SYDE1

Summary

SYDE1 (synapse defective Rho GTPase activating protein 1, HGNC:25824) is a protein-coding gene on chromosome 19p13.12, encoding Rho GTPase-activating protein SYDE1 (Q6ZW31). GTPase activator for the Rho-type GTPases.

The protein encoded by this gene is a Rho GTPase-activating protein highly expressed in placenta. The encoded protein is involved in cytoskeletal remodeling and trophoblast cell migration. Decreased expression of this gene has been associated with intrauterine growth restriction (IUGR).

Source: NCBI Gene 85360 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 129 total
• MANE Select transcript: NM_033025

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25824
Approved symbol	SYDE1
Name	synapse defective Rho GTPase activating protein 1
Location	19p13.12
Locus type	gene with protein product
Status	Approved
Aliases	7h3, FLJ13511, SYD1
Ensembl gene	ENSG00000105137
Ensembl biotype	protein_coding
OMIM	617377
Entrez	85360

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 protein_coding

ENST00000342784, ENST00000597977, ENST00000600252, ENST00000600440, ENST00000602203, ENST00000863343, ENST00000863344, ENST00000863345, ENST00000925189

RefSeq mRNA: 2 — MANE Select: NM_033025 NM_001300910, NM_033025

CCDS: CCDS12324, CCDS74299

Canonical transcript exons

ENST00000342784 — 8 exons

Exon	Start	End
ENSE00000689545	15111313	15111439
ENSE00000689546	15110521	15110735
ENSE00000689549	15107401	15107521
ENSE00001137355	15111632	15111792
ENSE00001234392	15109704	15110348
ENSE00001379114	15109056	15109397
ENSE00003087216	15113560	15114974
ENSE00003582784	15112346	15112571

Expression profiles

Bgee: expression breadth ubiquitous, 258 present calls, max score 91.88.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.2791 / max 77.1870, expressed in 1296 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
174303	8.2791	1296

Top tissues by expression

280 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
decidua	UBERON:0002450	91.88	gold quality
thoracic aorta	UBERON:0001515	91.76	gold quality
ascending aorta	UBERON:0001496	91.75	gold quality
descending thoracic aorta	UBERON:0002345	91.53	gold quality
aorta	UBERON:0000947	91.28	gold quality
popliteal artery	UBERON:0002250	90.98	gold quality
tibial artery	UBERON:0007610	90.97	gold quality
right coronary artery	UBERON:0001625	90.88	gold quality
stromal cell of endometrium	CL:0002255	90.53	gold quality
tendon of biceps brachii	UBERON:0008188	90.46	gold quality
placenta	UBERON:0001987	90.32	gold quality
coronary artery	UBERON:0001621	90.07	gold quality
left coronary artery	UBERON:0001626	90.07	gold quality
lower esophagus muscularis layer	UBERON:0035833	89.80	gold quality
lower esophagus	UBERON:0013473	89.72	gold quality
body of uterus	UBERON:0009853	89.17	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	89.16	gold quality
mucosa of stomach	UBERON:0001199	88.79	gold quality
apex of heart	UBERON:0002098	88.48	gold quality
endocervix	UBERON:0000458	88.41	gold quality
left uterine tube	UBERON:0001303	88.25	gold quality
muscle layer of sigmoid colon	UBERON:0035805	87.92	gold quality
myometrium	UBERON:0001296	87.75	gold quality
superficial temporal artery	UBERON:0001614	87.71	silver quality
metanephros cortex	UBERON:0010533	87.62	gold quality
right ovary	UBERON:0002118	87.18	gold quality
vena cava	UBERON:0004087	87.07	silver quality
cardia of stomach	UBERON:0001162	86.86	gold quality
endothelial cell	CL:0000115	86.58	gold quality
tongue squamous epithelium	UBERON:0006919	86.38	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-6701	yes	77.52
E-ANND-3	yes	4.50

