849	19306076
ENSE00003710688	19310097	19310200

Expression profiles

Bgee: expression breadth ubiquitous, 262 present calls, max score 94.64.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.9634 / max 199.4382, expressed in 1766 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
180139	7.9634	1766

Top tissues by expression

283 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	94.64	gold quality
right testis	UBERON:0004534	94.32	gold quality
right hemisphere of cerebellum	UBERON:0014890	94.31	gold quality
left testis	UBERON:0004533	94.20	gold quality
cerebellar hemisphere	UBERON:0002245	94.04	gold quality
cerebellar cortex	UBERON:0002129	93.94	gold quality
right frontal lobe	UBERON:0002810	93.65	gold quality
granulocyte	CL:0000094	93.59	gold quality
right adrenal gland	UBERON:0001233	93.41	gold quality
right adrenal gland cortex	UBERON:0035827	93.00	gold quality
left adrenal gland cortex	UBERON:0035825	92.70	gold quality
left adrenal gland	UBERON:0001234	92.50	gold quality
adenohypophysis	UBERON:0002196	92.35	gold quality
sural nerve	UBERON:0015488	92.26	gold quality
cingulate cortex	UBERON:0003027	92.21	gold quality
cerebellum	UBERON:0002037	92.15	gold quality
anterior cingulate cortex	UBERON:0009835	92.14	gold quality
apex of heart	UBERON:0002098	92.08	gold quality
hindlimb stylopod muscle	UBERON:0004252	92.05	gold quality
endothelial cell	CL:0000115	91.92	gold quality
adrenal tissue	UBERON:0018303	91.90	gold quality
metanephros cortex	UBERON:0010533	91.79	gold quality
Brodmann (1909) area 9	UBERON:0013540	91.78	gold quality
testis	UBERON:0000473	91.66	gold quality
adrenal cortex	UBERON:0001235	91.63	gold quality
right uterine tube	UBERON:0001302	91.63	gold quality
adrenal gland	UBERON:0002369	91.40	gold quality
pituitary gland	UBERON:0000007	91.32	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	91.31	gold quality
prefrontal cortex	UBERON:0000451	91.27	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

Target	Regulation
IL1B	Activation

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 88.4% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 6)

• Our results strongly support a role for SUGP1 as a novel regulator of cholesterol metabolism and suggest that it contributes to the relationship between rs10401969 and plasma cholesterol (PMID:27206982)
• SUGP1 loss is a common defect of spliceosomes with disease-causing SF3B1 mutations in myelodysplastic syndromes and cancers. (PMID:31474574)
• Mutations in SUGP1 that recapitulate mutant SF3B1 splicing dysregulation is associated with cancer. (PMID:32332164)
• Genetic alterations of SUGP1 mimic mutant-SF3B1 splice pattern in lung adenocarcinoma and other cancers. (PMID:33057152)
• DHX15 is involved in SUGP1-mediated RNA missplicing by mutant SF3B1 in cancer. (PMID:36459648)
• Splicing quality control mediated by DHX15 and its G-patch activator SUGP1. (PMID:37805921)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	sugp1	ENSDARG00000075936
mus_musculus	Sugp1	ENSMUSG00000011306
rattus_norvegicus	Sugp1	ENSRNOG00000052111
drosophila_melanogaster	CG31550	FBGN0051550

Paralogs (1): SUGP2 (ENSG00000064607)

Protein

Protein identifiers

SURP and G-patch domain-containing protein 1 — Q8IWZ8 (reviewed: Q8IWZ8)

Alternative names: RNA-binding protein RBP, Splicing factor 4

All UniProt accessions (7): Q8IWZ8, B4DVK3, K7ELR6, K7EM86, K7ES12, K7ESM0, V9GZ08

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in pre-mRNA splicing.

Subunit / interactions. Component of the spliceosome.

Subcellular location. Nucleus.

