SYNJ2BP

Summary

SYNJ2BP (synaptojanin 2 binding protein, HGNC:18955) is a protein-coding gene on chromosome 14q24.2, encoding Synaptojanin-2-binding protein (P57105). Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction.

Predicted to enable type II activin receptor binding activity. Involved in several processes, including negative regulation of endothelial cell migration; negative regulation of sprouting angiogenesis; and regulation of signal transduction. Located in mitochondrial outer membrane.

Source: NCBI Gene 55333 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 4 total
• MANE Select transcript: NM_018373

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18955
Approved symbol	SYNJ2BP
Name	synaptojanin 2 binding protein
Location	14q24.2
Locus type	gene with protein product
Status	Approved
Aliases	Arip2
Ensembl gene	ENSG00000213463
Ensembl biotype	protein_coding
OMIM	609411
Entrez	55333

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 6 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000256366, ENST00000554216, ENST00000863002, ENST00000863003, ENST00000863004, ENST00000863005, ENST00000936942

RefSeq mRNA: 1 — MANE Select: NM_018373 NM_018373

CCDS: CCDS9803

Canonical transcript exons

ENST00000256366 — 4 exons

Exon	Start	End
ENSE00000658851	70388470	70388606
ENSE00000807864	70366499	70373131
ENSE00002533202	70416900	70417090
ENSE00003584628	70375676	70375771

Expression profiles

Bgee: expression breadth ubiquitous, 290 present calls, max score 96.94.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 20.3357 / max 188.6881, expressed in 1723 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
143916	20.3357	1723

Top tissues by expression

296 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
renal medulla	UBERON:0000362	96.94	gold quality
cardia of stomach	UBERON:0001162	96.77	gold quality
body of tongue	UBERON:0011876	95.49	gold quality
pylorus	UBERON:0001166	95.24	gold quality
saphenous vein	UBERON:0007318	95.07	gold quality
biceps brachii	UBERON:0001507	94.81	gold quality
jejunum	UBERON:0002115	94.79	gold quality
vena cava	UBERON:0004087	94.78	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	94.61	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	94.52	gold quality
urethra	UBERON:0000057	94.47	gold quality
oocyte	CL:0000023	94.05	gold quality
jejunal mucosa	UBERON:0000399	93.76	gold quality
trigeminal ganglion	UBERON:0001675	93.67	gold quality
heart right ventricle	UBERON:0002080	93.51	gold quality
superior surface of tongue	UBERON:0007371	92.55	gold quality
epithelium of nasopharynx	UBERON:0001951	92.43	gold quality
nasopharynx	UBERON:0001728	92.41	gold quality
dorsal root ganglion	UBERON:0000044	92.23	gold quality
vastus lateralis	UBERON:0001379	92.16	gold quality
mucosa of sigmoid colon	UBERON:0004993	92.08	gold quality
tongue	UBERON:0001723	92.02	gold quality
seminal vesicle	UBERON:0000998	91.88	gold quality
pericardium	UBERON:0002407	91.86	gold quality
duodenum	UBERON:0002114	91.76	gold quality
left ventricle myocardium	UBERON:0006566	91.60	gold quality
subthalamic nucleus	UBERON:0001906	91.56	gold quality
myocardium	UBERON:0002349	91.52	gold quality
cauda epididymis	UBERON:0004360	91.38	gold quality
visceral pleura	UBERON:0002401	91.24	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	12.26
E-GEOD-111727	no	1165.45

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

252 targeting SYNJ2BP, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-511-3P	99.99	68.85	1467
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-1229-3P	99.97	66.49	906
HSA-MIR-512-3P	99.97	67.35	1049

Literature-anchored findings (GeneRIF, showing 8)

• These results suggest that ARIP2 is a putative growth-promoting factor involved in breast tumorigenesis and tumor development. (PMID:19349195)
• Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis. (PMID:24025447)
• Ubiquilins are a family of chaperones for cytosolically exposed transmembrane domains and use ubiquitin to triage clients, like Omp25, for degradation via coordinated intra- and intermolecular interactions. (PMID:27345149)
• Data found that SYNJ2BP was decreased in hepatocellular carcinoma (HCC) tissues and cell lines and provide evidence that SYNJ2BP may act as a tumor suppressor during HCC development activating DLL4 pathway. (PMID:27440153)
• The increased ARIP2 in the LPS-activated macrophages may play an anti-inflammatory role via inhibiting the production of pro-inflammatory cytokines by feedback regulation, which is related to the inhibition of CD14 expression on macrophages. (PMID:28871189)
• The mitochondrial outer membrane protein SYNJ2BP interacts with the cell adhesion molecule TMIGD1 and can recruit it to mitochondria. (PMID:32303178)
• The PDZ Domain Protein SYNJ2BP Regulates GRK-Dependent Sst2A Phosphorylation and Downstream MAPK Signaling. (PMID:33313679)
• SYNJ2BP ameliorates intervertebral disc degeneration by facilitating mitochondria-associated endoplasmic reticulum membrane formation and mitochondrial Zn[2+] homeostasis. (PMID:38158052)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	synj2bp	ENSDARG00000028321
mus_musculus	Synj2bp	ENSMUSG00000090935
rattus_norvegicus	Synj2bp	ENSRNOG00000006399

