SYT5

Summary

SYT5 (synaptotagmin 5, HGNC:11513) is a protein-coding gene on chromosome 19q13.42, encoding Synaptotagmin-5 (O00445). May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 [PubMed 7597049]).

Source: NCBI Gene 6861 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 63 total
• MANE Select transcript: NM_003180

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11513
Approved symbol	SYT5
Name	synaptotagmin 5
Location	19q13.42
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000129990
Ensembl biotype	protein_coding
OMIM	600782
Entrez	6861

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 14 protein_coding, 2 retained_intron, 1 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000354308, ENST00000537500, ENST00000585461, ENST00000587067, ENST00000588305, ENST00000589172, ENST00000590851, ENST00000590859, ENST00000592470, ENST00000592935, ENST00000592956, ENST00000868679, ENST00000868681, ENST00000868684, ENST00000868686, ENST00000868688, ENST00000868689, ENST00000948087

RefSeq mRNA: 2 — MANE Select: NM_003180 NM_001297774, NM_003180

CCDS: CCDS12919, CCDS74455

Canonical transcript exons

ENST00000354308 — 9 exons

Exon	Start	End
ENSE00001399834	55178963	55179086
ENSE00001420293	55180117	55180289
ENSE00002764071	55171196	55173684
ENSE00003218618	55178196	55178368
ENSE00003532046	55175709	55175876
ENSE00003626470	55175172	55175339
ENSE00003659981	55176005	55176124
ENSE00003661240	55174882	55174999
ENSE00003672621	55174517	55174650

Expression profiles

Bgee: expression breadth ubiquitous, 182 present calls, max score 97.61.

FANTOM5 (CAGE): breadth broad, TPM avg 5.7764 / max 231.4682, expressed in 433 samples.

FANTOM5 promoters (15 alternative TSS)

Promoter ID	TPM avg	Samples expressed
182736	1.8463	268
182745	1.6576	162
182743	1.3456	180
182739	0.1445	54
182735	0.1054	59
182744	0.1025	49
182737	0.0971	60
182742	0.0860	48
182741	0.0821	51
182738	0.0795	39

Top tissues by expression

284 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	97.61	gold quality
prefrontal cortex	UBERON:0000451	96.86	gold quality
right frontal lobe	UBERON:0002810	96.52	gold quality
cingulate cortex	UBERON:0003027	95.54	gold quality
anterior cingulate cortex	UBERON:0009835	95.52	gold quality
nucleus accumbens	UBERON:0001882	95.23	gold quality
caudate nucleus	UBERON:0001873	95.17	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	94.67	gold quality
Brodmann (1909) area 9	UBERON:0013540	94.12	gold quality
frontal cortex	UBERON:0001870	93.69	gold quality
putamen	UBERON:0001874	93.59	gold quality
Brodmann (1909) area 10	UBERON:0013541	93.51	gold quality
amygdala	UBERON:0001876	93.30	gold quality
neocortex	UBERON:0001950	93.30	gold quality
pituitary gland	UBERON:0000007	92.38	gold quality
telencephalon	UBERON:0001893	91.53	gold quality
cerebral cortex	UBERON:0000956	91.48	gold quality
adenohypophysis	UBERON:0002196	91.35	gold quality
forebrain	UBERON:0001890	91.24	gold quality
islet of Langerhans	UBERON:0000006	90.31	gold quality
hypothalamus	UBERON:0001898	90.18	gold quality
Ammon’s horn	UBERON:0001954	88.75	gold quality
brain	UBERON:0000955	87.97	gold quality
frontal pole	UBERON:0002795	87.57	gold quality
central nervous system	UBERON:0001017	87.45	gold quality
temporal lobe	UBERON:0001871	87.40	gold quality
superior frontal gyrus	UBERON:0002661	85.63	gold quality
Brodmann (1909) area 46	UBERON:0006483	83.90	gold quality
postcentral gyrus	UBERON:0002581	83.72	gold quality
middle frontal gyrus	UBERON:0002702	83.71	silver quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-HCAD-5	yes	14.61
E-ANND-3	yes	4.59

