SYT10

Summary

SYT10 (synaptotagmin 10, HGNC:19266) is a protein-coding gene on chromosome 12p11.1, encoding Synaptotagmin-10 (Q6XYQ8). Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb.

Predicted to enable several functions, including calcium ion binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Predicted to be involved in positive regulation of calcium ion-dependent exocytosis; presynaptic dense core vesicle exocytosis; and sensory perception of smell. Predicted to be located in transport vesicle membrane. Predicted to be active in several cellular components, including exocytic vesicle; glutamatergic synapse; and presynapse.

Source: NCBI Gene 341359 — RefSeq curated summary.

At a glance

• GWAS associations: 45
• Clinical variants (ClinVar): 86 total
• MANE Select transcript: NM_198992

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19266
Approved symbol	SYT10
Name	synaptotagmin 10
Location	12p11.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000110975
Ensembl biotype	protein_coding
Entrez	341359

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 1 protein_coding, 1 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000228567, ENST00000539102, ENST00000567656

RefSeq mRNA: 1 — MANE Select: NM_198992 NM_198992

CCDS: CCDS8732

Canonical transcript exons

ENST00000228567 — 7 exons

Exon	Start	End
ENSE00001133434	33374238	33376901
ENSE00001133441	33439372	33439819
ENSE00003501552	33382349	33382520
ENSE00003603664	33406789	33407356
ENSE00003628375	33385171	33385291
ENSE00003640024	33426138	33426495
ENSE00003681252	33379832	33379961

Expression profiles

Bgee: expression breadth broad, 93 present calls, max score 80.66.

FANTOM5 (CAGE): breadth broad, TPM avg 1.1824 / max 23.8052, expressed in 291 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
130418	0.9649	248
206666	0.1550	107
130419	0.0435	17
130417	0.0190	6

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.66	gold quality
sural nerve	UBERON:0015488	73.85	gold quality
right uterine tube	UBERON:0001302	68.97	gold quality
tibial nerve	UBERON:0001323	65.65	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	61.23	gold quality
superior frontal gyrus	UBERON:0002661	60.82	gold quality
muscle layer of sigmoid colon	UBERON:0035805	60.57	gold quality
fallopian tube	UBERON:0003889	58.82	gold quality
prefrontal cortex	UBERON:0000451	58.47	gold quality
rectum	UBERON:0001052	57.74	gold quality
pituitary gland	UBERON:0000007	57.04	gold quality
colonic epithelium	UBERON:0000397	54.71	gold quality
nucleus accumbens	UBERON:0001882	54.59	gold quality
colon	UBERON:0001155	53.46	gold quality
adult mammalian kidney	UBERON:0000082	52.89	gold quality
frontal cortex	UBERON:0001870	52.69	gold quality
embryo	UBERON:0000922	52.16	silver quality
ganglionic eminence	UBERON:0004023	52.16	silver quality
duodenum	UBERON:0002114	52.03	gold quality
adenohypophysis	UBERON:0002196	52.03	gold quality
ventricular zone	UBERON:0003053	51.78	silver quality
kidney	UBERON:0002113	51.53	gold quality
intestine	UBERON:0000160	51.37	gold quality
metanephros cortex	UBERON:0010533	49.95	gold quality
caudate nucleus	UBERON:0001873	49.16	gold quality
hypothalamus	UBERON:0001898	49.13	gold quality
stomach	UBERON:0000945	48.91	gold quality
fundus of stomach	UBERON:0001160	48.50	gold quality
smooth muscle tissue	UBERON:0001135	48.45	gold quality
corpus callosum	UBERON:0002336	48.42	silver quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.55
E-GEOD-124858	no	1.26

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

95 targeting SYT10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-3682-5P	99.93	67.97	1163
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-8063	99.91	69.76	3146
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-106A-5P	99.90	73.94	2683
HSA-MIR-548E-5P	99.89	72.73	4486
HSA-MIR-17-5P	99.89	73.83	2665
HSA-MIR-106B-5P	99.88	74.72	2795
HSA-MIR-20A-5P	99.88	74.76	2769
HSA-MIR-20B-5P	99.88	74.01	2621
HSA-MIR-519D-3P	99.88	73.97	2607

