SURF6

Summary

SURF6 (surfeit 6, HGNC:11478) is a protein-coding gene on chromosome 9q34.2, encoding Surfeit locus protein 6 (O75683). Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. It is a selective cancer dependency (DepMap: 83.9% of cell lines).

This gene encodes a conserved protein that is localized to the nucleolus. The encoded protein may function as a nucleolar-matrix protein with nucleic acid-binding properties. There is a pseudogene for this gene on chromosome Y. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 6838 — RefSeq curated summary.

At a glance

• GWAS associations: 37
• Clinical variants (ClinVar): 89 total
• Cancer dependency (DepMap): dependent in 83.9% of screened cell lines
• MANE Select transcript: NM_006753

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11478
Approved symbol	SURF6
Name	surfeit 6
Location	9q34.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ30322, RRP14
Ensembl gene	ENSG00000148296
Ensembl biotype	protein_coding
OMIM	185642
Entrez	6838

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 3 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000372022, ENST00000468290, ENST00000929310, ENST00000929311

RefSeq mRNA: 2 — MANE Select: NM_006753 NM_001278942, NM_006753

CCDS: CCDS6962

Canonical transcript exons

ENST00000372022 — 5 exons

Exon	Start	End
ENSE00000984167	133334392	133334601
ENSE00000984168	133333718	133333806
ENSE00000984169	133332548	133332760
ENSE00001456718	133328776	133332348
ENSE00001456725	133336039	133336188

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 94.76.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 34.1050 / max 367.9243, expressed in 1812 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
102980	20.8226	1800
102979	11.8616	1760
102978	1.0690	684
102981	0.3519	161

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	94.76	gold quality
mucosa of transverse colon	UBERON:0004991	90.66	gold quality
gastrocnemius	UBERON:0001388	87.14	gold quality
transverse colon	UBERON:0001157	87.10	gold quality
muscle of leg	UBERON:0001383	86.58	gold quality
substantia nigra	UBERON:0002038	86.29	gold quality
lower esophagus mucosa	UBERON:0035834	86.15	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	85.73	gold quality
granulocyte	CL:0000094	85.57	gold quality
temporal lobe	UBERON:0001871	85.52	gold quality
colon	UBERON:0001155	85.50	gold quality
small intestine	UBERON:0002108	85.49	gold quality
amygdala	UBERON:0001876	85.47	gold quality
small intestine Peyer’s patch	UBERON:0003454	85.47	gold quality
hypothalamus	UBERON:0001898	85.34	gold quality
skin of abdomen	UBERON:0001416	85.29	gold quality
skin of leg	UBERON:0001511	85.26	gold quality
right adrenal gland cortex	UBERON:0035827	85.25	gold quality
apex of heart	UBERON:0002098	85.20	gold quality
intestine	UBERON:0000160	85.19	gold quality
prefrontal cortex	UBERON:0000451	85.17	gold quality
zone of skin	UBERON:0000014	85.16	gold quality
left adrenal gland	UBERON:0001234	85.14	gold quality
right ovary	UBERON:0002118	85.11	gold quality
right adrenal gland	UBERON:0001233	85.09	gold quality
left adrenal gland cortex	UBERON:0035825	85.07	gold quality
skeletal muscle tissue	UBERON:0001134	85.02	gold quality
esophagus mucosa	UBERON:0002469	85.02	gold quality
putamen	UBERON:0001874	84.93	gold quality
Ammon’s horn	UBERON:0001954	84.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.42

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): MYC

miRNA regulators (miRDB)

32 targeting SURF6, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-8087	99.90	69.55	1351
HSA-MIR-130B-5P	99.83	68.50	1888
HSA-MIR-3942-3P	99.57	69.03	2854
HSA-MIR-766-3P	99.47	65.24	1811
HSA-MIR-145-3P	99.33	67.66	764
HSA-MIR-3978	99.24	68.39	2201
HSA-MIR-4717-3P	99.06	66.34	1072
HSA-MIR-4716-5P	98.82	68.57	1168
HSA-MIR-7705	98.69	67.47	543
HSA-MIR-5011-3P	98.63	64.81	638
HSA-MIR-4700-5P	98.63	67.43	1915
HSA-MIR-4782-5P	98.35	69.33	1474
HSA-MIR-5706	98.35	69.33	1463
HSA-MIR-561-5P	98.25	68.13	1365
HSA-MIR-4303	98.01	68.13	2304
HSA-MIR-4638-3P	97.90	65.75	905
HSA-MIR-8089	97.74	66.21	1698
HSA-MIR-4667-5P	97.61	66.67	1683
HSA-MIR-450B-3P	97.56	66.12	512
HSA-MIR-630	97.50	66.38	921
HSA-MIR-3116	97.07	65.78	1324
HSA-MIR-1913	97.07	66.20	1417
HSA-MIR-6839-5P	96.74	68.29	1088
HSA-MIR-378J	96.44	66.20	1020
HSA-MIR-1266-3P	96.23	66.36	778

