SYAP1

Summary

SYAP1 (synapse associated protein 1, HGNC:16273) is a protein-coding gene on chromosome Xp22.2, encoding Synapse-associated protein 1 (Q96A49). Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at ‘Ser-473’ after growth factor stimulation.

Involved in several processes, including TORC2 signaling; cellular response to epidermal growth factor stimulus; and cellular response to peptide hormone stimulus. Located in several cellular components, including Golgi apparatus; cytoplasmic side of plasma membrane; and nucleoplasm.

Source: NCBI Gene 94056 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 110 total
• MANE Select transcript: NM_032796

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16273
Approved symbol	SYAP1
Name	synapse associated protein 1
Location	Xp22.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ14495, PRO3113
Ensembl gene	ENSG00000169895
Ensembl biotype	protein_coding
Entrez	94056

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 11 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000380155, ENST00000495743, ENST00000896382, ENST00000896383, ENST00000896384, ENST00000896385, ENST00000896386, ENST00000896387, ENST00000896388, ENST00000939106, ENST00000939107, ENST00000968847

RefSeq mRNA: 1 — MANE Select: NM_032796 NM_032796

CCDS: CCDS14177

Canonical transcript exons

ENST00000380155 — 9 exons

Exon	Start	End
ENSE00001150585	16757162	16757309
ENSE00001150590	16756663	16756721
ENSE00001150594	16754945	16755093
ENSE00001150603	16743701	16743840
ENSE00001150608	16741716	16741789
ENSE00001150613	16736166	16736232
ENSE00001483909	16760232	16765340
ENSE00001483985	16719612	16719899
ENSE00003660043	16735227	16735345

Expression profiles

Bgee: expression breadth ubiquitous, 252 present calls, max score 95.69.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 84.3031 / max 1967.1136, expressed in 1827 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
195636	72.2337	1826
195637	9.6614	1551
195635	1.2690	873
195638	0.8197	209
195639	0.3193	65

Top tissues by expression

255 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney epithelium	UBERON:0004819	95.69	silver quality
calcaneal tendon	UBERON:0003701	93.32	gold quality
ileal mucosa	UBERON:0000331	93.31	gold quality
jejunal mucosa	UBERON:0000399	93.29	gold quality
tibialis anterior	UBERON:0001385	93.22	silver quality
adrenal tissue	UBERON:0018303	93.18	gold quality
left ventricle myocardium	UBERON:0006566	92.69	silver quality
upper arm skin	UBERON:0004263	92.59	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	91.81	gold quality
epithelium of nasopharynx	UBERON:0001951	91.79	gold quality
deltoid	UBERON:0001476	91.64	silver quality
bronchial epithelial cell	CL:0002328	91.22	gold quality
bronchus	UBERON:0002185	90.98	gold quality
jejunum	UBERON:0002115	90.97	gold quality
esophagus squamous epithelium	UBERON:0006920	90.93	gold quality
nasal cavity epithelium	UBERON:0005384	90.81	silver quality
myocardium	UBERON:0002349	90.47	silver quality
decidua	UBERON:0002450	90.34	gold quality
gingiva	UBERON:0001828	90.18	gold quality
oral cavity	UBERON:0000167	90.12	gold quality
duodenum	UBERON:0002114	89.95	gold quality
mucosa of sigmoid colon	UBERON:0004993	89.95	gold quality
colonic mucosa	UBERON:0000317	89.79	gold quality
gingival epithelium	UBERON:0001949	89.78	gold quality
vastus lateralis	UBERON:0001379	89.09	gold quality
sperm	CL:0000019	89.03	gold quality
quadriceps femoris	UBERON:0001377	88.98	silver quality
bone marrow	UBERON:0002371	88.80	gold quality
tendon	UBERON:0000043	88.74	gold quality
liver	UBERON:0002107	88.68	gold quality

Single-cell (SCXA)

Detected in 7 experiment(s), a significant marker in 5.