Literature-anchored findings (GeneRIF, showing 1)

• This cDNA clone is 3287 bp and contains an open reading frame from 299 to 1870 encoding a putative protein of 523 amino acids. It shares 94.6 and 94.8% homology to rat Syt 10 and mouse Syt 10 at protein level, respectively. (PMID:14756426)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	syt10	ENSDARG00000045750
mus_musculus	Syt10	ENSMUSG00000063260
rattus_norvegicus	Syt10	ENSRNOG00000014296

Paralogs (31): SYT7 (ENSG00000011347), SYT13 (ENSG00000019505), SYT1 (ENSG00000067715), RPH3A (ENSG00000089169), SYTL4 (ENSG00000102362), SYT17 (ENSG00000103528), SYT5 (ENSG00000129990), SYT11 (ENSG00000132718), SYT4 (ENSG00000132872), SYT6 (ENSG00000134207), SYTL2 (ENSG00000137501), SYT16 (ENSG00000139973), SYTL1 (ENSG00000142765), SYT14 (ENSG00000143469), SYT2 (ENSG00000143858), SYTL5 (ENSG00000147041), SYT8 (ENSG00000149043), DOC2A (ENSG00000149927), SYTL3 (ENSG00000164674), TC2N (ENSG00000165929), SYT9 (ENSG00000170743), SYT12 (ENSG00000173227), RPH3AL (ENSG00000181031), C2CD4C (ENSG00000183186), C2CD4A (ENSG00000198535), SYT15 (ENSG00000204176), C2CD4B (ENSG00000205502), SYT3 (ENSG00000213023), C2CD4D (ENSG00000225556), DOC2B (ENSG00000272636), SYT15B (ENSG00000277758)

Protein

Protein identifiers

Synaptotagmin-10 — Q6XYQ8 (reviewed: Q6XYQ8)

Alternative names: Synaptotagmin X

All UniProt accessions (2): Q6XYQ8, F5GZB8

UniProt curated annotations — full annotation on UniProt →

Function. Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis. Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis.

Subunit / interactions. Homodimer; disulfide-linked via the cysteine motif. Can also form heterodimers with SYT3, SYT6, SYT7 and SYT9.

Subcellular location. Cytoplasmic vesicle. Secretory vesicle membrane.

Tissue specificity. Expressed only in pancreas, lung and kidney.

Cofactor. Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.

Domain organisation. The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds. The first C2 domain mediates Ca(2+)-dependent phospholipid binding.

Similarity. Belongs to the synaptotagmin family.

RefSeq proteins (1): NP_945343* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000008	C2_dom	Domain
IPR001565	Synaptotagmin	Domain
IPR035892	C2_domain_sf	Homologous_superfamily

Pfam: PF00168

UniProt features (28 total): binding site 16, sequence variant 4, topological domain 2, domain 2, chain 1, transmembrane region 1, modified residue 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6XYQ8-F1	73.68	0.42

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (16): 320; 320; 321; 322; 322; 322; 325; 328; 328; 394; 400; 454 …

Post-translational modifications (1): 136

Function

Pathways and Gene Ontology

Reactome pathways

8 pathways

ID	Pathway
R-HSA-6794361	Neurexins and neuroligins
R-HSA-9768919	NPAS4 regulates expression of target genes
R-HSA-112316	Neuronal System
R-HSA-212436	Generic Transcription Pathway
R-HSA-6794362	Protein-protein interactions at synapses
R-HSA-73857	RNA Polymerase II Transcription
R-HSA-74160	Gene expression (Transcription)
R-HSA-9634815	Transcriptional Regulation by NPAS4

MSigDB gene sets: 121 (showing top): GOBP_POSITIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS, GOBP_REGULATION_OF_EXOCYTOSIS, GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_NEUROTRANSMITTER_TRANSPORT, GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_CELL_CELL_SIGNALING, GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT, chr12p11, GOBP_EXOCYTOSIS, GOBP_POSITIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY, GOBP_POSITIVE_REGULATION_OF_EXOCYTOSIS, GOBP_SECRETION, GOBP_REGULATION_OF_REGULATED_SECRETORY_PATHWAY, GOBP_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS, TGANTCA_AP1_C