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 83.9% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 5)

• we identified a consistently replicated loci at 9q34.2 (rs633862 near ABO and SURF6, P(meta) = 8.57 x 10(-7)) (P<0.05 in all three stages) (PMID:25134534)
• the panel of the GST-Surf6-dom protein partners, which were identified by mass-spectrometry, points to putative interactions of human SURF6 with a number of nuclear and nucleolar proteins of other functional groups (PMID:25898752)
• NPM1 and SURF6 form heterotypic liquid-like droplets in the nucleolus. (PMID:29483575)
• A Higher Level of Expression of the Nucleolar Protein SURF6 in Human Normal Activated Lymphocytes and in Lymphocytes of Patients with Lymphoproliferative Disorders. (PMID:33119830)
• Human nucleolar protein SURF6/RRP14 participates in early steps of pre-rRNA processing. (PMID:37450438)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	surf6	ENSDARG00000035427
mus_musculus	Surf6	ENSMUSG00000036160
rattus_norvegicus	Surf6	ENSRNOG00000005031
drosophila_melanogaster	Surf6	FBGN0038746
caenorhabditis_elegans		WBGENE00022765

Protein

Protein identifiers

Surfeit locus protein 6 — O75683 (reviewed: O75683)

All UniProt accessions (1): O75683

UniProt curated annotations — full annotation on UniProt →

Function. Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly.

Subcellular location. Nucleus. Nucleoplasm. Nucleolus.

Similarity. Belongs to the SURF6 family.

RefSeq proteins (2): NP_001265871, NP_006744* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007019	SURF6	Family
IPR029190	Rrp14/SURF6_C	Domain

Pfam: PF04935

UniProt features (25 total): compositionally biased region 9, sequence variant 5, region of interest 3, modified residue 3, sequence conflict 2, short sequence motif 2, chain 1

Structure

Experimental structures (PDB)

4 structures.

PDB	Method	Resolution (Å)
8FKQ	ELECTRON MICROSCOPY	2.76
8FKP	ELECTRON MICROSCOPY	2.85
8FKS	ELECTRON MICROSCOPY	2.88
8FKR	ELECTRON MICROSCOPY	2.89

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O75683-F1	75.53	0.41

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 74, 138, 229

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 92 (showing top): GOBP_RIBOSOME_BIOGENESIS, MODULE_255, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, MODULE_317, GOBP_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS, ZHOU_INFLAMMATORY_RESPONSE_LIVE_DN, RASHI_RESPONSE_TO_IONIZING_RADIATION_5, DANG_BOUND_BY_MYC, IVANOVA_HEMATOPOIESIS_INTERMEDIATE_PROGENITOR, GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS, GOBP_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS, LIU_SOX4_TARGETS_DN, MODULE_69, GOCC_NUCLEOLUS, DANG_REGULATED_BY_MYC_UP

GO Biological Process (3): ribosomal large subunit biogenesis (GO:0042273), ribosomal small subunit biogenesis (GO:0042274), ribosome biogenesis (GO:0042254)

GO Molecular Function (4): DNA binding (GO:0003677), RNA binding (GO:0003723), molecular condensate scaffold activity (GO:0140693), protein binding (GO:0005515)

