SULT4A1

Summary

SULT4A1 (sulfotransferase family 4A member 1, HGNC:14903) is a protein-coding gene on chromosome 22q13.31, encoding Sulfotransferase 4A1 (Q9BR01). Atypical sulfotransferase family member with very low affinity for 3’-phospho-5’-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol.

This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizophrenia.

Source: NCBI Gene 25830 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 25 total
• Druggable target: yes
• MANE Select transcript: NM_014351

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14903
Approved symbol	SULT4A1
Name	sulfotransferase family 4A member 1
Location	22q13.31
Locus type	gene with protein product
Status	Approved
Aliases	SULTX3, hBR-STL-1
Ensembl gene	ENSG00000130540
Ensembl biotype	protein_coding
OMIM	608359
Entrez	25830

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 2 protein_coding, 2 nonsense_mediated_decay, 1 retained_intron

ENST00000330884, ENST00000422525, ENST00000432404, ENST00000475131, ENST00000884819

RefSeq mRNA: 1 — MANE Select: NM_014351 NM_014351

CCDS: CCDS14051

Canonical transcript exons

ENST00000330884 — 7 exons

Exon	Start	End
ENSE00000656917	43841802	43841932
ENSE00001329677	43824509	43826113
ENSE00001898165	43862214	43862513
ENSE00003494578	43833640	43833734
ENSE00003551642	43839945	43840025
ENSE00003565255	43829060	43829198
ENSE00003687849	43838867	43838993

Expression profiles

Bgee: expression breadth ubiquitous, 187 present calls, max score 97.72.

FANTOM5 (CAGE): breadth broad, TPM avg 4.4216 / max 189.5421, expressed in 410 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
194515	2.3946	216
194516	1.7414	362
194514	0.2341	82
209495	0.0514	33

Top tissues by expression

287 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right frontal lobe	UBERON:0002810	97.72	gold quality
prefrontal cortex	UBERON:0000451	97.69	gold quality
Brodmann (1909) area 9	UBERON:0013540	97.43	gold quality
middle temporal gyrus	UBERON:0002771	97.34	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	97.25	gold quality
Brodmann (1909) area 10	UBERON:0013541	97.18	gold quality
frontal cortex	UBERON:0001870	97.14	gold quality
right hemisphere of cerebellum	UBERON:0014890	96.95	gold quality
cerebellar hemisphere	UBERON:0002245	96.87	gold quality
cerebellar cortex	UBERON:0002129	96.85	gold quality
neocortex	UBERON:0001950	96.52	gold quality
primary visual cortex	UBERON:0002436	96.52	gold quality
cingulate cortex	UBERON:0003027	96.49	gold quality
anterior cingulate cortex	UBERON:0009835	96.47	gold quality
frontal pole	UBERON:0002795	96.40	gold quality
lateral nuclear group of thalamus	UBERON:0002736	96.35	gold quality
Brodmann (1909) area 23	UBERON:0013554	96.30	gold quality
orbitofrontal cortex	UBERON:0004167	96.20	gold quality
cerebellum	UBERON:0002037	96.18	gold quality
occipital lobe	UBERON:0002021	95.99	gold quality
Brodmann (1909) area 46	UBERON:0006483	95.72	gold quality
cerebral cortex	UBERON:0000956	95.71	gold quality
substantia nigra pars compacta	UBERON:0001965	95.64	gold quality
superior frontal gyrus	UBERON:0002661	95.32	gold quality
cerebellar vermis	UBERON:0004720	95.22	gold quality
pons	UBERON:0000988	94.75	gold quality
cortical plate	UBERON:0005343	94.65	gold quality
telencephalon	UBERON:0001893	94.19	gold quality
hypothalamus	UBERON:0001898	94.00	gold quality
dorsal root ganglion	UBERON:0000044	93.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.93

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): ATF2, CREB1

miRNA regulators (miRDB)