Tissue specificity. Detected in adult testis and heart, and in adult and fetal brain, kidney and skeletal muscle.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8IWZ8-1	1, RNA-binding protein splice variant A	yes
Q8IWZ8-2	2, RNA-binding protein splice variant B

RefSeq proteins (1): NP_757386* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000061	Surp	Domain
IPR000467	G_patch_dom	Domain
IPR035967	SWAP/Surp_sf	Homologous_superfamily
IPR040169	SUGP1/2	Family

Pfam: PF01585, PF01805

UniProt features (30 total): modified residue 7, region of interest 5, helix 4, compositionally biased region 3, repeat 2, splice variant 2, sequence variant 2, chain 1, sequence conflict 1, turn 1, domain 1, short sequence motif 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
8EJM	X-RAY DIFFRACTION	1.8
8GXL	X-RAY DIFFRACTION	2.4
8GXM	X-RAY DIFFRACTION	2.81

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8IWZ8-F1	65.38	0.07

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (7): 132, 256, 326, 409, 411, 414, 485

Function

Pathways and Gene Ontology

Reactome pathways

6 pathways

ID	Pathway
R-HSA-72163	mRNA Splicing - Major Pathway
R-HSA-9770562	mRNA Polyadenylation
R-HSA-9918481	Dengue Virus-Host Interactions
R-HSA-72172	mRNA Splicing
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA
R-HSA-8953854	Metabolism of RNA

MSigDB gene sets: 102 (showing top): GGTGTGT_MIR329, CACCAGC_MIR138, REACTOME_MRNA_3_END_PROCESSING, REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA, TGTGTGA_MIR377, GOBP_RNA_SPLICING, ATGCTGG_MIR338, REACTOME_MRNA_SPLICING, CAAGGAT_MIR362, CCAGGTT_MIR490, CCCAGAG_MIR326, CAGCCTC_MIR4855P, GTGTGAG_MIR342, REACTOME_METABOLISM_OF_RNA, LIU_SOX4_TARGETS_UP

GO Biological Process (3): mRNA processing (GO:0006397), RNA splicing (GO:0008380), RNA processing (GO:0006396)

GO Molecular Function (4): RNA binding (GO:0003723), mRNA binding (GO:0003729), nucleic acid binding (GO:0003676), protein binding (GO:0005515)

GO Cellular Component (3): nucleoplasm (GO:0005654), spliceosomal complex (GO:0005681), nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-5 pathways:

Category	Pathways
mRNA Splicing	1
mRNA 3’-end processing	1
Dengue Virus Infection	1
Processing of Capped Intron-Containing Pre-mRNA	1
Metabolism of RNA	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA processing	2
binding	2
mRNA metabolic process	1
gene expression	1
RNA biosynthetic process	1
primary metabolic process	1
nucleic acid binding	1
RNA binding	1
nuclear lumen	1
cellular anatomical structure	1
nuclear protein-containing complex	1
ribonucleoprotein complex	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1882 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SUGP1	SRSF1	Q07955	816
SUGP1	SF3B1	O75533	658
SUGP1	U2AF2	P26368	586
SUGP1	NR2C2AP	Q86WQ0	533
SUGP1	GPATCH1	Q9BRR8	509
SUGP1	ANKRD30BL	A7E2S9	488
SUGP1	U2SURP	O15042	480
SUGP1	TAAR6	Q96RI8	448
SUGP1	SUGP2	Q8IX01	436
SUGP1	SLC35E1	Q96K37	434
SUGP1	YJEFN3	A6XGL0	430
SUGP1	CILP2	Q8IUL8	427
SUGP1	TM6SF2	Q9BZW4	418
SUGP1	NICN1	Q9BSH3	411
SUGP1	RAD51	Q06609	403

IntAct

96 interactions, top by confidence:

A	B	Type	Score
SUGP1	U2AF2	psi-mi:“MI:0915”(physical association)	0.820
U2AF2	SUGP1	psi-mi:“MI:0915”(physical association)	0.820
U2AF2	SUGP1	psi-mi:“MI:0407”(direct interaction)	0.820
YEATS4	ZNHIT1	psi-mi:“MI:0914”(association)	0.790
COMMD4	VPS26C	psi-mi:“MI:0914”(association)	0.730
GATAD2A	CDK2AP1	psi-mi:“MI:0914”(association)	0.730
SNRPD2	GEMIN2	psi-mi:“MI:0914”(association)	0.710
SF3B1	SAP18	psi-mi:“MI:0914”(association)	0.640
SNRPA1	U2SURP	psi-mi:“MI:0914”(association)	0.640
SUGP1	RBM17	psi-mi:“MI:0915”(physical association)	0.630
SUGP1	SF3B1	psi-mi:“MI:0915”(physical association)	0.620
SUGP1	SNRPB2	psi-mi:“MI:0915”(physical association)	0.550
COMTD1	IFRD1	psi-mi:“MI:0914”(association)	0.530
FAM177A1	SLC27A2	psi-mi:“MI:0914”(association)	0.530
EZH1	EPOP	psi-mi:“MI:0914”(association)	0.530
SUGP1	DHX15	psi-mi:“MI:0915”(physical association)	0.510
SUGP1	RBM10	psi-mi:“MI:0915”(physical association)	0.510
DHX15	SUGP1	psi-mi:“MI:0915”(physical association)	0.510
RBM10	SUGP1	psi-mi:“MI:0915”(physical association)	0.510
SF3A2	SUGP1	psi-mi:“MI:0915”(physical association)	0.400
Dync1li1	SSR3	psi-mi:“MI:0914”(association)	0.350
Mis12		psi-mi:“MI:0914”(association)	0.350
ZWINT	ARHGAP32	psi-mi:“MI:0914”(association)	0.350
RAB5C		psi-mi:“MI:0914”(association)	0.350
LDHD	METTL8	psi-mi:“MI:0914”(association)	0.350

BioGRID (186): SUGP1 (Affinity Capture-MS), SUGP1 (Affinity Capture-MS), SUGP1 (Affinity Capture-MS), SUGP1 (Affinity Capture-MS), SUGP1 (Affinity Capture-MS), SUGP1 (Affinity Capture-MS), DHX15 (Co-fractionation), SUGP1 (Affinity Capture-MS), SUGP1 (Affinity Capture-MS), SUGP1 (Affinity Capture-MS), SUGP1 (Affinity Capture-MS), SUGP1 (Affinity Capture-MS), SUGP1 (Affinity Capture-MS), SUGP1 (Affinity Capture-MS), SUGP1 (Affinity Capture-MS)

ESM2 similar proteins: A0M8S4, A0M8T5, A1A5Q0, B9EJA2, E1BTG2, E7F7X0, E9QA62, F7AEX0, O35867, O88665, Q00PJ1, Q02225, Q07DV1, Q07DW4, Q07DX4, Q07DY4, Q07E15, Q07E28, Q07E41, Q09YG9, Q09YI1, Q09YJ3, Q09YK4, Q09YM8, Q0VAK6, Q108T9, Q2IBA2, Q2IBD4, Q2IBE6, Q2IBF7, Q2IBF8, Q2QL82, Q2QLA2, Q2QLB3, Q2QLF8, Q2QLG9, Q2V2M9, Q3UHZ5, Q3UQU0, Q4V8E4

Diamond homologs: A0JMV4, A4IGK4, A4L691, A5DSB5, B2GV05, P15771, P52756, P70501, P98175, Q0IIX9, Q17784, Q1RMU5, Q5ZII9, Q66J74, Q68FU8, Q6C233, Q6DDU9, Q7TN31, Q7TQC7, Q8CH02, Q8CH09, Q8IWZ8, Q8IX01, Q8N302, Q91YE7, Q94C11, Q96BK5, Q99KG3, Q9CZX5, Q9NW75, Q9UTK6, A2VDN6, B9DHA6, G1SK22, O13900, O14399, O15042, P05759, P0C016, P0C030

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 126 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
mRNA Splicing	22	25.4×	2e-23
mRNA Polyadenylation	27	25.0×	1e-28
mRNA Splicing - Minor Pathway	10	23.6×	7e-10
Processing of Capped Intron-Containing Pre-mRNA	24	20.8×	2e-23
CHD1 and CHD2 subfamily	18	20.6×	3e-17
mRNA Splicing - Major Pathway	33	19.0×	3e-31
Dengue Virus-Host Interactions	26	12.5×	9e-20
SARS-CoV-2 modulates host translation machinery	5	11.8×	4e-03

GO biological processes:

GO term	Partners	Fold	FDR
U2-type prespliceosome assembly	14	76.0×	1e-21
negative regulation of mRNA splicing, via spliceosome	5	33.3×	4e-05
spliceosomal complex assembly	6	31.4×	4e-06
RNA splicing, via transesterification reactions	5	27.1×	1e-04
spliceosomal snRNP assembly	5	25.3×	1e-04
mRNA splicing, via spliceosome	28	22.3×	2e-27
mRNA transport	6	13.7×	3e-04
RNA splicing	17	13.0×	3e-12