GO Cellular Component (5): granular component (GO:0001652), nucleoplasm (GO:0005654), chromosome (GO:0005694), nucleolus (GO:0005730), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
ribonucleoprotein complex biogenesis	3
ribosome biogenesis	2
nucleic acid binding	2
cellular anatomical structure	2
nuclear lumen	2
intracellular membraneless organelle	2
protein-macromolecule adaptor activity	1
binding	1
nucleolus	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1810 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SURF6	MED22	Q15528	918
SURF6	NPM1	P06748	857
SURF6	SURF2	Q15527	840
SURF6	SURF1	Q15526	798
SURF6	RRP15	Q9Y3B9	774
SURF6	FBL	P22087	758
SURF6	RPL21	P46778	752
SURF6	WDR74	Q6RFH5	727
SURF6	GNL2	Q13823	723
SURF6	EBNA1BP2	Q99848	710
SURF6	RPF2	Q9H7B2	683
SURF6	RPL7L1	Q6DKI1	657
SURF6	SURF4	O15260	649
SURF6	LMX1B	O60663	632
SURF6	RSL24D1	Q9UHA3	612

IntAct

167 interactions, top by confidence:

A	B	Type	Score
CDK8	MED19	psi-mi:“MI:2364”(proximity)	0.850
PTK2	TGFB1I1	psi-mi:“MI:0914”(association)	0.680
H1-1	RRP8	psi-mi:“MI:0914”(association)	0.640
NPM1	NVL	psi-mi:“MI:0914”(association)	0.610
CSNK2A1	SURF6	psi-mi:“MI:0217”(phosphorylation reaction)	0.590
CSNK2A1	SURF6	psi-mi:“MI:0914”(association)	0.590
AURKB	SEC16A	psi-mi:“MI:2364”(proximity)	0.570
SURF6	FAM9B	psi-mi:“MI:0915”(physical association)	0.560
SURF6	RPL22	psi-mi:“MI:0915”(physical association)	0.560
RPL37A	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
MAK16	NVL	psi-mi:“MI:0914”(association)	0.530
RPL30	RRP8	psi-mi:“MI:0914”(association)	0.530
PUM3	RRP8	psi-mi:“MI:0914”(association)	0.530
E4F1	ZBTB24	psi-mi:“MI:0914”(association)	0.530
RPL6	MRPS14	psi-mi:“MI:0914”(association)	0.530
N	RBM47	psi-mi:“MI:0914”(association)	0.530
NSA2	TYW5	psi-mi:“MI:0914”(association)	0.530
RPS2	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
ZBTB48	ZBTB24	psi-mi:“MI:0914”(association)	0.530
ZNF71	DKC1	psi-mi:“MI:0914”(association)	0.530
H1-1	SURF6	psi-mi:“MI:0914”(association)	0.530
PUM3	SURF6	psi-mi:“MI:0914”(association)	0.530
ABT1	ZNF316	psi-mi:“MI:0914”(association)	0.530
ESR2	FBLL1	psi-mi:“MI:0914”(association)	0.460
SURF6	VAPA	psi-mi:“MI:0915”(physical association)	0.400
SURF6	VAPB	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (493): SURF6 (Affinity Capture-RNA), SURF6 (Affinity Capture-RNA), SURF6 (Affinity Capture-MS), SURF6 (Affinity Capture-MS), SURF6 (Affinity Capture-MS), SURF6 (Affinity Capture-MS), SURF6 (Affinity Capture-MS), SURF6 (Affinity Capture-MS), SURF6 (Affinity Capture-MS), SURF6 (Affinity Capture-MS), RRS1 (Co-fractionation), SURF6 (Co-fractionation), SURF6 (Affinity Capture-MS), SURF6 (Affinity Capture-MS), SURF6 (Affinity Capture-MS)

ESM2 similar proteins: A5PJN1, O57594, O75683, P0DPK0, P53352, P70279, Q05B65, Q0VCY3, Q17QR4, Q2KIV0, Q2TBX7, Q3KRF3, Q3U155, Q3ZCI6, Q58CQ0, Q5D1Z3, Q5NVE2, Q5R939, Q5RGP9, Q5XIB5, Q5XIG5, Q5ZIH9, Q5ZMG5, Q640V3, Q641W3, Q66H19, Q6NS45, Q6PK04, Q7ZWE7, Q8BG17, Q8BK35, Q8C6C7, Q8CIL4, Q8NDD1, Q8NEF9, Q8R0K4, Q8R2N0, Q8TF30, Q96J88, Q9CR02

Diamond homologs: O57594, O75683, P36080, P70279, Q0VCY3, Q23525, Q9I8B0, Q54G38, Q9VDS6