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

36 targeting SYT5, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-6856-5P	100.00	65.47	1298
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-219A-5P	99.91	73.36	735
HSA-MIR-4782-3P	99.88	73.31	735
HSA-MIR-6766-3P	99.88	73.38	732
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-6842-5P	99.80	67.54	1587
HSA-MIR-7110-5P	99.80	67.84	1712
HSA-MIR-6752-5P	99.59	67.32	1243
HSA-MIR-6751-5P	99.56	64.99	1145
HSA-MIR-486-3P	99.51	66.82	1901
HSA-MIR-6081	99.48	66.07	1446
HSA-MIR-330-3P	99.41	69.95	2521
HSA-MIR-889-5P	99.41	68.75	1025
HSA-MIR-7109-5P	99.18	66.13	1057
HSA-MIR-1253	99.12	67.08	1688
HSA-MIR-4651	99.06	67.57	2002
HSA-MIR-608	98.93	67.83	2013
HSA-MIR-508-3P	98.66	69.62	887
HSA-MIR-7155-5P	98.65	66.14	1290
HSA-MIR-3135B	98.61	65.33	1470
HSA-MIR-92A-1-5P	98.28	64.51	631
HSA-MIR-93-3P	98.15	66.65	1309
HSA-MIR-6819-5P	97.96	66.59	1071
HSA-MIR-6847-5P	97.93	66.74	1808
HSA-MIR-6737-5P	97.75	66.54	1044
HSA-MIR-4675	97.69	64.82	774
HSA-MIR-4741	97.69	64.14	883

Literature-anchored findings (GeneRIF, showing 4)

• results suggest a novel putative functional role for the GST-synaptotagmin V complex in human breast cancers. As this association of GST M1-synaptotagmin was not seen in adjacent non-cancerous tissues, this can be used as a marker for breast cancers. (PMID:15820774)
• This protein has been found differentially expressed in thalami from patients with schizophrenia. (PMID:20471030)
• crystals of synaptotagmin 5 belonged to the hexagonal space group P6(5), with unit-cell parameters a = b = 93.97, c = 28.05 A. (PMID:22102235)
• Ca(2+)-binding pocket of synaptotagmin 5 C2A domain (PMID:27793683)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Syt5	ENSMUSG00000004961
rattus_norvegicus	Syt5	ENSRNOG00000018217

Paralogs (31): SYT7 (ENSG00000011347), SYT13 (ENSG00000019505), SYT1 (ENSG00000067715), RPH3A (ENSG00000089169), SYTL4 (ENSG00000102362), SYT17 (ENSG00000103528), SYT10 (ENSG00000110975), SYT11 (ENSG00000132718), SYT4 (ENSG00000132872), SYT6 (ENSG00000134207), SYTL2 (ENSG00000137501), SYT16 (ENSG00000139973), SYTL1 (ENSG00000142765), SYT14 (ENSG00000143469), SYT2 (ENSG00000143858), SYTL5 (ENSG00000147041), SYT8 (ENSG00000149043), DOC2A (ENSG00000149927), SYTL3 (ENSG00000164674), TC2N (ENSG00000165929), SYT9 (ENSG00000170743), SYT12 (ENSG00000173227), RPH3AL (ENSG00000181031), C2CD4C (ENSG00000183186), C2CD4A (ENSG00000198535), SYT15 (ENSG00000204176), C2CD4B (ENSG00000205502), SYT3 (ENSG00000213023), C2CD4D (ENSG00000225556), DOC2B (ENSG00000272636), SYT15B (ENSG00000277758)

Protein

Protein identifiers

Synaptotagmin-5 — O00445 (reviewed: O00445)

Alternative names: Synaptotagmin V

All UniProt accessions (7): O00445, K7EJ95, K7EJC4, K7EJS7, K7EQ59, M0QYJ7, Q4FD32

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface.

Subunit / interactions. Homodimer. Interacts with both alpha- and beta-tubulin.

Subcellular location. Cytoplasmic vesicle. Secretory vesicle. Synaptic vesicle membrane. Recycling endosome membrane.

Cofactor. Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.

Similarity. Belongs to the synaptotagmin family.