Paralogs (2): COX16 (ENSG00000133983), KIAA1614 (ENSG00000135835)

Protein

Protein identifiers

Synaptojanin-2-binding protein — P57105 (reviewed: P57105)

Alternative names: Mitochondrial outer membrane protein 25

All UniProt accessions (1): P57105

UniProt curated annotations — full annotation on UniProt →

Function. Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction.

Subunit / interactions. Binds (via the PDZ domain) to isoform 2A of SYNJ2 (via the unique motif in the C-terminus). Interacts (via C-terminus) with RALBP1. Interacts (via PDZ domain) with ACVR2A (via C-terminus) and ACVR2B (via C-terminus). Forms a ternary complex with ACVR2A and RALBP1. Interacts with MAPK12. Interacts with DLL1; enhances DLL1 protein stability, and promotes notch signaling in endothelial cells.

Subcellular location. Mitochondrion outer membrane.

RefSeq proteins (1): NP_060843* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001478	PDZ	Domain
IPR036034	PDZ_sf	Homologous_superfamily
IPR050614	Synaptic_Scaffolding_LAP-MAGUK	Family

Pfam: PF00595

UniProt features (19 total): strand 8, helix 3, topological domain 2, chain 1, turn 1, transmembrane region 1, domain 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

9 structures.

PDB	Method	Resolution (Å)
2JIK	X-RAY DIFFRACTION	1.35
2JIN	X-RAY DIFFRACTION	1.5
7P73	X-RAY DIFFRACTION	1.85
7P74	X-RAY DIFFRACTION	1.9
8AEL	X-RAY DIFFRACTION	2.2
7PC9	X-RAY DIFFRACTION	2.4
7R2M	X-RAY DIFFRACTION	2.4
7R2T	X-RAY DIFFRACTION	2.5
2ENO	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P57105-F1	78.60	0.54

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 194 (showing top): GOBP_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION, GOBP_NEGATIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE, BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, GOBP_PROTEIN_TARGETING, GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_NEGATIVE_REGULATION_OF_MAPK_CASCADE, GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT, GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS, GOBP_SPROUTING_ANGIOGENESIS, chr14q24, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, GOBP_NEGATIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS, GOBP_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION

GO Biological Process (9): negative regulation of endothelial cell proliferation (GO:0001937), protein targeting (GO:0006605), Rho protein signal transduction (GO:0007266), regulation of Notch signaling pathway (GO:0008593), negative regulation of endothelial cell migration (GO:0010596), negative regulation of angiogenesis (GO:0016525), regulation of endocytosis (GO:0030100), negative regulation of ERK1 and ERK2 cascade (GO:0070373), negative regulation of sprouting angiogenesis (GO:1903671)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (3): mitochondrion (GO:0005739), mitochondrial outer membrane (GO:0005741), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
endothelial cell proliferation	1
regulation of endothelial cell proliferation	1
negative regulation of epithelial cell proliferation	1
establishment of protein localization	1
small GTPase-mediated signal transduction	1
Notch signaling pathway	1
regulation of signal transduction	1
regulation of endothelial cell migration	1
negative regulation of cell migration	1
endothelial cell migration	1
angiogenesis	1
regulation of angiogenesis	1
negative regulation of blood vessel morphogenesis	1
endocytosis	1
regulation of cellular component organization	1
regulation of vesicle-mediated transport	1
negative regulation of MAPK cascade	1
ERK1 and ERK2 cascade	1
regulation of ERK1 and ERK2 cascade	1
sprouting angiogenesis	1
negative regulation of angiogenesis	1
regulation of sprouting angiogenesis	1
binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
mitochondrial membrane	1
organelle outer membrane	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1076 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SYNJ2BP	A0A087WVV2	A0A087WVV2	987
SYNJ2BP	SYNJ2	O15056	892
SYNJ2BP	ABITRAM	Q9NX38	826
SYNJ2BP	RALA	P11233	776
SYNJ2BP	PEX26	Q7Z412	700
SYNJ2BP	SLAMF1	Q13291	672
SYNJ2BP	AMPH	P49418	669
SYNJ2BP	PEX6	Q13608	668
SYNJ2BP	SYNJ1	O43426	667
SYNJ2BP	ACVR2A	P27037	656
SYNJ2BP	TMIGD1	Q6UXZ0	623
SYNJ2BP	BIN1	O00499	549
SYNJ2BP	TOMM20	Q15388	505
SYNJ2BP	SH3GL2	Q99962	505
SYNJ2BP	BCAP31	P51572	496