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 172 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Peptide chain elongation	19	20.6×	5e-18
Viral mRNA Translation	19	20.6×	5e-18
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	19	20.4×	5e-18
Selenocysteine synthesis	19	19.5×	8e-18
Eukaryotic Translation Termination	19	19.5×	8e-18
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	19	19.1×	8e-18
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	19	19.1×	8e-18
Formation of a pool of free 40S subunits	19	18.2×	2e-17

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	20	23.0×	4e-19
positive regulation of viral genome replication	5	18.1×	9e-04
ribosomal large subunit biogenesis	6	16.5×	3e-04
negative regulation of proteasomal ubiquitin-dependent protein catabolic process	6	14.9×	4e-04
translation	23	14.7×	7e-18
ribosomal small subunit biogenesis	10	14.1×	5e-07
rRNA processing	15	13.2×	1e-10
regulation of alternative mRNA splicing, via spliceosome	6	9.1×	4e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

89 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	80
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

597 predictions. Top by Δscore:

Variant	Effect	Δscore
9:133332348:CCTGG:C	acceptor_loss	1.0000
9:133332350:T:C	acceptor_loss	1.0000
9:133332544:TCAC:T	donor_loss	1.0000
9:133332545:CACC:C	donor_loss	1.0000
9:133332546:A:AC	donor_gain	1.0000
9:133332546:ACC:A	donor_loss	1.0000
9:133332547:C:CC	donor_gain	1.0000
9:133332547:CCTT:C	donor_gain	1.0000
9:133332547:CCTTA:C	donor_gain	1.0000
9:133332756:CTGCC:C	acceptor_gain	1.0000
9:133332757:TGCC:T	acceptor_gain	1.0000
9:133332758:GCC:G	acceptor_gain	1.0000
9:133332759:CC:C	acceptor_gain	1.0000
9:133332759:CCC:C	acceptor_gain	1.0000
9:133332760:CC:C	acceptor_gain	1.0000
9:133332761:C:CC	acceptor_gain	1.0000
9:133332761:C:T	acceptor_gain	1.0000
9:133333713:CCTA:C	donor_loss	1.0000
9:133333714:CTAC:C	donor_loss	1.0000
9:133333716:ACCT:A	donor_loss	1.0000
9:133333717:CC:C	donor_loss	1.0000
9:133333803:CCAT:C	acceptor_gain	1.0000
9:133333804:CATC:C	acceptor_gain	1.0000
9:133333805:ATCT:A	acceptor_loss	1.0000
9:133333806:TCTGC:T	acceptor_loss	1.0000
9:133333807:C:CC	acceptor_gain	1.0000
9:133333807:CT:C	acceptor_loss	1.0000
9:133333808:T:A	acceptor_loss	1.0000
9:133334387:CTCA:C	donor_loss	1.0000
9:133334389:CA:C	donor_loss	1.0000

AlphaMissense

2305 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:133332145:C:A	W270C	0.988
9:133332145:C:G	W270C	0.988
9:133332034:C:A	W307C	0.985
9:133332034:C:G	W307C	0.985
9:133332554:G:C	F200L	0.983
9:133332554:G:T	F200L	0.983
9:133332556:A:G	F200L	0.983
9:133332126:C:G	A277P	0.978
9:133332147:A:G	W270R	0.978
9:133332147:A:T	W270R	0.978
9:133332127:C:A	K276N	0.970
9:133332127:C:G	K276N	0.970
9:133332110:A:G	I282T	0.968
9:133332081:C:G	A292P	0.965
9:133332710:T:A	R148S	0.960
9:133332710:T:G	R148S	0.960
9:133332110:A:C	I282S	0.958
9:133332257:C:T	G233E	0.955
9:133332258:C:A	G233W	0.954
9:133333737:A:G	I125T	0.954
9:133331906:A:G	I350T	0.950
9:133332036:A:G	W307R	0.949
9:133332036:A:T	W307R	0.949
9:133332137:A:G	L273P	0.949
9:133332146:C:G	W270S	0.948
9:133332239:A:G	L239P	0.948
9:133332067:C:A	K296N	0.946
9:133332067:C:G	K296N	0.946
9:133332120:C:A	G279C	0.941
9:133332251:T:A	N235I	0.940

dbSNP variants (sampled 300 via entrez): RS1000048160 (9:133337531 T>C), RS1000122228 (9:133336305 G>A,C,T), RS1000138401 (9:133329257 G>C), RS1000228948 (9:133332522 C>G,T), RS1000367033 (9:133328705 T>C), RS1000483231 (9:133328548 T>C), RS1000705740 (9:133329556 C>G), RS1000753728 (9:133336398 C>G), RS1000816913 (9:133329417 G>A,C,T), RS1001111930 (9:133328595 C>T), RS1001206222 (9:133334249 T>C), RS1001377200 (9:133338188 G>A), RS1001674312 (9:133333049 G>A), RS1001714486 (9:133329176 A>C,G,T), RS1001740482 (9:133329900 T>A,C)