Isoforms (2)

UniProt ID	Names	Canonical?
O00445-1	1	yes
O00445-2	2

RefSeq proteins (2): NP_001284703, NP_003171* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000008	C2_dom	Domain
IPR001565	Synaptotagmin	Domain
IPR035892	C2_domain_sf	Homologous_superfamily

Pfam: PF00168

UniProt features (43 total): binding site 17, strand 9, topological domain 2, splice variant 2, sequence variant 2, helix 2, domain 2, chain 1, transmembrane region 1, mutagenesis site 1, sequence conflict 1, turn 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
5H4Y	X-RAY DIFFRACTION	1.9
5H4Z	X-RAY DIFFRACTION	3.01

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O00445-F1	84.16	0.59

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (17): 139; 145; 197; 197; 198; 199; 199; 199; 202; 205; 205; 270 …

Mutagenesis-validated functional residues (1):

Position	Phenotype
202	does not affect ca(2+) affinity as measured by isothermal titration calorimetry of the mutant protein.

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-422356	Regulation of insulin secretion
R-HSA-1430728	Metabolism
R-HSA-163685	Integration of energy metabolism

MSigDB gene sets: 210 (showing top): GOBP_REGULATION_OF_VESICLE_FUSION, MORF_FLT1, MODULE_274, MORF_MSH3, GOCC_SECRETORY_GRANULE, GOBP_VESICLE_ORGANIZATION, MORF_BRCA1, GOBP_MEMBRANE_FUSION, GOBP_REGULATION_OF_EXOCYTOSIS, GOBP_NEUROTRANSMITTER_TRANSPORT, GOBP_VESICLE_MEDIATED_TRANSPORT, MORF_ESR1, GOBP_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION, MORF_RAD51L3, GOBP_CELL_CELL_SIGNALING

GO Biological Process (5): chemical synaptic transmission (GO:0007268), vesicle-mediated transport (GO:0016192), regulation of calcium ion-dependent exocytosis (GO:0017158), calcium-dependent activation of synaptic vesicle fusion (GO:0099502), regulation of synaptic vesicle exocytosis (GO:2000300)

GO Molecular Function (10): SNARE binding (GO:0000149), phosphatidylserine binding (GO:0001786), calcium ion binding (GO:0005509), calcium-dependent phospholipid binding (GO:0005544), phosphatidylinositol-4,5-bisphosphate binding (GO:0005546), syntaxin binding (GO:0019905), clathrin binding (GO:0030276), protein heterodimerization activity (GO:0046982), calcium ion sensor activity (GO:0061891), metal ion binding (GO:0046872)

GO Cellular Component (15): plasma membrane (GO:0005886), axon (GO:0030424), synaptic vesicle membrane (GO:0030672), dense core granule (GO:0031045), neuronal cell body (GO:0043025), perinuclear region of cytoplasm (GO:0048471), recycling endosome membrane (GO:0055038), exocytic vesicle (GO:0070382), neuronal dense core vesicle membrane (GO:0099012), proximal neuron projection (GO:1990769), endosome (GO:0005768), membrane (GO:0016020), cytoplasmic vesicle (GO:0031410), neuron projection (GO:0043005), synapse (GO:0045202)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Integration of energy metabolism	1
Metabolism	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of regulated secretory pathway	2
synaptic vesicle exocytosis	2
protein binding	2
phospholipid binding	2
neuron projection	2
cytoplasm	2
cellular anatomical structure	2
anterograde trans-synaptic signaling	1
transport	1
cellular process	1
calcium-ion regulated exocytosis	1
positive regulation of synaptic vesicle fusion to presynaptic active zone membrane	1
regulation of neurotransmitter secretion	1
anion binding	1
modified amino acid binding	1
metal ion binding	1
phosphatidylinositol phosphate binding	1
phosphatidylinositol bisphosphate binding	1
SNARE binding	1
protein dimerization activity	1
calcium ion binding	1
metal ion sensor activity	1
cation binding	1
membrane	1
cell periphery	1
synaptic vesicle	1
exocytic vesicle membrane	1
secretory granule	1
somatodendritic compartment	1
cell body	1
endosome membrane	1
recycling endosome	1
transport vesicle	1
secretory vesicle	1
dense core granule membrane	1
neuronal dense core vesicle	1
endomembrane system	1
cytoplasmic vesicle	1
intracellular vesicle	1
plasma membrane bounded cell projection	1