Disease & clinical

Clinical variants and AI predictions

ClinVar

110 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	87
Likely benign	7
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

2464 predictions. Top by Δscore:

Variant	Effect	Δscore
19:19276942:CGTA:C	donor_loss	1.0000
19:19276943:GTACC:G	donor_loss	1.0000
19:19276945:A:AC	donor_gain	1.0000
19:19276945:A:AT	donor_loss	1.0000
19:19276946:C:CC	donor_gain	1.0000
19:19276982:T:TA	donor_gain	1.0000
19:19277072:TGCCC:T	acceptor_gain	1.0000
19:19277073:GCCC:G	acceptor_gain	1.0000
19:19277074:CCC:C	acceptor_gain	1.0000
19:19277074:CCCC:C	acceptor_gain	1.0000
19:19277075:CC:C	acceptor_gain	1.0000
19:19277075:CCC:C	acceptor_gain	1.0000
19:19277076:CC:C	acceptor_gain	1.0000
19:19277077:C:CC	acceptor_gain	1.0000
19:19277077:C:T	acceptor_gain	1.0000
19:19277080:C:CT	acceptor_gain	1.0000
19:19277731:CACT:C	donor_loss	1.0000
19:19277732:A:AC	donor_gain	1.0000
19:19277733:C:CG	donor_gain	1.0000
19:19277733:CT:C	donor_gain	1.0000
19:19277733:CTT:C	donor_gain	1.0000
19:19277733:CTTG:C	donor_gain	1.0000
19:19277785:T:TA	donor_gain	1.0000
19:19277789:T:TA	donor_gain	1.0000
19:19277801:T:TA	donor_gain	1.0000
19:19277875:CCCTC:C	acceptor_gain	1.0000
19:19277876:CCTCC:C	acceptor_gain	1.0000
19:19277877:CTC:C	acceptor_gain	1.0000
19:19277880:C:CC	acceptor_gain	1.0000
19:19278685:CTCA:C	donor_loss	1.0000

AlphaMissense

4267 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:19276656:A:G	Y644H	1.000
19:19276663:T:A	R641S	1.000
19:19276663:T:G	R641S	1.000
19:19276664:C:A	R641I	1.000
19:19276664:C:G	R641T	1.000
19:19276669:A:C	N639K	1.000
19:19276669:A:T	N639K	1.000
19:19276948:A:G	L637P	1.000
19:19276953:G:C	N635K	1.000
19:19276953:G:T	N635K	1.000
19:19276961:G:C	R633G	1.000
19:19276962:G:C	F632L	1.000
19:19276962:G:T	F632L	1.000
19:19276963:A:G	F632S	1.000
19:19276964:A:G	F632L	1.000
19:19276970:A:C	Y630D	1.000
19:19276970:A:G	Y630H	1.000
19:19276972:G:T	A629D	1.000
19:19276975:A:G	L628P	1.000
19:19276980:C:A	M626I	1.000
19:19276980:C:G	M626I	1.000
19:19276980:C:T	M626I	1.000
19:19276981:A:C	M626R	1.000
19:19276981:A:G	M626T	1.000
19:19276981:A:T	M626K	1.000
19:19276983:C:A	R625S	1.000
19:19276983:C:G	R625S	1.000
19:19276984:C:A	R625M	1.000
19:19276984:C:G	R625T	1.000
19:19276990:C:G	R623P	1.000

dbSNP variants (sampled 300 via entrez): RS1000082428 (19:19315558 C>T), RS1000111035 (19:19307292 C>A,T), RS1000131551 (19:19278465 C>G,T), RS1000149750 (19:19296562 G>C), RS1000325109 (19:19283579 C>A,T), RS1000395995 (19:19305414 A>G), RS1000416418 (19:19284380 G>T), RS1000434564 (19:19304811 G>A), RS1000492082 (19:19309812 T>C), RS1000522234 (19:19294079 T>C), RS1000605085 (19:19296845 G>C), RS1000697065 (19:19315055 G>A), RS1000755385 (19:19288229 G>A), RS1000782455 (19:19300002 T>C), RS1000879557 (19:19282693 A>G)