IntAct

545 interactions, top by confidence:

A	B	Type	Score
ESYT1	ESYT2	psi-mi:“MI:0914”(association)	0.770
SYNJ2BP	USHBP1	psi-mi:“MI:0915”(physical association)	0.720
USHBP1	SYNJ2BP	psi-mi:“MI:0915”(physical association)	0.720
SYNJ2BP	AQP6	psi-mi:“MI:0915”(physical association)	0.680
E6	SYNJ2BP	psi-mi:“MI:0407”(direct interaction)	0.640
Tax	SYNJ2BP	psi-mi:“MI:0407”(direct interaction)	0.640
SYNJ2BP	Tax	psi-mi:“MI:0915”(physical association)	0.640
SYNJ2BP	E6	psi-mi:“MI:0915”(physical association)	0.640
SYNJ2BP	DLL1	psi-mi:“MI:0915”(physical association)	0.610
SYNJ2BP	RPS6KA1	psi-mi:“MI:0407”(direct interaction)	0.610
E6	SYNJ2BP	psi-mi:“MI:0407”(direct interaction)	0.610
SYNJ2BP	E6	psi-mi:“MI:0915”(physical association)	0.610
RPS6KA1	SYNJ2BP	psi-mi:“MI:0915”(physical association)	0.610
NET1	SYNJ2BP	psi-mi:“MI:0407”(direct interaction)	0.610
SLC16A3	CASK	psi-mi:“MI:0914”(association)	0.590
KARS1	SYNJ2BP	psi-mi:“MI:0407”(direct interaction)	0.590
RRBP1	SYNJ2BP	psi-mi:“MI:0407”(direct interaction)	0.590
VANGL1	SYNJ2BP	psi-mi:“MI:0407”(direct interaction)	0.590
SYNJ2BP	DLL4	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (167): USHBP1 (Two-hybrid), SYNJ2BP (Affinity Capture-MS), SYNJ2BP (Affinity Capture-MS), SYNJ2BP (Affinity Capture-MS), SYNJ2BP (Affinity Capture-MS), SYNJ2BP (Two-hybrid), BAG6 (Reconstituted Complex), UBQLN1 (Reconstituted Complex), UBQLN4 (Reconstituted Complex), ASNA1 (Reconstituted Complex), UBL4A (Reconstituted Complex), UBQLN2 (Reconstituted Complex), UBQLN1 (Reconstituted Complex), SYNJ2BP (Affinity Capture-MS), SYNJ2BP (Protein-peptide)

ESM2 similar proteins: A0A8C0TYJ0, A0A8I5ZNK2, A6QQZ7, A8KBF6, B2RYD2, O00560, O88506, O95747, P19517, P31016, P57105, P70175, P78352, Q12959, Q15139, Q15700, Q28C55, Q3T0C9, Q3US41, Q5PYH5, Q5PYH6, Q5PYH7, Q5R495, Q5T2T1, Q5U2Y3, Q62108, Q62696, Q62936, Q63622, Q640Z1, Q6DEZ7, Q6DJD3, Q6NXB2, Q6NXG1, Q6P0D7, Q6P9R2, Q6R005, Q7ZY29, Q811D0, Q863I2

Diamond homologs: A0A0G2K2P5, A0A8P0N4K0, C5IAW9, F1LW30, O08721, O08722, O08747, O62683, O95049, O95185, O97758, P39447, P57105, Q07157, Q0P5E6, Q13424, Q28626, Q32LE7, Q3T0C9, Q5EBL8, Q5ZIK2, Q61234, Q6NXB2, Q6QA76, Q6R653, Q6UXZ4, Q6ZN44, Q761X5, Q7KRY7, Q7T2Z5, Q80VW5, Q86UL8, Q8IV45, Q8IZJ1, Q8JGT4, Q8K1S2, Q8K1S3, Q8K1S4, Q95168, Q9CZG9

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 139 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
SLC-mediated transmembrane transport	10	6.7×	6e-04
Transport of small molecules	16	4.5×	2e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

4 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	4
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

737 predictions. Top by Δscore:

Variant	Effect	Δscore
14:70375670:ACCT:A	donor_loss	1.0000
14:70375671:CCTA:C	donor_loss	1.0000
14:70375672:CTA:C	donor_loss	1.0000
14:70375673:TA:T	donor_loss	1.0000
14:70375674:AC:A	donor_gain	1.0000
14:70375674:ACCCT:A	donor_loss	1.0000
14:70375675:C:CG	donor_loss	1.0000
14:70375675:CC:C	donor_gain	1.0000
14:70375767:TTTAC:T	acceptor_gain	1.0000
14:70375768:TTAC:T	acceptor_gain	1.0000
14:70375769:TAC:T	acceptor_gain	1.0000
14:70375772:C:CC	acceptor_gain	1.0000
14:70375772:C:G	acceptor_loss	1.0000
14:70388482:A:AC	donor_gain	1.0000
14:70388482:ATCAC:A	donor_gain	1.0000
14:70388489:T:A	donor_gain	1.0000
14:70388489:T:TA	donor_gain	1.0000
14:70388617:CA:C	acceptor_gain	1.0000
14:70416896:ATAC:A	donor_loss	1.0000
14:70416897:TACCT:T	donor_loss	1.0000
14:70416898:ACC:A	donor_loss	1.0000
14:70416898:ACCT:A	donor_loss	1.0000
14:70416899:C:CA	donor_loss	1.0000
14:70416929:T:TA	donor_gain	1.0000
14:70375674:A:AC	donor_gain	0.9900
14:70375674:ACC:A	donor_gain	0.9900
14:70375675:C:CC	donor_gain	0.9900
14:70375675:CCC:C	donor_gain	0.9900
14:70375675:CCCT:C	donor_gain	0.9900
14:70375705:AG:A	donor_gain	0.9900

AlphaMissense

942 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
14:70388477:A:G	I65T	1.000
14:70388540:A:T	V44D	1.000
14:70388591:A:T	I27N	1.000
14:70388597:A:G	F25S	1.000
14:70375692:A:G	L94P	0.999
14:70375719:A:G	F85S	0.999
14:70388472:A:G	S67P	0.999
14:70388477:A:C	I65S	0.999
14:70388495:A:G	L59P	0.999
14:70388495:A:T	L59H	0.999
14:70388591:A:C	I27S	0.999
14:70388600:C:A	G24V	0.999
14:70388601:C:G	G24R	0.999
14:70416917:A:G	L16P	0.999
14:70375741:G:C	H78D	0.998
14:70388477:A:T	I65N	0.998
14:70388483:T:A	D63V	0.998
14:70388483:T:C	D63G	0.998
14:70388498:C:G	R58P	0.998
14:70388582:C:T	G30E	0.998
14:70388585:C:A	G29V	0.998
14:70388585:C:T	G29D	0.998
14:70388586:C:A	G29C	0.998
14:70388586:C:G	G29R	0.998
14:70388591:A:G	I27T	0.998
14:70388600:C:T	G24D	0.998
14:70388601:C:A	G24C	0.998
14:70375722:A:G	L84P	0.997
14:70375732:C:G	A81P	0.997
14:70375767:T:A	N69I	0.997

dbSNP variants (sampled 300 via entrez): RS1000003707 (14:70387388 G>C,T), RS1000014228 (14:70404744 G>A), RS1000258763 (14:70400199 A>G), RS1000276119 (14:70380504 A>T), RS1000285168 (14:70392523 A>G), RS1000518135 (14:70414299 C>A), RS1000628183 (14:70368544 T>C), RS1000734824 (14:70375274 T>C), RS1000746111 (14:70379203 T>C), RS1000868192 (14:70417035 G>A,T), RS1000922813 (14:70386048 T>C), RS1000979830 (14:70371437 G>A), RS1001000250 (14:70388862 TAAAG>T), RS1001141443 (14:70410082 T>C), RS1001156147 (14:70395724 A>G)

Disease associations

OMIM: gene MIM:609411 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST002497_28	Blood pressure	6.000000e-07
GCST006612_94	LDL cholesterol	3.000000e-11
GCST007448_12	Normal facial asymmetry (angle of surface orientation score)	2.000000e-08
GCST010396_4	Gut microbiota (bacterial taxa, hurdle binary method)	9.000000e-06
GCST012137_4	Motor coordination	2.000000e-06

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0006335	systolic blood pressure
EFO:0004611	low density lipoprotein cholesterol measurement
EFO:0009751	facial asymmetry measurement
EFO:0007874	gut microbiome measurement
EFO:0010749	motor function measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cyclosporine	decreases expression	2
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	affects cotreatment, increases methylation	1
perfluorooctanoic acid	increases expression	1
4-aminophenylarsenoxide	affects binding, decreases reaction	1
CGP 52608	affects binding, increases reaction	1
abrine	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Temozolomide	decreases expression	1
Arsenic Trioxide	affects binding, decreases reaction	1
Fulvestrant	affects cotreatment, increases methylation	1
Acetaminophen	decreases expression	1
Air Pollutants	increases expression, increases abundance	1
Atrazine	decreases expression	1
Coumestrol	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Smoke	increases abundance, increases expression	1
Thimerosal	decreases expression	1
Thiram	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Tunicamycin	decreases expression	1
Valproic Acid	affects expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Antirheumatic Agents	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.