76 targeting SULT4A1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-6748-5P	100.00	65.81	1057
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-3912-5P	99.95	66.11	925
HSA-MIR-101-3P	99.94	75.03	2230
HSA-MIR-144-3P	99.94	73.98	2698
HSA-MIR-589-3P	99.91	69.62	2088
HSA-MIR-659-3P	99.85	70.69	1620
HSA-MIR-3121-3P	99.82	71.96	3630
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-448	99.79	72.37	2103
HSA-MIR-4319	99.76	69.83	2586
HSA-MIR-5002-5P	99.76	70.84	1763
HSA-MIR-3714	99.71	70.74	2671
HSA-MIR-4699-3P	99.71	70.15	3142
HSA-MIR-1283	99.69	72.42	3009
HSA-MIR-5093	99.67	69.26	2291
HSA-MIR-6512-3P	99.65	66.07	1468
HSA-MIR-6720-5P	99.65	66.22	1459
HSA-MIR-5700	99.64	69.88	2280
HSA-MIR-6134	99.63	65.68	1537
HSA-MIR-142-3P	99.62	71.30	974
HSA-MIR-4261	99.59	70.30	3415
HSA-MIR-1252-3P	99.55	67.71	2862
HSA-MIR-888-3P	99.53	69.77	1057
HSA-MIR-657	99.48	66.02	848
HSA-MIR-147B-5P	99.45	70.62	2432
HSA-MIR-513A-3P	99.39	70.63	3620

Literature-anchored findings (GeneRIF, showing 12)

• the first immunohistochemical localization of SULT4A1 in human brain (PMID:14623933)
• Candidate gene for schizophrenia susceptibility. (PMID:16152568)
• These results provide the first evidence of how genetic variation in Sult4A1 may be related to clinical symptoms and cognitive function in schizophrenia (PMID:18823757)
• The lack of polymorphisms in the coding region of the SULT4A1 gene is highly unusual and, along with its high conservation between species, suggests that SULT4A1 may have an important function in vivo. (PMID:19125109)
• Cytosolic SULT4A1 interacts with PIN1. (PMID:19439498)
• determination of SULT4A1-1 haplotype status might be useful for identifying patients who show an enhanced response to long-term olanzapine treatment. (PMID:21521020)
• This study provides a second replication of superior olanzapine response in SULT4A1-1-positive subjects compared with SULT4A1-1-negative subjects. (PMID:24956247)
• These results show that SULT4A1 is widely expressed in human tissues, but mostly as a splice variant that produces a rapidly degraded protein. Dimerization protects the protein from degradation. (PMID:24988429)
• Across three psychiatric disorders (n=2815 patients), we observed no consistent association between SULT4A1-1 status and atypical antipsychotic effect (PMID:25340730)
• Study using SH-SY5Y cells, human induced pluripotent stem cells, and mouse embryonic tissue revealed time-dependent changes in SULT4A1 protein and MBNL/CELF protein during differentiation supported their role in correctly splicing the SULT4A1 mRNA. Furthermore, ectopic expression of each factor produced efficient splicing in the minigene assay as well as correct splicing of the endogenous SULT4A1 mRNA. (PMID:30606728)
• Study in SULT4A1 knockout mice demonstrates that depletion of SULT4A1 induces oxidative stress in neurons and expression of SULT4A1 in human SH-SY5Y cells protects against oxidative-stress-induced mitochondrial dysfunction and cell death. Results suggest that SULT4A1 may have a crucial protective function against mitochondrial dysfunction and oxidative stress. (PMID:31266751)
• Interaction of the Brain-Selective Sulfotransferase SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein Expression and Function. (PMID:32152050)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	sult4a1	ENSDARG00000101967
mus_musculus	Sult4a1	ENSMUSG00000018865
rattus_norvegicus	Sult4a1	ENSRNOG00000046975
drosophila_melanogaster	St4	FBGN0033887
drosophila_melanogaster	St1	FBGN0034887
drosophila_melanogaster	St3	FBGN0265052

Paralogs (12): SULT2B1 (ENSG00000088002), SULT2A1 (ENSG00000105398), SULT1E1 (ENSG00000109193), SULT6B1 (ENSG00000138068), SULT1B1 (ENSG00000173597), SULT1C3 (ENSG00000196228), SULT1A1 (ENSG00000196502), SULT1A2 (ENSG00000197165), SULT1C4 (ENSG00000198075), SULT1C2 (ENSG00000198203), SULT1A4 (ENSG00000213648), SULT1A3 (ENSG00000261052)

Protein

Protein identifiers

Sulfotransferase 4A1 — Q9BR01 (reviewed: Q9BR01)

Alternative names: Brain sulfotransferase-like protein, Nervous system sulfotransferase

All UniProt accessions (3): Q9BR01, B7Z2E1, F8WE22

UniProt curated annotations — full annotation on UniProt →

Function. Atypical sulfotransferase family member with very low affinity for 3’-phospho-5’-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS.

Subcellular location. Cytoplasm.

