SYNGR2

Summary

SYNGR2 (synaptogyrin 2, HGNC:11499) is a protein-coding gene on chromosome 17q25.3, encoding Synaptogyrin-2 (O43760). May play a role in regulated exocytosis.

This gene encodes an integral membrane protein containing four transmembrane regions and a C-terminal cytoplasmic tail that is tyrosine phosphorylated. The exact function of this protein is unclear, but studies of a similar rat protein suggest that it may play a role in regulating membrane traffic in non-neuronal cells. The gene belongs to the synaptogyrin gene family. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 9144 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 35 total
• Druggable target: yes
• MANE Select transcript: NM_004710

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11499
Approved symbol	SYNGR2
Name	synaptogyrin 2
Location	17q25.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000108639
Ensembl biotype	protein_coding
OMIM	603926
Entrez	9144

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 11 protein_coding, 1 nonsense_mediated_decay, 1 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000225777, ENST00000585591, ENST00000588282, ENST00000589168, ENST00000589183, ENST00000589711, ENST00000590201, ENST00000591770, ENST00000592456, ENST00000862683, ENST00000862684, ENST00000862685, ENST00000862686, ENST00000968423

RefSeq mRNA: 3 — MANE Select: NM_004710 NM_001320523, NM_001363778, NM_004710

CCDS: CCDS11753, CCDS86641

Canonical transcript exons

ENST00000225777 — 4 exons

Exon	Start	End
ENSE00002946163	78168581	78168715
ENSE00003491282	78171510	78171649
ENSE00003528925	78170817	78171054
ENSE00003907923	78171739	78172720

Expression profiles

Bgee: expression breadth ubiquitous, 288 present calls, max score 98.68.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 69.5317 / max 632.9244, expressed in 1786 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
163033	69.0736	1786
163034	0.3891	146
163035	0.0689	17

Top tissues by expression

291 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	98.68	gold quality
right lung	UBERON:0002167	98.40	gold quality
body of pancreas	UBERON:0001150	98.37	gold quality
minor salivary gland	UBERON:0001830	98.31	gold quality
upper lobe of left lung	UBERON:0008952	98.17	gold quality
body of stomach	UBERON:0001161	98.13	gold quality
gastrocnemius	UBERON:0001388	98.12	gold quality
hindlimb stylopod muscle	UBERON:0004252	98.10	gold quality
skin of abdomen	UBERON:0001416	98.05	gold quality
skin of leg	UBERON:0001511	98.03	gold quality
saliva-secreting gland	UBERON:0001044	97.93	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	97.90	gold quality
upper lobe of lung	UBERON:0008948	97.90	gold quality
granulocyte	CL:0000094	97.85	gold quality
mucosa of stomach	UBERON:0001199	97.83	gold quality
spleen	UBERON:0002106	97.71	gold quality
lymph node	UBERON:0000029	97.67	gold quality
mouth mucosa	UBERON:0003729	97.64	gold quality
right coronary artery	UBERON:0001625	97.59	gold quality
lower esophagus muscularis layer	UBERON:0035833	97.56	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	97.56	gold quality
small intestine Peyer’s patch	UBERON:0003454	97.54	gold quality
lower esophagus	UBERON:0013473	97.54	gold quality
apex of heart	UBERON:0002098	97.52	gold quality
metanephros cortex	UBERON:0010533	97.42	gold quality
vermiform appendix	UBERON:0001154	97.36	gold quality
muscle of leg	UBERON:0001383	97.36	gold quality
spinal cord	UBERON:0002240	97.35	gold quality
esophagus	UBERON:0001043	97.29	gold quality
monocyte	CL:0000576	97.28	gold quality

Single-cell (SCXA)

Detected in 15 experiment(s), a significant marker in 15.

