SULT1A2

Summary

SULT1A2 (sulfotransferase family 1A member 2, HGNC:11454) is a protein-coding gene on chromosome 16p11.2, encoding Sulfotransferase 1A2 (P50226). Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters.

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Two alternatively spliced variants that encode the same protein have been described.

Source: NCBI Gene 6799 — RefSeq curated summary.

At a glance

• GWAS associations: 20
• Clinical variants (ClinVar): 73 total
• Druggable target: yes
• MANE Select transcript: NM_001054

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11454
Approved symbol	SULT1A2
Name	sulfotransferase family 1A member 2
Location	16p11.2
Locus type	gene with protein product
Status	Approved
Aliases	HAST4
Ensembl gene	ENSG00000197165
Ensembl biotype	protein_coding
OMIM	601292
Entrez	6799

Gene structure

Transcript identifiers

Ensembl transcripts: 52 — 51 protein_coding, 1 nonsense_mediated_decay

ENST00000335715, ENST00000395630, ENST00000526384, ENST00000533150, ENST00000534108, ENST00000898323, ENST00000898324, ENST00000898325, ENST00000898326, ENST00000898327, ENST00000898328, ENST00000898329, ENST00000898330, ENST00000898331, ENST00000898332, ENST00000898333, ENST00000898334, ENST00000898335, ENST00000898336, ENST00000898337, ENST00000898338, ENST00000898339, ENST00000898340, ENST00000898341, ENST00000898342, ENST00000898343, ENST00000898344, ENST00000898345, ENST00000898346, ENST00000898347, ENST00000898348, ENST00000898349, ENST00000898350, ENST00000898351, ENST00000898352, ENST00000898353, ENST00000898354, ENST00000898355, ENST00000898356, ENST00000898357, ENST00000898358, ENST00000898359, ENST00000898360, ENST00000898361, ENST00000898362, ENST00000898363, ENST00000898364, ENST00000898365, ENST00000966913, ENST00000966914, ENST00000966915, ENST00000966916

RefSeq mRNA: 10 — MANE Select: NM_001054 NM_001054, NM_001363863, NM_001400258, NM_001400259, NM_001400260, NM_001400261, NM_001400262, NM_001400263, NM_001400264, NM_177528

CCDS: CCDS10636, CCDS86513

Canonical transcript exons

ENST00000335715 — 8 exons

Exon	Start	End
ENSE00001594137	28595367	28595464
ENSE00001638355	28595783	28595934
ENSE00001736719	28596997	28597050
ENSE00001758609	28592263	28592443
ENSE00001759576	28595550	28595675
ENSE00003551762	28593252	28593346
ENSE00003652030	28593442	28593568
ENSE00003667965	28591943	28592140

Expression profiles

Bgee: expression breadth ubiquitous, 128 present calls, max score 95.24.

FANTOM5 (CAGE): breadth broad, TPM avg 0.5304 / max 42.5217, expressed in 196 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
156896	0.1934	77
156898	0.1372	69
156897	0.1012	43
156899	0.0985	51

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	95.24	gold quality
mucosa of transverse colon	UBERON:0004991	94.90	gold quality
right lobe of liver	UBERON:0001114	90.43	gold quality
liver	UBERON:0002107	89.14	gold quality
rectum	UBERON:0001052	84.48	gold quality
small intestine	UBERON:0002108	82.96	gold quality
small intestine Peyer’s patch	UBERON:0003454	82.95	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.36	gold quality
right lobe of thyroid gland	UBERON:0001119	76.92	gold quality
transverse colon	UBERON:0001157	76.81	gold quality
left lobe of thyroid gland	UBERON:0001120	76.40	gold quality
upper lobe of left lung	UBERON:0008952	76.20	gold quality
thyroid gland	UBERON:0002046	75.63	gold quality
right lung	UBERON:0002167	75.02	gold quality
lung	UBERON:0002048	73.27	gold quality
intestine	UBERON:0000160	72.03	gold quality
spleen	UBERON:0002106	70.72	gold quality
granulocyte	CL:0000094	70.62	gold quality
adult mammalian kidney	UBERON:0000082	69.24	gold quality
cerebellar hemisphere	UBERON:0002245	69.08	gold quality
cerebellum	UBERON:0002037	69.01	gold quality
cerebellar cortex	UBERON:0002129	68.99	gold quality
right hemisphere of cerebellum	UBERON:0014890	68.79	gold quality
placenta	UBERON:0001987	68.40	gold quality
colon	UBERON:0001155	68.34	gold quality
cortex of kidney	UBERON:0001225	67.90	gold quality
blood	UBERON:0000178	67.65	gold quality
right atrium auricular region	UBERON:0006631	67.60	gold quality
right adrenal gland cortex	UBERON:0035827	66.60	gold quality
kidney	UBERON:0002113	66.50	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-125970	yes	67.75
E-ANND-3	yes	8.77