GO Biological Process (6): exocytosis (GO:0006887), chemical synaptic transmission (GO:0007268), sensory perception of smell (GO:0007608), vesicle-mediated transport (GO:0016192), regulation of calcium ion-dependent exocytosis (GO:0017158), positive regulation of calcium ion-dependent exocytosis (GO:0045956)

GO Molecular Function (10): SNARE binding (GO:0000149), phosphatidylserine binding (GO:0001786), calcium ion binding (GO:0005509), calcium-dependent phospholipid binding (GO:0005544), phosphatidylinositol-4,5-bisphosphate binding (GO:0005546), protein homodimerization activity (GO:0042803), protein heterodimerization activity (GO:0046982), calcium ion sensor activity (GO:0061891), identical protein binding (GO:0042802), metal ion binding (GO:0046872)

GO Cellular Component (7): plasma membrane (GO:0005886), transport vesicle membrane (GO:0030658), exocytic vesicle (GO:0070382), presynapse (GO:0098793), glutamatergic synapse (GO:0098978), membrane (GO:0016020), cytoplasmic vesicle (GO:0031410)

Reactome top-level categories

Rollup of top-6 pathways:

Category	Pathways
Protein-protein interactions at synapses	1
Transcriptional Regulation by NPAS4	1
RNA Polymerase II Transcription	1
Neuronal System	1
Gene expression (Transcription)	1
Generic Transcription Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
calcium-ion regulated exocytosis	2
protein binding	2
phospholipid binding	2
protein dimerization activity	2
transport vesicle	2
synapse	2
cellular anatomical structure	2
vesicle-mediated transport	1
secretion by cell	1
vesicle fusion to plasma membrane	1
anterograde trans-synaptic signaling	1
sensory perception of chemical stimulus	1
transport	1
cellular process	1
regulation of regulated secretory pathway	1
regulation of calcium ion-dependent exocytosis	1
positive regulation of regulated secretory pathway	1
anion binding	1
modified amino acid binding	1
metal ion binding	1
phosphatidylinositol phosphate binding	1
phosphatidylinositol bisphosphate binding	1
identical protein binding	1
calcium ion binding	1
metal ion sensor activity	1
cation binding	1
membrane	1
cell periphery	1
cytoplasmic vesicle membrane	1
bounding membrane of organelle	1
secretory vesicle	1
cytoplasm	1
intracellular vesicle	1

Protein interactions and networks

STRING

894 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SYT10	KIAA1755	Q5JYT7	542
SYT10	SNAP25	P13795	531
SYT10	UNC13A	Q9UPW8	500
SYT10	SYT13	Q7L8C5	472
SYT10	AFAP1L1	Q8TED9	471
SYT10	RPH3AL	Q9UNE2	460
SYT10	CCDC141	Q6ZP82	458
SYT10	CPPED1	Q9BRF8	447
SYT10	VAMP1	P23763	433
SYT10	SYT1	P21579	429
SYT10	KLHL2	O95198	420
SYT10	TDRD5	Q8NAT2	420
SYT10	MED13L	Q71F56	418
SYT10	CPNE8	Q86YQ8	418
SYT10	RNPEP	Q9H4A4	416

IntAct

7 interactions, top by confidence:

A	B	Type	Score
SYT3	PGK2	psi-mi:“MI:0914”(association)	0.530
SYT6	SYT10	psi-mi:“MI:0914”(association)	0.350
SYT3	YES1	psi-mi:“MI:0914”(association)	0.350

BioGRID (8): SYT10 (Affinity Capture-MS), SYT10 (Affinity Capture-MS), SYT10 (Affinity Capture-MS), SYT10 (Affinity Capture-MS), SYT10 (Affinity Capture-MS), SYT10 (Affinity Capture-Western), SYT10 (Affinity Capture-MS), SYT10 (Affinity Capture-MS)