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

46 targeting SYDE1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-9718	99.94	68.91	918
HSA-MIR-302A-3P	99.89	71.23	1777
HSA-MIR-302B-3P	99.89	71.23	1777
HSA-MIR-302C-3P	99.89	71.20	1778
HSA-MIR-302D-3P	99.89	71.25	1777
HSA-MIR-182-5P	99.87	74.03	2589
HSA-MIR-6124	99.87	69.78	3551
HSA-MIR-6857-5P	99.87	65.32	985
HSA-MIR-373-3P	99.84	70.68	1668
HSA-MIR-520E-3P	99.84	70.55	1698
HSA-MIR-372-3P	99.83	70.58	1691
HSA-MIR-520A-3P	99.83	70.59	1687
HSA-MIR-520B-3P	99.83	70.56	1699
HSA-MIR-520C-3P	99.83	70.56	1699
HSA-MIR-520D-3P	99.83	70.78	1676
HSA-MIR-3934-3P	99.76	65.51	1351
HSA-MIR-1249-5P	99.61	66.55	2049
HSA-MIR-6797-5P	99.61	66.55	2084
HSA-MIR-136-5P	99.50	67.26	1153
HSA-MIR-3612	99.45	66.02	1333

Literature-anchored findings (GeneRIF, showing 1)

• a novel mechanism for GCM1 and SYDE1 in regulation of trophoblast cell migration and invasion during placental development (PMID:27917469)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	SYDE1	ENSDARG00000077440
mus_musculus	Syde1	ENSMUSG00000032714
rattus_norvegicus	Syde1	ENSRNOG00000007307
drosophila_melanogaster	RhoGAP100F	FBGN0039883
caenorhabditis_elegans		WBGENE00006363

Paralogs (4): SYDE2 (ENSG00000097096), CHN2 (ENSG00000106069), CHN1 (ENSG00000128656), ARHGAP35 (ENSG00000160007)

Protein

Protein identifiers

Rho GTPase-activating protein SYDE1 — Q6ZW31 (reviewed: Q6ZW31)

Alternative names: Synapse defective protein 1 homolog 1

All UniProt accessions (4): M0QXZ8, M0R101, M0R3D3, Q6ZW31

UniProt curated annotations — full annotation on UniProt →

Function. GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1.

Tissue specificity. Expressed in trophoblast cells of placental villi.

Post-translational modifications. Palmitoylated. Probably palmitoylated by ZDHHC3 and ZDHHC7.

Isoforms (2)

UniProt ID	Names	Canonical?
Q6ZW31-1	1	yes
Q6ZW31-2	2

RefSeq proteins (2): NP_001287839, NP_149014* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000008	C2_dom	Domain
IPR000198	RhoGAP_dom	Domain
IPR008936	Rho_GTPase_activation_prot	Homologous_superfamily
IPR052118	Rho-GAP_regulator	Family
IPR057459	SYDE1/2_C2	Domain

Pfam: PF00620, PF25336

UniProt features (21 total): modified residue 7, compositionally biased region 5, region of interest 3, domain 2, chain 1, site 1, splice variant 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6ZW31-F1	62.17	0.31

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 436 (arginine finger; crucial for gtp hydrolysis by stabilizing the transition state)

Post-translational modifications (7): 224, 231, 235, 244, 575, 681, 683

Function

Pathways and Gene Ontology

Reactome pathways

10 pathways

ID	Pathway
R-HSA-9013148	CDC42 GTPase cycle
R-HSA-9013404	RAC2 GTPase cycle
R-HSA-9013406	RHOQ GTPase cycle
R-HSA-9013409	RHOJ GTPase cycle
R-HSA-9013423	RAC3 GTPase cycle
R-HSA-9035034	RHOF GTPase cycle
R-HSA-162582	Signal Transduction
R-HSA-194315	Signaling by Rho GTPases
R-HSA-9012999	RHO GTPase cycle
R-HSA-9716542	Signaling by Rho GTPases, Miro GTPases and RHOBTB3

MSigDB gene sets: 126 (showing top): GOBP_POSITIVE_REGULATION_OF_REPRODUCTIVE_PROCESS, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, GOBP_ACTIVATION_OF_GTPASE_ACTIVITY, GOBP_REGULATION_OF_GTPASE_ACTIVITY, GOBP_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION, AATGGAG_MIR136, GOBP_AMEBOIDAL_TYPE_CELL_MIGRATION, GOBP_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY, GOBP_REGULATION_OF_HYDROLASE_ACTIVITY, GOBP_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION, GOBP_RAS_PROTEIN_SIGNAL_TRANSDUCTION, GOBP_REGULATION_OF_REPRODUCTIVE_PROCESS, GOBP_MULTI_MULTICELLULAR_ORGANISM_PROCESS, GOBP_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS, GOBP_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION

GO Biological Process (7): signal transduction (GO:0007165), cell migration (GO:0016477), actin cytoskeleton organization (GO:0030036), regulation of Ras protein signal transduction (GO:0046578), regulation of cytoskeleton organization (GO:0051493), activation of GTPase activity (GO:0090630), positive regulation of trophoblast cell migration (GO:1901165)

GO Molecular Function (2): GTPase activator activity (GO:0005096), GTPase regulator activity (GO:0030695)

GO Cellular Component (1): synaptic membrane (GO:0097060)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
RHO GTPase cycle	6
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	1
Signaling by Rho GTPases	1
Signal Transduction	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoskeleton organization	2
GTPase activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
cell motility	1
actin filament-based process	1
Ras protein signal transduction	1
regulation of small GTPase mediated signal transduction	1
regulation of organelle organization	1
positive regulation of GTPase activity	1
positive regulation of cell migration	1
positive regulation of developmental process	1
positive regulation of multicellular organismal process	1
trophoblast cell migration	1
regulation of trophoblast cell migration	1
positive regulation of reproductive process	1
enzyme activator activity	1
GTPase regulator activity	1
nucleoside-triphosphatase regulator activity	1
synapse	1
plasma membrane region	1

Protein interactions and networks

STRING

848 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SYDE1	HACL2	A1L0T0	538
SYDE1	NCAM1	P13591	461
SYDE1	PAK5	Q9P286	460
SYDE1	GCM1	Q9NP62	453
SYDE1	MEIOC	A2RUB1	436
SYDE1	PPP4R3A	Q6IN85	418
SYDE1	CNTROB	Q8N137	418
SYDE1	NLGN2	Q8NFZ4	416
SYDE1	RHOG	P35238	416
SYDE1	EPHX3	Q9H6B9	410
SYDE1	PDIK1L	Q8N165	406
SYDE1	RHOB	P01121	402
SYDE1	CBR3	O75828	402
SYDE1	PACSIN1	Q9BY11	400
SYDE1	GEN1	Q17RS7	398

IntAct

73 interactions, top by confidence:

A	B	Type	Score
KBTBD7	METTL15	psi-mi:“MI:0914”(association)	0.730
YWHAG	SHTN1	psi-mi:“MI:0914”(association)	0.560
YWHAB	SHTN1	psi-mi:“MI:0914”(association)	0.530
YWHAE	SHTN1	psi-mi:“MI:0914”(association)	0.530
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
SYDE1	Coq10b	psi-mi:“MI:0914”(association)	0.350
SYDE1	Ppfibp1	psi-mi:“MI:0914”(association)	0.350
Arhgap28	EZR	psi-mi:“MI:0914”(association)	0.350
YWHAH	SHTN1	psi-mi:“MI:0914”(association)	0.350
YWHAQ	SHTN1	psi-mi:“MI:0914”(association)	0.350
CALM1	MYO1C	psi-mi:“MI:0914”(association)	0.350
YWHAE	DEPDC5	psi-mi:“MI:0914”(association)	0.350
LURAP1	CIBAR1	psi-mi:“MI:0914”(association)	0.350
SYDE1	POLR2D	psi-mi:“MI:0914”(association)	0.350
APBB1	HERC2	psi-mi:“MI:0914”(association)	0.350
SYDE1	APBB1	psi-mi:“MI:0914”(association)	0.350
AFG2B	MMP24OS	psi-mi:“MI:0914”(association)	0.350
CTNNA1	EFCAB5	psi-mi:“MI:0914”(association)	0.350
DCLK1	SYDE1	psi-mi:“MI:0915”(physical association)	0.000
SIPA1L1	SYDE1	psi-mi:“MI:0915”(physical association)	0.000
KIF1C	SYDE1	psi-mi:“MI:0915”(physical association)	0.000
MAST3	SYDE1	psi-mi:“MI:0915”(physical association)	0.000
EIF4E2	SYDE1	psi-mi:“MI:0915”(physical association)	0.000
SRGAP2	SYDE1	psi-mi:“MI:0915”(physical association)	0.000
GIGYF1	SYDE1	psi-mi:“MI:0915”(physical association)	0.000
NADK	SYDE1	psi-mi:“MI:0915”(physical association)	0.000
NF1	SYDE1	psi-mi:“MI:0915”(physical association)	0.000
CDC25B	SYDE1	psi-mi:“MI:0915”(physical association)	0.000
CDC25C	SYDE1	psi-mi:“MI:0915”(physical association)	0.000
AFDN	SYDE1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (132): SYDE1 (Affinity Capture-MS), SYDE1 (Affinity Capture-MS), POLR2D (Affinity Capture-MS), KLHDC2 (Affinity Capture-MS), TYW3 (Affinity Capture-MS), POLR2A (Affinity Capture-MS), POLR2J (Affinity Capture-MS), RPAP2 (Affinity Capture-MS), POLR2I (Affinity Capture-MS), SYDE1 (Affinity Capture-MS), SYDE1 (Affinity Capture-MS), SYDE1 (Affinity Capture-MS), SYDE1 (Affinity Capture-MS), SYDE1 (Affinity Capture-MS), SYDE1 (Affinity Capture-MS)