Experiment	Marker?	Max mean expression
E-HCAD-4	yes	35.69
E-HCAD-5	yes	32.58
E-ANND-3	yes	13.92
E-MTAB-9388	yes	10.39
E-GEOD-135922	yes	7.07
E-MTAB-8060	no	237.84
E-MTAB-6524	no	196.28

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

103 targeting SYAP1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-223-3P	99.99	70.14	1140
HSA-MIR-499A-5P	99.98	70.79	1323
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-144-3P	99.94	73.98	2698
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-1-3P	99.93	72.35	1914
HSA-MIR-206	99.93	72.50	1893
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-613	99.91	71.50	1710
HSA-MIR-4753-3P	99.90	71.03	3786
HSA-MIR-380-3P	99.89	70.18	1978
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-4671-3P	99.88	72.46	1045
HSA-MIR-221-5P	99.86	65.45	1052

Literature-anchored findings (GeneRIF, showing 1)

• BSTA (SYAP!) promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation. (PMID:23300339)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	syap1	ENSDARG00000012946
mus_musculus	Syap1	ENSMUSG00000031357
rattus_norvegicus	Syap1	ENSRNOG00000004304
drosophila_melanogaster	Sap47	FBGN0013334
caenorhabditis_elegans	C16C2.4	WBGENE00007621

Paralogs (1): BSDC1 (ENSG00000160058)

Protein

Protein identifiers

Synapse-associated protein 1 — Q96A49 (reviewed: Q96A49)

Alternative names: BSD domain-containing signal transducer and Akt interactor protein

All UniProt accessions (1): Q96A49

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at ‘Ser-473’ after growth factor stimulation.

Subunit / interactions. Interacts (via phosphorylated form and BSD domain) with AKT1; this interaction is enhanced in a mTORC2-mediated manner in response to epidermal growth factor (EGF) stimulation and activates AKT1.

Subcellular location. Cytoplasm. Perinuclear region. Golgi apparatus. Perikaryon. Cell projection. Axon. Dendrite. Growth cone. Presynaptic cell membrane. Postsynaptic cell membrane. Membrane.

Tissue specificity. Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Post-translational modifications. Phosphorylated. Phosphorylation increases in a mTORC2-mediated manner in response to epidermal growth factor (EGF) stimulation.

RefSeq proteins (1): NP_116185* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR005607	BSD_dom	Domain
IPR035925	BSD_dom_sf	Homologous_superfamily
IPR051494	BSD_domain-containing	Family

Pfam: PF03909

UniProt features (17 total): helix 5, modified residue 3, sequence conflict 3, chain 1, domain 1, strand 1, turn 1, region of interest 1, mutagenesis site 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
1X3A	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96A49-F1	66.18	0.24

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 248, 269, 313

Mutagenesis-validated functional residues (1):

Position	Phenotype
198–199	inhibits interaction with akt1, mtorc2-mediated phosphorylation of akt1 at ‘ser-473’ and adipocyte differentiation.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 141 (showing top): GOBP_RESPONSE_TO_NITROGEN_COMPOUND, GOBP_REGULATION_OF_FAT_CELL_DIFFERENTIATION, TAATAAT_MIR126, GOBP_REGULATION_OF_PHOSPHORYLATION, GOBP_REGULATION_OF_NEURONAL_SYNAPTIC_PLASTICITY, GOBP_POSITIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION, GOBP_REGULATION_OF_SHORT_TERM_NEURONAL_SYNAPTIC_PLASTICITY, GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP, IVANOVA_HEMATOPOIESIS_MATURE_CELL, GOBP_REGULATION_OF_TRANSFERASE_ACTIVITY, GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, GOBP_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR, GOBP_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS, GOBP_CELL_CELL_SIGNALING, GOBP_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY

GO Biological Process (9): cell differentiation (GO:0030154), cellular response to insulin stimulus (GO:0032869), cellular response to platelet-derived growth factor stimulus (GO:0036120), TORC2 signaling (GO:0038203), positive regulation of fat cell differentiation (GO:0045600), regulation of short-term neuronal synaptic plasticity (GO:0048172), cellular response to epidermal growth factor stimulus (GO:0071364), positive regulation of protein serine/threonine kinase activity (GO:0071902), cellular response to insulin-like growth factor stimulus (GO:1990314)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (18): nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), Golgi apparatus (GO:0005794), cytosol (GO:0005829), cytoplasmic side of plasma membrane (GO:0009898), axon (GO:0030424), dendrite (GO:0030425), growth cone (GO:0030426), presynaptic membrane (GO:0042734), perikaryon (GO:0043204), synapse (GO:0045202), postsynaptic membrane (GO:0045211), perinuclear region of cytoplasm (GO:0048471), extracellular exosome (GO:0070062), plasma membrane (GO:0005886), membrane (GO:0016020), cell projection (GO:0042995)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	7
cytoplasm	3
cellular response to peptide hormone stimulus	2
cellular response to growth factor stimulus	2
intracellular membrane-bounded organelle	2
neuron projection	2
synaptic membrane	2
cellular developmental process	1
response to insulin	1
response to platelet-derived growth factor	1
TOR signaling	1
fat cell differentiation	1
positive regulation of cell differentiation	1
regulation of fat cell differentiation	1
regulation of neuronal synaptic plasticity	1
response to epidermal growth factor	1
protein serine/threonine kinase activity	1
positive regulation of protein kinase activity	1
regulation of protein serine/threonine kinase activity	1
binding	1
nuclear lumen	1
intracellular anatomical structure	1
endomembrane system	1
plasma membrane	1
cytoplasmic side of membrane	1
dendritic tree	1
site of polarized growth	1
distal axon	1
presynapse	1
neuronal cell body	1
cell junction	1
postsynapse	1
extracellular vesicle	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

718 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SYAP1	NOC4L	Q9BVI4	480
SYAP1	CTPS2	Q9NRF8	461
SYAP1	TXLNG	Q9NUQ3	456
SYAP1	REPS2	Q8NFH8	438
SYAP1	EIF2S3	P41091	429
SYAP1	RICTOR	Q6R327	419
SYAP1	CA5B	Q9Y2D0	403
SYAP1	AP1S2	P56377	372
SYAP1	CCDC125	Q86Z20	363
SYAP1	ATP5ME	P56385	360
SYAP1	ZRSR2	Q15696	357
SYAP1	FAM9A	Q8IZU1	357
SYAP1	PUDP	Q08623	355
SYAP1	DTX3	Q8N9I9	355
SYAP1	PABIR2	Q7Z309	352

IntAct

95 interactions, top by confidence:

A	B	Type	Score
MFN1	MFN2	psi-mi:“MI:0914”(association)	0.790
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
SYAP1	PIN1	psi-mi:“MI:0915”(physical association)	0.690
PIN1	POLR2D	psi-mi:“MI:0914”(association)	0.640
SYAP1	NDN	psi-mi:“MI:0915”(physical association)	0.600
IGF1R	PIK3R2	psi-mi:“MI:2364”(proximity)	0.590
INSR	PIK3R2	psi-mi:“MI:2364”(proximity)	0.570
SLC39A1	NME2P1	psi-mi:“MI:0914”(association)	0.560
THRA	SYAP1	psi-mi:“MI:0915”(physical association)	0.560
TNFRSF10C	SYAP1	psi-mi:“MI:0915”(physical association)	0.560
MIP	SYAP1	psi-mi:“MI:0915”(physical association)	0.560
ZFPL1	SYAP1	psi-mi:“MI:0915”(physical association)	0.560
ADIPOQ	SYAP1	psi-mi:“MI:0915”(physical association)	0.560
SNRNP27	UBA6	psi-mi:“MI:0914”(association)	0.530
TAS2R41	YKT6	psi-mi:“MI:0914”(association)	0.530
USP47	DENR	psi-mi:“MI:0914”(association)	0.530
CYP1A1	SNX3	psi-mi:“MI:0914”(association)	0.530
BAG2	HGS	psi-mi:“MI:0914”(association)	0.530
POT1	SYAP1	psi-mi:“MI:0915”(physical association)	0.510
NRAS	ESYT2	psi-mi:“MI:2364”(proximity)	0.480
OTUB1	EPM2A	psi-mi:“MI:0914”(association)	0.350
Ecd	AAR2	psi-mi:“MI:0914”(association)	0.350
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350

