SYNE1-AS1

Summary

SYNE1-AS1 (SYNE1 antisense RNA 1, HGNC:40793) is a long non-coding RNA gene on chromosome 6q25.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40793
Approved symbol	SYNE1-AS1
Name	SYNE1 antisense RNA 1
Location	6q25.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000234577
Ensembl biotype	lncRNA
Entrez	100505475
RNAcentral	URS000075D5DF — lncRNA, 718 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000412161

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000412161 — 2 exons

Exon	Start	End
ENSE00004142692	152381060	152381777
ENSE00004142693	152380489	152380593

Expression profiles

Bgee: expression breadth ubiquitous, 113 present calls, max score 71.07.

Top tissues by expression

113 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	71.07	silver quality
skeletal muscle tissue	UBERON:0001134	69.42	gold quality
ganglionic eminence	UBERON:0004023	66.77	gold quality
ventricular zone	UBERON:0003053	66.50	gold quality
bone marrow	UBERON:0002371	64.66	silver quality
hindlimb stylopod muscle	UBERON:0004252	61.90	gold quality
gall bladder	UBERON:0002110	61.09	gold quality
smooth muscle tissue	UBERON:0001135	60.24	gold quality
heart left ventricle	UBERON:0002084	59.98	gold quality
islet of Langerhans	UBERON:0000006	59.58	gold quality
heart	UBERON:0000948	58.94	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	57.98	gold quality
prefrontal cortex	UBERON:0000451	57.80	gold quality
liver	UBERON:0002107	57.70	gold quality
right atrium auricular region	UBERON:0006631	57.32	gold quality
adrenal tissue	UBERON:0018303	57.27	gold quality
right coronary artery	UBERON:0001625	56.80	gold quality
left coronary artery	UBERON:0001626	56.28	gold quality
blood	UBERON:0000178	56.15	gold quality
tibial artery	UBERON:0007610	55.63	gold quality
popliteal artery	UBERON:0002250	55.57	gold quality
calcaneal tendon	UBERON:0003701	55.52	gold quality
muscle of leg	UBERON:0001383	55.35	gold quality
monocyte	CL:0000576	55.19	gold quality
thoracic aorta	UBERON:0001515	54.40	gold quality
ascending aorta	UBERON:0001496	54.27	gold quality
lymph node	UBERON:0000029	54.23	gold quality
adult mammalian kidney	UBERON:0000082	53.82	gold quality
pancreas	UBERON:0001264	53.56	gold quality
gastrocnemius	UBERON:0001388	53.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• rescue assays demonstrated the function of SP1-SYNE1-AS1 axis in Cardiac hypertrophy (CH). In conclusion, SP1-induced upregulation of lncRNA SYNE1-AS1 promoted CH via miR-525-5p/SP1 axis. (PMID:30652310)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.