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 12)

• SULT1A2 polymorphisms in 230 Taiwanese breast cancer patients (PMID:12373301)
• the relationship among the polymorphisms of this enzyme and SULT1A1 in different types of cancers in Taiwanese (PMID:12469224)
• SULT1A1*2 and SULT1A2*2 are the major allelic variants in the Korean population (PMID:16133548)
• SULT1A1/SULT1A2 gene complex showed suggestive haplotypic association in the family-based cardiovascular disease study, with the greatest increase in risk conferred by the SULT1A2 235T allele (PMID:18259693)
• the structures of SULT1A2 and an allozyme of SULT1A1, SULT1A1 *3, bound with 3’-phosphoadenosine 5’-phosphate at 2.4 and 2.3A resolution, respectively, were determined. (PMID:20417180)
• the statistical hypothesis that SULT1A1 and SULT1A2 alleles are independently distributed was rejected; a strongly positive linkage was detected between SULT1A1*2 and SULT1A2*2 alleles in Turkey population (PMID:20936502)
• resequenced the SULT1A2 and SULT1A2 genes and identified 51 variations in ethnic Koreans, including 9 that were previously unknown. Allele frequencies, haplotype structures, LD blocks, and haplotype-tagging SNPs were determined. (PMID:23358261)
• SULT1A2 genotype also seems to play an important role in maintaining optimal levels of both 4OH-TAM and endoxifen. (PMID:23922954)
• It metabolizes breast cancer drugs like afimoxifene and endoxifen by sulfation. (PMID:26169578)
• The polymorphism of SULT1A2*2 is not associated with esophageal squamous cell carcinoma risk. (PMID:26455829)
• Suggest SULT1A1/1A2 play a central role in furfuryl alcohol bioactivation and the formation of hemoglobin adducts. (PMID:29908303)
• Association of SULT1A2 rs1059491 with obesity and dyslipidaemia in southern Chinese adults. (PMID:37142702)

Cross-species orthologs

15 orthologs

Organism	Symbol	Gene ID
danio_rerio	sult1st4	ENSDARG00000003181
danio_rerio	sult5a1	ENSDARG00000007769
danio_rerio	sult1st3	ENSDARG00000018361
danio_rerio	sult1st1	ENSDARG00000028275
danio_rerio	sult2st3	ENSDARG00000028367
danio_rerio	sult2st1	ENSDARG00000033170
danio_rerio	sult1st2	ENSDARG00000041540
danio_rerio	sult1st7	ENSDARG00000079079
danio_rerio	sult1st9	ENSDARG00000094996
danio_rerio	sult2st2	ENSDARG00000103785
mus_musculus	Sult5a1	ENSMUSG00000000739
rattus_norvegicus	Sult5a1	ENSRNOG00000015695
drosophila_melanogaster	St4	FBGN0033887
drosophila_melanogaster	St1	FBGN0034887
drosophila_melanogaster	St3	FBGN0265052

Paralogs (12): SULT2B1 (ENSG00000088002), SULT2A1 (ENSG00000105398), SULT1E1 (ENSG00000109193), SULT4A1 (ENSG00000130540), SULT6B1 (ENSG00000138068), SULT1B1 (ENSG00000173597), SULT1C3 (ENSG00000196228), SULT1A1 (ENSG00000196502), SULT1C4 (ENSG00000198075), SULT1C2 (ENSG00000198203), SULT1A4 (ENSG00000213648), SULT1A3 (ENSG00000261052)

Protein

Protein identifiers

Sulfotransferase 1A2 — P50226 (reviewed: P50226)

Alternative names: Aryl sulfotransferase 2, Phenol sulfotransferase 2, Phenol-sulfating phenol sulfotransferase 2

All UniProt accessions (4): E9PKR8, E9PKW4, E9PM76, P50226

UniProt curated annotations — full annotation on UniProt →

Function. Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.