BioGRID (194): SYAP1 (Co-fractionation), SYAP1 (Co-fractionation), SYAP1 (Co-fractionation), SYAP1 (Proximity Label-MS), SYAP1 (Affinity Capture-MS), SYAP1 (Affinity Capture-MS), SYAP1 (Affinity Capture-RNA), SYAP1 (Proximity Label-MS), SYAP1 (Affinity Capture-MS), SYAP1 (Affinity Capture-MS), PIN1 (Affinity Capture-MS), SYAP1 (Affinity Capture-MS), SYAP1 (Affinity Capture-MS), SYAP1 (Affinity Capture-MS), SYAP1 (Affinity Capture-MS)

ESM2 similar proteins: A0JNJ3, A0M8T5, A0PJT0, A2BIJ3, D3ZTQ1, O35867, O94876, P42566, P42567, P97578, Q00PJ1, Q02225, Q09YI1, Q09YK4, Q09YM8, Q16643, Q2IBF8, Q2QL82, Q2QLA2, Q2QLG9, Q2T9N1, Q3SX22, Q3UQU0, Q3USH5, Q5BJ78, Q5RDH2, Q5T1M5, Q5U3K5, Q5ZIK6, Q68EF0, Q69ZZ6, Q6INU2, Q6NTW1, Q6P9Q6, Q6TYB5, Q6ZPJ0, Q80Y55, Q8IWB9, Q8IWE2, Q8N0X7

Diamond homologs: Q960T2, Q96A49, Q9D5V6

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 97 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Constitutive Signaling by Aberrant PI3K in Cancer	5	8.1×	4e-03
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	6	7.4×	2e-03
RAF/MAP kinase cascade	8	6.3×	9e-04
PIP3 activates AKT signaling	7	6.0×	2e-03

GO biological processes:

GO term	Partners	Fold	FDR
obsolete protein targeting to mitochondrion	5	32.3×	4e-04
MAPK cascade	6	10.2×	5e-03
protein autophosphorylation	6	9.7×	5e-03
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	9	7.8×	1e-03
positive regulation of MAPK cascade	8	7.2×	3e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

110 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	29
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1062 predictions. Top by Δscore:

Variant	Effect	Δscore
X:16719895:CGGCA:C	donor_gain	1.0000
X:16719896:GGCA:G	donor_gain	1.0000
X:16719896:GGCAG:G	donor_gain	1.0000
X:16719897:GCA:G	donor_gain	1.0000
X:16719897:GCAG:G	donor_gain	1.0000
X:16719900:G:GG	donor_gain	1.0000
X:16735216:A:AG	acceptor_gain	1.0000
X:16735223:ACAG:A	acceptor_loss	1.0000
X:16735224:C:G	acceptor_gain	1.0000
X:16735224:CA:C	acceptor_loss	1.0000
X:16735225:A:AG	acceptor_gain	1.0000
X:16735226:G:GT	acceptor_gain	1.0000
X:16735226:GA:G	acceptor_gain	1.0000
X:16735226:GAC:G	acceptor_gain	1.0000
X:16735226:GACT:G	acceptor_gain	1.0000
X:16735226:GACTA:G	acceptor_gain	1.0000
X:16735342:CAAG:C	donor_loss	1.0000
X:16735343:AAG:A	donor_loss	1.0000
X:16735344:AG:A	donor_loss	1.0000
X:16735346:G:T	donor_loss	1.0000
X:16736163:CA:C	acceptor_loss	1.0000
X:16736164:A:AG	acceptor_gain	1.0000
X:16736164:A:AT	acceptor_loss	1.0000
X:16736165:G:GG	acceptor_gain	1.0000
X:16736165:G:GT	acceptor_loss	1.0000
X:16736165:GA:G	acceptor_gain	1.0000
X:16736165:GAC:G	acceptor_gain	1.0000
X:16736165:GACA:G	acceptor_gain	1.0000
X:16736228:GTCAG:G	donor_gain	1.0000
X:16741696:T:TA	acceptor_gain	1.0000

