SULT1A4

Summary

SULT1A4 (sulfotransferase family 1A member 4, HGNC:30004) is a protein-coding gene on chromosome 16p11.2, encoding Sulfotransferase 1A4 (P0DMN0). Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, (R)-adrenaline/epinephrine, (R)-noradrenaline/norepinephrine and serotonin) and phenolic and ca….

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16, this gene and SULT1A3 arose from a segmental duplication. Read-through transcription exists between this gene and the upstream SLX1B (SLX1 structure-specific endonuclease subunit homolog B) gene that encodes a protein containing GIY-YIG domains.

Source: NCBI Gene 445329 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 1 total — 1 pathogenic
• MANE Select transcript: NM_001017390

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30004
Approved symbol	SULT1A4
Name	sulfotransferase family 1A member 4
Location	16p11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000213648
Ensembl biotype	protein_coding
OMIM	615819
Entrez	445329

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 14 protein_coding, 2 nonsense_mediated_decay, 1 retained_intron

ENST00000360423, ENST00000562941, ENST00000563944, ENST00000565290, ENST00000569544, ENST00000871833, ENST00000871834, ENST00000871835, ENST00000871836, ENST00000871837, ENST00000871838, ENST00000871839, ENST00000871840, ENST00000871841, ENST00000923948, ENST00000957099, ENST00000957100

RefSeq mRNA: 1 — MANE Select: NM_001017390 NM_001017390

CCDS: CCDS32427

Canonical transcript exons

ENST00000360423 — 8 exons

Exon	Start	End
ENSE00001597207	29459913	29459985
ENSE00002423021	29464463	29464966
ENSE00003472186	29464160	29464340
ENSE00003596180	29461638	29461763
ENSE00003619854	29463567	29463661
ENSE00003650383	29463345	29463471
ENSE00003652785	29461382	29461533
ENSE00003661719	29461853	29461950

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 90.14.

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	90.14	gold quality
granulocyte	CL:0000094	88.10	gold quality
duodenum	UBERON:0002114	87.68	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.58	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.37	gold quality
cerebellar hemisphere	UBERON:0002245	80.50	gold quality
cerebellar cortex	UBERON:0002129	80.47	gold quality
cerebellum	UBERON:0002037	80.37	gold quality
monocyte	CL:0000576	80.29	gold quality
right hemisphere of cerebellum	UBERON:0014890	80.17	gold quality
apex of heart	UBERON:0002098	79.85	gold quality
leukocyte	CL:0000738	79.40	gold quality
right lung	UBERON:0002167	77.57	gold quality
right lobe of liver	UBERON:0001114	76.96	gold quality
right coronary artery	UBERON:0001625	76.76	gold quality
small intestine	UBERON:0002108	75.55	gold quality
small intestine Peyer’s patch	UBERON:0003454	75.43	gold quality
blood	UBERON:0000178	74.83	gold quality
transverse colon	UBERON:0001157	74.53	gold quality
primary visual cortex	UBERON:0002436	74.08	gold quality
rectum	UBERON:0001052	73.54	gold quality
cortex of kidney	UBERON:0001225	73.06	gold quality
spleen	UBERON:0002106	72.97	gold quality
vermiform appendix	UBERON:0001154	72.84	gold quality
adenohypophysis	UBERON:0002196	72.65	gold quality
intestine	UBERON:0000160	72.25	gold quality
myometrium	UBERON:0001296	72.20	gold quality
gall bladder	UBERON:0002110	72.08	gold quality
colon	UBERON:0001155	71.50	gold quality
omental fat pad	UBERON:0010414	71.32	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-MTAB-7606	no	12.68
E-ANND-3	no	2.56

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of acetaminophen and opioid drugs by the cytosolic sulfotransferase SULT1A3 (PMID:29705271)
• The results obtained showed clearly the differential enzymatic characteristics of SULT1A3 allozymes in mediating the sulfation of phenylephrine and salbutamol. This information may contribute toward a better understanding of the pharmacokinetics of these two drugs in individuals with distinct SULT1A3 and/or SULT1A4 genotypes. (PMID:31145702)