Subunit / interactions. Homodimer.

Subcellular location. Cytoplasm.

Similarity. Belongs to the sulfotransferase 1 family.

RefSeq proteins (10): NP_001045, NP_001350792, NP_001387187, NP_001387188, NP_001387189, NP_001387190, NP_001387191, NP_001387192, NP_001387193, NP_803564 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000863	Sulfotransferase_dom	Domain
IPR027417	P-loop_NTPase	Homologous_superfamily

Pfam: PF00685

Enzyme classification (BRENDA):

• EC 2.8.2.1 — aryl sulfotransferase (BRENDA: 19 organisms, 630 substrates, 215 inhibitors, 314 Km, 55 kcat entries)
• EC 2.8.2.2 — alcohol sulfotransferase (BRENDA: 13 organisms, 295 substrates, 100 inhibitors, 159 Km, 25 kcat entries)
• EC 2.8.2.9 — tyrosine-ester sulfotransferase (BRENDA: 4 organisms, 83 substrates, 56 inhibitors, 70 Km, 20 kcat entries)

Substrate kinetics (BRENDA)

227 substrates with measured Km, best-characterized 15. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
DOPAMINE	0.0006–11.3	39
4-NITROPHENOL	0.0001–30.9	36
DEHYDROEPIANDROSTERONE	0.0006–0.0179	23
3’-PHOSPHOADENYLYLSULFATE	0.0003–0.51	17
ACETAMINOPHEN	0.43–4.5	14
MORPHINE	3.8–10	13
O-DESMETHYL TRAMADOL	0.27–0.8	13
TAPENTADOL	0.09–0.84	13
3’-PHOSPHOADENYLYL SULFATE	0.0008–0.024	12
ANDROSTERONE	0.0002–0.0096	11
DAIDZEIN	0.0005–0.407	8
GENISTEIN	0.0005–0.371	8
6-HYDROXYMELATONIN	0.018–0.065	6
3’-PHOSPHOADENYLYLSULFATE	0.0001–0.1	6
4-NITROPHENOL	0.0077–1.25	6

Catalyzed reactions (Rhea), 1 shown:

• a phenol + 3’-phosphoadenylyl sulfate = an aryl sulfate + adenosine 3’,5’-bisphosphate + H(+) (RHEA:12164)

UniProt features (43 total): helix 15, binding site 7, sequence variant 6, strand 6, turn 6, chain 1, active site 1, sequence conflict 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
1Z29	X-RAY DIFFRACTION	2.4

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P50226-F1	96.76	0.97

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 108 (proton acceptor)

Ligand- & substrate-binding residues (7): 48–53; 106–108; 130; 138; 193; 227–232; 255–259

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-156584	Cytosolic sulfonation of small molecules
R-HSA-1430728	Metabolism
R-HSA-156580	Phase II - Conjugation of compounds
R-HSA-211859	Biological oxidations

MSigDB gene sets: 90 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_BRAIN_TUMORAL_MACROPHAGE_DN, GSE18804_BRAIN_VS_COLON_TUMORAL_MACROPHAGE_DN, GOBP_PHENOL_CONTAINING_COMPOUND_METABOLIC_PROCESS, REACTOME_BIOLOGICAL_OXIDATIONS, GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS, GOBP_SULFATION, GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS, RODRIGUES_NTN1_TARGETS_DN, GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS, ONKEN_UVEAL_MELANOMA_UP, chr16p11, GOBP_LIPID_METABOLIC_PROCESS, GOBP_ORGANIC_ACID_METABOLIC_PROCESS, GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS, TGGNNNNNNKCCAR_UNKNOWN

GO Biological Process (9): ethanol catabolic process (GO:0006068), catecholamine metabolic process (GO:0006584), xenobiotic metabolic process (GO:0006805), steroid metabolic process (GO:0008202), amine biosynthetic process (GO:0009309), phenol-containing compound metabolic process (GO:0018958), 3’-phosphoadenosine 5’-phosphosulfate metabolic process (GO:0050427), sulfation (GO:0051923), lipid metabolic process (GO:0006629)