AlphaMissense

2340 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:16741733:T:A	W127R	1.000
X:16741733:T:C	W127R	1.000
X:16754964:T:A	W199R	1.000
X:16754964:T:C	W199R	1.000
X:16754992:T:C	L208P	1.000
X:16741735:G:C	W127C	0.999
X:16741735:G:T	W127C	0.999
X:16743714:T:C	F150S	0.999
X:16743777:C:A	A171D	0.999
X:16743821:T:C	F186L	0.999
X:16743823:T:A	F186L	0.999
X:16743823:T:G	F186L	0.999
X:16743831:T:A	V189D	0.999
X:16754962:T:C	F198S	0.999
X:16754979:T:G	Y204D	0.999
X:16754982:C:A	R205S	0.999
X:16754983:G:C	R205P	0.999
X:16754988:T:C	S207P	0.999
X:16735254:C:A	A68D	0.998
X:16741782:T:C	L143S	0.998
X:16743720:G:C	R152P	0.998
X:16743797:G:C	D178H	0.998
X:16743807:T:C	L181P	0.998
X:16743819:G:C	R185T	0.998
X:16743820:A:C	R185S	0.998
X:16743820:A:T	R185S	0.998
X:16743828:T:C	L188P	0.998
X:16754961:T:C	F198L	0.998
X:16754963:C:A	F198L	0.998
X:16754963:C:G	F198L	0.998

dbSNP variants (sampled 300 via entrez): RS1000062367 (X:16718514 T>TC), RS1000273744 (X:16756330 T>A,G), RS1000291529 (X:16750245 T>C,G), RS1000324605 (X:16750491 G>C), RS1000413728 (X:16719243 G>A,C), RS1000466344 (X:16725452 G>C), RS1000488490 (X:16743233 C>T), RS1000536607 (X:16757831 C>T), RS1000636814 (X:16748137 G>A,T), RS1000773417 (X:16740011 G>A,C), RS1000839465 (X:16742058 C>G,T), RS1000839559 (X:16744075 A>G), RS1000961390 (X:16758179 G>C), RS1001020511 (X:16721498 C>T), RS1001300507 (X:16752491 C>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	3
Valproic Acid	increases expression	2
FR900359	affects phosphorylation	1
triphenyl phosphate	affects expression	1
arsenite	affects binding, increases reaction	1
coumarin	decreases phosphorylation	1
di-n-butylphosphoric acid	affects expression	1
ICG 001	decreases expression	1
bisphenol B	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Acetaminophen	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Caffeine	decreases phosphorylation	1
Doxorubicin	decreases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Hydrogen Peroxide	affects expression	1
Ivermectin	decreases expression	1
Smoke	decreases expression	1
Testosterone	decreases expression	1
Thiram	increases expression	1
Aflatoxin B1	increases expression	1
Cadmium Chloride	increases expression	1
Okadaic Acid	increases expression	1
Lactic Acid	decreases expression	1
Genistein	decreases expression, increases reaction	1
Particulate Matter	increases abundance, increases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B3IS	Abcam HEK293T SYAP1 KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.