ESM2 similar proteins: A0A0U1RQ45, A0A0U1RQS6, A0A2R8YCJ5, A2A699, A2AEV7, A6NGB7, A6NJG2, A6NKF7, A6NKL6, A6NL88, A8MVW0, A9JSM3, B2RU40, B8ZZ34, C9JH25, D4A9R4, J3QNX5, P0CG09, P98077, Q0VD38, Q14761, Q17QH7, Q29RK8, Q2KJ18, Q2M3V2, Q3SX20, Q5BJT1, Q5HZJ5, Q5RKR3, Q5T442, Q64697, Q69YZ2, Q6PB97, Q6PCT2, Q6UXK2, Q6ZMQ8, Q6ZVH7, Q6ZW31, Q80XF7, Q8BLS7

Diamond homologs: A0A0G2JTR4, A1A4S6, A2AB59, A2RUV4, A4IF90, A4II46, A6QNS3, A6X8Z5, A7KAX9, A7YY57, A8WRJ2, D3ZFJ3, E7EZG2, E7F3F0, F1LXF1, O14559, O94466, P11274, P15882, P30337, P34288, P38339, P46941, P52757, P55194, P81128, P97393, Q03070, Q08DP6, Q10164, Q12979, Q13017, Q15311, Q17QN0, Q20498, Q2M1Z3, Q3TBD2, Q3UIA2, Q52LW3, Q53QZ3

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 80 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	6	80.6×	3e-08
Activation of BAD and translocation to mitochondria	5	76.1×	5e-07
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	5	67.2×	8e-07
Activation of BH3-only proteins	5	49.6×	2e-06
RHO GTPases activate PKNs	6	38.1×	8e-07
Intrinsic Pathway for Apoptosis	5	29.3×	2e-05
Translocation of SLC2A4 (GLUT4) to the plasma membrane	7	21.6×	2e-06
SARS-CoV-1-host interactions	5	17.6×	2e-04

GO biological processes:

GO term	Partners	Fold	FDR
protein targeting	5	25.8×	3e-04
substantia nigra development	5	25.8×	3e-04
intracellular protein localization	7	10.3×	8e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

129 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	121
Likely benign	4
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

942 predictions. Top by Δscore:

Variant	Effect	Δscore
19:15107517:GCGCG:G	donor_gain	1.0000
19:15107519:GCG:G	donor_gain	1.0000
19:15107520:CG:C	donor_gain	1.0000
19:15107520:CGG:C	donor_loss	1.0000
19:15107521:GG:G	donor_gain	1.0000
19:15107522:G:GG	donor_gain	1.0000
19:15107522:GTA:G	donor_loss	1.0000
19:15107523:T:G	donor_loss	1.0000
19:15110516:CTCA:C	acceptor_loss	1.0000
19:15110519:A:AG	acceptor_gain	1.0000
19:15110519:AG:A	acceptor_gain	1.0000
19:15110520:G:GG	acceptor_gain	1.0000
19:15110520:GG:G	acceptor_gain	1.0000
19:15110520:GGGT:G	acceptor_gain	1.0000
19:15110732:GCGG:G	donor_gain	1.0000
19:15110734:GG:G	donor_gain	1.0000
19:15110735:GG:G	donor_gain	1.0000
19:15110735:GGTG:G	donor_loss	1.0000
19:15110736:G:GG	donor_gain	1.0000
19:15111310:CA:C	acceptor_loss	1.0000
19:15111311:A:AC	acceptor_loss	1.0000
19:15111312:GGTA:G	acceptor_gain	1.0000
19:15111409:G:GT	donor_gain	1.0000
19:15111436:ACTGG:A	donor_loss	1.0000
19:15111438:TGGTC:T	donor_loss	1.0000
19:15111439:GGTC:G	donor_loss	1.0000
19:15111440:G:GG	donor_gain	1.0000
19:15111440:GT:G	donor_loss	1.0000
19:15111441:T:G	donor_loss	1.0000
19:15111789:AAGGG:A	donor_loss	1.0000

AlphaMissense

4631 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:15111642:G:C	K476N	1.000
19:15111642:G:T	K476N	1.000
19:15111319:G:A	G433R	0.999
19:15111319:G:C	G433R	0.999
19:15111320:G:A	G433E	0.999
19:15111328:C:A	R436S	0.999
19:15111354:G:C	K444N	0.999
19:15111354:G:T	K444N	0.999
19:15111362:T:A	L447H	0.999
19:15111362:T:C	L447P	0.999
19:15111638:T:C	L475P	0.999
19:15111650:T:C	L479P	0.999
19:15112374:T:C	L536P	0.999
19:15112405:C:A	N546K	0.999
19:15112405:C:G	N546K	0.999
19:15112410:T:C	M548T	0.999
19:15112428:C:A	A554D	0.999
19:15112435:C:G	C556W	0.999
19:15112440:G:A	G558E	0.999
19:15110229:T:C	F319S	0.998
19:15110631:T:C	F396L	0.998
19:15110633:T:A	F396L	0.998
19:15110633:T:G	F396L	0.998
19:15110728:G:A	G428E	0.998
19:15111325:T:C	Y435H	0.998
19:15111332:T:C	L437P	0.998
19:15111335:G:A	C438Y	0.998
19:15111338:G:A	G439D	0.998
19:15111374:T:C	F451S	0.998
19:15111429:T:A	N469K	0.998

dbSNP variants (sampled 300 via entrez): RS1000107815 (19:15106561 A>G), RS1000113488 (19:15114456 G>A), RS1000297336 (19:15105723 T>C), RS1000351539 (19:15113092 C>T), RS1001292350 (19:15111867 G>C), RS1001376220 (19:15107883 G>A,T), RS1001474827 (19:15108528 G>A), RS1001767823 (19:15111081 G>A,C), RS1002180242 (19:15113056 C>T), RS1002326123 (19:15114621 C>A,G,T), RS1002843131 (19:15110056 G>A,T), RS1002959192 (19:15110346 G>A,C,T), RS1003119591 (19:15110387 C>A,T), RS1003150564 (19:15110071 C>T), RS1003889313 (19:15107611 G>A)

Disease associations

OMIM: gene MIM:617377 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST003771_20	Loneliness	8.000000e-07

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007865	loneliness measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

39 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression, increases methylation	5
Benzo(a)pyrene	decreases methylation, increases expression, increases methylation	2
Doxorubicin	decreases expression, affects response to substance	2
GSK-J4	increases expression	1
FR900359	affects phosphorylation	1
sodium arsenate	increases abundance, increases expression	1
terbufos	increases methylation	1
sodium arsenite	increases expression	1
sulindac sulfide	increases expression	1
cupric chloride	increases expression	1
coumarin	decreases phosphorylation	1
muconaldehyde	decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
(+)-JQ1 compound	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Temozolomide	increases expression	1
Leflunomide	decreases expression	1
Acetaminophen	decreases expression	1
Arbutin	decreases expression	1
Arsenic	increases abundance, increases expression	1
Calcitriol	increases expression	1
Cisplatin	decreases expression	1
Fonofos	increases methylation	1
Estradiol	increases expression, affects cotreatment	1
Lipopolysaccharides	increases expression, affects response to substance	1
Parathion	increases methylation	1
Silicon Dioxide	decreases methylation, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.