Disease associations

OMIM: gene MIM:185642 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

37 associations (top):

Study	Trait	p-value
GCST001793_1	Coagulation factor levels	4.000000e-34
GCST001793_4	Coagulation factor levels	1.000000e-128
GCST002214_2	Serum alkaline phosphatase levels	3.000000e-27
GCST002214_4	Serum alkaline phosphatase levels	1.000000e-56
GCST002576_3	Epithelial ovarian cancer	9.000000e-07
GCST003995_30	Tonsillectomy	9.000000e-09
GCST005014_183	Tonsillectomy	8.000000e-09
GCST008074_9	Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df)	2.000000e-07
GCST008077_40	LDL cholesterol levels	1.000000e-07
GCST008077_52	LDL cholesterol levels	7.000000e-29
GCST008077_8	LDL cholesterol levels	4.000000e-18
GCST008078_100	LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df)	1.000000e-114
GCST008078_143	LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df)	4.000000e-103
GCST008078_84	LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df)	3.000000e-07
GCST008078_90	LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df)	2.000000e-08
GCST008079_100	LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df)	8.000000e-09
GCST008079_111	LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df)	5.000000e-69
GCST008079_37	LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df)	4.000000e-86
GCST008079_90	LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df)	2.000000e-08
GCST008083_128	Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df)	1.000000e-06
GCST008083_28	Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df)	1.000000e-07
GCST008086_101	LDL cholesterol levels in current drinkers	1.000000e-07
GCST008086_116	LDL cholesterol levels in current drinkers	2.000000e-36
GCST008086_12	LDL cholesterol levels in current drinkers	8.000000e-47
GCST008086_52	LDL cholesterol levels in current drinkers	6.000000e-07
GCST009731_15	Blood protein levels in cardiovascular risk	6.000000e-13
GCST009731_40	Blood protein levels in cardiovascular risk	1.000000e-256
GCST010241_123	Apolipoprotein A1 levels	1.000000e-33
GCST010242_432	HDL cholesterol levels	3.000000e-21
GCST010243_174	Apolipoprotein B levels	3.000000e-53

EFO canonical traits (10, from GWAS)

EFO ID	Trait name
EFO:0004533	alkaline phosphatase measurement
EFO:0007924	tonsillectomy risk measurement
EFO:0004530	triglyceride measurement
EFO:0004611	low density lipoprotein cholesterol measurement
EFO:0004329	alcohol drinking
EFO:0010623	tissue factor measurement
EFO:0004614	apolipoprotein A 1 measurement
EFO:0004612	high density lipoprotein cholesterol measurement
EFO:0004615	apolipoprotein B measurement
EFO:0004847	age at onset

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cisplatin	decreases expression	2
Estradiol	increases expression	2
aristolochic acid I	increases expression	1
FR900359	affects phosphorylation	1
bisphenol A	decreases expression	1
deoxynivalenol	increases expression	1
trichostatin A	affects expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
perfluorooctanoic acid	decreases expression	1
coumarin	increases phosphorylation	1
nivalenol	increases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
perfluoro-n-nonanoic acid	decreases expression	1
perfluorohexanesulfonic acid	decreases expression	1
3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	decreases expression	1
Sunitinib	increases expression	1
Air Pollutants	increases abundance, affects expression	1
Benzo(a)pyrene	increases methylation	1
Cadmium	increases expression	1
Caffeine	decreases phosphorylation	1
Dimethyl Sulfoxide	increases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Lead	affects expression	1
Ozone	affects expression, increases abundance	1
Ribonucleotides	affects binding	1
Silicon Dioxide	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Tretinoin	decreases expression	1
Urethane	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2HX	Abcam HeLa SURF6 KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.