Cross-species orthologs

15 orthologs

Organism	Symbol	Gene ID
danio_rerio	sult1st4	ENSDARG00000003181
danio_rerio	sult5a1	ENSDARG00000007769
danio_rerio	sult1st3	ENSDARG00000018361
danio_rerio	sult1st1	ENSDARG00000028275
danio_rerio	sult2st3	ENSDARG00000028367
danio_rerio	sult2st1	ENSDARG00000033170
danio_rerio	sult1st2	ENSDARG00000041540
danio_rerio	sult1st7	ENSDARG00000079079
danio_rerio	sult1st9	ENSDARG00000094996
danio_rerio	sult2st2	ENSDARG00000103785
mus_musculus	Sult5a1	ENSMUSG00000000739
rattus_norvegicus	Sult5a1	ENSRNOG00000015695
drosophila_melanogaster	St4	FBGN0033887
drosophila_melanogaster	St1	FBGN0034887
drosophila_melanogaster	St3	FBGN0265052

Paralogs (12): SULT2B1 (ENSG00000088002), SULT2A1 (ENSG00000105398), SULT1E1 (ENSG00000109193), SULT4A1 (ENSG00000130540), SULT6B1 (ENSG00000138068), SULT1B1 (ENSG00000173597), SULT1C3 (ENSG00000196228), SULT1A1 (ENSG00000196502), SULT1A2 (ENSG00000197165), SULT1C4 (ENSG00000198075), SULT1C2 (ENSG00000198203), SULT1A3 (ENSG00000261052)

Protein

Protein identifiers

Sulfotransferase 1A4 — P0DMN0 (reviewed: P0DMN0)

Alternative names: Aryl sulfotransferase 1A3/1A4, Sulfotransferase 1A3/1A4

All UniProt accessions (5): A0A0A6YYL2, H3BNY7, H3BRT0, P0DMN0, Q1ET61

UniProt curated annotations — full annotation on UniProt →

Function. Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, (R)-adrenaline/epinephrine, (R)-noradrenaline/norepinephrine and serotonin) and phenolic and catechol drugs. Catalyzes the sulfation of T4 (L-thyroxine/3,5,3’,5’-tetraiodothyronine), T3 (3,5,3’-triiodothyronine), rT3 (3,3’,5’-triiodothyronine) and 3,3’-T2 (3,3’-diiodothyronine), with a substrate preference of 3,3’-T2 > rT3 > T3 > T4.

Subunit / interactions. Homodimer.

Subcellular location. Cytoplasm.

Post-translational modifications. The N-terminus is blocked.

Similarity. Belongs to the sulfotransferase 1 family.

RefSeq proteins (1): NP_001017390* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000863	Sulfotransferase_dom	Domain
IPR027417	P-loop_NTPase	Homologous_superfamily

Pfam: PF00685

Enzyme classification (BRENDA):

• EC 2.8.2.1 — aryl sulfotransferase (BRENDA: 19 organisms, 630 substrates, 215 inhibitors, 314 Km, 55 kcat entries)

Substrate kinetics (BRENDA)

81 substrates with measured Km, best-characterized 15. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
DOPAMINE	0.0006–11.3	39
4-NITROPHENOL	0.0001–30.9	36
3’-PHOSPHOADENYLYLSULFATE	0.0003–0.51	17
ACETAMINOPHEN	0.43–4.5	14
MORPHINE	3.8–10	13
O-DESMETHYL TRAMADOL	0.27–0.8	13
TAPENTADOL	0.09–0.84	13
3’-PHOSPHOADENYLYL SULFATE	0.0008–0.024	12
DAIDZEIN	0.0005–0.407	8
GENISTEIN	0.0005–0.371	8
6-HYDROXYMELATONIN	0.018–0.065	6
7-HYDROXYCOUMARIN	0.0005–0.003	4
ROTIGOTINE	0.0291–0.1191	4
2-AMINOPHENOL	0.009–0.223	3
3,3’,5-TRIIODO-L-THYRONINE	0.0387–0.126	3

Catalyzed reactions (Rhea), 11 shown:

• a phenol + 3’-phosphoadenylyl sulfate = an aryl sulfate + adenosine 3’,5’-bisphosphate + H(+) (RHEA:12164)
• 4-nitrophenol + 3’-phosphoadenylyl sulfate = 4-nitrophenyl sulfate + adenosine 3’,5’-bisphosphate (RHEA:66548)
• 3,3’,5-triiodo-L-thyronine + 3’-phosphoadenylyl sulfate = 3,3’,5-triiodo-L-thyronine sulfate + adenosine 3’,5’-bisphosphate + H(+) (RHEA:67876)
• dopamine + 3’-phosphoadenylyl sulfate = dopamine 3-O-sulfate + adenosine 3’,5’-bisphosphate + H(+) (RHEA:67880)
• dopamine + 3’-phosphoadenylyl sulfate = dopamine 4-O-sulfate + adenosine 3’,5’-bisphosphate + H(+) (RHEA:67884)
• 3,3’,5’-triiodo-L-thyronine + 3’-phosphoadenylyl sulfate = 3,3’,5’-triiodo-L-thyronine sulfate + adenosine 3’,5’-bisphosphate + H(+) (RHEA:67888)
• 3,3’-diiodo-L-thyronine + 3’-phosphoadenylyl sulfate = 3,3’-diiodo-L-thyronine sulfate + adenosine 3’,5’-bisphosphate + H(+) (RHEA:67892)
• serotonin + 3’-phosphoadenylyl sulfate = serotonin O-sulfate + adenosine 3’,5’-bisphosphate + H(+) (RHEA:83339)
• (R)-adrenaline + 3’-phosphoadenylyl sulfate = (R)-adrenaline 4’-O-sulfate + adenosine 3’,5’-bisphosphate + H(+) (RHEA:83343)
• (R)-noradrenaline + 3’-phosphoadenylyl sulfate = (R)-noradrenaline 4’-O-sulfate + adenosine 3’,5’-bisphosphate + H(+) (RHEA:83351)
• L-thyroxine + 3’-phosphoadenylyl sulfate = L-thyroxine sulfate + adenosine 3’,5’-bisphosphate + H(+) (RHEA:83575)

UniProt features (11 total): binding site 9, chain 1, active site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DMN0-F1	96.61	0.97

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 108 (proton acceptor)

Ligand- & substrate-binding residues (9): 257–259; 48–53; 86; 106–108; 130; 138; 146; 193; 227–232

Function

Pathways and Gene Ontology

Reactome pathways

6 pathways

ID	Pathway
R-HSA-156584	Cytosolic sulfonation of small molecules
R-HSA-9753281	Paracetamol ADME
R-HSA-1430728	Metabolism
R-HSA-156580	Phase II - Conjugation of compounds
R-HSA-211859	Biological oxidations
R-HSA-9748784	Drug ADME

MSigDB gene sets: 74 (showing top): GOBP_PHENOL_CONTAINING_COMPOUND_METABOLIC_PROCESS, GOBP_RESPONSE_TO_NITROGEN_COMPOUND, REACTOME_BIOLOGICAL_OXIDATIONS, GOBP_REGULATION_OF_HORMONE_LEVELS, GOBP_THYROID_HORMONE_METABOLIC_PROCESS, GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS, GOBP_SULFATION, GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS, GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS, GOBP_DOPAMINE_METABOLIC_PROCESS, chr16p11, GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, GOBP_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND, GOBP_INDOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS

GO Biological Process (9): steroid metabolic process (GO:0008202), thyroid hormone metabolic process (GO:0042403), epinephrine metabolic process (GO:0042414), norepinephrine metabolic process (GO:0042415), dopamine metabolic process (GO:0042417), serotonin metabolic process (GO:0042428), sulfation (GO:0051923), catecholamine metabolic process (GO:0006584), lipid metabolic process (GO:0006629)

GO Molecular Function (4): aryl sulfotransferase activity (GO:0004062), sulfotransferase activity (GO:0008146), protein binding (GO:0005515), transferase activity (GO:0016740)

GO Cellular Component (2): cytoplasm (GO:0005737), cytosol (GO:0005829)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
Phase II - Conjugation of compounds	1
Drug ADME	1
Biological oxidations	1
Metabolism	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
catecholamine metabolic process	3
phenol-containing compound metabolic process	2
cellular anatomical structure	2
lipid metabolic process	1
modified amino acid metabolic process	1
hormone metabolic process	1
indole-containing compound metabolic process	1
sulfur compound metabolic process	1
biogenic amine metabolic process	1
catechol-containing compound metabolic process	1
primary metabolic process	1
sulfotransferase activity	1
transferase activity, transferring sulphur-containing groups	1
binding	1
catalytic activity	1
intracellular anatomical structure	1
cytoplasm	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

33 interactions, top by confidence:

A	B	Type	Score
SULT1A1	SULT2B1	psi-mi:“MI:0914”(association)	0.830
KHDRBS2	SULT1A3	psi-mi:“MI:0915”(physical association)	0.560
SULT1A3	NIF3L1	psi-mi:“MI:0915”(physical association)	0.560
SULT1A3	SHMT1	psi-mi:“MI:0915”(physical association)	0.560
SHMT1	SULT1A3	psi-mi:“MI:0915”(physical association)	0.560
SULT1A3	KHDRBS2	psi-mi:“MI:0915”(physical association)	0.560
SULT1C2	SULT1C4	psi-mi:“MI:0914”(association)	0.530
SMN1	SULT1A3	psi-mi:“MI:0915”(physical association)	0.370
TK1	SULT1A3	psi-mi:“MI:0915”(physical association)	0.370
	SHTN1	psi-mi:“MI:0914”(association)	0.350
SULT4A1	SULT1A3	psi-mi:“MI:0914”(association)	0.350
MPPED2	SULT1A3	psi-mi:“MI:0914”(association)	0.350
SULT1A1	SULT1A3	psi-mi:“MI:0914”(association)	0.350
SULT1A2	SULT1A3	psi-mi:“MI:0914”(association)	0.350
TTC1	SULT1A3	psi-mi:“MI:0914”(association)	0.350
SULT1C3	SULT1A3	psi-mi:“MI:0914”(association)	0.350
SULT1A2	SULT2B1	psi-mi:“MI:0914”(association)	0.350
SULT4A1	SULT2B1	psi-mi:“MI:0914”(association)	0.350
SULT1A3	SULT2B1	psi-mi:“MI:0914”(association)	0.350
OTUD6B	SULT1A3	psi-mi:“MI:0914”(association)	0.350
ATF5	PTGES	psi-mi:“MI:0914”(association)	0.350
ATF5	ESYT2	psi-mi:“MI:0914”(association)	0.350
CREB1	NOP56	psi-mi:“MI:0914”(association)	0.350
CREB1	STK25	psi-mi:“MI:0914”(association)	0.350
ATF5	HAX1	psi-mi:“MI:0914”(association)	0.350
CREB1	ACOT7	psi-mi:“MI:0914”(association)	0.350

BioGRID (53): SULT1A3 (Two-hybrid), NIF3L1 (Two-hybrid), KHDRBS2 (Two-hybrid), SULT1A3 (Affinity Capture-MS), SULT1A3 (Affinity Capture-MS), SULT1A3 (Affinity Capture-MS), SULT1A3 (Affinity Capture-MS), SULT1A3 (Affinity Capture-MS), SULT1A3 (Affinity Capture-MS), SULT1A3 (Affinity Capture-MS), SULT1A3 (Affinity Capture-MS), SULT1A4 (Affinity Capture-MS), SULT1A3 (Positive Genetic), SULT1A3 (Affinity Capture-MS), SULT1A3 (Affinity Capture-MS)

ESM2 similar proteins: A0A2K5X3B6, B2RVI8, F1QYJ6, G3V9R3, O00338, O43704, O46503, O75897, P0CC03, P0DMM9, P0DMN0, P15709, P17988, P19217, P22789, P49887, P49888, P49891, P50225, P50226, P50227, P50234, P50235, P50236, P50237, P52840, P52841, P52842, P52843, P52844, P52846, P52847, Q06520, Q29476, Q3T0Y3, Q3UZZ6, Q6IMI4, Q6IMI6, Q6PH37, Q6WG17

Diamond homologs: A0A173GP47, A0A2K5X3B6, G3V9R3, O00338, O35400, O43704, O46503, O46640, O75897, P0DMM9, P0DMN0, P19217, P49887, P49888, P49891, P50236, P50237, P52839, P52840, P52842, P52844, P52847, P63046, P63047, Q29476, Q3T0Y3, Q3UZZ6, Q6IMI6, Q80VR3, Q8BGL3, Q8JG30, Q95JD5, Q9BR01, Q9C9D0, Q9D939, Q9FZ80, Q9QWG7, Q9WUW8, Q9WUW9, B2RVI8

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 26 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Cytosolic sulfonation of small molecules	7	191.2×	1e-13
Phase II - Conjugation of compounds	6	88.0×	1e-09
Biological oxidations	6	41.0×	1e-07

GO biological processes:

GO term	Partners	Fold	FDR
sulfation	8	337.0×	2e-17
3’-phosphoadenosine 5’-phosphosulfate metabolic process	7	314.6×	4e-15
xenobiotic metabolic process	6	35.8×	5e-07