GO Molecular Function (5): aryl sulfotransferase activity (GO:0004062), sulfotransferase activity (GO:0008146), flavonol 3-sulfotransferase activity (GO:0047894), protein binding (GO:0005515), transferase activity (GO:0016740)

GO Cellular Component (2): cytoplasm (GO:0005737), cytosol (GO:0005829)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Phase II - Conjugation of compounds	1
Biological oxidations	1
Metabolism	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
metabolic process	2
sulfur compound metabolic process	2
sulfotransferase activity	2
cellular anatomical structure	2
ethanol metabolic process	1
primary alcohol catabolic process	1
biogenic amine metabolic process	1
catechol-containing compound metabolic process	1
cellular response to xenobiotic stimulus	1
lipid metabolic process	1
biosynthetic process	1
amine metabolic process	1
purine ribonucleotide metabolic process	1
purine ribonucleoside bisphosphate metabolic process	1
oxoacid metabolic process	1
primary metabolic process	1
transferase activity, transferring sulphur-containing groups	1
binding	1
catalytic activity	1
intracellular anatomical structure	1
cytoplasm	1

Protein interactions and networks

STRING

498 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SULT1A2	GOT1	P17174	784
SULT1A2	STS	P08842	641
SULT1A2	APOBR	Q0VD83	507
SULT1A2	UGT1A4	P22310	505
SULT1A2	CYP1A2	P05177	486
SULT1A2	UGT1A6	P19224	477
SULT1A2	UGT1A10	Q9HAW8	477
SULT1A2	TUFM	P49411	472
SULT1A2	CYP1A1	P04798	466
SULT1A2	UGT1A7	Q9HAW7	448
SULT1A2	UGT2B7	P16662	434
SULT1A2	SH2B1	Q9NRF2	434
SULT1A2	UGT1A8	Q9HAW9	431
SULT1A2	NPIPB9	F8W1W9	431
SULT1A2	SLC35A2	P78381	430

IntAct

12 interactions, top by confidence:

A	B	Type	Score
SULT1A2	NIF3L1	psi-mi:“MI:0915”(physical association)	0.560
PHF11	SULT1A2	psi-mi:“MI:0915”(physical association)	0.400
STX19	SNAP23	psi-mi:“MI:0914”(association)	0.350
SULT1A1	SULT1A3	psi-mi:“MI:0914”(association)	0.350
SULT1A2	SULT1A3	psi-mi:“MI:0914”(association)	0.350
SULT1A2	SULT2B1	psi-mi:“MI:0914”(association)	0.350
SULT4A1	SULT2B1	psi-mi:“MI:0914”(association)	0.350
		psi-mi:“MI:0914”(association)	0.350

BioGRID (34): NIF3L1 (Two-hybrid), SULT1A2 (Affinity Capture-MS), SULT1A2 (Affinity Capture-MS), SULT1A2 (Affinity Capture-MS), SULT1A3 (Affinity Capture-MS), TRAPPC3 (Affinity Capture-MS), TRAPPC9 (Affinity Capture-MS), CALCOCO2 (Affinity Capture-MS), SULT1A2 (Affinity Capture-MS), SULT1A3 (Affinity Capture-MS), SULT1A2 (Affinity Capture-MS), SULT1A2 (Affinity Capture-MS), CALCOCO2 (Affinity Capture-MS), TRAPPC9 (Affinity Capture-MS), SULT1A2 (Proximity Label-MS)

ESM2 similar proteins: A0A2K5X3B6, B2RVI8, F1QYJ6, G3V9R3, O00338, O43704, O46503, O75897, P0CC03, P0DMM9, P0DMN0, P15709, P17988, P19217, P22789, P49887, P49888, P49891, P50225, P50226, P50227, P50234, P50235, P50236, P50237, P52840, P52841, P52842, P52843, P52844, P52846, P52847, Q06520, Q29476, Q3T0Y3, Q3UZZ6, Q6IMI4, Q6IMI6, Q6PH37, Q6WG17