ESM2 similar proteins: A0A8I3NFE2, A0FGR8, A0FGR9, A2AP18, A4IJ05, O08625, O08874, O15357, O75038, P51432, P70218, P70268, Q01970, Q12851, Q3TZZ7, Q3U7R1, Q4VX76, Q5DTI8, Q5FWL4, Q5M7N9, Q5R8Q5, Q5RAG2, Q5RCK6, Q5RJH2, Q61161, Q62807, Q63433, Q6DN12, Q6XYQ8, Q7ZWU7, Q812E4, Q86SS6, Q8K394, Q8TDW5, Q920M7, Q925C0, Q92918, Q99JE6, Q99N48, Q9BSJ8

Diamond homologs: A0A075F932, A0FGR8, A4IJ05, K8FE10, O00445, O00750, O08625, O08835, O35681, O43581, P04409, P05128, P05129, P05130, P05696, P10102, P10829, P13677, P17252, P20444, P21521, P21579, P21707, P24505, P24506, P24507, P29101, P34693, P40748, P40749, P41823, P41885, P46096, P46097, P47191, P47708, P47709, P47861, P48018, P50232

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

86 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	74
Likely benign	2
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

1484 predictions. Top by Δscore:

Variant	Effect	Δscore
12:33382345:ATAC:A	donor_loss	1.0000
12:33382346:TA:T	donor_loss	1.0000
12:33382347:A:C	donor_loss	1.0000
12:33382352:T:C	donor_gain	1.0000
12:33382516:AGGAT:A	acceptor_gain	1.0000
12:33382517:GGAT:G	acceptor_gain	1.0000
12:33382518:GAT:G	acceptor_gain	1.0000
12:33382518:GATC:G	acceptor_loss	1.0000
12:33382521:C:CC	acceptor_gain	1.0000
12:33382521:C:T	acceptor_loss	1.0000
12:33382522:T:C	acceptor_loss	1.0000
12:33385287:CTTTC:C	acceptor_gain	1.0000
12:33376902:C:CC	acceptor_gain	0.9900
12:33382342:CACAT:C	donor_loss	0.9900
12:33382343:ACATA:A	donor_loss	0.9900
12:33382347:A:AC	donor_gain	0.9900
12:33382348:C:CC	donor_gain	0.9900
12:33382348:CCTAT:C	donor_gain	0.9900
12:33382518:GATCT:G	acceptor_gain	0.9900
12:33382519:AT:A	acceptor_gain	0.9900
12:33382519:ATCT:A	acceptor_gain	0.9900
12:33407371:A:C	acceptor_gain	0.9900
12:33426131:T:A	donor_gain	0.9900
12:33426132:CCTTA:C	donor_loss	0.9900
12:33426133:CTTAC:C	donor_loss	0.9900
12:33426134:TTA:T	donor_loss	0.9900
12:33426135:T:TG	donor_loss	0.9900
12:33426136:A:AC	donor_gain	0.9900
12:33426136:ACCGG:A	donor_loss	0.9900
12:33426137:C:A	donor_loss	0.9900

AlphaMissense

3456 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:33379849:A:G	W495R	1.000
12:33379849:A:T	W495R	1.000
12:33379891:A:G	W481R	1.000
12:33379891:A:T	W481R	1.000
12:33379938:C:T	G465E	1.000
12:33382364:A:T	V452D	1.000
12:33382412:A:G	F436S	1.000
12:33382436:G:T	P428H	1.000
12:33382499:A:G	L407P	1.000
12:33382511:A:T	V403D	1.000
12:33385200:A:G	L390P	1.000
12:33385208:G:C	C387W	1.000
12:33385210:A:G	C387R	1.000
12:33385218:A:T	V384D	1.000
12:33385233:C:G	R379P	1.000
12:33406874:C:T	G331E	1.000
12:33406875:C:A	G331W	1.000
12:33379839:A:C	L498W	0.999
12:33379847:C:A	W495C	0.999
12:33379847:C:G	W495C	0.999
12:33379889:C:A	W481C	0.999
12:33379889:C:G	W481C	0.999
12:33379890:C:G	W481S	0.999
12:33379938:C:A	G465V	0.999
12:33379939:C:G	G465R	0.999
12:33379939:C:T	G465R	0.999
12:33382352:T:G	D456A	0.999
12:33382358:T:G	D454A	0.999
12:33382376:A:G	L448P	0.999
12:33382411:A:C	F436L	0.999