Experiment	Marker?	Max mean expression
E-MTAB-10855	yes	316.41
E-CURD-122	yes	99.48
E-MTAB-8142	yes	25.82
E-HCAD-13	yes	23.69
E-MTAB-9467	yes	21.03
E-CURD-46	yes	20.72
E-MTAB-9067	yes	14.51
E-MTAB-8498	yes	9.56
E-MTAB-9388	yes	8.09
E-MTAB-6678	yes	7.26
E-CURD-112	yes	5.20
E-MTAB-10042	yes	4.55
E-CURD-88	yes	4.48
E-MTAB-9801	yes	4.32
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): MYC

miRNA regulators (miRDB)

43 targeting SYNGR2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-4779	99.86	66.50	1583
HSA-MIR-609	99.82	64.26	505
HSA-MIR-34B-5P	99.78	67.56	1175
HSA-MIR-449C-5P	99.78	67.63	1168
HSA-MIR-320A-3P	99.77	69.73	2107
HSA-MIR-320B	99.77	69.73	2107
HSA-MIR-320C	99.77	69.73	2107
HSA-MIR-320D	99.77	69.73	2107
HSA-MIR-4429	99.77	69.62	2111
HSA-MIR-7856-5P	99.75	69.99	2901
HSA-MIR-2682-5P	99.73	67.38	1055
HSA-MIR-4699-3P	99.71	70.15	3142
HSA-MIR-3158-5P	99.65	67.51	1763
HSA-MIR-6715B-5P	99.64	69.63	1420
HSA-MIR-1287-3P	99.63	66.93	492
HSA-MIR-4499	99.62	67.29	1470
HSA-MIR-4269	99.55	69.89	1373
HSA-MIR-1912-3P	99.32	67.40	936
HSA-MIR-4685-5P	99.25	65.99	1563
HSA-MIR-6837-5P	99.25	65.47	1632
HSA-MIR-6734-3P	99.15	66.27	1627
HSA-MIR-4687-5P	99.14	66.26	488
HSA-MIR-4695-5P	99.06	64.87	1151
HSA-MIR-1295B-5P	99.03	67.50	810
HSA-MIR-935	98.82	69.36	1072
HSA-MIR-6776-5P	98.54	67.43	1304
HSA-MIR-4266	98.53	67.29	1035
HSA-MIR-6827-5P	98.46	64.88	1256

Literature-anchored findings (GeneRIF, showing 2)

• synaptogyrin-2 is essential to promoting the formation of the IBs to become virus factories for viral RNA replication through its interaction with NSs. These findings unveil the function of synaptogyrin-2 as an enhancer in viral infection. (PMID:27226560)
• Pan-cancer analysis of SYNGR2 with a focus on clinical implications and immune landscape in liver hepatocellular carcinoma. (PMID:37170221)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	syngr2b	ENSDARG00000104470
mus_musculus	Syngr2	ENSMUSG00000048277
rattus_norvegicus	Syngr2	ENSRNOG00000050547
caenorhabditis_elegans		WBGENE00004912

Paralogs (3): SYNGR1 (ENSG00000100321), SYNGR4 (ENSG00000105467), SYNGR3 (ENSG00000127561)

Protein

Protein identifiers

Synaptogyrin-2 — O43760 (reviewed: O43760)

Alternative names: Cellugyrin

All UniProt accessions (5): O43760, K7EJ35, K7ELD9, K7ELS8, K7ENG9

UniProt curated annotations — full annotation on UniProt →

Function. May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane. (Microbial infection) May play a role in the assembly of cytoplasmic inclusion bodies required for SFTS phlebovirus replication.

Subunit / interactions. (Microbial infection) Interacts with SFTS phlebovirus protein NSs; may be involved in virus replication.

Subcellular location. Cytoplasmic vesicle membrane. Cytoplasmic vesicle. Secretory vesicle. Synaptic vesicle membrane Lipid droplet.

Tissue specificity. Ubiquitous; low expression in brain.

Post-translational modifications. May be tyrosine phosphorylated by Src.

Induction. (Microbial infection) Up-regulated upon SFTS phlebovirus infection (at protein level).

Similarity. Belongs to the synaptogyrin family.

Isoforms (2)

UniProt ID	Names	Canonical?
O43760-1	1	yes
O43760-2	2

RefSeq proteins (3): NP_001307452, NP_001350707, NP_004701* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR008253	Marvel	Domain
IPR016579	Synaptogyrin	Family

Pfam: PF01284

UniProt features (10 total): transmembrane region 4, modified residue 2, chain 1, domain 1, splice variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O43760-F1	81.52	0.50