Protein interactions and networks

STRING

616 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SYT5	UBXN2B	Q14CS0	462
SYT5	NCKIPSD	Q9NZQ3	418
SYT5	RDH13	Q8NBN7	417
SYT5	ARFRP1	Q13795	414
SYT5	STXBP1	P61764	410
SYT5	VAMP2	P19065	382
SYT5	MPZL1	O95297	372
SYT5	NCKAP5L	Q9HCH0	370
SYT5	TMEM94	Q12767	369
SYT5	TFPT	P0C1Z6	367
SYT5	SNAP25	P13795	364
SYT5	SYN2	Q92777	350
SYT5	VAMP3	Q15836	343
SYT5	STX1A	Q16623	343
SYT5	VAMP8	Q9BV40	336

IntAct

19 interactions, top by confidence:

A	B	Type	Score
SYT5	SYT1	psi-mi:“MI:0914”(association)	0.530
SYT1	SYT5	psi-mi:“MI:0914”(association)	0.530
SYT2	SYT5	psi-mi:“MI:0915”(physical association)	0.400
SYT5	HTR6	psi-mi:“MI:0915”(physical association)	0.370
SYT5	SHANK3	psi-mi:“MI:0915”(physical association)	0.370
POLR2E	SYT5	psi-mi:“MI:0915”(physical association)	0.370
MAPT	SHTN1	psi-mi:“MI:0914”(association)	0.350
CACNA1C	SYT5	psi-mi:“MI:0914”(association)	0.350
CACNA1C	IGLL5	psi-mi:“MI:0914”(association)	0.350
CACNA1C	CACNB4	psi-mi:“MI:0914”(association)	0.350
CACNA1C	DISP2	psi-mi:“MI:0914”(association)	0.350
HCN1	POTEF	psi-mi:“MI:0914”(association)	0.350
DNAJC5	SYT5	psi-mi:“MI:2364”(proximity)	0.270
RAB1A	SYT5	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (17): ATP6V1C2 (Affinity Capture-MS), PALM2 (Affinity Capture-MS), SYT1 (Affinity Capture-MS), SYT1 (Affinity Capture-MS), ATP6V1C2 (Affinity Capture-MS), PALM2 (Affinity Capture-MS), DNAJC5 (FRET), SYT5 (Two-hybrid), SYT5 (Negative Genetic), SYT5 (Affinity Capture-Western), SYT5 (Two-hybrid), PALM2 (Affinity Capture-MS), ATP6V1C2 (Affinity Capture-MS), NEU2 (Affinity Capture-MS), SYT1 (Affinity Capture-MS)

ESM2 similar proteins: A0FGR8, A0FGR9, O00445, O08835, O35681, O75038, P05129, P10688, P10829, P10895, P21579, P21707, P21709, P24505, P24506, P29101, P40748, P41823, P46096, P46097, P47861, P48018, P51178, P54760, P63318, P63319, P70611, Q06418, Q14183, Q3TZZ7, Q3U7R1, Q4R4U2, Q5DTI8, Q5FWL4, Q5M7N9, Q5R4J5, Q5RAG2, Q60HC0, Q7TNF0, Q8K2J0

Diamond homologs: A0A075F932, A0FGR8, A4IJ05, K8FE10, O00445, O00750, O08625, O08835, O35681, O43581, P04409, P05128, P05129, P05130, P05696, P10102, P10829, P13677, P17252, P20444, P21521, P21579, P21707, P24505, P24506, P24507, P29101, P34693, P40748, P40749, P41823, P41885, P46096, P46097, P47191, P47708, P47709, P47861, P48018, P50232

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

63 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	58
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1471 predictions. Top by Δscore:

Variant	Effect	Δscore
19:55173695:C:CT	acceptor_gain	1.0000
19:55173697:C:CT	acceptor_gain	1.0000
19:55173698:G:T	acceptor_gain	1.0000
19:55174511:GCTCA:G	donor_loss	1.0000
19:55174512:CTCAC:C	donor_loss	1.0000
19:55174513:TCACC:T	donor_loss	1.0000
19:55174514:CACCT:C	donor_loss	1.0000
19:55174515:ACCTG:A	donor_loss	1.0000
19:55174516:C:CA	donor_loss	1.0000
19:55174646:TGGAT:T	acceptor_gain	1.0000
19:55174647:GGAT:G	acceptor_gain	1.0000
19:55174648:GAT:G	acceptor_gain	1.0000
19:55174649:AT:A	acceptor_gain	1.0000
19:55174651:C:CC	acceptor_gain	1.0000
19:55174651:CTGGG:C	acceptor_loss	1.0000
19:55174879:CACCT:C	donor_loss	1.0000
19:55174880:ACCTG:A	donor_loss	1.0000
19:55174881:C:G	donor_loss	1.0000
19:55174899:T:TA	donor_gain	1.0000
19:55174995:TCCTG:T	acceptor_gain	1.0000
19:55174996:CCTGC:C	acceptor_gain	1.0000
19:55174997:CTG:C	acceptor_gain	1.0000
19:55174998:TG:T	acceptor_gain	1.0000
19:55174999:GCTGA:G	acceptor_loss	1.0000
19:55175000:C:CC	acceptor_gain	1.0000
19:55175000:C:G	acceptor_loss	1.0000
19:55175001:T:G	acceptor_loss	1.0000
19:55175167:CTCA:C	donor_loss	1.0000
19:55175168:TCA:T	donor_loss	1.0000
19:55175169:CA:C	donor_loss	1.0000

AlphaMissense

2471 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:55173532:C:A	W371C	1.000
19:55173532:C:G	W371C	1.000
19:55173623:C:T	G341E	1.000
19:55174566:G:T	P304H	1.000
19:55174641:A:T	V279D	1.000
19:55174921:C:G	A263P	1.000
19:55174929:A:T	V260D	1.000
19:55173534:A:G	W371R	0.999
19:55173534:A:T	W371R	0.999
19:55173623:C:A	G341V	0.999
19:55173624:C:A	G341W	0.999
19:55174583:C:A	K298N	0.999
19:55174583:C:G	K298N	0.999
19:55174593:G:A	T295I	0.999
19:55174645:A:C	Y278D	0.999
19:55174647:G:T	P277Q	0.999
19:55174911:A:G	L266P	0.999
19:55174911:A:T	L266Q	0.999
19:55174935:A:T	V258D	0.999
19:55174941:A:G	L256P	0.999
19:55174941:A:T	L256H	0.999
19:55174968:A:G	L247P	0.999
19:55174968:A:T	L247H	0.999
19:55174986:C:A	G241V	0.999
19:55174986:C:T	G241E	0.999
19:55174987:C:A	G241W	0.999
19:55174987:C:G	G241R	0.999
19:55174987:C:T	G241R	0.999
19:55175257:C:T	G208E	0.999
19:55175764:G:A	T162I	0.999

dbSNP variants (sampled 300 via entrez): RS1000398942 (19:55181322 C>T), RS1000832513 (19:55178806 AC>A), RS1000859461 (19:55176642 G>A), RS1000953753 (19:55176902 G>A), RS1001604146 (19:55175436 G>A,T), RS1001947434 (19:55180923 C>T), RS1002301356 (19:55171988 A>G), RS1002755077 (19:55172324 G>A), RS1002870750 (19:55174204 G>A,C), RS1003191616 (19:55173039 G>T), RS1003215614 (19:55181937 C>G,T), RS1003307740 (19:55173369 G>A,C), RS1003681498 (19:55178006 G>A), RS1003954823 (19:55179282 C>G,T), RS1004430210 (19:55173443 G>A)

Disease associations

OMIM: gene MIM:600782 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST90002400_98	Plateletcrit	4.000000e-09
GCST90002401_300	Platelet distribution width	6.000000e-10

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0007985	platelet crit
EFO:0007984	platelet component distribution width

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

21 total (human), top 21 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects acetylation, affects methylation, increases expression	3
Air Pollutants	increases abundance, increases expression	2
Smoke	decreases expression, increases abundance, increases expression	2
aristolochic acid I	increases expression	1
sotorasib	affects cotreatment, decreases expression	1
ethyl-p-hydroxybenzoate	decreases expression	1
CGP 52608	affects binding, increases reaction	1
monomethylarsonous acid	affects acetylation, affects methylation	1
abrine	increases expression	1
trametinib	affects cotreatment, decreases expression	1
NVP-BKM120	affects cotreatment, decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Arsenic	affects methylation	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Methotrexate	decreases expression	1
Niclosamide	increases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Tretinoin	increases expression	1
Valproic Acid	increases methylation	1
Particulate Matter	increases abundance, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.