SYNAGE

Summary

SYNAGE (synapse stability regulating cerebellar lncRNA, HGNC:56730) is a long non-coding RNA gene on chromosome 16q12.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:56730
Approved symbol	SYNAGE
Name	synapse stability regulating cerebellar lncRNA
Location	16q12.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000279249
Ensembl biotype	lncRNA
Entrez	102724859
RNAcentral	URS0000EEBE3C — lncRNA, 6757 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 89 — 89 lncRNA

ENST00000564048, ENST00000564875, ENST00000569877, ENST00000623424, ENST00000643467, ENST00000647093, ENST00000647485, ENST00000653054, ENST00000653520, ENST00000653582, ENST00000654109, ENST00000654122, ENST00000654193, ENST00000654606, ENST00000654738, ENST00000654886, ENST00000654991, ENST00000655236, ENST00000655576, ENST00000655632, ENST00000655726, ENST00000656220, ENST00000656377, ENST00000656938, ENST00000657271, ENST00000657569, ENST00000658470, ENST00000659070, ENST00000659128, ENST00000659163, ENST00000659313, ENST00000659529, ENST00000659639, ENST00000659733, ENST00000660181, ENST00000660791, ENST00000661277, ENST00000661501, ENST00000661880, ENST00000662122, ENST00000662260, ENST00000662365, ENST00000662695, ENST00000662771, ENST00000662939, ENST00000663277, ENST00000663746, ENST00000663876, ENST00000663938, ENST00000664244, ENST00000664312, ENST00000664315, ENST00000664562, ENST00000664631, ENST00000664655, ENST00000664979, ENST00000665128, ENST00000665277, ENST00000665785, ENST00000666113, ENST00000666248, ENST00000666530, ENST00000667110, ENST00000667121, ENST00000667574, ENST00000667688, ENST00000668213, ENST00000668453, ENST00000668624, ENST00000668802, ENST00000668965, ENST00000669496, ENST00000669545, ENST00000669637, ENST00000669786, ENST00000670027, ENST00000670042, ENST00000670205, ENST00000670604, ENST00000670901, ENST00000671113, ENST00000671435, ENST00000671636, ENST00000671642, ENST00000701655, ENST00000731042, ENST00000731043, ENST00000731044, ENST00000731045

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000564048 — 4 exons

Exon	Start	End
ENSE00002581435	49336661	49336877
ENSE00002606661	49337232	49338438
ENSE00003829571	49330467	49330656
ENSE00003830371	49282098	49282232

Expression profiles

Bgee: expression breadth ubiquitous, 151 present calls, max score 97.33.

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cerebellar hemisphere	UBERON:0002245	97.33	gold quality
cerebellar cortex	UBERON:0002129	97.27	gold quality
right hemisphere of cerebellum	UBERON:0014890	96.49	gold quality
cerebellum	UBERON:0002037	96.42	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.93	gold quality
cerebellar vermis	UBERON:0004720	81.92	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.89	gold quality
buccal mucosa cell	CL:0002336	73.02	gold quality
right testis	UBERON:0004534	72.96	gold quality
left testis	UBERON:0004533	71.83	gold quality
testis	UBERON:0000473	70.61	gold quality
hypothalamus	UBERON:0001898	70.18	gold quality
bone marrow cell	CL:0002092	70.01	gold quality
pancreatic ductal cell	CL:0002079	68.20	silver quality
mucosa of transverse colon	UBERON:0004991	66.09	gold quality
cortical plate	UBERON:0005343	64.36	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.33	gold quality
ganglionic eminence	UBERON:0004023	63.47	gold quality
right frontal lobe	UBERON:0002810	62.73	gold quality
ventricular zone	UBERON:0003053	62.27	gold quality
spinal cord	UBERON:0002240	62.18	gold quality
Brodmann (1909) area 9	UBERON:0013540	61.90	gold quality
adenohypophysis	UBERON:0002196	61.45	gold quality
prefrontal cortex	UBERON:0000451	61.23	gold quality
gall bladder	UBERON:0002110	61.14	gold quality
islet of Langerhans	UBERON:0000006	60.97	gold quality
substantia nigra	UBERON:0002038	60.19	gold quality
heart left ventricle	UBERON:0002084	60.00	gold quality
brain	UBERON:0000955	59.97	gold quality
hindlimb stylopod muscle	UBERON:0004252	59.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.02

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.