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 1, 3

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 223 (showing top): WANG_RECURRENT_LIVER_CANCER_UP, ASTON_MAJOR_DEPRESSIVE_DISORDER_DN, GOBP_VESICLE_MEDIATED_TRANSPORT, BROWNE_HCMV_INFECTION_24HR_UP, GOBP_EXOCYTOSIS, LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_UP, GOBP_SECRETION, GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION, TIEN_INTESTINE_PROBIOTICS_24HR_UP, GOBP_MEMBRANE_ORGANIZATION, CHEN_HOXA5_TARGETS_9HR_DN, ZHU_CMV_24_HR_UP, DANG_BOUND_BY_MYC, SCHLOSSER_SERUM_RESPONSE_AUGMENTED_BY_MYC, NIKOLSKY_BREAST_CANCER_17Q21_Q25_AMPLICON

GO Biological Process (2): regulated exocytosis (GO:0045055), synaptic vesicle membrane organization (GO:0048499)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (9): lipid droplet (GO:0005811), membrane (GO:0016020), synaptic vesicle membrane (GO:0030672), neuromuscular junction (GO:0031594), extracellular exosome (GO:0070062), synaptic vesicle (GO:0008021), cytoplasmic vesicle membrane (GO:0030659), cytoplasmic vesicle (GO:0031410), synapse (GO:0045202)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
exocytosis	1
endomembrane system organization	1
membrane organization	1
binding	1
intracellular membraneless organelle	1
cellular anatomical structure	1
synaptic vesicle	1
exocytic vesicle membrane	1
synapse	1
extracellular vesicle	1
exocytic vesicle	1
presynapse	1
vesicle membrane	1
cytoplasmic vesicle	1
cytoplasm	1
intracellular vesicle	1
cell junction	1

Protein interactions and networks

STRING

759 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SYNGR2	TMC8	Q8IU68	922
SYNGR2	TMC6	Q7Z403	902
SYNGR2	TK1	P04183	737
SYNGR2	SYNPR	Q8TBG9	734
SYNGR2	CANX	P27824	641
SYNGR2	ANKFN1	Q8N957	471
SYNGR2	TMEM235	A6NFC5	446
SYNGR2	C17orf67	Q0P5P2	435
SYNGR2	TMEM50B	P56557	431
SYNGR2	ITSN2	Q9NZM3	393
SYNGR2	FLYWCH2	Q96CP2	387
SYNGR2	A0A0A6YYG9	A0A0A6YYG9	380
SYNGR2	VRTN	Q9H8Y1	373
SYNGR2	TMEM181	Q9P2C4	368
SYNGR2	C17orf99	Q6UX52	366

IntAct

96 interactions, top by confidence:

A	B	Type	Score
PRELID1	TRIAP1	psi-mi:“MI:0914”(association)	0.730
SCARA3	SYNGR2	psi-mi:“MI:0915”(physical association)	0.560
SYNGR2	SCARA3	psi-mi:“MI:0915”(physical association)	0.560
SYNGR2	GPR35	psi-mi:“MI:0915”(physical association)	0.550
SLC7A1	TMEM223	psi-mi:“MI:0914”(association)	0.530
HTR2C	KLRG2	psi-mi:“MI:0914”(association)	0.530
ADGRG5	KLRG2	psi-mi:“MI:0914”(association)	0.530
GPR52	SYNGR2	psi-mi:“MI:0914”(association)	0.530
SLCO1B1	SYNGR2	psi-mi:“MI:0914”(association)	0.530
ANKRD22	ESYT2	psi-mi:“MI:0914”(association)	0.530
PCDHAC2	TMEM223	psi-mi:“MI:0914”(association)	0.530
SLC22A9	GPR89A	psi-mi:“MI:0914”(association)	0.530
LPAR1	TMEM223	psi-mi:“MI:0914”(association)	0.530
PRRT2	NDUFS4	psi-mi:“MI:0914”(association)	0.530
SYNGR2	BDKRB2	psi-mi:“MI:0915”(physical association)	0.370
SYNGR2	C5AR2	psi-mi:“MI:0915”(physical association)	0.370
SYNGR2	CCR4	psi-mi:“MI:0915”(physical association)	0.370
SYNGR2	DRD2	psi-mi:“MI:0915”(physical association)	0.370
SYNGR2	F2RL1	psi-mi:“MI:0915”(physical association)	0.370
SYNGR2	LTB4R2	psi-mi:“MI:0915”(physical association)	0.370
SYNGR2	E6	psi-mi:“MI:0915”(physical association)	0.370
SYNGR2	FATE1	psi-mi:“MI:0915”(physical association)	0.370
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
ADGRE5	TMEM223	psi-mi:“MI:0914”(association)	0.350
PCDHAC2	TMEM223	psi-mi:“MI:0914”(association)	0.350
VIPR2	C15orf61	psi-mi:“MI:0914”(association)	0.350
FPR2	GPR89A	psi-mi:“MI:0914”(association)	0.350
TACR1	GPR89A	psi-mi:“MI:0914”(association)	0.350