Tissue specificity. Highly expressed in the cerebral cortex and frontal lobe, slightly less in the cerebellum, occipital and temporal lobes, relatively low in the medulla and putamen, and lowest in the spinal cord. No expression detected in the pancreas. Highly expressed in fetal brain and occipital lobe, slightly less in the whole brain, frontal lobe, hippocampus, and lung, very low expression in cerebellum, medulla oblongata, temporal lobe, testis, kidney and appendix.

Similarity. Belongs to the sulfotransferase 1 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9BR01-1	1	yes
Q9BR01-2	2

RefSeq proteins (1): NP_055166* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000863	Sulfotransferase_dom	Domain
IPR027417	P-loop_NTPase	Homologous_superfamily

Pfam: PF00685

Enzyme classification (BRENDA):

• EC 2.8.2.1 — aryl sulfotransferase (BRENDA: 19 organisms, 630 substrates, 215 inhibitors, 314 Km, 55 kcat entries)

Substrate kinetics (BRENDA)

81 substrates with measured Km, best-characterized 15. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
DOPAMINE	0.0006–11.3	39
4-NITROPHENOL	0.0001–30.9	36
3’-PHOSPHOADENYLYLSULFATE	0.0003–0.51	17
ACETAMINOPHEN	0.43–4.5	14
MORPHINE	3.8–10	13
O-DESMETHYL TRAMADOL	0.27–0.8	13
TAPENTADOL	0.09–0.84	13
3’-PHOSPHOADENYLYL SULFATE	0.0008–0.024	12
DAIDZEIN	0.0005–0.407	8
GENISTEIN	0.0005–0.371	8
6-HYDROXYMELATONIN	0.018–0.065	6
7-HYDROXYCOUMARIN	0.0005–0.003	4
ROTIGOTINE	0.0291–0.1191	4
2-AMINOPHENOL	0.009–0.223	3
3,3’,5-TRIIODO-L-THYRONINE	0.0387–0.126	3

UniProt features (31 total): helix 15, strand 8, modified residue 3, sequence conflict 2, chain 1, turn 1, splice variant 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
1ZD1	X-RAY DIFFRACTION	2.24

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BR01-F1	87.72	0.71

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 8, 11, 205

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-156584	Cytosolic sulfonation of small molecules
R-HSA-1430728	Metabolism
R-HSA-156580	Phase II - Conjugation of compounds
R-HSA-211859	Biological oxidations

MSigDB gene sets: 180 (showing top): ATF_B, GOBP_DENDRITE_DEVELOPMENT, REACTOME_BIOLOGICAL_OXIDATIONS, MORF_FLT1, CAR_TNFRSF25, MORF_MSH3, MODULE_45, MORF_BRCA1, GOBP_NEUROGENESIS, MORF_ESR1, MODULE_16, GOBP_SULFATION, MORF_RAD51L3, MODULE_66, ATF1_Q6

GO Biological Process (5): steroid metabolic process (GO:0008202), sulfation (GO:0051923), dendrite arborization (GO:0140059), lipid metabolic process (GO:0006629), sulfur compound metabolic process (GO:0006790)

GO Molecular Function (4): sulfotransferase activity (GO:0008146), identical protein binding (GO:0042802), protein binding (GO:0005515), transferase activity (GO:0016740)

GO Cellular Component (3): cytoplasm (GO:0005737), mitochondrion (GO:0005739), cytosol (GO:0005829)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Phase II - Conjugation of compounds	1
Biological oxidations	1
Metabolism	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
cytoplasm	2
lipid metabolic process	1
sulfur compound metabolic process	1
dendrite morphogenesis	1
neuron projection arborization	1
primary metabolic process	1
metabolic process	1
transferase activity, transferring sulphur-containing groups	1
protein binding	1
binding	1
catalytic activity	1
intracellular anatomical structure	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1390 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SULT4A1	SLC35B2	Q8TB61	924
SULT4A1	SLC35D3	Q5M8T2	743
SULT4A1	SLC35D2	Q76EJ3	681
SULT4A1	SLC35D1	Q9NTN3	669
SULT4A1	RABL2B	Q9UNT1	512
SULT4A1	CTXN1	P60606	490
SULT4A1	PAPSS1	O43252	448
SULT4A1	RABL2A	Q9UBK7	447
SULT4A1	KMT2E	Q8IZD2	435
SULT4A1	KCNH7	Q9NS40	424
SULT4A1	BEX1	Q9HBH7	413
SULT4A1	LZTS1	Q9Y250	412
SULT4A1	SHANK3	Q9BYB0	411
SULT4A1	PAPSS2	O95340	406
SULT4A1	PARVB	Q9HBI1	400