Disease associations

OMIM: gene MIM:607992 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

37 associations (top):

Study	Trait	p-value
GCST000807_10	LDL cholesterol	1.000000e-11
GCST002149_11	Schizophrenia	3.000000e-09
GCST002539_89	Schizophrenia	4.000000e-10
GCST002632_1	Hepatic lipid content in extreme obesity	3.000000e-07
GCST003681_18	C-reactive protein levels or triglyceride levels (pleiotropy)	2.000000e-32
GCST006612_60	LDL cholesterol	8.000000e-42
GCST006803_88	Schizophrenia	7.000000e-12
GCST006867_82	Type 2 diabetes	4.000000e-12
GCST007294_16	Body fat distribution (trunk fat ratio)	2.000000e-07
GCST007294_35	Body fat distribution (trunk fat ratio)	1.000000e-10
GCST007295_166	Body fat distribution (leg fat ratio)	2.000000e-11
GCST007295_22	Body fat distribution (leg fat ratio)	3.000000e-07
GCST008103_10	Bipolar disorder	1.000000e-09
GCST008115_2	Bipolar I disorder	3.000000e-09
GCST008116_4	Bipolar II disorder	4.000000e-06
GCST008529_12	Tea consumption	7.000000e-09
GCST008745_23	Estimated glomerular filtration rate in non-diabetics	4.000000e-09
GCST009363_38	Triglyceride levels x short total sleep time interaction (2df test)	5.000000e-32
GCST009364_19	Triglyceride levels x long total sleep time interaction (2df test)	5.000000e-30
GCST009365_25	LDL cholesterol levels x short total sleep time interaction (2df test)	1.000000e-22
GCST010002_52	Refractive error	4.000000e-29
GCST010243_160	Apolipoprotein B levels	2.000000e-28
GCST010243_219	Apolipoprotein B levels	3.000000e-121
GCST010244_41	Triglyceride levels	2.000000e-48
GCST010245_192	LDL cholesterol levels	9.000000e-37
GCST010245_214	LDL cholesterol levels	2.000000e-158
GCST010703_335	Brain morphology (MOSTest)	3.000000e-10
GCST010861_5	Nonalcoholic steatohepatitis	1.000000e-07
GCST010988_19	Adult body size	2.000000e-13
GCST011051_5	Postprandial triglyceride levels	8.000000e-09

EFO canonical traits (13, from GWAS)

EFO ID	Trait name
EFO:0004611	low density lipoprotein cholesterol measurement
EFO:0006506	hepatic lipid content measurement
EFO:0004458	C-reactive protein measurement
EFO:0004530	triglyceride measurement
EFO:0004341	body fat distribution
EFO:0009963	bipolar I disorder
EFO:0009964	bipolar II disorder
EFO:0010091	tea consumption measurement
EFO:0004615	apolipoprotein B measurement
EFO:0004346	neuroimaging measurement
EFO:0005689	non-high density lipoprotein cholesterol measurement
EFO:0007984	platelet component distribution width
EFO:0004309	platelet count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs10401969	SUGP1		0.00	0

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Lead	affects expression, decreases expression	2
aristolochic acid I	increases expression	1
FR900359	increases phosphorylation	1
bisphenol F	affects cotreatment, increases methylation	1
triphenyl phosphate	affects expression	1
bisphenol A	affects cotreatment, increases methylation	1
quercitrin	increases expression	1
trichostatin A	affects expression	1
beta-lapachone	increases expression	1
benzo(e)pyrene	decreases methylation	1
ferrous chloride	decreases expression	1
aflatoxin B2	decreases methylation	1
coumarin	increases phosphorylation	1
di-n-butylphosphoric acid	affects expression	1
abrine	increases expression	1
Temozolomide	increases expression	1
Sunitinib	decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Leflunomide	decreases expression	1
Atrazine	decreases expression	1
Doxorubicin	decreases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Methapyrilene	decreases methylation	1
Polychlorinated Biphenyls	affects expression	1
Ribonucleotides	affects binding	1
Silicon Dioxide	decreases methylation	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Urethane	increases expression	1
Valproic Acid	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.