BioGRID (105): SCARA3 (Two-hybrid), SYNGR2 (Affinity Capture-MS), SYNGR2 (Affinity Capture-MS), SYNGR2 (Affinity Capture-MS), SYNGR2 (Two-hybrid), SYNGR2 (Two-hybrid), SYNGR2 (Affinity Capture-MS), SYNGR2 (Affinity Capture-MS), SYNGR2 (Affinity Capture-MS), SYNGR2 (Affinity Capture-MS), SYNGR2 (Affinity Capture-MS), SYNGR2 (Affinity Capture-MS), SYNGR2 (Affinity Capture-MS), SYNGR2 (Affinity Capture-MS), SYNGR2 (Affinity Capture-MS)

ESM2 similar proteins: A2VE58, A3KQ86, A6H7B0, A7E3W5, A8MWL6, B2RZ87, O43759, O43760, O43761, O54980, O55100, O55101, O76735, O95473, P07825, P08247, P0DI73, P20488, P22831, P47987, P79826, Q08AU7, Q08DL4, Q28793, Q2YDD6, Q5EBF8, Q5R703, Q5RER2, Q5XGR0, Q5XIT3, Q5YJC1, Q62277, Q62876, Q642A2, Q6RW13, Q7JYV2, Q7TQJ1, Q8BGN8, Q8R191, Q8TBG9

Diamond homologs: A2VE58, A7E3W5, A8MWL6, O43759, O43760, O43761, O54980, O55100, O55101, O76735, O95473, Q2YDD6, Q5R703, Q62876, Q7JYV2, Q8R191, Q9Z1L2

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 105 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Class A/1 (Rhodopsin-like receptors)	13	15.8×	4e-10
GPCR ligand binding	13	13.7×	1e-09
Peptide ligand-binding receptors	8	9.7×	8e-05
Signaling by GPCR	13	8.5×	3e-07
G alpha (q) signalling events	9	8.5×	6e-05
G alpha (s) signalling events	7	8.4×	7e-04
GPCR downstream signalling	11	7.8×	1e-05
G alpha (i) signalling events	10	6.4×	1e-04

GO biological processes:

GO term	Partners	Fold	FDR
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	9	22.4×	4e-08
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	5	19.1×	6e-04
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	5	17.7×	7e-04
positive regulation of cytosolic calcium ion concentration	13	17.3×	4e-10
phospholipase C-activating G protein-coupled receptor signaling pathway	11	16.5×	2e-08
adenylate cyclase-activating G protein-coupled receptor signaling pathway	10	12.8×	8e-07
chemotaxis	7	10.8×	4e-04
G protein-coupled receptor signaling pathway	17	7.0×	4e-08

Disease & clinical

Clinical variants and AI predictions

ClinVar

35 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	23
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

649 predictions. Top by Δscore:

Variant	Effect	Δscore
17:78168716:G:GA	donor_loss	1.0000
17:78168716:G:GG	donor_gain	1.0000
17:78168717:T:G	donor_loss	1.0000
17:78170849:T:TA	acceptor_gain	1.0000
17:78171054:GGTAT:G	donor_loss	1.0000
17:78171055:G:GC	donor_loss	1.0000
17:78171504:CCCCA:C	acceptor_loss	1.0000
17:78171505:CCCAG:C	acceptor_loss	1.0000
17:78171506:CCA:C	acceptor_loss	1.0000
17:78171507:CAGC:C	acceptor_loss	1.0000
17:78171508:A:AG	acceptor_gain	1.0000
17:78171509:G:GG	acceptor_gain	1.0000
17:78171509:GCT:G	acceptor_gain	1.0000
17:78171646:CTGG:C	donor_loss	1.0000
17:78171648:GG:G	donor_gain	1.0000
17:78171649:GG:G	donor_gain	1.0000
17:78171650:G:GG	donor_gain	1.0000
17:78171651:T:A	donor_loss	1.0000
17:78171734:T:TA	acceptor_gain	1.0000
17:78171734:TGCA:T	acceptor_loss	1.0000
17:78171737:A:AG	acceptor_gain	1.0000
17:78171737:A:T	acceptor_loss	1.0000
17:78171737:AG:A	acceptor_gain	1.0000
17:78171737:AGG:A	acceptor_gain	1.0000
17:78171737:AGGGT:A	acceptor_gain	1.0000
17:78171738:G:GC	acceptor_gain	1.0000
17:78171738:GG:G	acceptor_gain	1.0000
17:78171738:GGG:G	acceptor_gain	1.0000
17:78171738:GGGT:G	acceptor_gain	1.0000
17:78171738:GGGTG:G	acceptor_gain	1.0000