Diamond homologs: A0A173GP47, A0A2K5X3B6, B2RVI8, F1QYJ6, G3V9R3, O00204, O00338, O35400, O35403, O43704, O46503, O46640, O75897, P0CC03, P0DMM9, P0DMN0, P15709, P17988, P19217, P22789, P49887, P49888, P49891, P50225, P50226, P50227, P50234, P50235, P50236, P50237, P52835, P52836, P52837, P52838, P52840, P52841, P52842, P52843, P52844, P52846

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

73 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	60
Likely benign	5
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1017 predictions. Top by Δscore:

Variant	Effect	Δscore
16:28592136:CATGC:C	acceptor_gain	1.0000
16:28592137:ATGC:A	acceptor_gain	1.0000
16:28592138:TGC:T	acceptor_gain	1.0000
16:28592139:GC:G	acceptor_gain	1.0000
16:28592140:CC:C	acceptor_gain	1.0000
16:28592141:C:CC	acceptor_gain	1.0000
16:28592141:CTG:C	acceptor_loss	1.0000
16:28592142:T:A	acceptor_loss	1.0000
16:28592260:TAC:T	donor_loss	1.0000
16:28592261:A:AC	donor_gain	1.0000
16:28592262:C:CC	donor_gain	1.0000
16:28592262:CCT:C	donor_gain	1.0000
16:28592262:CCTTT:C	donor_gain	1.0000
16:28592266:T:A	donor_gain	1.0000
16:28592479:TTG:T	acceptor_gain	1.0000
16:28592480:TG:T	acceptor_gain	1.0000
16:28592480:TGCT:T	acceptor_loss	1.0000
16:28592481:GC:G	acceptor_loss	1.0000
16:28592482:C:CC	acceptor_gain	1.0000
16:28593474:T:A	donor_gain	1.0000
16:28593565:CCAC:C	acceptor_gain	1.0000
16:28593566:CACC:C	acceptor_gain	1.0000
16:28593569:C:CA	acceptor_loss	1.0000
16:28593570:T:A	acceptor_loss	1.0000
16:28595361:TCTCA:T	donor_loss	1.0000
16:28595362:CTCA:C	donor_loss	1.0000
16:28595363:TCACC:T	donor_loss	1.0000
16:28595364:CA:C	donor_loss	1.0000
16:28595366:C:G	donor_loss	1.0000
16:28595465:C:CC	acceptor_gain	1.0000

AlphaMissense

1954 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:28595787:C:A	K48N	0.985
16:28595787:C:G	K48N	0.985
16:28592273:G:C	F255L	0.983
16:28592273:G:T	F255L	0.983
16:28592275:A:G	F255L	0.983
16:28593467:G:C	F158L	0.981
16:28593467:G:T	F158L	0.981
16:28593469:A:G	F158L	0.981
16:28593542:C:A	K133N	0.980
16:28593542:C:G	K133N	0.980
16:28592408:A:C	F210L	0.979
16:28592408:A:T	F210L	0.979
16:28592410:A:G	F210L	0.979
16:28593455:G:C	F162L	0.975
16:28593455:G:T	F162L	0.975
16:28593457:A:G	F162L	0.975
16:28593515:G:C	F142L	0.975
16:28593515:G:T	F142L	0.975
16:28593517:A:G	F142L	0.975
16:28593332:A:G	W172R	0.971
16:28593332:A:T	W172R	0.971
16:28593311:A:G	W179R	0.970
16:28593311:A:T	W179R	0.970
16:28593541:C:G	D134H	0.969
16:28592088:G:C	F276L	0.968
16:28592088:G:T	F276L	0.968
16:28592090:A:G	F276L	0.968
16:28593564:A:T	V126D	0.967
16:28595581:G:C	F81L	0.966
16:28595581:G:T	F81L	0.966

dbSNP variants (sampled 300 via entrez): RS1000239720 (16:28594201 A>C,T), RS1000822859 (16:28594452 ATATT>A), RS1001580254 (16:28598056 T>A,C), RS1001693338 (16:28593940 C>T), RS1001873413 (16:28594113 G>A,C,T), RS1002178126 (16:28598227 T>C), RS1002764692 (16:28597244 A>G,T), RS1003547303 (16:28596216 G>A,T), RS1004674909 (16:28594738 C>T), RS1005073667 (16:28597856 G>A), RS1005268686 (16:28593795 C>T), RS1006048896 (16:28597203 G>A), RS1006069970 (16:28596845 G>A,C), RS1006322834 (16:28593080 C>G,T), RS1006535355 (16:28597814 C>A)