IntAct

27 interactions, top by confidence:

A	B	Type	Score
SULT4A1	MAPK8IP3	psi-mi:“MI:0915”(physical association)	0.670
SULT4A1	SULT4A1	psi-mi:“MI:0915”(physical association)	0.670
SULT4A1	PIN1	psi-mi:“MI:0915”(physical association)	0.580
PIN1	SULT4A1	psi-mi:“MI:0915”(physical association)	0.580
BCL6B	SULT4A1	psi-mi:“MI:0915”(physical association)	0.560
TGM1	SULT4A1	psi-mi:“MI:0915”(physical association)	0.560
SULT4A1	POT1	psi-mi:“MI:0915”(physical association)	0.510
SULT4A1	AKT1	psi-mi:“MI:0915”(physical association)	0.370
PRNP	CARNS1	psi-mi:“MI:0914”(association)	0.350
SULT4A1		psi-mi:“MI:0914”(association)	0.350
SULT4A1	SULT1A3	psi-mi:“MI:0914”(association)	0.350
BCL6B	TUBA3C	psi-mi:“MI:0914”(association)	0.350
SULT4A1	SULT2B1	psi-mi:“MI:0914”(association)	0.350
POT1	SULT4A1	psi-mi:“MI:0915”(physical association)	0.000
SULT4A1	MAPK8IP3	psi-mi:“MI:0915”(physical association)	0.000
SULT4A1	TGM1	psi-mi:“MI:0915”(physical association)	0.000
SULT4A1	SULT4A1	psi-mi:“MI:0915”(physical association)	0.000
RUNX1	SULT4A1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (44): DPH2 (Affinity Capture-MS), ANKRD13C (Affinity Capture-MS), DPH1 (Affinity Capture-MS), SULT4A1 (Affinity Capture-MS), SULT4A1 (Two-hybrid), SULT4A1 (Affinity Capture-MS), PARVG (Affinity Capture-MS), SULT1A1 (Affinity Capture-MS), ERMN (Affinity Capture-MS), SULT1A3 (Affinity Capture-MS), MAPK3 (Biochemical Activity), PPP2R4 (Biochemical Activity), PPP2R2B (Reconstituted Complex), PPP2R2B (Affinity Capture-Western), SULT4A1 (Two-hybrid)

ESM2 similar proteins: A0A2H5AIX7, F1B282, F1B283, H2DH22, K4CI52, O24312, O42231, O42430, O42457, O81928, P04798, P37114, P37115, P48522, P56591, P63046, P63047, P92994, P93596, P93846, Q04468, Q05JG2, Q07217, Q09J79, Q42797, Q43033, Q43054, Q43067, Q43240, Q5KQT7, Q5W6F1, Q6GUR1, Q6TBX7, Q92095, Q92100, Q92109, Q92110, Q92116, Q949P1, Q94IP1

Diamond homologs: A0A173GP47, A0A2K5X3B6, G3V9R3, O00338, O35400, O43704, O46503, O46640, O75897, P0DMM9, P0DMN0, P19217, P49887, P49888, P49891, P50236, P50237, P52839, P52840, P52842, P52844, P52847, P63046, P63047, Q29476, Q3T0Y3, Q3UZZ6, Q6IMI6, Q80VR3, Q8BGL3, Q8JG30, Q95JD5, Q9BR01, Q9C9D0, Q9D939, Q9FZ80, Q9QWG7, Q9WUW8, Q9WUW9, B2RVI8

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MAPK3	down-regulates	SULT4A1	phosphorylation

Disease & clinical

Clinical variants and AI predictions

ClinVar

25 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	19
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1919 predictions. Top by Δscore:

Variant	Effect	Δscore
22:43829055:CGTA:C	donor_loss	1.0000
22:43829056:GTA:G	donor_loss	1.0000
22:43829057:TA:T	donor_loss	1.0000
22:43829058:A:AC	donor_gain	1.0000
22:43829058:AC:A	donor_gain	1.0000
22:43829058:ACC:A	donor_gain	1.0000
22:43829059:C:CC	donor_gain	1.0000
22:43829059:C:CT	donor_loss	1.0000
22:43829059:CC:C	donor_gain	1.0000
22:43829059:CCC:C	donor_gain	1.0000
22:43833730:GCCCA:G	acceptor_gain	1.0000
22:43833731:CCCA:C	acceptor_gain	1.0000
22:43833731:CCCAC:C	acceptor_gain	1.0000
22:43833732:CCA:C	acceptor_gain	1.0000
22:43833732:CCAC:C	acceptor_gain	1.0000
22:43833733:CA:C	acceptor_gain	1.0000
22:43833733:CAC:C	acceptor_gain	1.0000
22:43833735:C:CC	acceptor_gain	1.0000
22:43838866:CG:C	donor_gain	1.0000
22:43838872:T:C	donor_gain	1.0000
22:43838994:C:A	acceptor_loss	1.0000
22:43838995:T:A	acceptor_loss	1.0000
22:43839940:CTTA:C	donor_loss	1.0000
22:43839941:TTAC:T	donor_loss	1.0000
22:43839942:TACC:T	donor_loss	1.0000
22:43839943:A:AC	donor_gain	1.0000
22:43839943:A:T	donor_loss	1.0000
22:43839944:C:CC	donor_gain	1.0000
22:43839944:C:CT	donor_loss	1.0000
22:43840021:AGTTC:A	acceptor_gain	1.0000

AlphaMissense

1890 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
22:43826099:A:G	W253R	0.999
22:43826099:A:T	W253R	0.999
22:43833720:A:G	W175R	0.999
22:43833720:A:T	W175R	0.999
22:43838892:G:C	F161L	0.999
22:43838892:G:T	F161L	0.999
22:43838894:A:G	F161L	0.999
22:43838967:C:A	K136N	0.999
22:43838967:C:G	K136N	0.999
22:43838971:G:T	P135H	0.999
22:43838973:G:C	N134K	0.999
22:43838973:G:T	N134K	0.999
22:43839996:G:C	S110R	0.999
22:43839996:G:T	S110R	0.999
22:43839998:T:G	S110R	0.999
22:43826086:A:G	F257S	0.998
22:43833697:G:C	F182L	0.998
22:43833697:G:T	F182L	0.998
22:43833699:A:G	F182L	0.998
22:43838880:A:C	F165L	0.998
22:43838880:A:T	F165L	0.998
22:43838882:A:G	F165L	0.998
22:43838893:A:G	F161S	0.998
22:43838940:G:C	F145L	0.998
22:43838940:G:T	F145L	0.998
22:43838942:A:G	F145L	0.998
22:43838977:C:G	R133P	0.998
22:43839991:A:G	L112P	0.998
22:43839995:G:C	H111D	0.998
22:43862228:G:A	T52I	0.998

dbSNP variants (sampled 300 via entrez): RS1000061949 (22:43832084 C>A), RS1000074666 (22:43845187 C>G), RS1000111178 (22:43856999 T>C), RS1000211923 (22:43860446 C>A,T), RS1000310438 (22:43850073 G>A,C), RS1000341945 (22:43855114 C>T), RS1000368215 (22:43842581 C>G,T), RS1000441978 (22:43842780 G>A), RS1000479692 (22:43824140 A>G), RS1000565741 (22:43860732 T>C,G), RS1000575929 (22:43827378 C>T), RS1000608732 (22:43829742 C>T), RS1000646241 (22:43840755 G>A), RS1000714775 (22:43858562 C>G), RS1000771574 (22:43835350 G>C)

Disease associations

OMIM: gene MIM:608359 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST001843_4	Type 2 diabetes (dietary heme iron intake interaction)	9.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0008355	dietary heme iron intake measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL1743298 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

20 total (human), top 20 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
ethylbenzene	affects cotreatment, decreases expression, increases methylation	1
trichostatin A	increases expression	1
4-nitrophenol	increases metabolic processing	1
2-naphthol	increases metabolic processing	1
CGP 52608	affects binding, increases reaction	1
Resveratrol	increases expression	1
Sunitinib	decreases expression	1
Arsenic	increases methylation	1
Benzo(a)pyrene	increases methylation	1
Estrone	increases metabolic processing	1
Lead	affects expression	1
Rotenone	decreases expression	1
Thyroxine	increases metabolic processing	1
Toluene	affects cotreatment, decreases expression, increases methylation	1
Triclosan	increases expression	1
Triiodothyronine	increases metabolic processing	1
Xylenes	affects cotreatment, decreases expression, increases methylation	1
2-Naphthylamine	increases metabolic processing	1
8-Bromo Cyclic Adenosine Monophosphate	increases expression	1
Aflatoxin B1	decreases methylation	1

ChEMBL screening assays

1 unique, capped per target: 1 admet

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL1743313	ADMET	Major substrate of human cytosolic sulfotransferase SULT4A1_v1	Casarett and Doull’s Toxicology The Basic Science of Poisons, 7th edition

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.