AlphaMissense

1463 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:78171539:T:C	F123L	0.983
17:78171541:C:A	F123L	0.983
17:78171541:C:G	F123L	0.983
17:78171626:A:C	S152R	0.982
17:78171628:C:A	S152R	0.982
17:78171628:C:G	S152R	0.982
17:78171515:T:A	W115R	0.974
17:78171515:T:C	W115R	0.974
17:78171647:T:A	W159R	0.974
17:78171647:T:C	W159R	0.974
17:78171527:T:A	W119R	0.972
17:78171527:T:C	W119R	0.972
17:78171883:T:C	F208L	0.956
17:78171885:C:A	F208L	0.956
17:78171885:C:G	F208L	0.956
17:78171623:T:C	F151L	0.949
17:78171625:C:A	F151L	0.949
17:78171625:C:G	F151L	0.949
17:78171560:T:A	W130R	0.947
17:78171560:T:C	W130R	0.947
17:78171562:G:C	W130C	0.945
17:78171562:G:T	W130C	0.945
17:78171739:G:C	G160R	0.943
17:78171019:G:C	R101P	0.930
17:78171536:G:C	G122R	0.930
17:78171031:T:A	V105D	0.929
17:78170835:T:C	F40L	0.927
17:78170837:C:A	F40L	0.927
17:78170837:C:G	F40L	0.927
17:78168701:C:A	R29S	0.922

dbSNP variants (sampled 300 via entrez): RS1000204801 (17:78168376 C>G), RS1000633548 (17:78172066 G>A,C), RS1001118230 (17:78167137 T>A), RS1001710991 (17:78168073 C>T), RS1001791632 (17:78172441 C>A), RS1001951393 (17:78167408 G>GT), RS1002089454 (17:78172309 T>C,G), RS1002395769 (17:78168314 G>C), RS1002893358 (17:78169269 T>C,G), RS1003737771 (17:78173021 T>G), RS1003981144 (17:78173121 C>T), RS1004187537 (17:78166579 A>T), RS1004463446 (17:78173295 T>C), RS1004814932 (17:78166625 G>A), RS1006559859 (17:78170005 C>T)

Disease associations

OMIM: gene MIM:603926 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST003325_4	Lung cancer	4.000000e-07
GCST003326_4	Adenocarcinoma	1.000000e-06
GCST90002403_324	Red blood cell count	1.000000e-12

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004305	erythrocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066492 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 4 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.72	Kd	1906	nM	CHEMBL5653589
5.72	ED50	1906	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 4 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149534: Binding affinity to human SYNGR2 incubated for 45 mins by Kinobead based pull down assay	kd	1.9062	uM

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression, increases methylation	6
aristolochic acid I	decreases expression	1
FR900359	increases phosphorylation	1
triphenyl phosphate	affects expression	1
bisphenol A	affects cotreatment, increases methylation	1
arsenite	affects binding, decreases reaction	1
sodium arsenite	increases expression	1
cobaltous chloride	decreases expression	1
potassium chromate(VI)	increases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
entinostat	increases expression	1
2,2’,4,4’,5-brominated diphenyl ether	increases expression	1
MT19c compound	decreases expression	1
Bortezomib	decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Benzo(a)pyrene	increases methylation	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Diethylhexyl Phthalate	increases expression	1
Doxorubicin	increases expression	1
Estradiol	affects cotreatment, decreases expression	1
Ivermectin	decreases expression	1
Smoke	decreases expression	1
Thiram	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Tretinoin	decreases expression	1
Triclosan	decreases expression	1
Vanadates	decreases expression	1
1-Methyl-4-phenylpyridinium	increases expression	1
Antirheumatic Agents	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652576	Binding	Binding affinity to human SYNGR2 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B3IT	Abcam HEK293T SYNGR2 KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.