dbSNP variants (sampled 300 via entrez): RS1000045311 (12:33434856 C>A,T), RS1000103954 (12:33392605 T>C), RS1000177843 (12:33380339 T>C), RS1000194539 (12:33377553 A>G), RS1000227721 (12:33387018 A>G), RS1000282256 (12:33428618 G>A), RS1000337785 (12:33416610 A>C,G), RS1000358293 (12:33422995 C>A), RS1000389072 (12:33406228 A>T), RS1000389364 (12:33422852 A>G), RS1000530421 (12:33410750 A>G), RS1000556059 (12:33441184 A>G), RS1000611723 (12:33428950 G>T), RS1000791899 (12:33411085 T>G), RS1000982772 (12:33404596 C>G,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

45 associations (top):

Study	Trait	p-value
GCST001969_4	Heart rate	6.000000e-24
GCST003818_39	Resting heart rate	7.000000e-34
GCST003984_3	Parkinson’s disease	4.000000e-21
GCST004732_4	Heart rate variability traits (pvRSA/HF)	2.000000e-14
GCST004732_6	Heart rate variability traits (pvRSA/HF)	6.000000e-15
GCST004733_11	Heart rate variability traits (RMSSD)	2.000000e-22
GCST004733_20	Heart rate variability traits (RMSSD)	3.000000e-20
GCST004734_4	Heart rate variability traits (SDNN)	7.000000e-13
GCST004734_5	Heart rate variability traits (SDNN)	3.000000e-15
GCST005787_10	Heart rate response to exercise	2.000000e-11
GCST005787_7	Heart rate response to exercise	3.000000e-10
GCST005788_19	Heart rate response to recovery post exercise	1.000000e-26
GCST005789_2	Resting heart rate	4.000000e-12
GCST005789_21	Resting heart rate	5.000000e-11
GCST005845_8	Heart rate increase in response to exercise	3.000000e-30
GCST005846_13	Heart rate response to recovery post exercise (10 sec)	5.000000e-66
GCST005847_14	Heart rate response to recovery post exercise (20 sec)	3.000000e-58
GCST005848_2	Heart rate response to recovery post exercise (50 sec)	8.000000e-54
GCST005849_5	Heart rate response to recovery post exercise (40 sec)	2.000000e-57
GCST005850_11	Heart rate response to recovery post exercise (30 sec)	4.000000e-56
GCST007217_7	RR interval (heart rate)	6.000000e-09
GCST007565_131	Morning person	1.000000e-27
GCST007565_200	Morning person	7.000000e-31
GCST007565_204	Morning person	3.000000e-35
GCST007565_212	Morning person	3.000000e-40
GCST007565_31	Morning person	2.000000e-14
GCST007565_71	Morning person	4.000000e-22
GCST007576_332	Chronotype	3.000000e-40
GCST009391_1141	Metabolite levels	8.000000e-06
GCST010242_238	HDL cholesterol levels	1.000000e-08

EFO canonical traits (8, from GWAS)

EFO ID	Trait name
EFO:0008003	heart rate variability measurement
EFO:0009184	heart rate response to exercise
EFO:0009185	heart rate response to recovery post exercise
EFO:0004831	RR interval
EFO:0008328	chronotype measurement
EFO:0010458	alpha-hydroxybutyric acid measurement
EFO:0004612	high density lipoprotein cholesterol measurement
EFO:0004327	electrocardiography

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases expression, increases methylation	2
CGP 52608	affects binding, increases reaction	1
Resveratrol	affects cotreatment, decreases expression	1
Ethanol	increases expression	1
Caffeine	decreases expression	1
Copper	affects cotreatment, decreases expression	1
Tobacco Smoke Pollution	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.