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
979441	GRCh37/hg19 16p11.2(chr16:29383808-30177240)x3	Pathogenic

SpliceAI

1236 predictions. Top by Δscore:

Variant	Effect	Δscore
16:29461529:GTCTG:G	donor_gain	1.0000
16:29461531:CTG:C	donor_gain	1.0000
16:29461531:CTGG:C	donor_loss	1.0000
16:29461532:TG:T	donor_gain	1.0000
16:29461533:GG:G	donor_gain	1.0000
16:29461533:GGTA:G	donor_loss	1.0000
16:29461534:G:GG	donor_gain	1.0000
16:29461535:T:G	donor_loss	1.0000
16:29461636:A:AG	acceptor_gain	1.0000
16:29461636:A:G	acceptor_loss	1.0000
16:29461636:AG:A	acceptor_gain	1.0000
16:29461637:G:GT	acceptor_gain	1.0000
16:29461637:GG:G	acceptor_gain	1.0000
16:29461637:GGC:G	acceptor_gain	1.0000
16:29461637:GGCA:G	acceptor_gain	1.0000
16:29461637:GGCAC:G	acceptor_gain	1.0000
16:29461693:G:GT	donor_gain	1.0000
16:29461714:C:G	donor_gain	1.0000
16:29461760:TCAGG:T	donor_loss	1.0000
16:29461761:CAGGT:C	donor_loss	1.0000
16:29461762:AGG:A	donor_loss	1.0000
16:29461763:GG:G	donor_loss	1.0000
16:29461764:G:GG	donor_loss	1.0000
16:29461765:T:A	donor_loss	1.0000
16:29463340:TGCA:T	acceptor_loss	1.0000
16:29463341:GCAGG:G	acceptor_loss	1.0000
16:29463342:CAG:C	acceptor_loss	1.0000
16:29463343:A:C	acceptor_loss	1.0000
16:29463343:AGGT:A	acceptor_gain	1.0000
16:29463344:GGTG:G	acceptor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1002467103 (16:29461304 A>G), RS1004158662 (16:29462065 A>T), RS1019512313 (16:29462187 G>A,T), RS1026856292 (16:29461961 G>C), RS1046612729 (16:29461297 A>T), RS1046645580 (16:29465047 G>A), RS1053924276 (16:29458102 G>A), RS1055487526 (16:29461311 A>G), RS1156507869 (16:29459427 G>A), RS1157802727 (16:29462034 C>T), RS1157947068 (16:29464813 C>T), RS1158033941 (16:29458380 C>G), RS1159478544 (16:29461566 G>T), RS1159838096 (16:29458714 T>C), RS1159941767 (16:29462439 C>A)

Disease associations

OMIM: gene MIM:615819 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB clinical annotations

2 annotations.

Variant	Type	Level	Drugs	Phenotypes
rs757573592	Metabolism/PK	3	acetaminophen
rs757573592	Metabolism/PK	3	morphine

PharmGKB variants

2 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs767263838	SULT1A4	3	0.00	4	morphine;tapentadol;o-desmethyltramadol;tramadol;acetaminophen
rs757573592	SULT1A4	3	0.00	4	acetaminophen;morphine;tapentadol;o-desmethyltramadol;tramadol

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, affects expression	2
decabromobiphenyl ether	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
tetrabromobisphenol A	decreases expression	1
glycidamide	increases expression	1
nutlin 3	affects cotreatment, increases secretion	1
2-amino-14,16-dimethyloctadecan-3-ol	decreases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, decreases expression	1
pentabrominated diphenyl ether 100	decreases expression	1
hexabrominated diphenyl ether 153	decreases expression	1
Irinotecan	increases expression	1
Ropivacaine	increases sulfation	1
Acetaminophen	increases expression	1
Caffeine	decreases phosphorylation	1
Catechin	affects cotreatment, decreases expression	1
Dactinomycin	affects cotreatment, increases secretion	1
Diethylhexyl Phthalate	affects cotreatment, affects expression	1
Estradiol	affects cotreatment, decreases expression	1
Colforsin	affects cotreatment, affects expression	1
Manganese	decreases expression	1
Smoke	decreases expression	1
Valproic Acid	increases methylation	1
Aflatoxin B1	decreases methylation	1
Okadaic Acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.