Disease associations

OMIM: gene MIM:601292 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

20 associations (top):

Study	Trait	p-value
GCST000531_2	Inflammatory bowel disease (early onset)	2.000000e-09
GCST000830_13	Body mass index	2.000000e-20
GCST001725_52	Inflammatory bowel disease	1.000000e-21
GCST002598_62	Educational attainment	1.000000e-06
GCST003435_31	Body fat percentage	1.000000e-08
GCST003435_41	Body fat percentage	7.000000e-07
GCST004131_83	Inflammatory bowel disease	2.000000e-12
GCST004132_69	Crohn’s disease	3.000000e-10
GCST006409_24	Allergic rhinitis	5.000000e-10
GCST007044_23	Extremely high intelligence	2.000000e-08
GCST007293_116	Body fat distribution (arm fat ratio)	2.000000e-08
GCST007293_16	Body fat distribution (arm fat ratio)	4.000000e-09
GCST007293_43	Body fat distribution (arm fat ratio)	2.000000e-12
GCST007294_71	Body fat distribution (trunk fat ratio)	2.000000e-12
GCST007294_97	Body fat distribution (trunk fat ratio)	1.000000e-11
GCST007295_20	Body fat distribution (leg fat ratio)	3.000000e-06
GCST007295_44	Body fat distribution (leg fat ratio)	1.000000e-21
GCST007295_79	Body fat distribution (leg fat ratio)	2.000000e-24
GCST010133_15	Lamb consumption	3.000000e-08
GCST010703_152	Brain morphology (MOSTest)	3.000000e-09

EFO canonical traits (7, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index
EFO:0004784	self reported educational attainment
EFO:0007800	body fat percentage
EFO:0004337	intelligence
EFO:0004341	body fat distribution
EFO:0008111	diet measurement
EFO:0004346	neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (2): CHEMBL1743292 (SINGLE PROTEIN), CHEMBL3542433 (PROTEIN FAMILY)

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

3 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs1059491	NPIPB8, SULT1A2		0.00	0
rs1136703	NPIPB8, SULT1A2		0.00	0
rs1801030	NPIPB8, SULT1A1, SULT1A2		0.00	0

CTD chemical–gene interactions

46 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	affects cotreatment, increases response to substance, increases activity, increases metabolic processing, increases abundance	3
bisphenol A	affects expression, decreases methylation	2
mercuric bromide	increases expression, affects cotreatment	2
3-nitrobenzanthrone	affects cotreatment, increases activity, increases reaction, increases reduction	2
entinostat	increases expression, affects cotreatment	2
Panobinostat	affects cotreatment, increases expression	2
Benzo(a)pyrene	decreases expression, decreases methylation	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Tetrachlorodibenzodioxin	increases expression	2
Valproic Acid	increases expression	2
Cyclosporine	decreases expression	2
p-Chloromercuribenzoic Acid	affects cotreatment, increases expression	2
afuresertib	increases expression	1
methyleugenol	decreases expression	1
5-hydroxymethylfurfural	affects cotreatment, increases response to substance, increases activity	1
ethyl-p-hydroxybenzoate	increases expression	1
N-hydroxy-4-aminobiphenyl	increases sulfation	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
2-amino-3-methyl-9H-pyrido(2,3-b)indole	increases activity	1
1-hydroxypyrene	increases metabolic processing	1
catechol	increases sulfation	1
caffeic acid	increases sulfation	1
fipronil	affects cotreatment, increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	increases expression, affects cotreatment	1
2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct	increases abundance, increases metabolic processing	1
dorsomorphin	affects cotreatment, increases expression	1
bisphenol S	increases methylation	1
Resveratrol	increases sulfation	1
Sunitinib	decreases expression	1
Arsenic Trioxide	increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 admet

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL1743315	ADMET	Major substrate of human cytosolic sulfotransferase SULT1A2	Casarett and Doull’s Toxicology The Basic Science of Poisons, 7th edition

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.